EPHA3 (EPH receptor A3)

Gene

• Entrez ID: 2042
• Gene name: EPH receptor A3
• Gene symbol: EPHA3
• Synonyms: EK4, ETK, ETK1, HEK, HEK4, TYRO4
• Chromosome: 3
• Chromosome location: 3p11.1
• Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically ha

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT966382	hsa-miR-1322	CLIP-seq
MIRT966383	hsa-miR-135a	CLIP-seq
MIRT966384	hsa-miR-135b	CLIP-seq
MIRT966385	hsa-miR-23a	CLIP-seq
MIRT966386	hsa-miR-23b	CLIP-seq
MIRT966387	hsa-miR-23c	CLIP-seq
MIRT966388	hsa-miR-3121-3p	CLIP-seq
MIRT966389	hsa-miR-3692	CLIP-seq
MIRT966390	hsa-miR-3910	CLIP-seq
MIRT966391	hsa-miR-3922-5p	CLIP-seq
MIRT966392	hsa-miR-4297	CLIP-seq
MIRT966393	hsa-miR-4691-3p	CLIP-seq
MIRT966394	hsa-miR-4729	CLIP-seq
MIRT966395	hsa-miR-4789-5p	CLIP-seq
MIRT966396	hsa-miR-4802-3p	CLIP-seq
MIRT966397	hsa-miR-1257	CLIP-seq
MIRT966398	hsa-miR-203	CLIP-seq
MIRT966399	hsa-miR-3200-5p	CLIP-seq
MIRT966400	hsa-miR-3616-5p	CLIP-seq
MIRT966401	hsa-miR-3647-5p	CLIP-seq
MIRT966402	hsa-miR-3682-5p	CLIP-seq
MIRT966403	hsa-miR-4427	CLIP-seq
MIRT966404	hsa-miR-4680-3p	CLIP-seq
MIRT966405	hsa-miR-4766-5p	CLIP-seq
MIRT966406	hsa-miR-4795-5p	CLIP-seq
MIRT966407	hsa-miR-573	CLIP-seq
MIRT966398	hsa-miR-203	CLIP-seq
MIRT966399	hsa-miR-3200-5p	CLIP-seq
MIRT966405	hsa-miR-4766-5p	CLIP-seq
MIRT966398	hsa-miR-203	CLIP-seq
MIRT966399	hsa-miR-3200-5p	CLIP-seq
MIRT966405	hsa-miR-4766-5p	CLIP-seq
MIRT1986233	hsa-miR-3646	CLIP-seq
MIRT1986234	hsa-miR-3929	CLIP-seq
MIRT1986235	hsa-miR-4311	CLIP-seq
MIRT1986236	hsa-miR-4419b	CLIP-seq
MIRT1986237	hsa-miR-4478	CLIP-seq
MIRT1986235	hsa-miR-4311	CLIP-seq
MIRT2220852	hsa-miR-545	CLIP-seq
MIRT2428606	hsa-miR-586	CLIP-seq
MIRT2437018	hsa-miR-208a	CLIP-seq
MIRT2437019	hsa-miR-208b	CLIP-seq
MIRT2437020	hsa-miR-3617	CLIP-seq
MIRT2437021	hsa-miR-4666-5p	CLIP-seq
MIRT2437022	hsa-miR-499-5p	CLIP-seq
MIRT2437023	hsa-miR-641	CLIP-seq
MIRT2465229	hsa-miR-198	CLIP-seq
MIRT2524546	hsa-miR-1305	CLIP-seq
MIRT2524547	hsa-miR-607	CLIP-seq
MIRT2524546	hsa-miR-1305	CLIP-seq
MIRT2680175	hsa-miR-3613-3p	CLIP-seq
MIRT2524547	hsa-miR-607	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AES	Unknown	20676368

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA	21873635
GO:0005003	Function	Ephrin receptor activity	IDA	11519828
GO:0005004	Function	GPI-linked ephrin receptor activity	IDA	11870224
GO:0005005	Function	Transmembrane-ephrin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11519828, 11870224, 21135139
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005769	Component	Early endosome	IDA	21135139
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	11870224, 21135139
GO:0007155	Process	Cell adhesion	IEA
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007275	Process	Multicellular organism development	IBA	21873635
GO:0007411	Process	Axon guidance	IBA	21873635
GO:0010717	Process	Regulation of epithelial to mesenchymal transition	ISS
GO:0010976	Process	Positive regulation of neuron projection development	IMP	17910947
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016477	Process	Cell migration	ISS
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IDA
GO:0031965	Component	Nuclear membrane	IDA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IDA	11870224
GO:0033674	Process	Positive regulation of kinase activity	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043087	Process	Regulation of GTPase activity	IDA	11870224
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0045806	Process	Negative regulation of endocytosis	IDA
GO:0048013	Process	Ephrin receptor signaling pathway	IDA	11870224
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0051893	Process	Regulation of focal adhesion assembly	IDA	11870224
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IDA	11870224
GO:0071300	Process	Cellular response to retinoic acid	IMP	17910947
GO:0097155	Process	Fasciculation of sensory neuron axon	ISS
GO:0097156	Process	Fasciculation of motor neuron axon	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IDA

Other IDs

• MIM: 179611
• HGNC: 3387
• e!Ensembl: ENSG00000044524

Protein

• UniProt ID: P29320
• Protein name: Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
• Protein function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is
• PDB: 2GSF, 2QO2, 2QO7, 2QO9, 2QOB, 2QOC, 2QOD, 2QOF, 2QOI, 2QOK, 2QOL, 2QON, 2QOO, 2QOQ, 3DZQ, 3FXX, 3FY2, 4G2F, 4GK2, 4GK3, 4GK4, 4L0P, 4P4C, 4P5Q, 4P5Z, 4TWN, 4TWO, 6IN0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01404	Ephrin_lbd	30 → 202	Ephrin receptor ligand binding domain	Domain
  PF07699	Ephrin_rec_like	263 → 306	Putative ephrin-receptor like	Family
  PF00041	fn3	327 → 422	Fibronectin type III domain	Domain
  PF00041	fn3	437 → 521	Fibronectin type III domain	Domain
  PF14575	EphA2_TM	542 → 618	Ephrin type-A receptor 2 transmembrane domain	Domain
  PF07714	PK_Tyr_Ser-Thr	621 → 878	Protein tyrosine and serine/threonine kinase	Domain
  PF07647	SAM_2	908 → 973	SAM domain (Sterile alpha motif)	Domain

• Sequence:

  MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDE
  HYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETF
  NLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFY
  LAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPP
  RMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDG
  SMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFN
  IICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSS
  PPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQ
  ETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESS
  QVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPH
  TYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT
  EKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTV
  IQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT
  TRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG
  YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSN
  LLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVG
  PQKKIISSIKALETQSKNGPVPV

• Sequence length: 983

Pathways

KEGG:

Axon guidance

Reactome:

EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	30061737, 29892015
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Lung carcinoma	Squamous cell carcinoma of lung, Carcinoma of lung, Large cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382

Unknown
Disease name	Disease term	dbSNP ID	References
Malignant neoplasm	Malignant Neoplasms
Pancreatic adenocarcinoma	Pancreatic Ductal Adenocarcinoma	rs121908291, rs139375029, rs587780197, rs587780198, rs587780200, rs374741161, rs368806050, rs113676921, rs587780753, rs550499593, rs143544548, rs587780754, rs587780755, rs587780756, rs114593924, rs587780757, rs587780758, rs532961259, rs587780759, rs535155432, rs543821321, rs587780760, rs587780761, rs368350042, rs368890611, rs200060953, rs559000839, rs587780762, rs142116575, rs150764613, rs62333013, rs59633770, rs370602081, rs759105985, rs535118290, rs528879194, rs863224705, rs758706279, rs780516159, rs863224383, rs863224384, rs777359545, rs863224385, rs570874237, rs863224386, rs753092219, rs769161509, rs143417961, rs140360991, rs201707558, rs863224702, rs754158038, rs863224382, rs761530979, rs780692056, rs863224703, rs114250766, rs113515140, rs863224704, rs561750970, rs864622627, rs864622590, rs864622422, rs864622140, rs730882137, rs864622087, rs864622226, rs864622591, rs864622321, rs864622158, rs864622531, rs767729090, rs749041581, rs768485147, rs864622234, rs864622355, rs864622316, rs864622388, rs764242515, rs778134231, rs771679229, rs746599370, rs551131343, rs878854264, rs878854265, rs878854266, rs878854267, rs878854268, rs376654786, rs373500403, rs114171764, rs376394488, rs61051061, rs1806729, rs548068667, rs781516286, rs1059444, rs750112132, rs7673220, rs1060502975, rs778471055, rs925242863, rs143717202, rs372414187, rs927644209, rs764265611, rs1060502976, rs554297134, rs997146277, rs1060502974, rs1060504775, rs200020758, rs1060502973, rs777453756, rs952110792, rs1553965295, rs1553973196, rs1177108180, rs1477864263, rs368472947, rs182571219, rs1553984987, rs1263751006, rs201979617, rs1358006173, rs151071844, rs115937217, rs568490721, rs189021816, rs1319983866, rs1553965480, rs1553969553, rs1385898569, rs1553965526, rs1553968628, rs763802548, rs752296365, rs1553965214, rs1474793366, rs1553965326, rs778313832, rs1318598425, rs1470434769, rs755223646, rs557697540, rs747702421, rs1560940853, rs1560839872, rs1216822754, rs751364707, rs372708613, rs1560929667, rs1306250811, rs774034818, rs551420048, rs1581871066, rs1221751077, rs1220928329, rs759161069, rs757164572, rs115274645, rs769973229, rs115988233, rs767384375, rs778210310, rs1305250587, rs1239099971, rs1025237623, rs1211489449, rs900642927, rs1400689367, rs140584890, rs757885388, rs1231114395, rs996343137, rs1275232115, rs1046350904, rs762267147, rs373066707, rs867266337, rs1460784357, rs748432333, rs769517051, rs1560937938, rs750033888, rs781065277, rs1751999027, rs1246689760, rs1752077261, rs1754079127, rs1754736103, rs1757056910, rs114673468, rs756934356, rs1176026649, rs1762161869, rs200399043, rs1447433925, rs1389221540, rs893660432, rs1762582426
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	rs199865688, rs397515994, rs757096307	29892015, 30061737