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ENSA (endosulfine alpha)

Gene

2029

Endosulfine alpha

ENSA

ARPP-19e

1q21.3

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive

Show/Hide all(307)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051695	hsa-let-7e-5p	CLASH	23622248
MIRT036994	hsa-miR-877-3p	CLASH	23622248
MIRT676892	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT676891	hsa-miR-1245a	HITS-CLIP	23824327
MIRT676890	hsa-miR-8079	HITS-CLIP	23824327
MIRT676889	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT676888	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676887	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT676886	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT676885	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT676884	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT676883	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT676882	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT676881	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676880	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676879	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676878	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676877	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT676876	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT676875	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676874	hsa-miR-640	HITS-CLIP	23824327
MIRT676873	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT676872	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676871	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT636582	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT636581	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT636580	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT636579	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT636578	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT636577	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT636576	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT636575	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT636574	hsa-miR-4284	HITS-CLIP	23824327
MIRT636573	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT636572	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT560478	hsa-miR-4428	PAR-CLIP	20371350
MIRT560476	hsa-miR-4463	PAR-CLIP	20371350
MIRT560477	hsa-miR-6873-5p	PAR-CLIP	20371350
MIRT560475	hsa-miR-5584-5p	PAR-CLIP	20371350
MIRT560474	hsa-miR-873-3p	PAR-CLIP	20371350
MIRT560473	hsa-miR-6124	PAR-CLIP	20371350
MIRT560472	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560471	hsa-miR-6077	PAR-CLIP	20371350
MIRT560470	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT676892	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT676891	hsa-miR-1245a	HITS-CLIP	23824327
MIRT676890	hsa-miR-8079	HITS-CLIP	23824327
MIRT676889	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT676888	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676887	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT676886	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT676885	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT676884	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT676883	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT676882	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT676881	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676880	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676879	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676878	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676877	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT676876	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT676875	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676874	hsa-miR-640	HITS-CLIP	23824327
MIRT676873	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT676872	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676871	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT636582	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT636581	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT636580	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT636579	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT636578	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT636577	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT636576	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT636575	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT636574	hsa-miR-4284	HITS-CLIP	23824327
MIRT636573	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT636572	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT560478	hsa-miR-4428	PAR-CLIP	20371350
MIRT560476	hsa-miR-4463	PAR-CLIP	20371350
MIRT560477	hsa-miR-6873-5p	PAR-CLIP	20371350
MIRT560475	hsa-miR-5584-5p	PAR-CLIP	20371350
MIRT560474	hsa-miR-873-3p	PAR-CLIP	20371350
MIRT560473	hsa-miR-6124	PAR-CLIP	20371350
MIRT560472	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560471	hsa-miR-6077	PAR-CLIP	20371350
MIRT560470	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT964153	hsa-miR-1	CLIP-seq
MIRT964154	hsa-miR-150	CLIP-seq
MIRT964155	hsa-miR-1587	CLIP-seq
MIRT964156	hsa-miR-206	CLIP-seq
MIRT964157	hsa-miR-2355-5p	CLIP-seq
MIRT964158	hsa-miR-3121-5p	CLIP-seq
MIRT964159	hsa-miR-3145-3p	CLIP-seq
MIRT964160	hsa-miR-3145-5p	CLIP-seq
MIRT964161	hsa-miR-3151	CLIP-seq
MIRT964162	hsa-miR-3170	CLIP-seq
MIRT964163	hsa-miR-3653	CLIP-seq
MIRT964164	hsa-miR-3658	CLIP-seq
MIRT964165	hsa-miR-4286	CLIP-seq
MIRT964166	hsa-miR-4307	CLIP-seq
MIRT964167	hsa-miR-4437	CLIP-seq
MIRT964168	hsa-miR-4447	CLIP-seq
MIRT964169	hsa-miR-4472	CLIP-seq
MIRT964170	hsa-miR-4674	CLIP-seq
MIRT964171	hsa-miR-4691-5p	CLIP-seq
MIRT964172	hsa-miR-4713-5p	CLIP-seq
MIRT964173	hsa-miR-4760-3p	CLIP-seq
MIRT964174	hsa-miR-485-3p	CLIP-seq
MIRT964175	hsa-miR-491-5p	CLIP-seq
MIRT964176	hsa-miR-532-3p	CLIP-seq
MIRT964177	hsa-miR-574-3p	CLIP-seq
MIRT964178	hsa-miR-613	CLIP-seq
MIRT964179	hsa-miR-760	CLIP-seq
MIRT964180	hsa-miR-873	CLIP-seq
MIRT964153	hsa-miR-1	CLIP-seq
MIRT964181	hsa-miR-101	CLIP-seq
MIRT964182	hsa-miR-1184	CLIP-seq
MIRT964183	hsa-miR-1205	CLIP-seq
MIRT964184	hsa-miR-1207-5p	CLIP-seq
MIRT964185	hsa-miR-1225-3p	CLIP-seq
MIRT964186	hsa-miR-1260	CLIP-seq
MIRT964187	hsa-miR-1260b	CLIP-seq
MIRT964188	hsa-miR-1266	CLIP-seq
MIRT964189	hsa-miR-1302	CLIP-seq
MIRT964190	hsa-miR-1321	CLIP-seq
MIRT964191	hsa-miR-139-5p	CLIP-seq
MIRT964192	hsa-miR-147b	CLIP-seq
MIRT964154	hsa-miR-150	CLIP-seq
MIRT964193	hsa-miR-188-3p	CLIP-seq
MIRT964156	hsa-miR-206	CLIP-seq
MIRT964194	hsa-miR-28-5p	CLIP-seq
MIRT964195	hsa-miR-298	CLIP-seq
MIRT964196	hsa-miR-3120-3p	CLIP-seq
MIRT964197	hsa-miR-3120-5p	CLIP-seq
MIRT964198	hsa-miR-3125	CLIP-seq
MIRT964199	hsa-miR-3126-3p	CLIP-seq
MIRT964200	hsa-miR-3128	CLIP-seq
MIRT964201	hsa-miR-3139	CLIP-seq
MIRT964159	hsa-miR-3145-3p	CLIP-seq
MIRT964160	hsa-miR-3145-5p	CLIP-seq
MIRT964161	hsa-miR-3151	CLIP-seq
MIRT964202	hsa-miR-3156-3p	CLIP-seq
MIRT964203	hsa-miR-3157-5p	CLIP-seq
MIRT964204	hsa-miR-3158-5p	CLIP-seq
MIRT964205	hsa-miR-3194-3p	CLIP-seq
MIRT964206	hsa-miR-3200-5p	CLIP-seq
MIRT964163	hsa-miR-3653	CLIP-seq
MIRT964164	hsa-miR-3658	CLIP-seq
MIRT964207	hsa-miR-3660	CLIP-seq
MIRT964208	hsa-miR-3662	CLIP-seq
MIRT964209	hsa-miR-3664-3p	CLIP-seq
MIRT964210	hsa-miR-3670	CLIP-seq
MIRT964211	hsa-miR-3907	CLIP-seq
MIRT964212	hsa-miR-3910	CLIP-seq
MIRT964213	hsa-miR-3916	CLIP-seq
MIRT964214	hsa-miR-409-3p	CLIP-seq
MIRT964215	hsa-miR-4270	CLIP-seq
MIRT964216	hsa-miR-4271	CLIP-seq
MIRT964217	hsa-miR-4283	CLIP-seq
MIRT964218	hsa-miR-4298	CLIP-seq
MIRT964166	hsa-miR-4307	CLIP-seq
MIRT964219	hsa-miR-4441	CLIP-seq
MIRT964220	hsa-miR-4518	CLIP-seq
MIRT964221	hsa-miR-4526	CLIP-seq
MIRT964222	hsa-miR-4534	CLIP-seq
MIRT964223	hsa-miR-4645-3p	CLIP-seq
MIRT964224	hsa-miR-4653-3p	CLIP-seq
MIRT964225	hsa-miR-4661-5p	CLIP-seq
MIRT964226	hsa-miR-4690-3p	CLIP-seq
MIRT964227	hsa-miR-4691-3p	CLIP-seq
MIRT964171	hsa-miR-4691-5p	CLIP-seq
MIRT964228	hsa-miR-4700-3p	CLIP-seq
MIRT964172	hsa-miR-4713-5p	CLIP-seq
MIRT964229	hsa-miR-4716-5p	CLIP-seq
MIRT964230	hsa-miR-4720-5p	CLIP-seq
MIRT964231	hsa-miR-4725-3p	CLIP-seq
MIRT964232	hsa-miR-4728-5p	CLIP-seq
MIRT964233	hsa-miR-4729	CLIP-seq
MIRT964234	hsa-miR-4731-5p	CLIP-seq
MIRT964235	hsa-miR-4733-3p	CLIP-seq
MIRT964236	hsa-miR-4739	CLIP-seq
MIRT964237	hsa-miR-4756-5p	CLIP-seq
MIRT964173	hsa-miR-4760-3p	CLIP-seq
MIRT964238	hsa-miR-4762-5p	CLIP-seq
MIRT964239	hsa-miR-4763-3p	CLIP-seq
MIRT964240	hsa-miR-4797-5p	CLIP-seq
MIRT964241	hsa-miR-4799-3p	CLIP-seq
MIRT964174	hsa-miR-485-3p	CLIP-seq
MIRT964242	hsa-miR-486-3p	CLIP-seq
MIRT964243	hsa-miR-494	CLIP-seq
MIRT964244	hsa-miR-498	CLIP-seq
MIRT964245	hsa-miR-513c	CLIP-seq
MIRT964246	hsa-miR-514b-5p	CLIP-seq
MIRT964176	hsa-miR-532-3p	CLIP-seq
MIRT964247	hsa-miR-545	CLIP-seq
MIRT964178	hsa-miR-613	CLIP-seq
MIRT964248	hsa-miR-708	CLIP-seq
MIRT964180	hsa-miR-873	CLIP-seq
MIRT964249	hsa-miR-877	CLIP-seq
MIRT964153	hsa-miR-1	CLIP-seq
MIRT964156	hsa-miR-206	CLIP-seq
MIRT964160	hsa-miR-3145-5p	CLIP-seq
MIRT964166	hsa-miR-4307	CLIP-seq
MIRT964178	hsa-miR-613	CLIP-seq
MIRT964186	hsa-miR-1260	CLIP-seq
MIRT964187	hsa-miR-1260b	CLIP-seq
MIRT964250	hsa-miR-1280	CLIP-seq
MIRT964251	hsa-miR-1305	CLIP-seq
MIRT964154	hsa-miR-150	CLIP-seq
MIRT964160	hsa-miR-3145-5p	CLIP-seq
MIRT964171	hsa-miR-4691-5p	CLIP-seq
MIRT964172	hsa-miR-4713-5p	CLIP-seq
MIRT964173	hsa-miR-4760-3p	CLIP-seq
MIRT964174	hsa-miR-485-3p	CLIP-seq
MIRT964176	hsa-miR-532-3p	CLIP-seq
MIRT964154	hsa-miR-150	CLIP-seq
MIRT964226	hsa-miR-4690-3p	CLIP-seq
MIRT2220275	hsa-miR-3667-3p	CLIP-seq
MIRT2448871	hsa-miR-1248	CLIP-seq
MIRT2448872	hsa-miR-3124-3p	CLIP-seq
MIRT2448873	hsa-miR-4446-5p	CLIP-seq
MIRT2448874	hsa-miR-4755-5p	CLIP-seq
MIRT2448875	hsa-miR-4778-3p	CLIP-seq
MIRT2465225	hsa-miR-1253	CLIP-seq
MIRT2465226	hsa-miR-143	CLIP-seq
MIRT2465227	hsa-miR-4770	CLIP-seq
MIRT2465228	hsa-miR-580	CLIP-seq
MIRT964184	hsa-miR-1207-5p	CLIP-seq
MIRT964190	hsa-miR-1321	CLIP-seq
MIRT964191	hsa-miR-139-5p	CLIP-seq
MIRT2524169	hsa-miR-3064-5p	CLIP-seq
MIRT964160	hsa-miR-3145-5p	CLIP-seq
MIRT964161	hsa-miR-3151	CLIP-seq
MIRT2524170	hsa-miR-3179	CLIP-seq
MIRT2524171	hsa-miR-3202	CLIP-seq
MIRT2524172	hsa-miR-331-3p	CLIP-seq
MIRT964210	hsa-miR-3670	CLIP-seq
MIRT964212	hsa-miR-3910	CLIP-seq
MIRT964215	hsa-miR-4270	CLIP-seq
MIRT964216	hsa-miR-4271	CLIP-seq
MIRT964219	hsa-miR-4441	CLIP-seq
MIRT2524173	hsa-miR-4476	CLIP-seq
MIRT2524174	hsa-miR-4688	CLIP-seq
MIRT964228	hsa-miR-4700-3p	CLIP-seq
MIRT2524175	hsa-miR-4722-5p	CLIP-seq
MIRT964231	hsa-miR-4725-3p	CLIP-seq
MIRT964232	hsa-miR-4728-5p	CLIP-seq
MIRT964233	hsa-miR-4729	CLIP-seq
MIRT964235	hsa-miR-4733-3p	CLIP-seq
MIRT964236	hsa-miR-4739	CLIP-seq
MIRT964237	hsa-miR-4756-5p	CLIP-seq
MIRT964239	hsa-miR-4763-3p	CLIP-seq
MIRT964240	hsa-miR-4797-5p	CLIP-seq
MIRT964242	hsa-miR-486-3p	CLIP-seq
MIRT964243	hsa-miR-494	CLIP-seq
MIRT2524176	hsa-miR-508-5p	CLIP-seq
MIRT2524177	hsa-miR-515-5p	CLIP-seq
MIRT2524178	hsa-miR-604	CLIP-seq
MIRT2524179	hsa-miR-647	CLIP-seq
MIRT964242	hsa-miR-486-3p	CLIP-seq
MIRT964242	hsa-miR-486-3p	CLIP-seq
MIRT964153	hsa-miR-1	CLIP-seq
MIRT964184	hsa-miR-1207-5p	CLIP-seq
MIRT964188	hsa-miR-1266	CLIP-seq
MIRT964190	hsa-miR-1321	CLIP-seq
MIRT964191	hsa-miR-139-5p	CLIP-seq
MIRT964156	hsa-miR-206	CLIP-seq
MIRT2524169	hsa-miR-3064-5p	CLIP-seq
MIRT964160	hsa-miR-3145-5p	CLIP-seq
MIRT964161	hsa-miR-3151	CLIP-seq
MIRT964203	hsa-miR-3157-5p	CLIP-seq
MIRT2524170	hsa-miR-3179	CLIP-seq
MIRT2524171	hsa-miR-3202	CLIP-seq
MIRT2524172	hsa-miR-331-3p	CLIP-seq
MIRT964163	hsa-miR-3653	CLIP-seq
MIRT964164	hsa-miR-3658	CLIP-seq
MIRT964209	hsa-miR-3664-3p	CLIP-seq
MIRT2220275	hsa-miR-3667-3p	CLIP-seq
MIRT964210	hsa-miR-3670	CLIP-seq
MIRT964212	hsa-miR-3910	CLIP-seq
MIRT964215	hsa-miR-4270	CLIP-seq
MIRT964216	hsa-miR-4271	CLIP-seq
MIRT964166	hsa-miR-4307	CLIP-seq
MIRT2680094	hsa-miR-4436b-5p	CLIP-seq
MIRT964219	hsa-miR-4441	CLIP-seq
MIRT2524173	hsa-miR-4476	CLIP-seq
MIRT964220	hsa-miR-4518	CLIP-seq
MIRT2524174	hsa-miR-4688	CLIP-seq
MIRT964227	hsa-miR-4691-3p	CLIP-seq
MIRT964228	hsa-miR-4700-3p	CLIP-seq
MIRT2524175	hsa-miR-4722-5p	CLIP-seq
MIRT964231	hsa-miR-4725-3p	CLIP-seq
MIRT964232	hsa-miR-4728-5p	CLIP-seq
MIRT964233	hsa-miR-4729	CLIP-seq
MIRT964235	hsa-miR-4733-3p	CLIP-seq
MIRT964236	hsa-miR-4739	CLIP-seq
MIRT964237	hsa-miR-4756-5p	CLIP-seq
MIRT964239	hsa-miR-4763-3p	CLIP-seq
MIRT964240	hsa-miR-4797-5p	CLIP-seq
MIRT964242	hsa-miR-486-3p	CLIP-seq
MIRT964243	hsa-miR-494	CLIP-seq
MIRT2524176	hsa-miR-508-5p	CLIP-seq
MIRT2524177	hsa-miR-515-5p	CLIP-seq
MIRT2524178	hsa-miR-604	CLIP-seq
MIRT964178	hsa-miR-613	CLIP-seq
MIRT2524179	hsa-miR-647	CLIP-seq
MIRT964180	hsa-miR-873	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	ISS
GO:0000278	Process	Mitotic cell cycle	ISS
GO:0004864	Function	Protein phosphatase inhibitor activity	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IDA	9653196
GO:0005515	Function	Protein binding	IPI	21044950
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007584	Process	Response to nutrient	TAS	9653196
GO:0008200	Function	Ion channel inhibitor activity	TAS	9653196
GO:0019212	Function	Phosphatase inhibitor activity	ISS
GO:0019870	Function	Potassium channel inhibitor activity	IDA	9653196
GO:0019888	Function	Protein phosphatase regulator activity	ISS
GO:0032515	Process	Negative regulation of phosphoprotein phosphatase activity	IEA
GO:0035308	Process	Negative regulation of protein dephosphorylation	IBA	21873635
GO:0050796	Process	Regulation of insulin secretion	IDA	9653196
GO:0051301	Process	Cell division	IEA
GO:0051721	Function	Protein phosphatase 2A binding	ISS

MIM	HGNC	e!Ensembl
603061	3360	ENSG00000143420

Protein

UniProt ID

O43768

Protein name

Alpha-endosulfine (ARPP-19e)

Protein function

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04667	Endosulfine	10 → 114	cAMP-regulated phosphoprotein/endosulfine conserved region	Family

Sequence

MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQK
GQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQV
E

Sequence length

121

Interactions

View interactions

	Reactome
			MASTL Facilitates Mitotic Progression

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Hypoplastic left heart syndrome	HYPOPLASTIC LEFT HEART SYNDROME 1, HYPOPLASTIC LEFT HEART SYNDROME 2	rs1554284604, rs1843006535	26965164

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Myocardial ischemia	Myocardial Ischemia		16214533

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