ZBTB7C (zinc finger and BTB domain containing 7C)

Gene

• Entrez ID: 201501
• Gene name: Zinc finger and BTB domain containing 7C
• Gene symbol: ZBTB7C
• Synonyms: APM-1, APM1, ZBTB36, ZNF857C
• Chromosome: 18
• Chromosome location: 18q21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018542	hsa-miR-335-5p	Microarray	18185580
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT642849	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT642849	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT642848	hsa-miR-1972	HITS-CLIP	23824327
MIRT642847	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT642849	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT642849	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT642848	hsa-miR-1972	HITS-CLIP	23824327
MIRT642847	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT621567	hsa-miR-8485	HITS-CLIP	23824327
MIRT621566	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621565	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT756287	hsa-miR-26a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	37562773
MIRT1504787	hsa-miR-1229	CLIP-seq
MIRT1504788	hsa-miR-1238	CLIP-seq
MIRT1504789	hsa-miR-1321	CLIP-seq
MIRT1504790	hsa-miR-1538	CLIP-seq
MIRT1504791	hsa-miR-1827	CLIP-seq
MIRT1504792	hsa-miR-185	CLIP-seq
MIRT1504793	hsa-miR-2110	CLIP-seq
MIRT1504794	hsa-miR-28-5p	CLIP-seq
MIRT1504795	hsa-miR-3120-3p	CLIP-seq
MIRT1504796	hsa-miR-3139	CLIP-seq
MIRT1504797	hsa-miR-3144-5p	CLIP-seq
MIRT1504798	hsa-miR-3150a-3p	CLIP-seq
MIRT1504799	hsa-miR-3173-3p	CLIP-seq
MIRT1504800	hsa-miR-3183	CLIP-seq
MIRT1504801	hsa-miR-3184	CLIP-seq
MIRT1504802	hsa-miR-3191	CLIP-seq
MIRT1504803	hsa-miR-342-3p	CLIP-seq
MIRT1504804	hsa-miR-3612	CLIP-seq
MIRT1504805	hsa-miR-377	CLIP-seq
MIRT1504806	hsa-miR-378g	CLIP-seq
MIRT1504807	hsa-miR-3940-3p	CLIP-seq
MIRT1504808	hsa-miR-3974	CLIP-seq
MIRT1504809	hsa-miR-423-5p	CLIP-seq
MIRT1504810	hsa-miR-4266	CLIP-seq
MIRT1504811	hsa-miR-4270	CLIP-seq
MIRT1504812	hsa-miR-4292	CLIP-seq
MIRT1504813	hsa-miR-4306	CLIP-seq
MIRT1504814	hsa-miR-4419a	CLIP-seq
MIRT1504815	hsa-miR-4420	CLIP-seq
MIRT1504816	hsa-miR-4428	CLIP-seq
MIRT1504817	hsa-miR-4437	CLIP-seq
MIRT1504818	hsa-miR-4441	CLIP-seq
MIRT1504819	hsa-miR-4459	CLIP-seq
MIRT1504820	hsa-miR-4476	CLIP-seq
MIRT1504821	hsa-miR-4510	CLIP-seq
MIRT1504822	hsa-miR-4533	CLIP-seq
MIRT1504823	hsa-miR-4644	CLIP-seq
MIRT1504824	hsa-miR-4652-5p	CLIP-seq
MIRT1504825	hsa-miR-4668-5p	CLIP-seq
MIRT1504826	hsa-miR-4674	CLIP-seq
MIRT1504827	hsa-miR-4695-5p	CLIP-seq
MIRT1504828	hsa-miR-4722-3p	CLIP-seq
MIRT1504829	hsa-miR-4723-3p	CLIP-seq
MIRT1504830	hsa-miR-4728-5p	CLIP-seq
MIRT1504831	hsa-miR-4739	CLIP-seq
MIRT1504832	hsa-miR-4745-3p	CLIP-seq
MIRT1504833	hsa-miR-4747-3p	CLIP-seq
MIRT1504834	hsa-miR-4756-5p	CLIP-seq
MIRT1504835	hsa-miR-493	CLIP-seq
MIRT1504836	hsa-miR-508-5p	CLIP-seq
MIRT1504837	hsa-miR-545	CLIP-seq
MIRT1504838	hsa-miR-548p	CLIP-seq
MIRT1504839	hsa-miR-634	CLIP-seq
MIRT1504840	hsa-miR-650	CLIP-seq
MIRT1504841	hsa-miR-651	CLIP-seq
MIRT1504842	hsa-miR-665	CLIP-seq
MIRT1504843	hsa-miR-708	CLIP-seq
MIRT1504844	hsa-miR-766	CLIP-seq
MIRT1504845	hsa-miR-873	CLIP-seq
MIRT1504788	hsa-miR-1238	CLIP-seq
MIRT1504800	hsa-miR-3183	CLIP-seq
MIRT1504829	hsa-miR-4723-3p	CLIP-seq
MIRT1922504	hsa-miR-4753-3p	CLIP-seq
MIRT1504788	hsa-miR-1238	CLIP-seq
MIRT1504800	hsa-miR-3183	CLIP-seq
MIRT1504829	hsa-miR-4723-3p	CLIP-seq
MIRT1922504	hsa-miR-4753-3p	CLIP-seq
MIRT2151982	hsa-miR-1178	CLIP-seq
MIRT2151983	hsa-miR-1202	CLIP-seq
MIRT2151984	hsa-miR-129-5p	CLIP-seq
MIRT1504800	hsa-miR-3183	CLIP-seq
MIRT2151985	hsa-miR-3664-3p	CLIP-seq
MIRT2151986	hsa-miR-3934	CLIP-seq
MIRT2151987	hsa-miR-3972	CLIP-seq
MIRT2151988	hsa-miR-4423-5p	CLIP-seq
MIRT2151989	hsa-miR-4694-5p	CLIP-seq
MIRT1504829	hsa-miR-4723-3p	CLIP-seq
MIRT2151990	hsa-miR-4755-3p	CLIP-seq
MIRT2151991	hsa-miR-663b	CLIP-seq
MIRT2151992	hsa-miR-767-3p	CLIP-seq
MIRT1504845	hsa-miR-873	CLIP-seq
MIRT2372371	hsa-miR-124	CLIP-seq
MIRT2372372	hsa-miR-1243	CLIP-seq
MIRT2372373	hsa-miR-1254	CLIP-seq
MIRT2372374	hsa-miR-125a-5p	CLIP-seq
MIRT2372375	hsa-miR-125b	CLIP-seq
MIRT2372376	hsa-miR-127-5p	CLIP-seq
MIRT1504792	hsa-miR-185	CLIP-seq
MIRT2372377	hsa-miR-3116	CLIP-seq
MIRT2372378	hsa-miR-3117-5p	CLIP-seq
MIRT2372379	hsa-miR-3169	CLIP-seq
MIRT2372380	hsa-miR-3185	CLIP-seq
MIRT2372381	hsa-miR-3591-3p	CLIP-seq
MIRT2372382	hsa-miR-3611	CLIP-seq
MIRT2372383	hsa-miR-3622a-5p	CLIP-seq
MIRT2372384	hsa-miR-3650	CLIP-seq
MIRT2372385	hsa-miR-3914	CLIP-seq
MIRT2372386	hsa-miR-3915	CLIP-seq
MIRT2372387	hsa-miR-3928	CLIP-seq
MIRT1504808	hsa-miR-3974	CLIP-seq
MIRT2372388	hsa-miR-4254	CLIP-seq
MIRT2372389	hsa-miR-4265	CLIP-seq
MIRT2372390	hsa-miR-4296	CLIP-seq
MIRT1504813	hsa-miR-4306	CLIP-seq
MIRT2372391	hsa-miR-4319	CLIP-seq
MIRT2372392	hsa-miR-4320	CLIP-seq
MIRT2372393	hsa-miR-4322	CLIP-seq
MIRT2372394	hsa-miR-4417	CLIP-seq
MIRT1504814	hsa-miR-4419a	CLIP-seq
MIRT2372395	hsa-miR-4434	CLIP-seq
MIRT2372396	hsa-miR-4436a	CLIP-seq
MIRT2372397	hsa-miR-4446-3p	CLIP-seq
MIRT1504820	hsa-miR-4476	CLIP-seq
MIRT1504821	hsa-miR-4510	CLIP-seq
MIRT2372398	hsa-miR-4515	CLIP-seq
MIRT2372399	hsa-miR-4516	CLIP-seq
MIRT2372400	hsa-miR-4530	CLIP-seq
MIRT2372401	hsa-miR-4640-5p	CLIP-seq
MIRT2372402	hsa-miR-4642	CLIP-seq
MIRT1504823	hsa-miR-4644	CLIP-seq
MIRT2372403	hsa-miR-4700-3p	CLIP-seq
MIRT2372404	hsa-miR-4712-3p	CLIP-seq
MIRT2372405	hsa-miR-4721	CLIP-seq
MIRT2372406	hsa-miR-4726-5p	CLIP-seq
MIRT2372407	hsa-miR-4761-5p	CLIP-seq
MIRT2372408	hsa-miR-4797-5p	CLIP-seq
MIRT2372409	hsa-miR-506	CLIP-seq
MIRT2372410	hsa-miR-513a-5p	CLIP-seq
MIRT2372411	hsa-miR-544b	CLIP-seq
MIRT2372412	hsa-miR-548v	CLIP-seq
MIRT2372413	hsa-miR-564	CLIP-seq
MIRT2372414	hsa-miR-602	CLIP-seq
MIRT2372415	hsa-miR-610	CLIP-seq
MIRT2372416	hsa-miR-625	CLIP-seq
MIRT2372417	hsa-miR-628-5p	CLIP-seq
MIRT2372418	hsa-miR-647	CLIP-seq
MIRT2372419	hsa-miR-664	CLIP-seq
MIRT1504845	hsa-miR-873	CLIP-seq
MIRT2372420	hsa-miR-922	CLIP-seq
MIRT1504797	hsa-miR-3144-5p	CLIP-seq
MIRT2372380	hsa-miR-3185	CLIP-seq
MIRT1504802	hsa-miR-3191	CLIP-seq
MIRT2372382	hsa-miR-3611	CLIP-seq
MIRT2372384	hsa-miR-3650	CLIP-seq
MIRT1504806	hsa-miR-378g	CLIP-seq
MIRT2665400	hsa-miR-4287	CLIP-seq
MIRT1504812	hsa-miR-4292	CLIP-seq
MIRT2665401	hsa-miR-4308	CLIP-seq
MIRT1504817	hsa-miR-4437	CLIP-seq
MIRT2665402	hsa-miR-4469	CLIP-seq
MIRT1504824	hsa-miR-4652-5p	CLIP-seq
MIRT2665403	hsa-miR-4667-5p	CLIP-seq
MIRT1504826	hsa-miR-4674	CLIP-seq
MIRT2665404	hsa-miR-4685-3p	CLIP-seq
MIRT2665405	hsa-miR-4700-5p	CLIP-seq
MIRT1504797	hsa-miR-3144-5p	CLIP-seq
MIRT1504802	hsa-miR-3191	CLIP-seq
MIRT1504806	hsa-miR-378g	CLIP-seq
MIRT2665400	hsa-miR-4287	CLIP-seq
MIRT1504812	hsa-miR-4292	CLIP-seq
MIRT2665401	hsa-miR-4308	CLIP-seq
MIRT1504817	hsa-miR-4437	CLIP-seq
MIRT2665402	hsa-miR-4469	CLIP-seq
MIRT1504824	hsa-miR-4652-5p	CLIP-seq
MIRT2665403	hsa-miR-4667-5p	CLIP-seq
MIRT1504826	hsa-miR-4674	CLIP-seq
MIRT2665404	hsa-miR-4685-3p	CLIP-seq
MIRT2665405	hsa-miR-4700-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0003674	Function	Molecular_function	ND
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	9427755
GO:0045600	Process	Positive regulation of fat cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1903025	Process	Regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IEA

Other IDs

• MIM: 616591
• HGNC: 31700
• e!Ensembl: ENSG00000184828

Protein

• UniProt ID: A1YPR0
• Protein name: Zinc finger and BTB domain-containing protein 7C (Affected by papillomavirus DNA integration in ME180 cells protein 1) (APM-1) (Zinc finger and BTB domain-containing protein 36) (Zinc finger protein 857C)
• Protein function: May be a tumor suppressor gene.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	24 → 129	BTB/POZ domain	Domain
  PF00096	zf-C2H2	392 → 414	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	448 → 469	Zinc finger, C2H2 type	Domain

• Sequence:

  MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQEYRTHRSVLAACSKYFK
  KLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAGNVKHILNAARMLEIQCIV
  NVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEEEEDDDDDTEDFADQENLPDP
  QDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGHLGVIRDFSIESLLRENLYPKAN
  IPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKNRKIKEEEKEELPPP
  PPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGGLFPPWPLVEERKLKP
  KASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCTICEVRFTRQDKLKIHMRKHTGERPY
  LCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRG
  RKPAAWRAASLLFGPGGPAPDKAAFVMPPALGEVGGHLGGAAVCLPGPSPAKHFLAAPKG
  ALSLQELERQFEETQMKLFGRAQLEAERNAGGLLAFALAENVAAARPYFPLPDPWAAGLA
  GLPGLAGLNHVASMSEANN

• Sequence length: 619

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Systemic onset juvenile chronic arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	27927641
Rheumatoid arthritis	Rheumatoid Arthritis, Systemic Juvenile	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	27927641

Unknown
Disease name	Disease term	dbSNP ID	References
Still disease	Juvenile-Onset Still Disease		27927641