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FBXO45 (F-box protein 45)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
200933
Gene nameGene Name - the full gene name approved by the HGNC.
F-box protein 45
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
FBXO45
SynonymsGene synonyms aliases
Fbx45
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
SummarySummary of gene provided in NCBI Entrez Gene.
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023967 hsa-miR-1-3p Microarray 18668037
MIRT049278 hsa-miR-92a-3p CLASH 23622248
MIRT039138 hsa-miR-769-5p CLASH 23622248
MIRT703623 hsa-miR-3974 HITS-CLIP 23313552
MIRT703622 hsa-miR-624-3p HITS-CLIP 23313552
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001764 Process Neuron migration IEA
GO:0005515 Function Protein binding IPI 19581926
GO:0006511 Process Ubiquitin-dependent protein catabolic process IDA 19581926
GO:0006974 Process Cellular response to DNA damage stimulus IDA 19581926
GO:0014069 Component Postsynaptic density IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P0C2W1
Protein name F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)
Protein function Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but also plays an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12937 F-box-like
37 85
F-box-like
Domain
PF00622 SPRY
154 281
SPRY domain
Family
Sequence
Sequence length 286
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 24878430

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