Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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200933 |
Gene nameGene Name - the full gene name approved by the HGNC.
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F-box protein 45 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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FBXO45 |
SynonymsGene synonyms aliases
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Fbx45 |
ChromosomeChromosome number
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3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q29 |
SummarySummary of gene provided in NCBI Entrez Gene.
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Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P0C2W1 |
Protein name |
F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45) |
Protein function |
Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but also plays an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF12937 |
F-box-like |
37 → 85 |
F-box-like |
Domain |
PF00622 |
SPRY |
154 → 281 |
SPRY domain |
Family |
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Sequence |
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Sequence length |
286 |
Interactions |
View interactions |
Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
24878430 |
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