EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

Gene

• Entrez ID: 1981
• Gene name: Eukaryotic translation initiation factor 4 gamma 1
• Gene symbol: EIF4G1
• Synonyms: EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
• Chromosome: 3
• Chromosome location: 3q27.1
• Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition o

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs111290936	C>T	Risk-factor	Missense variant, coding sequence variant
rs112176450	G>A,T	Risk-factor	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023744	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT025464	hsa-miR-34a-5p	Sequencing	20371350
MIRT027930	hsa-miR-96-5p	Sequencing	20371350
MIRT031636	hsa-miR-16-5p	Proteomics	18668040
MIRT044854	hsa-miR-320a	CLASH	23622248
MIRT040339	hsa-miR-615-3p	CLASH	23622248
MIRT037839	hsa-miR-455-3p	CLASH	23622248
MIRT037651	hsa-miR-744-5p	CLASH	23622248
MIRT052684	hsa-miR-1260b	CLASH	23622248
MIRT437405	hsa-miR-520c-3p	BL	24497838
MIRT440735	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440735	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT958717	hsa-miR-1324	CLIP-seq
MIRT958718	hsa-miR-3127-3p	CLIP-seq
MIRT958719	hsa-miR-3131	CLIP-seq
MIRT958720	hsa-miR-3157-5p	CLIP-seq
MIRT958721	hsa-miR-361-3p	CLIP-seq
MIRT958722	hsa-miR-3690	CLIP-seq
MIRT958723	hsa-miR-3942-3p	CLIP-seq
MIRT958724	hsa-miR-3945	CLIP-seq
MIRT958725	hsa-miR-4254	CLIP-seq
MIRT958726	hsa-miR-4269	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT958728	hsa-miR-4323	CLIP-seq
MIRT958729	hsa-miR-4438	CLIP-seq
MIRT958730	hsa-miR-4452	CLIP-seq
MIRT958731	hsa-miR-4514	CLIP-seq
MIRT958732	hsa-miR-4530	CLIP-seq
MIRT958733	hsa-miR-4632	CLIP-seq
MIRT958734	hsa-miR-4645-5p	CLIP-seq
MIRT958735	hsa-miR-4673	CLIP-seq
MIRT958736	hsa-miR-4691-3p	CLIP-seq
MIRT958737	hsa-miR-4692	CLIP-seq
MIRT958738	hsa-miR-4693-3p	CLIP-seq
MIRT958739	hsa-miR-4715-3p	CLIP-seq
MIRT958740	hsa-miR-4722-3p	CLIP-seq
MIRT958741	hsa-miR-4731-5p	CLIP-seq
MIRT958742	hsa-miR-4740-3p	CLIP-seq
MIRT958743	hsa-miR-4760-3p	CLIP-seq
MIRT958744	hsa-miR-4765	CLIP-seq
MIRT958745	hsa-miR-4793-5p	CLIP-seq
MIRT958746	hsa-miR-486-3p	CLIP-seq
MIRT958747	hsa-miR-499-3p	CLIP-seq
MIRT958748	hsa-miR-499a-3p	CLIP-seq
MIRT958749	hsa-miR-503	CLIP-seq
MIRT958750	hsa-miR-5095	CLIP-seq
MIRT958751	hsa-miR-611	CLIP-seq
MIRT958752	hsa-miR-642b	CLIP-seq
MIRT958753	hsa-miR-1909	CLIP-seq
MIRT958754	hsa-miR-214	CLIP-seq
MIRT958719	hsa-miR-3131	CLIP-seq
MIRT958721	hsa-miR-361-3p	CLIP-seq
MIRT958755	hsa-miR-3619-5p	CLIP-seq
MIRT958722	hsa-miR-3690	CLIP-seq
MIRT958724	hsa-miR-3945	CLIP-seq
MIRT958725	hsa-miR-4254	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT958756	hsa-miR-4492	CLIP-seq
MIRT958757	hsa-miR-4498	CLIP-seq
MIRT958758	hsa-miR-4505	CLIP-seq
MIRT958732	hsa-miR-4530	CLIP-seq
MIRT958734	hsa-miR-4645-5p	CLIP-seq
MIRT958759	hsa-miR-4651	CLIP-seq
MIRT958735	hsa-miR-4673	CLIP-seq
MIRT958738	hsa-miR-4693-3p	CLIP-seq
MIRT958741	hsa-miR-4731-5p	CLIP-seq
MIRT958742	hsa-miR-4740-3p	CLIP-seq
MIRT958760	hsa-miR-4742-5p	CLIP-seq
MIRT958744	hsa-miR-4765	CLIP-seq
MIRT958745	hsa-miR-4793-5p	CLIP-seq
MIRT958746	hsa-miR-486-3p	CLIP-seq
MIRT958749	hsa-miR-503	CLIP-seq
MIRT958761	hsa-miR-608	CLIP-seq
MIRT958751	hsa-miR-611	CLIP-seq
MIRT958762	hsa-miR-761	CLIP-seq
MIRT958763	hsa-miR-762	CLIP-seq
MIRT958718	hsa-miR-3127-3p	CLIP-seq
MIRT958726	hsa-miR-4269	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT958729	hsa-miR-4438	CLIP-seq
MIRT958750	hsa-miR-5095	CLIP-seq
MIRT1984011	hsa-miR-1293	CLIP-seq
MIRT958717	hsa-miR-1324	CLIP-seq
MIRT958753	hsa-miR-1909	CLIP-seq
MIRT1984012	hsa-miR-1915	CLIP-seq
MIRT958754	hsa-miR-214	CLIP-seq
MIRT958718	hsa-miR-3127-3p	CLIP-seq
MIRT958719	hsa-miR-3131	CLIP-seq
MIRT958720	hsa-miR-3157-5p	CLIP-seq
MIRT1984013	hsa-miR-329	CLIP-seq
MIRT958721	hsa-miR-361-3p	CLIP-seq
MIRT958755	hsa-miR-3619-5p	CLIP-seq
MIRT1984014	hsa-miR-362-3p	CLIP-seq
MIRT1984015	hsa-miR-3657	CLIP-seq
MIRT1984016	hsa-miR-3675-3p	CLIP-seq
MIRT1984017	hsa-miR-3675-5p	CLIP-seq
MIRT1984018	hsa-miR-3679-3p	CLIP-seq
MIRT958722	hsa-miR-3690	CLIP-seq
MIRT1984019	hsa-miR-369-3p	CLIP-seq
MIRT1984020	hsa-miR-374a	CLIP-seq
MIRT1984021	hsa-miR-374b	CLIP-seq
MIRT1984022	hsa-miR-3937	CLIP-seq
MIRT958723	hsa-miR-3942-3p	CLIP-seq
MIRT958724	hsa-miR-3945	CLIP-seq
MIRT958725	hsa-miR-4254	CLIP-seq
MIRT958726	hsa-miR-4269	CLIP-seq
MIRT1984023	hsa-miR-4283	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT958728	hsa-miR-4323	CLIP-seq
MIRT958729	hsa-miR-4438	CLIP-seq
MIRT1984024	hsa-miR-4483	CLIP-seq
MIRT1984025	hsa-miR-4489	CLIP-seq
MIRT958756	hsa-miR-4492	CLIP-seq
MIRT958757	hsa-miR-4498	CLIP-seq
MIRT958758	hsa-miR-4505	CLIP-seq
MIRT1984026	hsa-miR-4529-5p	CLIP-seq
MIRT958732	hsa-miR-4530	CLIP-seq
MIRT958733	hsa-miR-4632	CLIP-seq
MIRT958734	hsa-miR-4645-5p	CLIP-seq
MIRT958759	hsa-miR-4651	CLIP-seq
MIRT1984027	hsa-miR-4669	CLIP-seq
MIRT958735	hsa-miR-4673	CLIP-seq
MIRT958736	hsa-miR-4691-3p	CLIP-seq
MIRT958738	hsa-miR-4693-3p	CLIP-seq
MIRT958739	hsa-miR-4715-3p	CLIP-seq
MIRT958740	hsa-miR-4722-3p	CLIP-seq
MIRT958741	hsa-miR-4731-5p	CLIP-seq
MIRT958742	hsa-miR-4740-3p	CLIP-seq
MIRT958760	hsa-miR-4742-5p	CLIP-seq
MIRT958744	hsa-miR-4765	CLIP-seq
MIRT958745	hsa-miR-4793-5p	CLIP-seq
MIRT958746	hsa-miR-486-3p	CLIP-seq
MIRT1984028	hsa-miR-498	CLIP-seq
MIRT958747	hsa-miR-499-3p	CLIP-seq
MIRT958748	hsa-miR-499a-3p	CLIP-seq
MIRT958749	hsa-miR-503	CLIP-seq
MIRT958750	hsa-miR-5095	CLIP-seq
MIRT1984029	hsa-miR-513a-3p	CLIP-seq
MIRT958761	hsa-miR-608	CLIP-seq
MIRT958751	hsa-miR-611	CLIP-seq
MIRT958752	hsa-miR-642b	CLIP-seq
MIRT958762	hsa-miR-761	CLIP-seq
MIRT958763	hsa-miR-762	CLIP-seq
MIRT958717	hsa-miR-1324	CLIP-seq
MIRT958718	hsa-miR-3127-3p	CLIP-seq
MIRT958719	hsa-miR-3131	CLIP-seq
MIRT958720	hsa-miR-3157-5p	CLIP-seq
MIRT958721	hsa-miR-361-3p	CLIP-seq
MIRT1984018	hsa-miR-3679-3p	CLIP-seq
MIRT1984022	hsa-miR-3937	CLIP-seq
MIRT958724	hsa-miR-3945	CLIP-seq
MIRT958726	hsa-miR-4269	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT958728	hsa-miR-4323	CLIP-seq
MIRT958729	hsa-miR-4438	CLIP-seq
MIRT958756	hsa-miR-4492	CLIP-seq
MIRT958757	hsa-miR-4498	CLIP-seq
MIRT958758	hsa-miR-4505	CLIP-seq
MIRT958731	hsa-miR-4514	CLIP-seq
MIRT1984026	hsa-miR-4529-5p	CLIP-seq
MIRT958732	hsa-miR-4530	CLIP-seq
MIRT958733	hsa-miR-4632	CLIP-seq
MIRT958734	hsa-miR-4645-5p	CLIP-seq
MIRT958735	hsa-miR-4673	CLIP-seq
MIRT958736	hsa-miR-4691-3p	CLIP-seq
MIRT958737	hsa-miR-4692	CLIP-seq
MIRT958738	hsa-miR-4693-3p	CLIP-seq
MIRT958739	hsa-miR-4715-3p	CLIP-seq
MIRT958740	hsa-miR-4722-3p	CLIP-seq
MIRT958741	hsa-miR-4731-5p	CLIP-seq
MIRT958742	hsa-miR-4740-3p	CLIP-seq
MIRT958760	hsa-miR-4742-5p	CLIP-seq
MIRT958745	hsa-miR-4793-5p	CLIP-seq
MIRT958746	hsa-miR-486-3p	CLIP-seq
MIRT958747	hsa-miR-499-3p	CLIP-seq
MIRT958748	hsa-miR-499a-3p	CLIP-seq
MIRT958749	hsa-miR-503	CLIP-seq
MIRT958750	hsa-miR-5095	CLIP-seq
MIRT958751	hsa-miR-611	CLIP-seq
MIRT958752	hsa-miR-642b	CLIP-seq
MIRT958763	hsa-miR-762	CLIP-seq
MIRT958726	hsa-miR-4269	CLIP-seq
MIRT958729	hsa-miR-4438	CLIP-seq
MIRT958747	hsa-miR-499-3p	CLIP-seq
MIRT958748	hsa-miR-499a-3p	CLIP-seq
MIRT958750	hsa-miR-5095	CLIP-seq
MIRT958752	hsa-miR-642b	CLIP-seq
MIRT958722	hsa-miR-3690	CLIP-seq
MIRT958725	hsa-miR-4254	CLIP-seq
MIRT958745	hsa-miR-4793-5p	CLIP-seq
MIRT1984011	hsa-miR-1293	CLIP-seq
MIRT958753	hsa-miR-1909	CLIP-seq
MIRT958754	hsa-miR-214	CLIP-seq
MIRT958718	hsa-miR-3127-3p	CLIP-seq
MIRT958755	hsa-miR-3619-5p	CLIP-seq
MIRT1984015	hsa-miR-3657	CLIP-seq
MIRT1984017	hsa-miR-3675-5p	CLIP-seq
MIRT1984018	hsa-miR-3679-3p	CLIP-seq
MIRT1984022	hsa-miR-3937	CLIP-seq
MIRT1984023	hsa-miR-4283	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT1984024	hsa-miR-4483	CLIP-seq
MIRT1984025	hsa-miR-4489	CLIP-seq
MIRT958756	hsa-miR-4492	CLIP-seq
MIRT958757	hsa-miR-4498	CLIP-seq
MIRT958758	hsa-miR-4505	CLIP-seq
MIRT1984026	hsa-miR-4529-5p	CLIP-seq
MIRT958733	hsa-miR-4632	CLIP-seq
MIRT958734	hsa-miR-4645-5p	CLIP-seq
MIRT958759	hsa-miR-4651	CLIP-seq
MIRT1984027	hsa-miR-4669	CLIP-seq
MIRT958735	hsa-miR-4673	CLIP-seq
MIRT958739	hsa-miR-4715-3p	CLIP-seq
MIRT958760	hsa-miR-4742-5p	CLIP-seq
MIRT958761	hsa-miR-608	CLIP-seq
MIRT958762	hsa-miR-761	CLIP-seq
MIRT958763	hsa-miR-762	CLIP-seq
MIRT1984011	hsa-miR-1293	CLIP-seq
MIRT958753	hsa-miR-1909	CLIP-seq
MIRT958754	hsa-miR-214	CLIP-seq
MIRT958718	hsa-miR-3127-3p	CLIP-seq
MIRT958719	hsa-miR-3131	CLIP-seq
MIRT958721	hsa-miR-361-3p	CLIP-seq
MIRT958755	hsa-miR-3619-5p	CLIP-seq
MIRT1984015	hsa-miR-3657	CLIP-seq
MIRT1984017	hsa-miR-3675-5p	CLIP-seq
MIRT1984018	hsa-miR-3679-3p	CLIP-seq
MIRT1984022	hsa-miR-3937	CLIP-seq
MIRT958724	hsa-miR-3945	CLIP-seq
MIRT1984023	hsa-miR-4283	CLIP-seq
MIRT958727	hsa-miR-4313	CLIP-seq
MIRT1984024	hsa-miR-4483	CLIP-seq
MIRT1984025	hsa-miR-4489	CLIP-seq
MIRT958756	hsa-miR-4492	CLIP-seq
MIRT958757	hsa-miR-4498	CLIP-seq
MIRT958758	hsa-miR-4505	CLIP-seq
MIRT1984026	hsa-miR-4529-5p	CLIP-seq
MIRT958732	hsa-miR-4530	CLIP-seq
MIRT958733	hsa-miR-4632	CLIP-seq
MIRT958734	hsa-miR-4645-5p	CLIP-seq
MIRT958759	hsa-miR-4651	CLIP-seq
MIRT1984027	hsa-miR-4669	CLIP-seq
MIRT958735	hsa-miR-4673	CLIP-seq
MIRT958739	hsa-miR-4715-3p	CLIP-seq
MIRT958741	hsa-miR-4731-5p	CLIP-seq
MIRT958760	hsa-miR-4742-5p	CLIP-seq
MIRT958746	hsa-miR-486-3p	CLIP-seq
MIRT958749	hsa-miR-503	CLIP-seq
MIRT958761	hsa-miR-608	CLIP-seq
MIRT958751	hsa-miR-611	CLIP-seq
MIRT958762	hsa-miR-761	CLIP-seq
MIRT958763	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0001662	Process	Behavioral fear response	IEA
GO:0002191	Process	Cap-dependent translational initiation	TAS	25765080
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	TAS	25255371
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0003729	Function	MRNA binding	IDA	24092755
GO:0003743	Function	Translation initiation factor activity	IBA	21873635
GO:0003743	Function	Translation initiation factor activity	TAS	8961935, 9372926
GO:0005515	Function	Protein binding	IPI	10523622, 10970864, 10996799, 12054647, 12086624, 14701818, 15153109, 15361857, 15567442, 15713657, 16513844, 16556936, 16772376, 16932749, 17284590, 17468741, 18606994, 18955708, 19203580, 19716330, 20212144, 21191102, 22872150, 23023399, 23409027, 23478064, 23665581, 23788676, 240
GO:0005524	Function	ATP binding	IDA	25255371
GO:0005634	Component	Nucleus	IMP	18426977
GO:0005737	Component	Cytoplasm	IDA	23814182
GO:0005737	Component	Cytoplasm	IMP	18426977
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005844	Component	Polysome	IMP	18426977
GO:0006412	Process	Translation	IMP	18426977
GO:0006412	Process	Translation	IPI	24092755
GO:0006413	Process	Translational initiation	NAS	25255371
GO:0006413	Process	Translational initiation	TAS	18426977
GO:0006446	Process	Regulation of translational initiation	IMP	19648179
GO:0006446	Process	Regulation of translational initiation	NAS	8961935, 9372926
GO:0008135	Function	Translation factor activity, RNA binding	IMP	18426977
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IDA	23814182
GO:0008190	Function	Eukaryotic initiation factor 4E binding	TAS	25765080
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0010507	Process	Negative regulation of autophagy	IMP	18426977
GO:0010801	Process	Negative regulation of peptidyl-threonine phosphorylation	IMP	18426977
GO:0010942	Process	Positive regulation of cell death	IGI	25533483
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	IBA	21873635
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	IDA	25255371
GO:0030307	Process	Positive regulation of cell growth	IMP	18426977
GO:0031369	Function	Translation initiation factor binding	TAS	25765080
GO:0031669	Process	Cellular response to nutrient levels	IMP	18426977
GO:0032270	Process	Positive regulation of cellular protein metabolic process	IMP	18426977
GO:0032502	Process	Developmental process	TAS	25765080
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IMP	18426977
GO:0034645	Process	Cellular macromolecule biosynthetic process	IGI	18426977
GO:0036493	Process	Positive regulation of translation in response to endoplasmic reticulum stress	IMP	29062139
GO:0042802	Function	Identical protein binding	IPI	16698552
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0060090	Function	Molecular adaptor activity	TAS	25255371
GO:0060964	Process	Regulation of gene silencing by miRNA	TAS	25765080
GO:0080135	Process	Regulation of cellular response to stress	TAS	25765080
GO:0097009	Process	Energy homeostasis	IMP	18426977
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IMP	18426977
GO:1901215	Process	Negative regulation of neuron death	TAS	25765080
GO:1905537	Process	Positive regulation of eukaryotic translation initiation factor 4F complex assembly	IMP	18426977
GO:1905606	Process	Regulation of presynapse assembly	IGI	25533483
GO:1905612	Process	Positive regulation of mRNA cap binding	IDA	23409027
GO:1905618	Process	Positive regulation of miRNA mediated inhibition of translation	IDA	23409027
GO:1905696	Process	Regulation of polysome binding	IMP	18426977

Other IDs

• MIM: 600495
• HGNC: 3296
• e!Ensembl: ENSG00000114867

Protein

• UniProt ID: Q04637
• Protein name: Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)
• Protein function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either w
• PDB: 1LJ2, 1UG3, 2W97, 4AZA, 4F02, 5EHC, 5EI3, 5EIR, 5T46, 5ZK5, 6ZMW, 8HUJ, 8J7R, 8OZ0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02854	MIF4G	761 → 989	MIF4G domain	Family
  PF02847	MA3	1242 → 1354	MA3 domain	Family
  PF02020	W2	1520 → 1599	eIF4-gamma/eIF5/eIF2-epsilon	Family

• Sequence:

  MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
  SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
  PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
  RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
  IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
  TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
  PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
  PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
  EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
  VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
  WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
  NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
  MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
  KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
  KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
  FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
  QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
  QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
  NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
  VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
  PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
  EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
  EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
  GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
  EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
  VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
  YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN

• Sequence length: 1599

Pathways

KEGG:

Viral myocarditis

Reactome:

ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Akinesia	Akinesia	rs606231129, rs606231131, rs606231132, rs118203995, rs606231133, rs104894299, rs104894300, rs786200904, rs786200905, rs104894294, rs121909254, rs121909255, rs121909256, rs150376433, rs863223335, rs751889864, rs559933584, rs761899995, rs797045528, rs551423795, rs886037842, rs560525099, rs775583136, rs1349476281, rs794727884, rs1479498379, rs1555142142, rs1558010146, rs1558003446, rs1554757237, rs770987150, rs768892432, rs1558008455, rs1560224831, rs1558005340, rs747595523, rs1567568217, rs774070092, rs776532930, rs765096923, rs1560200925, rs201947904, rs1595903667, rs376573993, rs778172294, rs759488854, rs761584017, rs769850502
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Parkinson disease	Parkinsonian Disorders, PARKINSON DISEASE 18	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	26740508, 25368108, 21907011
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313

Unknown
Disease name	Disease term	dbSNP ID	References
Cerebral cortical atrophy	Cerebral cortical atrophy
Dementia	Dementia
Dyskinetic syndrome	Dyskinetic syndrome
Dysphagia	Deglutition Disorders
Dyssomnia	Dyssomnias
Hereditary parkinson`s disease	Hereditary late-onset Parkinson disease
Mental depression	Depressive disorder	rs587778876, rs587778877
Sleep disorders	Sleep Disorders