EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1965 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Eukaryotic translation initiation factor 2 subunit alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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EIF2S1 |
SynonymsGene synonyms aliases
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EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A |
ChromosomeChromosome number
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14 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q23.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0003743 |
Function |
Translation initiation factor activity |
IBA |
21873635 |
GO:0003743 |
Function |
Translation initiation factor activity |
IDA |
16289705 |
GO:0005515 |
Function |
Protein binding |
IPI |
9431994, 11500362, 16288713, 16932749, 17894550, 18596238, 18971339, 22323517, 25393282, 28514442, 32296183 |
GO:0005634 |
Component |
Nucleus |
IEA |
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GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0005844 |
Component |
Polysome |
TAS |
2948954 |
GO:0005850 |
Component |
Eukaryotic translation initiation factor 2 complex |
IBA |
21873635 |
GO:0005850 |
Component |
Eukaryotic translation initiation factor 2 complex |
IDA |
23063529 |
GO:0005851 |
Component |
Eukaryotic translation initiation factor 2B complex |
IBA |
21873635 |
GO:0005851 |
Component |
Eukaryotic translation initiation factor 2B complex |
IDA |
11323413 |
GO:0006413 |
Process |
Translational initiation |
TAS |
|
GO:0007568 |
Process |
Aging |
IEA |
|
GO:0010494 |
Component |
Cytoplasmic stress granule |
ISS |
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GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0032057 |
Process |
Negative regulation of translational initiation in response to stress |
ISS |
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GO:0033290 |
Component |
Eukaryotic 48S preinitiation complex |
IBA |
21873635 |
GO:0034063 |
Process |
Stress granule assembly |
ISS |
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GO:0034198 |
Process |
Cellular response to amino acid starvation |
ISS |
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GO:0034599 |
Process |
Cellular response to oxidative stress |
ISS |
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GO:0034605 |
Process |
Cellular response to heat |
IEA |
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GO:0034644 |
Process |
Cellular response to UV |
ISS |
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GO:0034976 |
Process |
Response to endoplasmic reticulum stress |
IMP |
18508033 |
GO:0034976 |
Process |
Response to endoplasmic reticulum stress |
ISS |
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GO:0036499 |
Process |
PERK-mediated unfolded protein response |
NAS |
22934019 |
GO:0043022 |
Function |
Ribosome binding |
IBA |
21873635 |
GO:0043022 |
Function |
Ribosome binding |
IDA |
17894550 |
GO:0043614 |
Component |
Multi-eIF complex |
IBA |
21873635 |
GO:0044207 |
Component |
Translation initiation ternary complex |
IEA |
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GO:0045202 |
Component |
Synapse |
IEA |
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GO:0046777 |
Process |
Protein autophosphorylation |
IEA |
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GO:0055085 |
Process |
Transmembrane transport |
TAS |
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GO:0070062 |
Component |
Extracellular exosome |
HDA |
20458337 |
GO:0097451 |
Component |
Glial limiting end-foot |
IEA |
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GO:1901216 |
Process |
Positive regulation of neuron death |
IMP |
18508033 |
GO:1905098 |
Process |
Negative regulation of guanyl-nucleotide exchange factor activity |
IEA |
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GO:1990737 |
Process |
Response to manganese-induced endoplasmic reticulum stress |
IEA |
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GO:2000676 |
Process |
Positive regulation of type B pancreatic cell apoptotic process |
IEA |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P05198 |
Protein name |
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) |
Protein function |
Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA bindin |
PDB |
1KL9
,
1Q8K
,
6K71
,
6K72
,
6O81
,
6O85
,
6O9Z
,
6YBV
,
6ZMW
,
6ZP4
,
7A09
,
7D43
,
7D44
,
7D45
,
7F66
,
7F67
,
7NZM
,
7QP6
,
7QP7
,
7SYR
,
7SYS
,
8OZ0
,
8PJ1
,
8PJ2
,
8PJ3
,
8PJ4
,
8PPL
,
8QZZ
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00575 |
S1 |
14 → 88 |
S1 RNA binding domain |
Domain |
PF07541 |
EIF_2_alpha |
130 → 244 |
Eukaryotic translation initiation factor 2 alpha subunit |
Family |
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Sequence |
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Sequence length |
315 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Alzheimer disease |
Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset |
rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 |
17406652 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
19834500 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Cognitive disorder |
Cognition Disorders |
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17406652 |
Grand mal status epilepticus |
Grand Mal Status Epilepticus |
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15003282 |
Nonconvulsive status epilepticus |
Non-Convulsive Status Epilepticus |
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15003282 |
Osteosarcoma |
Osteosarcoma |
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14767549 |
Petit mal status |
Petit mal status |
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15003282 |
Senile dementia |
Presenile dementia, Acute Confusional Senile Dementia |
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17406652 |
Status epilepticus |
Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical |
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15003282 |
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