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EGR3 (early growth response 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1960
Gene nameGene Name - the full gene name approved by the HGNC.
Early growth response 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
EGR3
SynonymsGene synonyms aliases
EGR-3, PILOT
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the t
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004963 hsa-let-7a-5p qRT-PCR 17942906
MIRT018262 hsa-miR-335-5p Microarray 18185580
MIRT029689 hsa-miR-26b-5p Microarray 19088304
MIRT542153 hsa-miR-8485 HITS-CLIP 21572407
MIRT542152 hsa-miR-603 HITS-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
NFATC1 Unknown 9819402
NFATC2 Unknown 9819402
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q06889
Protein name Early growth response protein 3 (EGR-3) (Zinc finger protein pilot)
Protein function Probable transcription factor involved in muscle spindle development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11928 DUF3446
87 156
Early growth response N-terminal domain
Domain
PF00096 zf-C2H2
275 299
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
305 327
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
333 355
Zinc finger, C2H2 type
Domain
Sequence
MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVVHYNQMATENVMDIGLT
NEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGAL
STQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSE
PVSFHDPQGNPGLAYSPQDYQSAK
PALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIH
PGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHT
GHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKE
KKAEKGGAPSASSAPPVSLAPVVTTCA
Sequence length 387
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  C-type lectin receptor signaling pathway
Hepatitis B
Viral carcinogenesis
  NGF-stimulated transcription
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 20537399, 22276163
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 21421043, 20633309, 19204725
Mental depression Mental Depression, Depressive disorder rs587778876, rs587778877 19204725
Rubral tremor Tremor, Rubral 16091474

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