Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1960 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Early growth response 3 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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EGR3 |
SynonymsGene synonyms aliases
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EGR-3, PILOT |
ChromosomeChromosome number
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8 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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8p21.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the t |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
|
Transcription factor |
Regulation |
Reference |
NFATC1 |
Unknown |
9819402 |
NFATC2 |
Unknown |
9819402 |
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
ISA |
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GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
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GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IEA |
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GO:0001938 |
Process |
Positive regulation of endothelial cell proliferation |
IMP |
18059339 |
GO:0002042 |
Process |
Cell migration involved in sprouting angiogenesis |
IDA |
18059339 |
GO:0003700 |
Function |
DNA-binding transcription factor activity |
TAS |
1906159, 9731539 |
GO:0005634 |
Component |
Nucleus |
IEA |
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GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0007274 |
Process |
Neuromuscular synaptic transmission |
IEA |
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GO:0007422 |
Process |
Peripheral nervous system development |
IEA |
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GO:0007517 |
Process |
Muscle organ development |
TAS |
9731539 |
GO:0007623 |
Process |
Circadian rhythm |
TAS |
9488654 |
GO:0033089 |
Process |
Positive regulation of T cell differentiation in thymus |
IEA |
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GO:0035767 |
Process |
Endothelial cell chemotaxis |
IMP |
18059339 |
GO:0035924 |
Process |
Cellular response to vascular endothelial growth factor stimulus |
IMP |
18059339 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IMP |
18059339 |
GO:0044344 |
Process |
Cellular response to fibroblast growth factor stimulus |
IMP |
18059339 |
GO:0045202 |
Component |
Synapse |
IEA |
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GO:0045586 |
Process |
Regulation of gamma-delta T cell differentiation |
IEA |
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GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IEA |
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GO:0046872 |
Function |
Metal ion binding |
IEA |
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GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q06889 |
Protein name |
Early growth response protein 3 (EGR-3) (Zinc finger protein pilot) |
Protein function |
Probable transcription factor involved in muscle spindle development. |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF11928 |
DUF3446 |
87 → 156 |
Early growth response N-terminal domain |
Domain |
PF00096 |
zf-C2H2 |
275 → 299 |
Zinc finger, C2H2 type |
Domain |
PF00096 |
zf-C2H2 |
305 → 327 |
Zinc finger, C2H2 type |
Domain |
PF00096 |
zf-C2H2 |
333 → 355 |
Zinc finger, C2H2 type |
Domain |
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Sequence |
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Sequence length |
387 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
20537399, 22276163 |
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