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EFNA5 (ephrin A5)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1946
Gene nameGene Name - the full gene name approved by the HGNC.
Ephrin A5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
EFNA5
SynonymsGene synonyms aliases
AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018356 hsa-miR-335-5p Microarray 18185580
MIRT049051 hsa-miR-92a-3p CLASH 23622248
MIRT658811 hsa-miR-10a-3p HITS-CLIP 23824327
MIRT658810 hsa-miR-362-5p HITS-CLIP 23824327
MIRT658809 hsa-miR-500b-5p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001934 Process Positive regulation of protein phosphorylation NAS 19036963
GO:0005168 Function Neurotrophin TRKA receptor binding NAS 19036963
GO:0005169 Function Neurotrophin TRKB receptor binding NAS 19036963
GO:0005170 Function Neurotrophin TRKC receptor binding NAS 19036963
GO:0005515 Function Protein binding IPI 19836338, 20228801, 20505120, 23812375, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P52803
Protein name Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Protein function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on ad
PDB 2X11 , 3MX0 , 4BK5 , 4BKA , 4L0P , 4M4R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00812 Ephrin
29 158
Ephrin
Domain
Sequence
MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQL
FTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFV
RPTNSCMKTIGVHDRVFDVNDK
VENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
Sequence length 228
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Axon guidance
MicroRNAs in cancer
  EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203

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