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B3GNT6 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6)

Gene

192134

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6

B3GNT6

B3Gn-T6, BGnT-6, beta-1,3-Gn-T6, beta3Gn-T6

11q13.5

The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans,

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs781821239	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant, synonymous variant

Show/Hide all(276)

miRTarBase ID	miRNA	Experiments	Reference
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	28735896
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	28735896
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	28735896
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	28735896
MIRT613464	hsa-miR-3909	HITS-CLIP	28735896
MIRT613464	hsa-miR-3909	HITS-CLIP	28735896
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	28735896
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	28735896
MIRT613460	hsa-miR-527	HITS-CLIP	28735896
MIRT613460	hsa-miR-527	HITS-CLIP	28735896
MIRT613462	hsa-miR-548aw	HITS-CLIP	28735896
MIRT613462	hsa-miR-548aw	HITS-CLIP	28735896
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	28735896
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	28735896
MIRT613459	hsa-miR-676-3p	HITS-CLIP	28735896
MIRT613459	hsa-miR-676-3p	HITS-CLIP	28735896
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	28735896
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	28735896
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT613466	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT613465	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT613464	hsa-miR-3909	HITS-CLIP	23824327
MIRT613463	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT613462	hsa-miR-548aw	HITS-CLIP	23824327
MIRT613461	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT613460	hsa-miR-527	HITS-CLIP	23824327
MIRT613459	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT613458	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT813372	hsa-miR-1207-5p	CLIP-seq
MIRT813373	hsa-miR-122	CLIP-seq
MIRT813374	hsa-miR-1226	CLIP-seq
MIRT813375	hsa-miR-1231	CLIP-seq
MIRT813376	hsa-miR-1281	CLIP-seq
MIRT813377	hsa-miR-1286	CLIP-seq
MIRT813378	hsa-miR-1297	CLIP-seq
MIRT813379	hsa-miR-1307	CLIP-seq
MIRT813380	hsa-miR-150	CLIP-seq
MIRT813381	hsa-miR-1908	CLIP-seq
MIRT813382	hsa-miR-1915	CLIP-seq
MIRT813383	hsa-miR-1976	CLIP-seq
MIRT813384	hsa-miR-26a	CLIP-seq
MIRT813385	hsa-miR-26b	CLIP-seq
MIRT813386	hsa-miR-3135b	CLIP-seq
MIRT813387	hsa-miR-3143	CLIP-seq
MIRT813388	hsa-miR-3194-3p	CLIP-seq
MIRT813389	hsa-miR-3622a-5p	CLIP-seq
MIRT813390	hsa-miR-3652	CLIP-seq
MIRT813391	hsa-miR-3674	CLIP-seq
MIRT813392	hsa-miR-4279	CLIP-seq
MIRT813393	hsa-miR-4284	CLIP-seq
MIRT813394	hsa-miR-431	CLIP-seq
MIRT813395	hsa-miR-4423-3p	CLIP-seq
MIRT813396	hsa-miR-4430	CLIP-seq
MIRT813397	hsa-miR-4436b-5p	CLIP-seq
MIRT813398	hsa-miR-4465	CLIP-seq
MIRT813399	hsa-miR-4638-5p	CLIP-seq
MIRT813400	hsa-miR-4707-5p	CLIP-seq
MIRT813401	hsa-miR-4717-3p	CLIP-seq
MIRT813402	hsa-miR-4722-3p	CLIP-seq
MIRT813403	hsa-miR-4726-3p	CLIP-seq
MIRT813404	hsa-miR-4730	CLIP-seq
MIRT813405	hsa-miR-4736	CLIP-seq
MIRT813406	hsa-miR-4762-5p	CLIP-seq
MIRT813407	hsa-miR-4763-3p	CLIP-seq
MIRT813408	hsa-miR-4772-3p	CLIP-seq
MIRT813409	hsa-miR-515-5p	CLIP-seq
MIRT813410	hsa-miR-564	CLIP-seq
MIRT813411	hsa-miR-654-3p	CLIP-seq
MIRT813412	hsa-miR-663	CLIP-seq
MIRT813413	hsa-miR-711	CLIP-seq
MIRT813373	hsa-miR-122	CLIP-seq
MIRT1940457	hsa-miR-1265	CLIP-seq
MIRT1940458	hsa-miR-1273f	CLIP-seq
MIRT813376	hsa-miR-1281	CLIP-seq
MIRT813379	hsa-miR-1307	CLIP-seq
MIRT813386	hsa-miR-3135b	CLIP-seq
MIRT813388	hsa-miR-3194-3p	CLIP-seq
MIRT813390	hsa-miR-3652	CLIP-seq
MIRT813393	hsa-miR-4284	CLIP-seq
MIRT813394	hsa-miR-431	CLIP-seq
MIRT813396	hsa-miR-4430	CLIP-seq
MIRT1940459	hsa-miR-4534	CLIP-seq
MIRT813399	hsa-miR-4638-5p	CLIP-seq
MIRT813408	hsa-miR-4772-3p	CLIP-seq
MIRT813410	hsa-miR-564	CLIP-seq
MIRT813373	hsa-miR-122	CLIP-seq
MIRT2179440	hsa-miR-128	CLIP-seq
MIRT813376	hsa-miR-1281	CLIP-seq
MIRT813378	hsa-miR-1297	CLIP-seq
MIRT813379	hsa-miR-1307	CLIP-seq
MIRT2179441	hsa-miR-140-3p	CLIP-seq
MIRT813380	hsa-miR-150	CLIP-seq
MIRT813382	hsa-miR-1915	CLIP-seq
MIRT813383	hsa-miR-1976	CLIP-seq
MIRT813384	hsa-miR-26a	CLIP-seq
MIRT813385	hsa-miR-26b	CLIP-seq
MIRT813386	hsa-miR-3135b	CLIP-seq
MIRT2179442	hsa-miR-3144-5p	CLIP-seq
MIRT813388	hsa-miR-3194-3p	CLIP-seq
MIRT813390	hsa-miR-3652	CLIP-seq
MIRT2179443	hsa-miR-3659	CLIP-seq
MIRT2179444	hsa-miR-3692	CLIP-seq
MIRT2179445	hsa-miR-3911	CLIP-seq
MIRT813392	hsa-miR-4279	CLIP-seq
MIRT813393	hsa-miR-4284	CLIP-seq
MIRT813394	hsa-miR-431	CLIP-seq
MIRT813396	hsa-miR-4430	CLIP-seq
MIRT813397	hsa-miR-4436b-5p	CLIP-seq
MIRT813398	hsa-miR-4465	CLIP-seq
MIRT813399	hsa-miR-4638-5p	CLIP-seq
MIRT2179446	hsa-miR-4658	CLIP-seq
MIRT813402	hsa-miR-4722-3p	CLIP-seq
MIRT813403	hsa-miR-4726-3p	CLIP-seq
MIRT813408	hsa-miR-4772-3p	CLIP-seq
MIRT813410	hsa-miR-564	CLIP-seq
MIRT2179447	hsa-miR-574-5p	CLIP-seq
MIRT813373	hsa-miR-122	CLIP-seq
MIRT813379	hsa-miR-1307	CLIP-seq
MIRT813386	hsa-miR-3135b	CLIP-seq
MIRT813388	hsa-miR-3194-3p	CLIP-seq
MIRT813390	hsa-miR-3652	CLIP-seq
MIRT813393	hsa-miR-4284	CLIP-seq
MIRT813396	hsa-miR-4430	CLIP-seq
MIRT813399	hsa-miR-4638-5p	CLIP-seq
MIRT813410	hsa-miR-564	CLIP-seq
MIRT813376	hsa-miR-1281	CLIP-seq
MIRT813378	hsa-miR-1297	CLIP-seq
MIRT813380	hsa-miR-150	CLIP-seq
MIRT813382	hsa-miR-1915	CLIP-seq
MIRT813383	hsa-miR-1976	CLIP-seq
MIRT813384	hsa-miR-26a	CLIP-seq
MIRT813385	hsa-miR-26b	CLIP-seq
MIRT813392	hsa-miR-4279	CLIP-seq
MIRT813398	hsa-miR-4465	CLIP-seq
MIRT813402	hsa-miR-4722-3p	CLIP-seq
MIRT813403	hsa-miR-4726-3p	CLIP-seq
MIRT813373	hsa-miR-122	CLIP-seq
MIRT813376	hsa-miR-1281	CLIP-seq
MIRT813378	hsa-miR-1297	CLIP-seq
MIRT813379	hsa-miR-1307	CLIP-seq
MIRT813380	hsa-miR-150	CLIP-seq
MIRT813382	hsa-miR-1915	CLIP-seq
MIRT813383	hsa-miR-1976	CLIP-seq
MIRT813384	hsa-miR-26a	CLIP-seq
MIRT813385	hsa-miR-26b	CLIP-seq
MIRT813386	hsa-miR-3135b	CLIP-seq
MIRT813390	hsa-miR-3652	CLIP-seq
MIRT813392	hsa-miR-4279	CLIP-seq
MIRT813393	hsa-miR-4284	CLIP-seq
MIRT2482925	hsa-miR-433	CLIP-seq
MIRT813396	hsa-miR-4430	CLIP-seq
MIRT2482926	hsa-miR-4454	CLIP-seq
MIRT813398	hsa-miR-4465	CLIP-seq
MIRT813399	hsa-miR-4638-5p	CLIP-seq
MIRT813402	hsa-miR-4722-3p	CLIP-seq
MIRT813403	hsa-miR-4726-3p	CLIP-seq
MIRT813408	hsa-miR-4772-3p	CLIP-seq
MIRT813410	hsa-miR-564	CLIP-seq
MIRT813373	hsa-miR-122	CLIP-seq
MIRT813376	hsa-miR-1281	CLIP-seq
MIRT813378	hsa-miR-1297	CLIP-seq
MIRT813379	hsa-miR-1307	CLIP-seq
MIRT813380	hsa-miR-150	CLIP-seq
MIRT813382	hsa-miR-1915	CLIP-seq
MIRT813383	hsa-miR-1976	CLIP-seq
MIRT813384	hsa-miR-26a	CLIP-seq
MIRT813385	hsa-miR-26b	CLIP-seq
MIRT813386	hsa-miR-3135b	CLIP-seq
MIRT813390	hsa-miR-3652	CLIP-seq
MIRT813392	hsa-miR-4279	CLIP-seq
MIRT813393	hsa-miR-4284	CLIP-seq
MIRT2482925	hsa-miR-433	CLIP-seq
MIRT813396	hsa-miR-4430	CLIP-seq
MIRT2482926	hsa-miR-4454	CLIP-seq
MIRT813398	hsa-miR-4465	CLIP-seq
MIRT813399	hsa-miR-4638-5p	CLIP-seq
MIRT813402	hsa-miR-4722-3p	CLIP-seq
MIRT813403	hsa-miR-4726-3p	CLIP-seq
MIRT813408	hsa-miR-4772-3p	CLIP-seq
MIRT813410	hsa-miR-564	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0006486	Process	Protein glycosylation	IBA	21873635
GO:0008375	Function	Acetylglucosaminyltransferase activity	IBA	21873635
GO:0008376	Function	Acetylgalactosaminyltransferase activity	IBA	21873635
GO:0008378	Function	Galactosyltransferase activity	IDA	11821425
GO:0008532	Function	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA	21873635
GO:0009101	Process	Glycoprotein biosynthetic process	NAS	11821425
GO:0016020	Component	Membrane	NAS	11821425
GO:0016021	Component	Integral component of membrane	IEA
GO:0016266	Process	O-glycan processing	TAS
GO:0016269	Process	O-glycan processing, core 3	NAS	11821425
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0030311	Process	Poly-N-acetyllactosamine biosynthetic process	IBA	21873635
GO:0047223	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	NAS	11821425
GO:0106327	Function	Acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IEA
GO:0106328	Function	Acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IEA

MIM	HGNC	e!Ensembl
615315	24141	ENSG00000198488

Protein

UniProt ID

Q6ZMB0

Protein name

Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.147) (Core 3 synthase) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6) (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (

Protein function

Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01762	Galactosyl_T	131 → 327	Galactosyltransferase	Family

Sequence

MAFPCRRSLTAKTLACLLVGVSFLALQQWFLQAPRSPREERSPQEETPEGPTDAPAADEP
PSELVPGPPCVANASANATADFEQLPARIQDFLRYRHCRHFPLLWDAPAKCAGGRGVFLL
LAVKSAPEHYERRELIRRTWGQERSYGGRPVRRLFLLGTPGPEDEARAERLAELVALEAR
EHGDVLQWAFADTFLNLTLKHLHLLDWLAARCPHARFLLSGDDDVFVHTANVVRFLQAQP
PGRHLFSGQLMEGSVPIRDSWSKYFVPPQLFPGSAYPVYCSGGGFLLSGPTARALRAAAR
HTPLFPIDDAYMGMCLERAGLAPSGHEGIRPFGVQLPGAQQSSFDPCMYRELLLVHRFAP
YEMLLMWKALHSPALSCDRGHRVS

Sequence length

384

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Metabolic pathways		O-linked glycosylation of mucins

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia, Childhood	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26508570

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