EEF1A1 (eukaryotic translation elongation factor 1 alpha 1)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1915 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Eukaryotic translation elongation factor 1 alpha 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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EEF1A1 |
SynonymsGene synonyms aliases
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CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, EF1A1, EF1alpha1, GRAF-1EF, LENG7, PTI1, eEF1A-1 |
ChromosomeChromosome number
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6 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6q13 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and panc |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000049 |
Function |
TRNA binding |
IDA |
12426392 |
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0003746 |
Function |
Translation elongation factor activity |
IBA |
21873635 |
GO:0003746 |
Function |
Translation elongation factor activity |
TAS |
17595531 |
GO:0003924 |
Function |
GTPase activity |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
9852145, 15161933, 16712842, 16828757, 17373842, 17980171, 18000879, 18624398, 19158340, 20618440, 20838377, 20849852, 23260144, 24209753, 24705354, 25464930, 26030842, 26497934, 28514442, 31980649, 32296183, 32814053 |
GO:0005516 |
Function |
Calmodulin binding |
IEA |
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GO:0005525 |
Function |
GTP binding |
TAS |
3512269 |
GO:0005576 |
Component |
Extracellular region |
TAS |
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GO:0005615 |
Component |
Extracellular space |
HDA |
23580065 |
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IDA |
8743958, 9852145, 17177976 |
GO:0005730 |
Component |
Nucleolus |
IDA |
9852145 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
8743958, 9852145, 17177976, 17980171, 24209753 |
GO:0005737 |
Component |
Cytoplasm |
ISS |
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GO:0005737 |
Component |
Cytoplasm |
TAS |
3512269 |
GO:0005829 |
Component |
Cytosol |
IDA |
19158340 |
GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0005853 |
Component |
Eukaryotic translation elongation factor 1 complex |
TAS |
2564392 |
GO:0005886 |
Component |
Plasma membrane |
IDA |
26497934 |
GO:0006412 |
Process |
Translation |
IBA |
21873635 |
GO:0006414 |
Process |
Translational elongation |
IBA |
21873635 |
GO:0006414 |
Process |
Translational elongation |
TAS |
8812466 |
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0019900 |
Function |
Kinase binding |
IPI |
18263879 |
GO:0019901 |
Function |
Protein kinase binding |
IPI |
17177976, 17595531 |
GO:0030864 |
Component |
Cortical actin cytoskeleton |
IDA |
19158340 |
GO:0032587 |
Component |
Ruffle membrane |
IDA |
19158340 |
GO:0034774 |
Component |
Secretory granule lumen |
TAS |
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GO:0043312 |
Process |
Neutrophil degranulation |
TAS |
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GO:0070062 |
Component |
Extracellular exosome |
HDA |
12519789, 19056867, 19199708, 20458337 |
GO:0071364 |
Process |
Cellular response to epidermal growth factor stimulus |
IDA |
9852145 |
GO:0098574 |
Component |
Cytoplasmic side of lysosomal membrane |
NAS |
20797626 |
GO:1900022 |
Process |
Regulation of D-erythro-sphingosine kinase activity |
IDA |
18263879 |
GO:1904714 |
Process |
Regulation of chaperone-mediated autophagy |
NAS |
20797626 |
GO:1904813 |
Component |
Ficolin-1-rich granule lumen |
TAS |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P68104 |
Protein name |
Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) |
Protein function |
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, P |
PDB |
3C5J
,
6ZMO
,
8G60
,
8G6J
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00009 |
GTP_EFTU |
5 → 238 |
Elongation factor Tu GTP binding domain |
Domain |
PF03144 |
GTP_EFTU_D2 |
260 → 327 |
Elongation factor Tu domain 2 |
Domain |
PF03143 |
GTP_EFTU_D3 |
333 → 442 |
Elongation factor Tu C-terminal domain |
Domain |
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Sequence |
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Sequence length |
462 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Carcinoma |
Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma |
rs121912654, rs555607708, rs786202962, rs1564055259 |
12376462 |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 |
19424620 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Anaplastic carcinoma |
Anaplastic carcinoma |
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12376462 |
Stomach neoplasms |
Malignant neoplasm of stomach, Stomach Neoplasms |
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19424620 |
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