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TSC22D3 (TSC22 domain family member 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1831
Gene nameGene Name - the full gene name approved by the HGNC.
TSC22 domain family member 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TSC22D3
SynonymsGene synonyms aliases
DIP, DSIPI, GILZ, TSC-22R
ChromosomeChromosome number
X
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq22.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects o
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004547 hsa-miR-18a-5p qRT-PCR 19131573
MIRT004548 hsa-miR-124-3p qRT-PCR 19131573
MIRT005359 hsa-miR-182-5p Luciferase reporter assay, qRT-PCR 20656788
MIRT018941 hsa-miR-335-5p Microarray 18185580
MIRT050637 hsa-miR-19b-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IEA
GO:0005829 Component Cytosol TAS
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
GO:0006970 Process Response to osmotic stress IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q99576
Protein name TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R)
Protein function Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-i
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01166 TSC22
58 114
TSC-22/dip/bun family
Coiled-coil
Sequence
MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDL
VKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLS
PEEPAP
ESPQVPEAPGGSAV
Sequence length 134
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Stimuli-sensing channels
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Hyperinsulinism Hyperinsulinism rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180 22556341
Unknown
Disease name Disease term dbSNP ID References
Compensatory hyperinsulinemia Compensatory Hyperinsulinemia 22556341
Endogenous hyperinsulinism Endogenous Hyperinsulinism 22556341
Exogenous hyperinsulinism Exogenous Hyperinsulinism 22556341
Testicular diseases Testicular Diseases 22556341

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