Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1831 |
Gene nameGene Name - the full gene name approved by the HGNC.
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TSC22 domain family member 3 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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TSC22D3 |
SynonymsGene synonyms aliases
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DIP, DSIPI, GILZ, TSC-22R |
ChromosomeChromosome number
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X |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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Xq22.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects o |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0005515 |
Function |
Protein binding |
IPI |
32296183 |
GO:0005634 |
Component |
Nucleus |
IEA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IEA |
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GO:0006970 |
Process |
Response to osmotic stress |
IEA |
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GO:0034220 |
Process |
Ion transmembrane transport |
TAS |
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GO:0070236 |
Process |
Negative regulation of activation-induced cell death of T cells |
IEA |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q99576 |
Protein name |
TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) |
Protein function |
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-i |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01166 |
TSC22 |
58 → 114 |
TSC-22/dip/bun family |
Coiled-coil |
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Sequence |
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Sequence length |
134 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Hyperinsulinism |
Hyperinsulinism |
rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180 |
22556341 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Compensatory hyperinsulinemia |
Compensatory Hyperinsulinemia |
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22556341 |
Endogenous hyperinsulinism |
Endogenous Hyperinsulinism |
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22556341 |
Exogenous hyperinsulinism |
Exogenous Hyperinsulinism |
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22556341 |
Testicular diseases |
Testicular Diseases |
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22556341 |
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