DPP4 (dipeptidyl peptidase 4)

Gene

• Entrez ID: 1803
• Gene name: Dipeptidyl peptidase 4
• Gene symbol: DPP4
• Synonyms: ADABP, ADCP2, CD26, DPPIV, TP103
• Chromosome: 2
• Chromosome location: 2q24.2
• Summary: The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT755410	hsa-let-7b-5p	qRT-PCR	36073344
MIRT944211	hsa-miR-1273g	CLIP-seq
MIRT944212	hsa-miR-1305	CLIP-seq
MIRT944213	hsa-miR-4294	CLIP-seq
MIRT944214	hsa-miR-924	CLIP-seq
MIRT944211	hsa-miR-1273g	CLIP-seq
MIRT1979585	hsa-miR-1289	CLIP-seq
MIRT944212	hsa-miR-1305	CLIP-seq
MIRT1979586	hsa-miR-3198	CLIP-seq
MIRT944213	hsa-miR-4294	CLIP-seq
MIRT1979587	hsa-miR-4309	CLIP-seq
MIRT944214	hsa-miR-924	CLIP-seq
MIRT2436875	hsa-miR-2861	CLIP-seq
MIRT2436876	hsa-miR-3193	CLIP-seq
MIRT2436877	hsa-miR-34a	CLIP-seq
MIRT2436878	hsa-miR-34c-5p	CLIP-seq
MIRT2436879	hsa-miR-4488	CLIP-seq
MIRT2436880	hsa-miR-449a	CLIP-seq
MIRT2436881	hsa-miR-449b	CLIP-seq
MIRT2436882	hsa-miR-4697-5p	CLIP-seq
MIRT2436883	hsa-miR-637	CLIP-seq
MIRT2519073	hsa-miR-1200	CLIP-seq
MIRT2519074	hsa-miR-1227	CLIP-seq
MIRT2519075	hsa-miR-1269	CLIP-seq
MIRT2519076	hsa-miR-1269b	CLIP-seq
MIRT944211	hsa-miR-1273g	CLIP-seq
MIRT1979585	hsa-miR-1289	CLIP-seq
MIRT944212	hsa-miR-1305	CLIP-seq
MIRT2519077	hsa-miR-146b-3p	CLIP-seq
MIRT2519078	hsa-miR-148a	CLIP-seq
MIRT2519079	hsa-miR-148b	CLIP-seq
MIRT2519080	hsa-miR-152	CLIP-seq
MIRT2519081	hsa-miR-153	CLIP-seq
MIRT2519082	hsa-miR-186	CLIP-seq
MIRT2519083	hsa-miR-188-5p	CLIP-seq
MIRT2519084	hsa-miR-204	CLIP-seq
MIRT2519085	hsa-miR-2052	CLIP-seq
MIRT2519086	hsa-miR-211	CLIP-seq
MIRT2519087	hsa-miR-22	CLIP-seq
MIRT2519088	hsa-miR-23a	CLIP-seq
MIRT2519089	hsa-miR-23b	CLIP-seq
MIRT2519090	hsa-miR-23c	CLIP-seq
MIRT2436875	hsa-miR-2861	CLIP-seq
MIRT2519091	hsa-miR-3074-5p	CLIP-seq
MIRT2519092	hsa-miR-3133	CLIP-seq
MIRT2519093	hsa-miR-3157-3p	CLIP-seq
MIRT2519094	hsa-miR-3160-5p	CLIP-seq
MIRT2519095	hsa-miR-3173-5p	CLIP-seq
MIRT2436876	hsa-miR-3193	CLIP-seq
MIRT1979586	hsa-miR-3198	CLIP-seq
MIRT2436877	hsa-miR-34a	CLIP-seq
MIRT2436878	hsa-miR-34c-5p	CLIP-seq
MIRT2519096	hsa-miR-3646	CLIP-seq
MIRT2519097	hsa-miR-3662	CLIP-seq
MIRT2519098	hsa-miR-3672	CLIP-seq
MIRT2519099	hsa-miR-3676	CLIP-seq
MIRT2519100	hsa-miR-3913-3p	CLIP-seq
MIRT2519101	hsa-miR-3914	CLIP-seq
MIRT2519102	hsa-miR-3940-5p	CLIP-seq
MIRT2519103	hsa-miR-4264	CLIP-seq
MIRT2519104	hsa-miR-4287	CLIP-seq
MIRT2519105	hsa-miR-4293	CLIP-seq
MIRT944213	hsa-miR-4294	CLIP-seq
MIRT1979587	hsa-miR-4309	CLIP-seq
MIRT2519106	hsa-miR-4324	CLIP-seq
MIRT2519107	hsa-miR-4328	CLIP-seq
MIRT2519108	hsa-miR-4329	CLIP-seq
MIRT2519109	hsa-miR-4330	CLIP-seq
MIRT2519110	hsa-miR-4421	CLIP-seq
MIRT2519111	hsa-miR-4446-5p	CLIP-seq
MIRT2519112	hsa-miR-4469	CLIP-seq
MIRT2519113	hsa-miR-448	CLIP-seq
MIRT2436879	hsa-miR-4488	CLIP-seq
MIRT2436880	hsa-miR-449a	CLIP-seq
MIRT2436881	hsa-miR-449b	CLIP-seq
MIRT2519114	hsa-miR-4507	CLIP-seq
MIRT2519115	hsa-miR-452	CLIP-seq
MIRT2519116	hsa-miR-4529-3p	CLIP-seq
MIRT2519117	hsa-miR-4645-3p	CLIP-seq
MIRT2519118	hsa-miR-4659a-5p	CLIP-seq
MIRT2519119	hsa-miR-4659b-5p	CLIP-seq
MIRT2519120	hsa-miR-4676-3p	CLIP-seq
MIRT2519121	hsa-miR-4685-3p	CLIP-seq
MIRT2519122	hsa-miR-4697-3p	CLIP-seq
MIRT2436882	hsa-miR-4697-5p	CLIP-seq
MIRT2519123	hsa-miR-4755-5p	CLIP-seq
MIRT2519124	hsa-miR-4768-5p	CLIP-seq
MIRT2519125	hsa-miR-4776-3p	CLIP-seq
MIRT2519126	hsa-miR-4797-3p	CLIP-seq
MIRT2519127	hsa-miR-489	CLIP-seq
MIRT2519128	hsa-miR-498	CLIP-seq
MIRT2519129	hsa-miR-499-3p	CLIP-seq
MIRT2519130	hsa-miR-499a-3p	CLIP-seq
MIRT2519131	hsa-miR-520f	CLIP-seq
MIRT2519132	hsa-miR-544b	CLIP-seq
MIRT2519133	hsa-miR-548a-3p	CLIP-seq
MIRT2519134	hsa-miR-548e	CLIP-seq
MIRT2519135	hsa-miR-548f	CLIP-seq
MIRT2519136	hsa-miR-548g	CLIP-seq
MIRT2519137	hsa-miR-570	CLIP-seq
MIRT2519138	hsa-miR-596	CLIP-seq
MIRT2519139	hsa-miR-622	CLIP-seq
MIRT2519140	hsa-miR-623	CLIP-seq
MIRT2436883	hsa-miR-637	CLIP-seq
MIRT2519141	hsa-miR-642a	CLIP-seq
MIRT2519142	hsa-miR-874	CLIP-seq
MIRT2519143	hsa-miR-888	CLIP-seq
MIRT2519144	hsa-miR-9	CLIP-seq
MIRT944214	hsa-miR-924	CLIP-seq
MIRT2519145	hsa-miR-942	CLIP-seq
MIRT2519073	hsa-miR-1200	CLIP-seq
MIRT2519075	hsa-miR-1269	CLIP-seq
MIRT2519076	hsa-miR-1269b	CLIP-seq
MIRT944211	hsa-miR-1273g	CLIP-seq
MIRT1979585	hsa-miR-1289	CLIP-seq
MIRT944212	hsa-miR-1305	CLIP-seq
MIRT2519077	hsa-miR-146b-3p	CLIP-seq
MIRT2519078	hsa-miR-148a	CLIP-seq
MIRT2519079	hsa-miR-148b	CLIP-seq
MIRT2519080	hsa-miR-152	CLIP-seq
MIRT2519081	hsa-miR-153	CLIP-seq
MIRT2519084	hsa-miR-204	CLIP-seq
MIRT2519085	hsa-miR-2052	CLIP-seq
MIRT2519086	hsa-miR-211	CLIP-seq
MIRT2519087	hsa-miR-22	CLIP-seq
MIRT2519088	hsa-miR-23a	CLIP-seq
MIRT2519089	hsa-miR-23b	CLIP-seq
MIRT2519090	hsa-miR-23c	CLIP-seq
MIRT2436875	hsa-miR-2861	CLIP-seq
MIRT2519091	hsa-miR-3074-5p	CLIP-seq
MIRT2519093	hsa-miR-3157-3p	CLIP-seq
MIRT2519094	hsa-miR-3160-5p	CLIP-seq
MIRT2519095	hsa-miR-3173-5p	CLIP-seq
MIRT2436876	hsa-miR-3193	CLIP-seq
MIRT1979586	hsa-miR-3198	CLIP-seq
MIRT2436877	hsa-miR-34a	CLIP-seq
MIRT2436878	hsa-miR-34c-5p	CLIP-seq
MIRT2679443	hsa-miR-3622b-5p	CLIP-seq
MIRT2519097	hsa-miR-3662	CLIP-seq
MIRT2519098	hsa-miR-3672	CLIP-seq
MIRT2519099	hsa-miR-3676	CLIP-seq
MIRT2519100	hsa-miR-3913-3p	CLIP-seq
MIRT2519101	hsa-miR-3914	CLIP-seq
MIRT2519102	hsa-miR-3940-5p	CLIP-seq
MIRT2519103	hsa-miR-4264	CLIP-seq
MIRT2519104	hsa-miR-4287	CLIP-seq
MIRT2519105	hsa-miR-4293	CLIP-seq
MIRT944213	hsa-miR-4294	CLIP-seq
MIRT1979587	hsa-miR-4309	CLIP-seq
MIRT2519106	hsa-miR-4324	CLIP-seq
MIRT2519107	hsa-miR-4328	CLIP-seq
MIRT2519109	hsa-miR-4330	CLIP-seq
MIRT2519110	hsa-miR-4421	CLIP-seq
MIRT2519111	hsa-miR-4446-5p	CLIP-seq
MIRT2519112	hsa-miR-4469	CLIP-seq
MIRT2519113	hsa-miR-448	CLIP-seq
MIRT2436879	hsa-miR-4488	CLIP-seq
MIRT2436880	hsa-miR-449a	CLIP-seq
MIRT2436881	hsa-miR-449b	CLIP-seq
MIRT2519114	hsa-miR-4507	CLIP-seq
MIRT2519115	hsa-miR-452	CLIP-seq
MIRT2519116	hsa-miR-4529-3p	CLIP-seq
MIRT2519117	hsa-miR-4645-3p	CLIP-seq
MIRT2519118	hsa-miR-4659a-5p	CLIP-seq
MIRT2519119	hsa-miR-4659b-5p	CLIP-seq
MIRT2519120	hsa-miR-4676-3p	CLIP-seq
MIRT2519121	hsa-miR-4685-3p	CLIP-seq
MIRT2679444	hsa-miR-4694-3p	CLIP-seq
MIRT2519122	hsa-miR-4697-3p	CLIP-seq
MIRT2436882	hsa-miR-4697-5p	CLIP-seq
MIRT2519123	hsa-miR-4755-5p	CLIP-seq
MIRT2519124	hsa-miR-4768-5p	CLIP-seq
MIRT2519125	hsa-miR-4776-3p	CLIP-seq
MIRT2519126	hsa-miR-4797-3p	CLIP-seq
MIRT2519127	hsa-miR-489	CLIP-seq
MIRT2519128	hsa-miR-498	CLIP-seq
MIRT2519129	hsa-miR-499-3p	CLIP-seq
MIRT2519130	hsa-miR-499a-3p	CLIP-seq
MIRT2519131	hsa-miR-520f	CLIP-seq
MIRT2679445	hsa-miR-522	CLIP-seq
MIRT2519132	hsa-miR-544b	CLIP-seq
MIRT2519137	hsa-miR-570	CLIP-seq
MIRT2519138	hsa-miR-596	CLIP-seq
MIRT2519140	hsa-miR-623	CLIP-seq
MIRT2436883	hsa-miR-637	CLIP-seq
MIRT2519141	hsa-miR-642a	CLIP-seq
MIRT2519142	hsa-miR-874	CLIP-seq
MIRT2519144	hsa-miR-9	CLIP-seq
MIRT944214	hsa-miR-924	CLIP-seq
MIRT2519145	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IDA	23486063
GO:0001662	Process	Behavioral fear response	IEA
GO:0001666	Process	Response to hypoxia	IDA	16670267
GO:0002020	Function	Protease binding	IPI	16651416
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	EXP	8100523, 8798518, 15584901
GO:0005102	Function	Signaling receptor binding	IPI	10900005
GO:0005515	Function	Protein binding	IPI	7594462, 8101391, 14684150, 17287217, 17549790, 18275857, 21314817, 22001206, 23486063, 23831647, 23835475, 25461530, 29669833, 32203189, 32275855
GO:0005576	Component	Extracellular region	TAS
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	16670267
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0006508	Process	Proteolysis	IDA	27198182
GO:0007155	Process	Cell adhesion	IEA
GO:0008236	Function	Serine-type peptidase activity	IDA	14684150
GO:0008239	Function	Dipeptidyl-peptidase activity	IBA	21873635
GO:0008239	Function	Dipeptidyl-peptidase activity	IDA	10593948, 14684150, 16651416, 17549790, 27198182
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	17549790
GO:0009986	Component	Cell surface	IDA	7594462, 8101391, 10900005, 11772392
GO:0010716	Process	Negative regulation of extracellular matrix disassembly	IDA	16651416
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	15052268
GO:0030027	Component	Lamellipodium	IDA	16651416
GO:0030139	Component	Endocytic vesicle	IDA	10900005
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0031295	Process	T cell costimulation	IDA	10900005, 17287217
GO:0033632	Process	Regulation of cell-cell adhesion mediated by integrin	IDA	11772392
GO:0035641	Process	Locomotory exploration behavior	IEA
GO:0036343	Process	Psychomotor behavior	IEA
GO:0042110	Process	T cell activation	IDA	7594462
GO:0042802	Function	Identical protein binding	IPI	22001206
GO:0042803	Function	Protein homodimerization activity	IPI	14684150, 15448155
GO:0043542	Process	Endothelial cell migration	IDA	16651416
GO:0045121	Component	Membrane raft	IEA
GO:0045499	Function	Chemorepellent activity	IDA	23677473
GO:0045499	Function	Chemorepellent activity	IMP	23677473
GO:0046581	Component	Intercellular canaliculus	IEA
GO:0046718	Process	Viral entry into host cell	IEA
GO:0050796	Process	Regulation of insulin secretion	TAS
GO:0050919	Process	Negative chemotaxis	IEA
GO:0070062	Component	Extracellular exosome	HDA	11487543, 19056867, 19199708, 20458337, 21362503, 23533145
GO:0090024	Process	Negative regulation of neutrophil chemotaxis	IMP	23677473

Other IDs

• MIM: 102720
• HGNC: 3009
• e!Ensembl: ENSG00000197635

Protein

• UniProt ID: P27487
• Protein name: Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl
• Protein function: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell c
• PDB: 1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00930	DPPIV_N	108 → 479	Dipeptidyl peptidase IV (DPP IV) N-terminal region	Family
  PF00326	Peptidase_S9	559 → 765	Prolyl oligopeptidase family	Domain

• Sequence:

  MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
  RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
  VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
  PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
  YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
  CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
  EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
  EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
  TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
  PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
  FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
  YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
  KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP

• Sequence length: 766

Pathways

KEGG:

Virion - Hepatitis viruses
Protein digestion and absorption

Reactome:

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	24782177

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	25635612, 21630437, 21630437, 25635612