DOK1 (docking protein 1)

Gene

• Entrez ID: 1796
• Gene name: Docking protein 1
• Gene symbol: DOK1
• Synonyms: P62DOK, pp62
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcrip

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1979248	hsa-miR-1343	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518688	hsa-miR-4281	CLIP-seq
MIRT2518689	hsa-miR-4662a-5p	CLIP-seq
MIRT2518690	hsa-miR-4715-3p	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Unknown	23028047

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 22190034, 22252131, 23822091
GO:0005634	Component	Nucleus	IDA	23822091
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	9008160, 10799545
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10799545
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IEA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0007411	Process	Axon guidance	TAS
GO:0038145	Process	Macrophage colony-stimulating factor signaling pathway	IEA
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 602919
• HGNC: 2990
• e!Ensembl: ENSG00000115325

Protein

• UniProt ID: Q99704
• Protein name: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates int
• PDB: 2V76
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	4 → 119	PH domain	Domain
  PF02174	IRS	151 → 254	PTB domain (IRS-1 type)	Domain

• Sequence:

  MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRL
  DCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFP
  KGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEA
  ERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGND
  IFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPL
  DSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDP
  IYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPL
  LAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGS
  T

• Sequence length: 481

Pathways

Reactome:

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	20139980
Ovarian cancer	Malignant neoplasm of ovary	rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828, rs80357208, rs55770810, rs80358165, rs80358010, rs587780226, rs536907995, rs139414606, rs371638537, rs574552037, rs730881647, rs747993448, rs786202125, rs786202962, rs121913321, rs189261858, rs869320800, rs753023295, rs779466229, rs752411477, rs80357438, rs191486604, rs760874290, rs752780954, rs760782298, rs1555591361, rs1555578360, rs1555588460, rs1555587401, rs747427602, rs112675807, rs80357393	21856257

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		20139980
Ovarian neoplasm	ovarian neoplasm		21856257