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POLR3H (RNA polymerase III subunit H)

Gene

171568

RNA polymerase III subunit H

POLR3H

C25, RPC22.9, RPC8

22q13.2

Show/Hide all(165)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047813	hsa-miR-30d-5p	CLASH	23622248
MIRT043433	hsa-miR-331-3p	CLASH	23622248
MIRT043160	hsa-miR-324-5p	CLASH	23622248
MIRT042471	hsa-miR-423-3p	CLASH	23622248
MIRT042331	hsa-miR-484	CLASH	23622248
MIRT039879	hsa-miR-615-3p	CLASH	23622248
MIRT038118	hsa-miR-423-5p	CLASH	23622248
MIRT035985	hsa-miR-1301-3p	CLASH	23622248
MIRT1249367	hsa-miR-1273g	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT1249369	hsa-miR-3179	CLIP-seq
MIRT1249370	hsa-miR-323b-5p	CLIP-seq
MIRT1249371	hsa-miR-4447	CLIP-seq
MIRT1249372	hsa-miR-4472	CLIP-seq
MIRT1249373	hsa-miR-4649-3p	CLIP-seq
MIRT1249374	hsa-miR-4792	CLIP-seq
MIRT1249375	hsa-miR-541	CLIP-seq
MIRT1249376	hsa-miR-654-5p	CLIP-seq
MIRT1249377	hsa-miR-1182	CLIP-seq
MIRT1249378	hsa-miR-193a-5p	CLIP-seq
MIRT1249379	hsa-miR-3136-3p	CLIP-seq
MIRT1249369	hsa-miR-3179	CLIP-seq
MIRT1249380	hsa-miR-3202	CLIP-seq
MIRT1249381	hsa-miR-3612	CLIP-seq
MIRT1249382	hsa-miR-3974	CLIP-seq
MIRT1249383	hsa-miR-4443	CLIP-seq
MIRT1249384	hsa-miR-4476	CLIP-seq
MIRT1249373	hsa-miR-4649-3p	CLIP-seq
MIRT1249385	hsa-miR-4697-3p	CLIP-seq
MIRT1249386	hsa-miR-4704-3p	CLIP-seq
MIRT1249387	hsa-miR-4761-5p	CLIP-seq
MIRT1249374	hsa-miR-4792	CLIP-seq
MIRT1249388	hsa-miR-650	CLIP-seq
MIRT1249389	hsa-miR-665	CLIP-seq
MIRT2073653	hsa-miR-1227	CLIP-seq
MIRT1249378	hsa-miR-193a-5p	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT2073655	hsa-miR-2682	CLIP-seq
MIRT2073656	hsa-miR-29a	CLIP-seq
MIRT2073657	hsa-miR-29b	CLIP-seq
MIRT2073658	hsa-miR-29c	CLIP-seq
MIRT2073659	hsa-miR-3157-3p	CLIP-seq
MIRT2073660	hsa-miR-3190	CLIP-seq
MIRT2073661	hsa-miR-3606	CLIP-seq
MIRT2073662	hsa-miR-3614-5p	CLIP-seq
MIRT1249382	hsa-miR-3974	CLIP-seq
MIRT2073663	hsa-miR-4256	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2073665	hsa-miR-4423-3p	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2073667	hsa-miR-4468	CLIP-seq
MIRT2073668	hsa-miR-449c	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2073670	hsa-miR-4512	CLIP-seq
MIRT2073671	hsa-miR-4640-5p	CLIP-seq
MIRT2073672	hsa-miR-4660	CLIP-seq
MIRT2073673	hsa-miR-4688	CLIP-seq
MIRT1249386	hsa-miR-4704-3p	CLIP-seq
MIRT2073674	hsa-miR-4710	CLIP-seq
MIRT2073675	hsa-miR-4715-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073677	hsa-miR-4726-5p	CLIP-seq
MIRT2073678	hsa-miR-4733-3p	CLIP-seq
MIRT2073679	hsa-miR-4742-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT1249387	hsa-miR-4761-5p	CLIP-seq
MIRT2073681	hsa-miR-488	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2073683	hsa-miR-646	CLIP-seq
MIRT2073684	hsa-miR-663b	CLIP-seq
MIRT2073685	hsa-miR-671-5p	CLIP-seq
MIRT2073686	hsa-miR-874	CLIP-seq
MIRT2073687	hsa-miR-891b	CLIP-seq
MIRT2073688	hsa-miR-938	CLIP-seq
MIRT2073689	hsa-miR-940	CLIP-seq
MIRT2432220	hsa-miR-1972	CLIP-seq
MIRT2432221	hsa-miR-4650-5p	CLIP-seq
MIRT2073653	hsa-miR-1227	CLIP-seq
MIRT2456876	hsa-miR-1252	CLIP-seq
MIRT2456877	hsa-miR-138	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT2456878	hsa-miR-3123	CLIP-seq
MIRT2456879	hsa-miR-320e	CLIP-seq
MIRT2456880	hsa-miR-337-3p	CLIP-seq
MIRT2456881	hsa-miR-375	CLIP-seq
MIRT2456882	hsa-miR-3925-5p	CLIP-seq
MIRT2456883	hsa-miR-4273	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2456884	hsa-miR-4320	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2456885	hsa-miR-4456	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2456886	hsa-miR-4677-5p	CLIP-seq
MIRT2456887	hsa-miR-4708-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT2456888	hsa-miR-4777-5p	CLIP-seq
MIRT2456889	hsa-miR-4781-5p	CLIP-seq
MIRT2456890	hsa-miR-516a-3p	CLIP-seq
MIRT2456891	hsa-miR-518d-5p	CLIP-seq
MIRT2456892	hsa-miR-519b-5p	CLIP-seq
MIRT2456893	hsa-miR-519c-5p	CLIP-seq
MIRT2456894	hsa-miR-520c-5p	CLIP-seq
MIRT2456895	hsa-miR-526a	CLIP-seq
MIRT1249375	hsa-miR-541	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2456896	hsa-miR-589	CLIP-seq
MIRT1249376	hsa-miR-654-5p	CLIP-seq
MIRT2456897	hsa-miR-744	CLIP-seq
MIRT2456898	hsa-miR-765	CLIP-seq
MIRT2456876	hsa-miR-1252	CLIP-seq
MIRT2597476	hsa-miR-1291	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT2456878	hsa-miR-3123	CLIP-seq
MIRT2597477	hsa-miR-3173-3p	CLIP-seq
MIRT2597478	hsa-miR-3173-5p	CLIP-seq
MIRT2456881	hsa-miR-375	CLIP-seq
MIRT2597479	hsa-miR-3918	CLIP-seq
MIRT2456882	hsa-miR-3925-5p	CLIP-seq
MIRT2456883	hsa-miR-4273	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2456884	hsa-miR-4320	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2073670	hsa-miR-4512	CLIP-seq
MIRT2456886	hsa-miR-4677-5p	CLIP-seq
MIRT2456887	hsa-miR-4708-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT2456888	hsa-miR-4777-5p	CLIP-seq
MIRT2456891	hsa-miR-518d-5p	CLIP-seq
MIRT2456892	hsa-miR-519b-5p	CLIP-seq
MIRT2456893	hsa-miR-519c-5p	CLIP-seq
MIRT2456894	hsa-miR-520c-5p	CLIP-seq
MIRT2456895	hsa-miR-526a	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2597480	hsa-miR-570	CLIP-seq
MIRT2456896	hsa-miR-589	CLIP-seq
MIRT2456898	hsa-miR-765	CLIP-seq
MIRT2456876	hsa-miR-1252	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT2456878	hsa-miR-3123	CLIP-seq
MIRT2456881	hsa-miR-375	CLIP-seq
MIRT2456882	hsa-miR-3925-5p	CLIP-seq
MIRT2456883	hsa-miR-4273	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2456884	hsa-miR-4320	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2456886	hsa-miR-4677-5p	CLIP-seq
MIRT2456887	hsa-miR-4708-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT2456888	hsa-miR-4777-5p	CLIP-seq
MIRT2456891	hsa-miR-518d-5p	CLIP-seq
MIRT2456892	hsa-miR-519b-5p	CLIP-seq
MIRT2456893	hsa-miR-519c-5p	CLIP-seq
MIRT2456894	hsa-miR-520c-5p	CLIP-seq
MIRT2456895	hsa-miR-526a	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2597480	hsa-miR-570	CLIP-seq
MIRT2456896	hsa-miR-589	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003899	Function	DNA-directed 5'-3' RNA polymerase activity	IDA	12391170
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA	12391170
GO:0005654	Component	Nucleoplasm	TAS
GO:0005666	Component	RNA polymerase III complex	IBA	21873635
GO:0005666	Component	RNA polymerase III complex	IDA	12391170
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	IDA	12391170
GO:0006383	Process	Transcription by RNA polymerase III	IDA	12391170
GO:0006384	Process	Transcription initiation from RNA polymerase III promoter	IBA	21873635
GO:0032481	Process	Positive regulation of type I interferon production	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045087	Process	Innate immune response	IEA
GO:0051607	Process	Defense response to virus	IEA

MIM	HGNC	e!Ensembl
619801	30349	ENSG00000100413

Protein

UniProt ID

Q9Y535

Protein name

DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)

Protein function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III)

PDB

7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03876	SHS2_Rpb7-N	8 → 64	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	Domain
PF08292	RNA_pol_Rbc25	83 → 201	RNA polymerase III subunit Rpc25	Domain

Sequence

MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN

Sequence length

204

Interactions

View interactions

	KEGG		Reactome
	RNA polymerase Cytosolic DNA-sensing pathway		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Cerebellar-retinal degeneration	INFANTILE CEREBELLAR-RETINAL DEGENERATION	rs786200924, rs786204828, rs786204829, rs786204830, rs1114167284, rs1601927180, rs1601936467
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Optic atrophy	OPTIC ATROPHY 9	rs121434508, rs267607017, rs80356524, rs80356525, rs879255560, rs104893753, rs80356529, rs397515360, rs104893620, rs199476104, rs199476112, rs199476118, rs398124298, rs770066665, rs398124299, rs61750185, rs672601379, rs727504060, rs786204830, rs794727804, rs199946797, rs863224127, rs863224131, rs863224134, rs863224906, rs372054380, rs886037828, rs764791523, rs145639028, rs1057519312, rs1064794257, rs1064794656, rs1064797303, rs774265764, rs760337383, rs1553784985, rs72653786, rs1555229948, rs1555119216, rs761743852, rs1553785338, rs1020764190, rs782581701, rs1560408865, rs761460379, rs773022324, rs782740998, rs1560327427, rs80356528, rs1734162973, rs1716524583, rs1057368575

Show/Hide Unknown Diseases (7)

Unknown
Disease name	Disease term	dbSNP ID	References
46, xx gonadal dysgenesis	46,XX gonadal dysgenesis
46,xx gonadal dysgenesis	Pure Gonadal Dysgenesis, 46, XX		30830215
Arachnoid cyst	Arachnoid Cysts
Frontal bossing	Frontal bossing
Gonadal dysgenesis	Gonadal Dysgenesis, 46,XX		30830215
Movement disorders	Movement Disorders		22405087, 26992325, 28545339, 25351951
Sensorineural hearing loss	Sensorineural hearing loss, bilateral

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