ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19)

Gene

• Entrez ID: 171019
• Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 19
• Gene symbol: ADAMTS19
• Synonyms: CVDP2
• Chromosome: 5
• Chromosome location: 5q23.3
• Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT766516	hsa-miR-103a	CLIP-seq
MIRT766517	hsa-miR-107	CLIP-seq
MIRT766518	hsa-miR-1184	CLIP-seq
MIRT766519	hsa-miR-1197	CLIP-seq
MIRT766520	hsa-miR-1205	CLIP-seq
MIRT766521	hsa-miR-1206	CLIP-seq
MIRT766522	hsa-miR-1244	CLIP-seq
MIRT766523	hsa-miR-125a-3p	CLIP-seq
MIRT766524	hsa-miR-1261	CLIP-seq
MIRT766525	hsa-miR-1286	CLIP-seq
MIRT766526	hsa-miR-129-3p	CLIP-seq
MIRT766527	hsa-miR-1297	CLIP-seq
MIRT766528	hsa-miR-1299	CLIP-seq
MIRT766529	hsa-miR-1303	CLIP-seq
MIRT766530	hsa-miR-154	CLIP-seq
MIRT766531	hsa-miR-181a	CLIP-seq
MIRT766532	hsa-miR-181b	CLIP-seq
MIRT766533	hsa-miR-181c	CLIP-seq
MIRT766534	hsa-miR-181d	CLIP-seq
MIRT766535	hsa-miR-185	CLIP-seq
MIRT766536	hsa-miR-1976	CLIP-seq
MIRT766537	hsa-miR-214	CLIP-seq
MIRT766538	hsa-miR-224	CLIP-seq
MIRT766539	hsa-miR-26a	CLIP-seq
MIRT766540	hsa-miR-26b	CLIP-seq
MIRT766541	hsa-miR-29a	CLIP-seq
MIRT766542	hsa-miR-29b	CLIP-seq
MIRT766543	hsa-miR-29c	CLIP-seq
MIRT766544	hsa-miR-3120-3p	CLIP-seq
MIRT766545	hsa-miR-3146	CLIP-seq
MIRT766546	hsa-miR-3150a-3p	CLIP-seq
MIRT766547	hsa-miR-3158-5p	CLIP-seq
MIRT766548	hsa-miR-3160-5p	CLIP-seq
MIRT766549	hsa-miR-3175	CLIP-seq
MIRT766550	hsa-miR-3613-3p	CLIP-seq
MIRT766551	hsa-miR-3619-5p	CLIP-seq
MIRT766552	hsa-miR-3651	CLIP-seq
MIRT766553	hsa-miR-3665	CLIP-seq
MIRT766554	hsa-miR-374a	CLIP-seq
MIRT766555	hsa-miR-374b	CLIP-seq
MIRT766556	hsa-miR-384	CLIP-seq
MIRT766557	hsa-miR-3929	CLIP-seq
MIRT766558	hsa-miR-3941	CLIP-seq
MIRT766559	hsa-miR-4251	CLIP-seq
MIRT766560	hsa-miR-4262	CLIP-seq
MIRT766561	hsa-miR-4306	CLIP-seq
MIRT766562	hsa-miR-4326	CLIP-seq
MIRT766563	hsa-miR-433	CLIP-seq
MIRT766564	hsa-miR-4419b	CLIP-seq
MIRT766565	hsa-miR-4436a	CLIP-seq
MIRT766566	hsa-miR-4465	CLIP-seq
MIRT766567	hsa-miR-4478	CLIP-seq
MIRT766568	hsa-miR-4639-5p	CLIP-seq
MIRT766569	hsa-miR-4643	CLIP-seq
MIRT766570	hsa-miR-4644	CLIP-seq
MIRT766571	hsa-miR-4652-3p	CLIP-seq
MIRT766572	hsa-miR-466	CLIP-seq
MIRT766573	hsa-miR-4666-5p	CLIP-seq
MIRT766574	hsa-miR-4668-5p	CLIP-seq
MIRT766575	hsa-miR-4672	CLIP-seq
MIRT766576	hsa-miR-4676-5p	CLIP-seq
MIRT766577	hsa-miR-4687-5p	CLIP-seq
MIRT766578	hsa-miR-4760-3p	CLIP-seq
MIRT766579	hsa-miR-4782-5p	CLIP-seq
MIRT766580	hsa-miR-4789-3p	CLIP-seq
MIRT766581	hsa-miR-491-5p	CLIP-seq
MIRT766582	hsa-miR-502-5p	CLIP-seq
MIRT766583	hsa-miR-516b	CLIP-seq
MIRT766584	hsa-miR-539	CLIP-seq
MIRT766585	hsa-miR-541	CLIP-seq
MIRT766586	hsa-miR-542-3p	CLIP-seq
MIRT766587	hsa-miR-544	CLIP-seq
MIRT766588	hsa-miR-575	CLIP-seq
MIRT766589	hsa-miR-654-5p	CLIP-seq
MIRT766590	hsa-miR-657	CLIP-seq
MIRT766591	hsa-miR-761	CLIP-seq
MIRT766592	hsa-miR-922	CLIP-seq
MIRT766593	hsa-miR-939	CLIP-seq
MIRT766522	hsa-miR-1244	CLIP-seq
MIRT766524	hsa-miR-1261	CLIP-seq
MIRT766528	hsa-miR-1299	CLIP-seq
MIRT766529	hsa-miR-1303	CLIP-seq
MIRT766531	hsa-miR-181a	CLIP-seq
MIRT766532	hsa-miR-181b	CLIP-seq
MIRT766533	hsa-miR-181c	CLIP-seq
MIRT766534	hsa-miR-181d	CLIP-seq
MIRT766535	hsa-miR-185	CLIP-seq
MIRT766538	hsa-miR-224	CLIP-seq
MIRT766541	hsa-miR-29a	CLIP-seq
MIRT766542	hsa-miR-29b	CLIP-seq
MIRT766543	hsa-miR-29c	CLIP-seq
MIRT1925815	hsa-miR-302f	CLIP-seq
MIRT1925816	hsa-miR-3119	CLIP-seq
MIRT1925817	hsa-miR-3140-3p	CLIP-seq
MIRT766545	hsa-miR-3146	CLIP-seq
MIRT766546	hsa-miR-3150a-3p	CLIP-seq
MIRT766549	hsa-miR-3175	CLIP-seq
MIRT1925818	hsa-miR-320e	CLIP-seq
MIRT1925819	hsa-miR-335	CLIP-seq
MIRT1925820	hsa-miR-369-3p	CLIP-seq
MIRT1925821	hsa-miR-421	CLIP-seq
MIRT766560	hsa-miR-4262	CLIP-seq
MIRT1925822	hsa-miR-4282	CLIP-seq
MIRT766561	hsa-miR-4306	CLIP-seq
MIRT1925823	hsa-miR-4480	CLIP-seq
MIRT1925824	hsa-miR-4503	CLIP-seq
MIRT766568	hsa-miR-4639-5p	CLIP-seq
MIRT766570	hsa-miR-4644	CLIP-seq
MIRT766572	hsa-miR-466	CLIP-seq
MIRT766576	hsa-miR-4676-5p	CLIP-seq
MIRT1925825	hsa-miR-4679	CLIP-seq
MIRT1925826	hsa-miR-4698	CLIP-seq
MIRT1925827	hsa-miR-4709-5p	CLIP-seq
MIRT766578	hsa-miR-4760-3p	CLIP-seq
MIRT1925828	hsa-miR-4764-5p	CLIP-seq
MIRT1925829	hsa-miR-4768-5p	CLIP-seq
MIRT766579	hsa-miR-4782-5p	CLIP-seq
MIRT766581	hsa-miR-491-5p	CLIP-seq
MIRT766583	hsa-miR-516b	CLIP-seq
MIRT766585	hsa-miR-541	CLIP-seq
MIRT1925830	hsa-miR-548ac	CLIP-seq
MIRT1925831	hsa-miR-548ae	CLIP-seq
MIRT1925832	hsa-miR-548aj	CLIP-seq
MIRT1925833	hsa-miR-548am	CLIP-seq
MIRT1925834	hsa-miR-548d-3p	CLIP-seq
MIRT1925835	hsa-miR-548x	CLIP-seq
MIRT1925836	hsa-miR-548z	CLIP-seq
MIRT766588	hsa-miR-575	CLIP-seq
MIRT1925837	hsa-miR-590-3p	CLIP-seq
MIRT1925838	hsa-miR-640	CLIP-seq
MIRT1925839	hsa-miR-649	CLIP-seq
MIRT766589	hsa-miR-654-5p	CLIP-seq
MIRT766593	hsa-miR-939	CLIP-seq
MIRT766521	hsa-miR-1206	CLIP-seq
MIRT766522	hsa-miR-1244	CLIP-seq
MIRT766524	hsa-miR-1261	CLIP-seq
MIRT766528	hsa-miR-1299	CLIP-seq
MIRT766531	hsa-miR-181a	CLIP-seq
MIRT766532	hsa-miR-181b	CLIP-seq
MIRT766533	hsa-miR-181c	CLIP-seq
MIRT766534	hsa-miR-181d	CLIP-seq
MIRT766538	hsa-miR-224	CLIP-seq
MIRT2167197	hsa-miR-3680	CLIP-seq
MIRT2167198	hsa-miR-3973	CLIP-seq
MIRT766560	hsa-miR-4262	CLIP-seq
MIRT766563	hsa-miR-433	CLIP-seq
MIRT2167199	hsa-miR-4426	CLIP-seq
MIRT2167200	hsa-miR-4647	CLIP-seq
MIRT2167201	hsa-miR-4662b	CLIP-seq
MIRT766576	hsa-miR-4676-5p	CLIP-seq
MIRT1925826	hsa-miR-4698	CLIP-seq
MIRT766579	hsa-miR-4782-5p	CLIP-seq
MIRT2167202	hsa-miR-4798-3p	CLIP-seq
MIRT766583	hsa-miR-516b	CLIP-seq
MIRT2167203	hsa-miR-520g	CLIP-seq
MIRT2167204	hsa-miR-520h	CLIP-seq
MIRT766588	hsa-miR-575	CLIP-seq
MIRT2167205	hsa-miR-599	CLIP-seq
MIRT766521	hsa-miR-1206	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0006508	Process	Proteolysis	IEA
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 607513
• HGNC: 17111
• e!Ensembl: ENSG00000145808

Protein

• UniProt ID: Q8TE59
• Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	146 → 273	Reprolysin family propeptide	Family
  PF01421	Reprolysin	325 → 546	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF17771	ADAM_CR_2	559 → 626	ADAM cysteine-rich domain	Domain
  PF00090	TSP_1	637 → 685	Thrombospondin type 1 domain	Domain
  PF05986	ADAM_spacer1	790 → 900	ADAM-TS Spacer 1	Family
  PF19030	TSP1_ADAMTS	919 → 976		Domain
  PF19030	TSP1_ADAMTS	980 → 1036		Domain
  PF19030	TSP1_ADAMTS	1040 → 1088		Domain
  PF19030	TSP1_ADAMTS	1091 → 1143		Domain

• Sequence:

  MRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADP
  GWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQ
  ELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLL
  RRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG
  GGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDK
  GRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNL
  FQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMST
  NWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTI
  AHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNC
  LLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKE
  CRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC
  PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE
  KPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG
  VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN
  SDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIP
  SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY
  LTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC
  IGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAE
  DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL
  QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYA
  QKLQQKS

• Sequence length: 1207

Pathways

Reactome:

Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease name	Disease term	dbSNP ID	References
Ovarian failure	Ovarian Failure, Premature		19508998
Psychosexual dysfunction	Psychosexual dysfunction		22445761
Sexual dysfunction	Sexual Dysfunction		22445761