ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16)

Gene

• Entrez ID: 170690
• Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 16
• Gene symbol: ADAMTS16
• Synonyms: ADAMTS16s
• Chromosome: 5
• Chromosome location: 5p15.32
• Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegri

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018023	hsa-miR-335-5p	Microarray	18185580
MIRT766432	hsa-miR-1	CLIP-seq
MIRT766433	hsa-miR-1343	CLIP-seq
MIRT766434	hsa-miR-2052	CLIP-seq
MIRT766435	hsa-miR-206	CLIP-seq
MIRT766436	hsa-miR-296-3p	CLIP-seq
MIRT766437	hsa-miR-3065-3p	CLIP-seq
MIRT766438	hsa-miR-3171	CLIP-seq
MIRT766439	hsa-miR-3673	CLIP-seq
MIRT766440	hsa-miR-3687	CLIP-seq
MIRT766441	hsa-miR-4442	CLIP-seq
MIRT766442	hsa-miR-4490	CLIP-seq
MIRT766443	hsa-miR-4668-3p	CLIP-seq
MIRT766444	hsa-miR-4708-5p	CLIP-seq
MIRT766445	hsa-miR-4768-3p	CLIP-seq
MIRT766446	hsa-miR-4773	CLIP-seq
MIRT766447	hsa-miR-613	CLIP-seq
MIRT2167149	hsa-miR-128	CLIP-seq
MIRT2167150	hsa-miR-27a	CLIP-seq
MIRT2167151	hsa-miR-27b	CLIP-seq
MIRT2167152	hsa-miR-3155	CLIP-seq
MIRT2167153	hsa-miR-3155b	CLIP-seq
MIRT2167154	hsa-miR-4284	CLIP-seq
MIRT2167155	hsa-miR-484	CLIP-seq
MIRT2167156	hsa-miR-494	CLIP-seq
MIRT2425982	hsa-miR-142-5p	CLIP-seq
MIRT2425983	hsa-miR-216b	CLIP-seq
MIRT2425984	hsa-miR-3163	CLIP-seq
MIRT2425985	hsa-miR-4803	CLIP-seq
MIRT2425986	hsa-miR-548a-5p	CLIP-seq
MIRT2425987	hsa-miR-548ab	CLIP-seq
MIRT2425988	hsa-miR-548ak	CLIP-seq
MIRT2425989	hsa-miR-548b-5p	CLIP-seq
MIRT2425990	hsa-miR-548c-3p	CLIP-seq
MIRT2425991	hsa-miR-548c-5p	CLIP-seq
MIRT2425992	hsa-miR-548d-5p	CLIP-seq
MIRT2425993	hsa-miR-548h	CLIP-seq
MIRT2425994	hsa-miR-548i	CLIP-seq
MIRT2425995	hsa-miR-548j	CLIP-seq
MIRT2425996	hsa-miR-548k	CLIP-seq
MIRT2425997	hsa-miR-548l	CLIP-seq
MIRT2425998	hsa-miR-548w	CLIP-seq
MIRT2425999	hsa-miR-548y	CLIP-seq
MIRT2426000	hsa-miR-559	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001658	Process	Branching involved in ureteric bud morphogenesis	IEA
GO:0003073	Process	Regulation of systemic arterial blood pressure	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0006508	Process	Proteolysis	IEA
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0048232	Process	Male gamete generation	IEA
GO:1902017	Process	Regulation of cilium assembly	IEA

Other IDs

• MIM: 607510
• HGNC: 17108
• e!Ensembl: ENSG00000145536

Protein

• UniProt ID: Q8TE57
• Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	61 → 205	Reprolysin family propeptide	Family
  PF01421	Reprolysin	291 → 495	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF17771	ADAM_CR_2	508 → 575	ADAM cysteine-rich domain	Domain
  PF00090	TSP_1	590 → 640	Thrombospondin type 1 domain	Domain
  PF05986	ADAM_spacer1	746 → 858	ADAM-TS Spacer 1	Family
  PF19030	TSP1_ADAMTS	931 → 986		Domain
  PF19030	TSP1_ADAMTS	990 → 1047		Domain
  PF19030	TSP1_ADAMTS	1055 → 1114		Domain
  PF19030	TSP1_ADAMTS	1130 → 1180		Domain
  PF08686	PLAC	1190 → 1220	PLAC (protease and lacunin) domain	Domain

• Sequence:

  MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEY
  DLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVA
  PGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL
  RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRL
  GLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDK
  KMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH
  TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTIN
  EDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLH
  KFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKA
  LWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSR
  TCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRF
  RGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERV
  GCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMN
  VSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIV
  ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL
  KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY
  DSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSA
  RAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAE
  KYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTA
  SCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLV
  PQHGMCSHKFYGKQCCKTCSKSNL

• Sequence length: 1224

Pathways

Reactome:

Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glaucoma	Glaucoma, Open-Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	22428042
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24039173

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		24039173
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	24039173
Ovarian neoplasm	ovarian neoplasm		30557369