PSORS1C2 (psoriasis susceptibility 1 candidate 2)

Gene

• Entrez ID: 170680
• Gene name: Psoriasis susceptibility 1 candidate 2
• Gene symbol: PSORS1C2
• Synonyms: C6orf17, SPR1
• Chromosome: 6
• Chromosome location: 6p21.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT711690	hsa-miR-490-5p	HITS-CLIP	19536157
MIRT711689	hsa-miR-1468-5p	HITS-CLIP	19536157
MIRT711690	hsa-miR-490-5p	HITS-CLIP	19536157
MIRT711689	hsa-miR-1468-5p	HITS-CLIP	19536157
MIRT1271076	hsa-miR-1254	CLIP-seq
MIRT1271077	hsa-miR-1270	CLIP-seq
MIRT1271078	hsa-miR-1292	CLIP-seq
MIRT1271079	hsa-miR-3116	CLIP-seq
MIRT1271080	hsa-miR-4254	CLIP-seq
MIRT1271081	hsa-miR-4471	CLIP-seq
MIRT1271082	hsa-miR-4646-5p	CLIP-seq
MIRT1271083	hsa-miR-4683	CLIP-seq
MIRT1271084	hsa-miR-4708-5p	CLIP-seq
MIRT1271085	hsa-miR-550a	CLIP-seq
MIRT1271086	hsa-miR-620	CLIP-seq
MIRT1271087	hsa-miR-661	CLIP-seq
MIRT1271076	hsa-miR-1254	CLIP-seq
MIRT1271077	hsa-miR-1270	CLIP-seq
MIRT1271078	hsa-miR-1292	CLIP-seq
MIRT1271079	hsa-miR-3116	CLIP-seq
MIRT1271080	hsa-miR-4254	CLIP-seq
MIRT1271081	hsa-miR-4471	CLIP-seq
MIRT1271082	hsa-miR-4646-5p	CLIP-seq
MIRT1271083	hsa-miR-4683	CLIP-seq
MIRT1271084	hsa-miR-4708-5p	CLIP-seq
MIRT1271085	hsa-miR-550a	CLIP-seq
MIRT1271086	hsa-miR-620	CLIP-seq
MIRT1271087	hsa-miR-661	CLIP-seq
MIRT1271076	hsa-miR-1254	CLIP-seq
MIRT1271077	hsa-miR-1270	CLIP-seq
MIRT1271078	hsa-miR-1292	CLIP-seq
MIRT1271079	hsa-miR-3116	CLIP-seq
MIRT1271080	hsa-miR-4254	CLIP-seq
MIRT1271081	hsa-miR-4471	CLIP-seq
MIRT1271082	hsa-miR-4646-5p	CLIP-seq
MIRT1271083	hsa-miR-4683	CLIP-seq
MIRT1271084	hsa-miR-4708-5p	CLIP-seq
MIRT1271085	hsa-miR-550a	CLIP-seq
MIRT1271086	hsa-miR-620	CLIP-seq
MIRT1271087	hsa-miR-661	CLIP-seq
MIRT1271076	hsa-miR-1254	CLIP-seq
MIRT1271077	hsa-miR-1270	CLIP-seq
MIRT1271078	hsa-miR-1292	CLIP-seq
MIRT1271079	hsa-miR-3116	CLIP-seq
MIRT1271080	hsa-miR-4254	CLIP-seq
MIRT1271081	hsa-miR-4471	CLIP-seq
MIRT1271082	hsa-miR-4646-5p	CLIP-seq
MIRT1271083	hsa-miR-4683	CLIP-seq
MIRT1271084	hsa-miR-4708-5p	CLIP-seq
MIRT1271085	hsa-miR-550a	CLIP-seq
MIRT1271086	hsa-miR-620	CLIP-seq
MIRT1271087	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005575	Component	Cellular_component	ND
GO:0005576	Component	Extracellular region	IEA
GO:0008150	Process	Biological_process	ND

Other IDs

• MIM: 613526
• HGNC: 17199
• e!Ensembl: ENSG00000204538

Protein

• UniProt ID: Q9UIG4
• Protein name: Psoriasis susceptibility 1 candidate gene 2 protein (Protein SPR1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15356	SPR1	23 → 136	Psoriasis susceptibility locus 2	Family

• Sequence:

  MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPL
  FEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDN
  RPQEEPDLDPPREEYR

• Sequence length: 136

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Multiple myeloma	Multiple Myeloma	rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962, rs751524927, rs1575079076, rs1575446356, rs1478603808, rs1578264146, rs1578673280, rs1579484570, rs1579491104, rs1171390403, rs1582867955, rs764264135, rs951047896, rs890521687, rs1581495906, rs1587941402, rs1003155450, rs1588299621, rs1591100766, rs1591693095, rs1029296641, rs1593107841, rs1208575764, rs1593835248, rs1594406727, rs1594966387, rs1595889508, rs1159294530, rs1597073318, rs1135402871, rs1599413207, rs1418268495, rs1212577459, rs1600394490, rs1455074519, rs1603113792, rs1603415028, rs1602247047, rs1603452612	23955597
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	30626913

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	30626913
Oral ulcer	Oral Ulcer		30837455
Scleroderma	Systemic Scleroderma		21750679