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GIMAP1 (GTPase, IMAP family member 1)

Gene

170575

GTPase, IMAP family member 1

GIMAP1

HIMAP1, IAN2, IMAP1, IMAP38

7q36.1

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be

Show/Hide all(204)

miRTarBase ID	miRNA	Experiments	Reference
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	23824327
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	23824327
MIRT608957	hsa-miR-3689e	HITS-CLIP	23824327
MIRT608956	hsa-miR-3689f	HITS-CLIP	23824327
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608953	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	24906430
MIRT608961	hsa-miR-892a	HITS-CLIP	24906430
MIRT608960	hsa-miR-4494	HITS-CLIP	24906430
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	24906430
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	24906430
MIRT608957	hsa-miR-3689e	HITS-CLIP	24906430
MIRT608956	hsa-miR-3689f	HITS-CLIP	24906430
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608953	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT608957	hsa-miR-3689e	HITS-CLIP	27418678
MIRT608957	hsa-miR-3689e	HITS-CLIP	27418678
MIRT608957	hsa-miR-3689e	HITS-CLIP	27418678
MIRT608956	hsa-miR-3689f	HITS-CLIP	27418678
MIRT608956	hsa-miR-3689f	HITS-CLIP	27418678
MIRT608956	hsa-miR-3689f	HITS-CLIP	27418678
MIRT608960	hsa-miR-4494	HITS-CLIP	27418678
MIRT608960	hsa-miR-4494	HITS-CLIP	27418678
MIRT608960	hsa-miR-4494	HITS-CLIP	27418678
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	27418678
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	27418678
MIRT608953	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608953	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608953	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608961	hsa-miR-892a	HITS-CLIP	27418678
MIRT608961	hsa-miR-892a	HITS-CLIP	27418678
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	23824327
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	23824327
MIRT608957	hsa-miR-3689e	HITS-CLIP	23824327
MIRT608956	hsa-miR-3689f	HITS-CLIP	23824327
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608953	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1018887	hsa-miR-122	CLIP-seq
MIRT1018888	hsa-miR-1248	CLIP-seq
MIRT1018889	hsa-miR-1254	CLIP-seq
MIRT1018890	hsa-miR-125a-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018892	hsa-miR-1307	CLIP-seq
MIRT1018893	hsa-miR-217	CLIP-seq
MIRT1018894	hsa-miR-3116	CLIP-seq
MIRT1018895	hsa-miR-3127-3p	CLIP-seq
MIRT1018896	hsa-miR-3140-5p	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018898	hsa-miR-3155	CLIP-seq
MIRT1018899	hsa-miR-3155b	CLIP-seq
MIRT1018900	hsa-miR-3166	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018902	hsa-miR-3663-5p	CLIP-seq
MIRT1018903	hsa-miR-3678-3p	CLIP-seq
MIRT1018904	hsa-miR-3915	CLIP-seq
MIRT1018905	hsa-miR-3928	CLIP-seq
MIRT1018906	hsa-miR-3934	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018908	hsa-miR-4254	CLIP-seq
MIRT1018909	hsa-miR-4258	CLIP-seq
MIRT1018910	hsa-miR-4284	CLIP-seq
MIRT1018911	hsa-miR-4495	CLIP-seq
MIRT1018912	hsa-miR-451b	CLIP-seq
MIRT1018913	hsa-miR-4638-5p	CLIP-seq
MIRT1018914	hsa-miR-4663	CLIP-seq
MIRT1018915	hsa-miR-4711-5p	CLIP-seq
MIRT1018916	hsa-miR-4713-5p	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018919	hsa-miR-4766-3p	CLIP-seq
MIRT1018920	hsa-miR-4771	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT1018922	hsa-miR-4778-3p	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT1018924	hsa-miR-4790-3p	CLIP-seq
MIRT1018925	hsa-miR-484	CLIP-seq
MIRT1018926	hsa-miR-514	CLIP-seq
MIRT1018927	hsa-miR-514b-3p	CLIP-seq
MIRT1018928	hsa-miR-548a-3p	CLIP-seq
MIRT1018929	hsa-miR-548e	CLIP-seq
MIRT1018930	hsa-miR-548f	CLIP-seq
MIRT1018931	hsa-miR-548g	CLIP-seq
MIRT1018932	hsa-miR-564	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT1018934	hsa-miR-640	CLIP-seq
MIRT1018935	hsa-miR-764	CLIP-seq
MIRT1018890	hsa-miR-125a-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018898	hsa-miR-3155	CLIP-seq
MIRT1018899	hsa-miR-3155b	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018902	hsa-miR-3663-5p	CLIP-seq
MIRT1018906	hsa-miR-3934	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT1018925	hsa-miR-484	CLIP-seq
MIRT1018934	hsa-miR-640	CLIP-seq
MIRT1018935	hsa-miR-764	CLIP-seq
MIRT1018887	hsa-miR-122	CLIP-seq
MIRT1018889	hsa-miR-1254	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018892	hsa-miR-1307	CLIP-seq
MIRT2001675	hsa-miR-150	CLIP-seq
MIRT1018893	hsa-miR-217	CLIP-seq
MIRT1018894	hsa-miR-3116	CLIP-seq
MIRT2001676	hsa-miR-3147	CLIP-seq
MIRT1018898	hsa-miR-3155	CLIP-seq
MIRT1018899	hsa-miR-3155b	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018902	hsa-miR-3663-5p	CLIP-seq
MIRT2001677	hsa-miR-3942-3p	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018908	hsa-miR-4254	CLIP-seq
MIRT1018910	hsa-miR-4284	CLIP-seq
MIRT2001678	hsa-miR-4425	CLIP-seq
MIRT2001679	hsa-miR-4446-5p	CLIP-seq
MIRT2001680	hsa-miR-450b-3p	CLIP-seq
MIRT2001681	hsa-miR-4520a-3p	CLIP-seq
MIRT1018913	hsa-miR-4638-5p	CLIP-seq
MIRT1018915	hsa-miR-4711-5p	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT1018925	hsa-miR-484	CLIP-seq
MIRT2001682	hsa-miR-520g	CLIP-seq
MIRT2001683	hsa-miR-520h	CLIP-seq
MIRT1018932	hsa-miR-564	CLIP-seq
MIRT2001684	hsa-miR-769-3p	CLIP-seq
MIRT2001685	hsa-miR-938	CLIP-seq
MIRT1018887	hsa-miR-122	CLIP-seq
MIRT1018889	hsa-miR-1254	CLIP-seq
MIRT1018892	hsa-miR-1307	CLIP-seq
MIRT1018894	hsa-miR-3116	CLIP-seq
MIRT2234751	hsa-miR-3173-3p	CLIP-seq
MIRT2234752	hsa-miR-3184	CLIP-seq
MIRT2234753	hsa-miR-3194-3p	CLIP-seq
MIRT2234754	hsa-miR-3907	CLIP-seq
MIRT2234755	hsa-miR-423-5p	CLIP-seq
MIRT1018908	hsa-miR-4254	CLIP-seq
MIRT1018913	hsa-miR-4638-5p	CLIP-seq
MIRT2234756	hsa-miR-4688	CLIP-seq
MIRT2234757	hsa-miR-4779	CLIP-seq
MIRT1018932	hsa-miR-564	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT2538737	hsa-miR-1208	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT2538738	hsa-miR-3064-3p	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT2538739	hsa-miR-3653	CLIP-seq
MIRT2538740	hsa-miR-3658	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT2538741	hsa-miR-4252	CLIP-seq
MIRT2538742	hsa-miR-4317	CLIP-seq
MIRT2538743	hsa-miR-4715-3p	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT2538744	hsa-miR-4760-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005525	Function	GTP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016021	Component	Integral component of membrane	IEA

MIM	HGNC	e!Ensembl
608084	23237	ENSG00000213203

Protein

UniProt ID

Q8WWP7

Protein name

GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1)

Protein function

May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).

PDB

3V70

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04548	AIG1	28 → 238	AIG1 family	Domain

Sequence

MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGAT
SVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQ
LGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAE
CGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERL
RRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAV
AEVGPD

Sequence length

306

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

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