ZNF169 (zinc finger protein 169)

Gene

• Entrez ID: 169841
• Gene name: Zinc finger protein 169
• Gene symbol: ZNF169
• Synonyms: -
• Chromosome: 9
• Chromosome location: 9q22.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT495561	hsa-miR-5571-5p	PAR-CLIP	22291592
MIRT495562	hsa-miR-3529-3p	PAR-CLIP	22291592
MIRT495560	hsa-miR-1976	PAR-CLIP	22291592
MIRT495559	hsa-miR-376a-3p	PAR-CLIP	22291592
MIRT495558	hsa-miR-376b-3p	PAR-CLIP	22291592
MIRT495561	hsa-miR-5571-5p	PAR-CLIP	22291592
MIRT495562	hsa-miR-3529-3p	PAR-CLIP	22291592
MIRT495560	hsa-miR-1976	PAR-CLIP	22291592
MIRT495559	hsa-miR-376a-3p	PAR-CLIP	22291592
MIRT495558	hsa-miR-376b-3p	PAR-CLIP	22291592
MIRT495561	hsa-miR-5571-5p	PAR-CLIP	22291592
MIRT495562	hsa-miR-3529-3p	PAR-CLIP	22291592
MIRT495560	hsa-miR-1976	PAR-CLIP	22291592
MIRT495559	hsa-miR-376a-3p	PAR-CLIP	22291592
MIRT495558	hsa-miR-376b-3p	PAR-CLIP	22291592
MIRT495561	hsa-miR-5571-5p	PAR-CLIP	22291592
MIRT495562	hsa-miR-3529-3p	PAR-CLIP	22291592
MIRT495560	hsa-miR-1976	PAR-CLIP	22291592
MIRT495559	hsa-miR-376a-3p	PAR-CLIP	22291592
MIRT495558	hsa-miR-376b-3p	PAR-CLIP	22291592
MIRT1517063	hsa-miR-1204	CLIP-seq
MIRT1517064	hsa-miR-3120-5p	CLIP-seq
MIRT1517065	hsa-miR-3148	CLIP-seq
MIRT1517066	hsa-miR-3190	CLIP-seq
MIRT1517067	hsa-miR-3647-3p	CLIP-seq
MIRT1517068	hsa-miR-3714	CLIP-seq
MIRT1517069	hsa-miR-3978	CLIP-seq
MIRT1517070	hsa-miR-4435	CLIP-seq
MIRT1517071	hsa-miR-4752	CLIP-seq
MIRT1517072	hsa-miR-671-5p	CLIP-seq
MIRT2156115	hsa-miR-148a	CLIP-seq
MIRT2156116	hsa-miR-148b	CLIP-seq
MIRT2156117	hsa-miR-152	CLIP-seq
MIRT2156118	hsa-miR-1827	CLIP-seq
MIRT2156119	hsa-miR-2682	CLIP-seq
MIRT2156120	hsa-miR-298	CLIP-seq
MIRT2156121	hsa-miR-3145-3p	CLIP-seq
MIRT2156122	hsa-miR-34a	CLIP-seq
MIRT2156123	hsa-miR-34c-5p	CLIP-seq
MIRT2156124	hsa-miR-3646	CLIP-seq
MIRT2156125	hsa-miR-4311	CLIP-seq
MIRT2156126	hsa-miR-4316	CLIP-seq
MIRT2156127	hsa-miR-449a	CLIP-seq
MIRT2156128	hsa-miR-449b	CLIP-seq
MIRT2156129	hsa-miR-449c	CLIP-seq
MIRT2375672	hsa-miR-1273e	CLIP-seq
MIRT2375673	hsa-miR-296-5p	CLIP-seq
MIRT2375674	hsa-miR-3672	CLIP-seq
MIRT2375675	hsa-miR-4506	CLIP-seq
MIRT2375676	hsa-miR-450b-3p	CLIP-seq
MIRT2375677	hsa-miR-4713-3p	CLIP-seq
MIRT2375678	hsa-miR-552	CLIP-seq
MIRT2375679	hsa-miR-576-5p	CLIP-seq
MIRT2375680	hsa-miR-638	CLIP-seq
MIRT2375681	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 603404
• HGNC: 12957
• e!Ensembl: ENSG00000175787

Protein

• UniProt ID: Q14929
• Protein name: Zinc finger protein 169
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	13 → 54	KRAB box	Family
  PF00096	zf-C2H2	234 → 256	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	262 → 284	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	290 → 312	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	318 → 340	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	346 → 368	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	374 → 396	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	402 → 424	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	430 → 452	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	458 → 480	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	486 → 508	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	542 → 564	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	570 → 595	Zinc finger, C2H2 type	Domain

• Sequence:

  MSPGLLTTRKEALMAFRDVAVAFTQKEWKLLSSAQRTLYREVMLENYSHLVSLGIAFSKP
  KLIEQLEQGDEPWREENEHLLDLCPEPRTEFQPSFPHLVAFSSSQLLRQYALSGHPTQIF
  PSSSAGGDFQLEAPRCSSEKGESGETEGPDSSLRKRPSRISRTFFSPHQGDPVEWVEGNR
  EGGTDLRLAQRMSLGGSDTMLKGADTSESGAVIRGNYRLGLSKKSSLFSHQKHHVCPECG
  RGFCQRSDLIKHQRTHTGEKPYLCPECGRRFSQKASLSIHQRKHSGEKPYVCRECGRHFR
  YTSSLTNHKRIHSGERPFVCQECGRGFRQKIALLLHQRTHLEEKPFVCPECGRGFCQKAS
  LLQHQSSHTGERPFLCLECGRSFRQQSLLLSHQVTHSGEKPYVCAECGHSFRQKVTLIRH
  QRTHTGEKPYLCPQCGRGFSQKVTLIGHQRTHTGEKPYLCPDCGRGFGQKVTLIRHQRTH
  TGEKPYLCPKCGRAFGFKSLLTRHQRTHSEEELYVDRVCGQGLGQKSHLISDQRTHSGEK
  PCICDECGRGFGFKSALIRHQRTHSGEKPYVCRECGRGFSQKSHLHRHRRTKSGHQLLPQ
  EVF

• Sequence length: 603

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	29273807