SLC30A8 (solute carrier family 30 member 8)

Gene

• Entrez ID: 169026
• Gene name: Solute carrier family 30 member 8
• Gene symbol: SLC30A8
• Synonyms: ZNT8, ZnT-8
• Chromosome: 8
• Chromosome location: 8q24.11
• Summary: The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalize

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1359590	hsa-miR-140-3p	CLIP-seq
MIRT1359591	hsa-miR-146b-3p	CLIP-seq
MIRT1359592	hsa-miR-3157-3p	CLIP-seq
MIRT1359593	hsa-miR-3173-5p	CLIP-seq
MIRT1359594	hsa-miR-320a	CLIP-seq
MIRT1359595	hsa-miR-320b	CLIP-seq
MIRT1359596	hsa-miR-320c	CLIP-seq
MIRT1359597	hsa-miR-320d	CLIP-seq
MIRT1359598	hsa-miR-4429	CLIP-seq
MIRT1359599	hsa-miR-4453	CLIP-seq
MIRT1359600	hsa-miR-4514	CLIP-seq
MIRT1359601	hsa-miR-4538	CLIP-seq
MIRT1359602	hsa-miR-4645-5p	CLIP-seq
MIRT1359603	hsa-miR-4673	CLIP-seq
MIRT1359604	hsa-miR-4679	CLIP-seq
MIRT1359605	hsa-miR-4692	CLIP-seq
MIRT1359606	hsa-miR-4755-3p	CLIP-seq
MIRT1359607	hsa-miR-514	CLIP-seq
MIRT1359608	hsa-miR-514b-3p	CLIP-seq
MIRT1359609	hsa-miR-640	CLIP-seq
MIRT1359610	hsa-miR-874	CLIP-seq
MIRT1359611	hsa-miR-940	CLIP-seq
MIRT1359612	hsa-miR-103a	CLIP-seq
MIRT1359613	hsa-miR-107	CLIP-seq
MIRT1359614	hsa-miR-10a	CLIP-seq
MIRT1359615	hsa-miR-10b	CLIP-seq
MIRT1359616	hsa-miR-1302	CLIP-seq
MIRT1359617	hsa-miR-183	CLIP-seq
MIRT1359618	hsa-miR-194	CLIP-seq
MIRT1359619	hsa-miR-25	CLIP-seq
MIRT1359620	hsa-miR-3127-5p	CLIP-seq
MIRT1359621	hsa-miR-3144-3p	CLIP-seq
MIRT1359622	hsa-miR-3163	CLIP-seq
MIRT1359623	hsa-miR-32	CLIP-seq
MIRT1359624	hsa-miR-33a	CLIP-seq
MIRT1359625	hsa-miR-33b	CLIP-seq
MIRT1359626	hsa-miR-363	CLIP-seq
MIRT1359627	hsa-miR-3662	CLIP-seq
MIRT1359628	hsa-miR-367	CLIP-seq
MIRT1359629	hsa-miR-380	CLIP-seq
MIRT1359630	hsa-miR-3944-5p	CLIP-seq
MIRT1359631	hsa-miR-4261	CLIP-seq
MIRT1359632	hsa-miR-4270	CLIP-seq
MIRT1359633	hsa-miR-4292	CLIP-seq
MIRT1359634	hsa-miR-4298	CLIP-seq
MIRT1359635	hsa-miR-4441	CLIP-seq
MIRT1359636	hsa-miR-4495	CLIP-seq
MIRT1359637	hsa-miR-4735-5p	CLIP-seq
MIRT1359638	hsa-miR-495	CLIP-seq
MIRT1359639	hsa-miR-545	CLIP-seq
MIRT1359640	hsa-miR-548a-5p	CLIP-seq
MIRT1359641	hsa-miR-548ab	CLIP-seq
MIRT1359642	hsa-miR-548ak	CLIP-seq
MIRT1359643	hsa-miR-548b-5p	CLIP-seq
MIRT1359644	hsa-miR-548c-5p	CLIP-seq
MIRT1359645	hsa-miR-548d-5p	CLIP-seq
MIRT1359646	hsa-miR-548h	CLIP-seq
MIRT1359647	hsa-miR-548i	CLIP-seq
MIRT1359648	hsa-miR-548j	CLIP-seq
MIRT1359649	hsa-miR-548k	CLIP-seq
MIRT1359650	hsa-miR-548l	CLIP-seq
MIRT1359651	hsa-miR-548w	CLIP-seq
MIRT1359652	hsa-miR-548y	CLIP-seq
MIRT1359653	hsa-miR-559	CLIP-seq
MIRT1359654	hsa-miR-595	CLIP-seq
MIRT1359655	hsa-miR-676	CLIP-seq
MIRT1359656	hsa-miR-767-5p	CLIP-seq
MIRT1359657	hsa-miR-875-5p	CLIP-seq
MIRT1359658	hsa-miR-92a	CLIP-seq
MIRT1359659	hsa-miR-92b	CLIP-seq
MIRT2106430	hsa-miR-1272	CLIP-seq
MIRT2106431	hsa-miR-1273f	CLIP-seq
MIRT2106432	hsa-miR-1322	CLIP-seq
MIRT2106433	hsa-miR-143	CLIP-seq
MIRT1359617	hsa-miR-183	CLIP-seq
MIRT2106434	hsa-miR-186	CLIP-seq
MIRT1359618	hsa-miR-194	CLIP-seq
MIRT2106435	hsa-miR-205	CLIP-seq
MIRT2106436	hsa-miR-2117	CLIP-seq
MIRT2106437	hsa-miR-2467-3p	CLIP-seq
MIRT2106438	hsa-miR-298	CLIP-seq
MIRT2106439	hsa-miR-3133	CLIP-seq
MIRT1359621	hsa-miR-3144-3p	CLIP-seq
MIRT2106440	hsa-miR-3613-3p	CLIP-seq
MIRT2106441	hsa-miR-3678-3p	CLIP-seq
MIRT1359629	hsa-miR-380	CLIP-seq
MIRT2106442	hsa-miR-3907	CLIP-seq
MIRT2106443	hsa-miR-4272	CLIP-seq
MIRT2106444	hsa-miR-4273	CLIP-seq
MIRT2106445	hsa-miR-4276	CLIP-seq
MIRT2106446	hsa-miR-4282	CLIP-seq
MIRT2106447	hsa-miR-431	CLIP-seq
MIRT1359636	hsa-miR-4495	CLIP-seq
MIRT2106448	hsa-miR-4666-5p	CLIP-seq
MIRT2106449	hsa-miR-4738-3p	CLIP-seq
MIRT2106450	hsa-miR-4756-3p	CLIP-seq
MIRT2106451	hsa-miR-4770	CLIP-seq
MIRT2106452	hsa-miR-4776-3p	CLIP-seq
MIRT2106453	hsa-miR-4778-3p	CLIP-seq
MIRT1359638	hsa-miR-495	CLIP-seq
MIRT2106454	hsa-miR-513c	CLIP-seq
MIRT2106455	hsa-miR-514b-5p	CLIP-seq
MIRT1359640	hsa-miR-548a-5p	CLIP-seq
MIRT1359641	hsa-miR-548ab	CLIP-seq
MIRT1359642	hsa-miR-548ak	CLIP-seq
MIRT1359643	hsa-miR-548b-5p	CLIP-seq
MIRT1359644	hsa-miR-548c-5p	CLIP-seq
MIRT1359645	hsa-miR-548d-5p	CLIP-seq
MIRT1359646	hsa-miR-548h	CLIP-seq
MIRT1359647	hsa-miR-548i	CLIP-seq
MIRT1359648	hsa-miR-548j	CLIP-seq
MIRT1359649	hsa-miR-548k	CLIP-seq
MIRT1359650	hsa-miR-548l	CLIP-seq
MIRT1359651	hsa-miR-548w	CLIP-seq
MIRT1359652	hsa-miR-548y	CLIP-seq
MIRT1359653	hsa-miR-559	CLIP-seq
MIRT2106456	hsa-miR-586	CLIP-seq
MIRT1359657	hsa-miR-875-5p	CLIP-seq
MIRT1359612	hsa-miR-103a	CLIP-seq
MIRT1359613	hsa-miR-107	CLIP-seq
MIRT2330731	hsa-miR-1236	CLIP-seq
MIRT1359617	hsa-miR-183	CLIP-seq
MIRT1359618	hsa-miR-194	CLIP-seq
MIRT1359621	hsa-miR-3144-3p	CLIP-seq
MIRT1359629	hsa-miR-380	CLIP-seq
MIRT2330732	hsa-miR-3919	CLIP-seq
MIRT1359630	hsa-miR-3944-5p	CLIP-seq
MIRT1359636	hsa-miR-4495	CLIP-seq
MIRT2330733	hsa-miR-4753-3p	CLIP-seq
MIRT2106452	hsa-miR-4776-3p	CLIP-seq
MIRT2106453	hsa-miR-4778-3p	CLIP-seq
MIRT2330734	hsa-miR-4797-5p	CLIP-seq
MIRT1359638	hsa-miR-495	CLIP-seq
MIRT2330735	hsa-miR-499-3p	CLIP-seq
MIRT2330736	hsa-miR-499a-3p	CLIP-seq
MIRT2330737	hsa-miR-541	CLIP-seq
MIRT1359639	hsa-miR-545	CLIP-seq
MIRT2330738	hsa-miR-615-5p	CLIP-seq
MIRT2330739	hsa-miR-654-5p	CLIP-seq
MIRT1359657	hsa-miR-875-5p	CLIP-seq
MIRT2330740	hsa-miR-942	CLIP-seq
MIRT2106436	hsa-miR-2117	CLIP-seq
MIRT2106444	hsa-miR-4273	CLIP-seq
MIRT2106454	hsa-miR-513c	CLIP-seq
MIRT2106455	hsa-miR-514b-5p	CLIP-seq
MIRT2106456	hsa-miR-586	CLIP-seq
MIRT1359618	hsa-miR-194	CLIP-seq
MIRT1359621	hsa-miR-3144-3p	CLIP-seq
MIRT1359629	hsa-miR-380	CLIP-seq
MIRT1359636	hsa-miR-4495	CLIP-seq
MIRT1359638	hsa-miR-495	CLIP-seq
MIRT1359657	hsa-miR-875-5p	CLIP-seq
MIRT1359612	hsa-miR-103a	CLIP-seq
MIRT1359613	hsa-miR-107	CLIP-seq
MIRT1359617	hsa-miR-183	CLIP-seq
MIRT1359618	hsa-miR-194	CLIP-seq
MIRT1359621	hsa-miR-3144-3p	CLIP-seq
MIRT1359629	hsa-miR-380	CLIP-seq
MIRT1359630	hsa-miR-3944-5p	CLIP-seq
MIRT1359636	hsa-miR-4495	CLIP-seq
MIRT2106448	hsa-miR-4666-5p	CLIP-seq
MIRT1359638	hsa-miR-495	CLIP-seq
MIRT1359639	hsa-miR-545	CLIP-seq
MIRT1359657	hsa-miR-875-5p	CLIP-seq
MIRT1359612	hsa-miR-103a	CLIP-seq
MIRT1359613	hsa-miR-107	CLIP-seq
MIRT1359617	hsa-miR-183	CLIP-seq
MIRT1359618	hsa-miR-194	CLIP-seq
MIRT1359621	hsa-miR-3144-3p	CLIP-seq
MIRT1359629	hsa-miR-380	CLIP-seq
MIRT1359630	hsa-miR-3944-5p	CLIP-seq
MIRT1359636	hsa-miR-4495	CLIP-seq
MIRT1359638	hsa-miR-495	CLIP-seq
MIRT1359639	hsa-miR-545	CLIP-seq
MIRT1359657	hsa-miR-875-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005385	Function	Zinc ion transmembrane transporter activity	IBA	21873635
GO:0005385	Function	Zinc ion transmembrane transporter activity	IDA	15331542
GO:0005385	Function	Zinc ion transmembrane transporter activity	TAS
GO:0005515	Function	Protein binding	IPI	24955142, 25416956, 25910212, 32296183
GO:0005794	Component	Golgi apparatus	IDA	15331542
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	15331542
GO:0006829	Process	Zinc ion transport	IDA	15331542
GO:0006882	Process	Cellular zinc ion homeostasis	ISS
GO:0008270	Function	Zinc ion binding	IC	15331542
GO:0009749	Process	Response to glucose	IBA	21873635
GO:0009749	Process	Response to glucose	IMP	16984975
GO:0010043	Process	Response to zinc ion	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0030073	Process	Insulin secretion	IBA	21873635
GO:0030073	Process	Insulin secretion	IMP	16984975
GO:0030141	Component	Secretory granule	IDA	15331542
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	ISS
GO:0032024	Process	Positive regulation of insulin secretion	ISS
GO:0032119	Process	Sequestering of zinc ion	IDA	15331542
GO:0034341	Process	Response to interferon-gamma	IEA
GO:0042593	Process	Glucose homeostasis	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0060627	Process	Regulation of vesicle-mediated transport	ISS
GO:0061088	Process	Regulation of sequestering of zinc ion	IBA	21873635
GO:0061088	Process	Regulation of sequestering of zinc ion	ISS
GO:0070555	Process	Response to interleukin-1	IEA
GO:0071577	Process	Zinc ion transmembrane transport	IBA	21873635

Other IDs

• MIM: 611145
• HGNC: 20303
• e!Ensembl: ENSG00000164756

Protein

• UniProt ID: Q8IWU4
• Protein name: Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8)
• Protein function: Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:2787531
• PDB: 6XPD, 6XPE, 6XPF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01545	Cation_efflux	74 → 275	Cation efflux family	Family

• Sequence:

  MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPT
  EKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFS
  LWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMII
  VSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYF
  KPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSV
  HSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPD
  CLFCEDPCD

• Sequence length: 369

Pathways

Reactome:

Insulin processing
Zinc efflux and compartmentalization by the SLC30 family

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Aortic aneurysm	Aortic Aneurysm, Abdominal	rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953, rs794728021, rs8046180, rs797045725, rs876657852, rs878854466, rs886038978, rs746972765, rs886039303, rs886040965, rs886040966, rs886040967, rs886229659, rs1553781304, rs1060502531, rs1553795301, rs1553803235, rs1213452826, rs869025352, rs1553780501, rs1553785222, rs1382893400, rs1554841990, rs1430822242, rs1567692384, rs1576422965, rs1596712899, rs2059732940, rs2041090817, rs1439991530	22055160
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	21814517
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	20581827, 29632382, 22885922, 20424817, 24584071, 17463246, 21461562, 28869590, 21779873, 19401414, 21874001, 30595370, 17463248, 17293876, 30718926, 27189021, 17463249, 19542200, 24509480, 22325160, 23300278, 19479076, 29358691, 26818947, 19734900, 31118516, 22693455, 23945395, 22158537, 26961502, 29703844, 21647700, 31217584, 30054458
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	21347282
Diabetic nephropathy	Diabetic Nephropathy		29703844
Kidney failure	Kidney Failure, Chronic		29703844