DDB1 (damage specific DNA binding protein 1)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
1642 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Damage specific DNA binding protein 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
DDB1 |
SynonymsGene synonyms aliases
|
DDBA, UV-DDB1, WHIKERS, XAP1, XPCE, XPE, XPE-BF |
ChromosomeChromosome number
|
11 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
11q12.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following |
miRNAmiRNA information provided by mirtarbase database.
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|
Transcription factors
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000715 |
Process |
Nucleotide-excision repair, DNA damage recognition |
TAS |
|
GO:0000717 |
Process |
Nucleotide-excision repair, DNA duplex unwinding |
TAS |
|
GO:0000781 |
Component |
Chromosome, telomeric region |
HDA |
19135898 |
GO:0003677 |
Function |
DNA binding |
TAS |
8798680 |
GO:0003684 |
Function |
Damaged DNA binding |
IDA |
22334663 |
GO:0005515 |
Function |
Protein binding |
IPI |
9418871, 12732143, 14739464, 16227264, 16473935, 16949367, 16964240, 17041588, 17314515, 17360488, 17932509, 19109893, 19264781, 19651607, 19966799, 20223979, 20855601, 21113133, 21145461, 21988832, 22039351, 22157821, 22810585, 22822215, 23238014, 23314863, 24292623, 24412650, 2613 |
GO:0005615 |
Component |
Extracellular space |
HDA |
22664934 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
18593899, 20223979 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
18593899, 20223979, 23137809 |
GO:0006281 |
Process |
DNA repair |
IBA |
21873635 |
GO:0006281 |
Process |
DNA repair |
TAS |
8798680 |
GO:0006283 |
Process |
Transcription-coupled nucleotide-excision repair |
TAS |
|
GO:0006293 |
Process |
Nucleotide-excision repair, preincision complex stabilization |
TAS |
|
GO:0006294 |
Process |
Nucleotide-excision repair, preincision complex assembly |
TAS |
|
GO:0006295 |
Process |
Nucleotide-excision repair, DNA incision, 3'-to lesion |
TAS |
|
GO:0006296 |
Process |
Nucleotide-excision repair, DNA incision, 5'-to lesion |
TAS |
|
GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
IDA |
11673459 |
GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
IMP |
26431207 |
GO:0006974 |
Process |
Cellular response to DNA damage stimulus |
IMP |
16949367 |
GO:0010498 |
Process |
Proteasomal protein catabolic process |
IMP |
25970626 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0016567 |
Process |
Protein ubiquitination |
IDA |
26431207, 28886238 |
GO:0016567 |
Process |
Protein ubiquitination |
IMP |
28437394 |
GO:0030674 |
Function |
Protein-macromolecule adaptor activity |
IPI |
14739464 |
GO:0031464 |
Component |
Cul4A-RING E3 ubiquitin ligase complex |
IDA |
12732143, 14739464, 18794347, 20129063, 20223979 |
GO:0031465 |
Component |
Cul4B-RING E3 ubiquitin ligase complex |
IDA |
18794347, 21628527, 22334663 |
GO:0032991 |
Component |
Protein-containing complex |
IMP |
28437394 |
GO:0033683 |
Process |
Nucleotide-excision repair, DNA incision |
TAS |
|
GO:0035518 |
Process |
Histone H2A monoubiquitination |
IDA |
22334663 |
GO:0035861 |
Component |
Site of double-strand break |
IBA |
21873635 |
GO:0042769 |
Process |
DNA damage response, detection of DNA damage |
TAS |
|
GO:0043161 |
Process |
Proteasome-mediated ubiquitin-dependent protein catabolic process |
IBA |
21873635 |
GO:0043161 |
Process |
Proteasome-mediated ubiquitin-dependent protein catabolic process |
IMP |
14739464, 20223979 |
GO:0043687 |
Process |
Post-translational protein modification |
TAS |
|
GO:0044877 |
Function |
Protein-containing complex binding |
IPI |
11564863 |
GO:0045070 |
Process |
Positive regulation of viral genome replication |
IMP |
23137809 |
GO:0045722 |
Process |
Positive regulation of gluconeogenesis |
ISS |
|
GO:0045732 |
Process |
Positive regulation of protein catabolic process |
IMP |
16949367 |
GO:0046726 |
Process |
Positive regulation by virus of viral protein levels in host cell |
IMP |
23137809 |
GO:0048511 |
Process |
Rhythmic process |
IEA |
|
GO:0051702 |
Process |
Biological process involved in interaction with symbiont |
IDA |
23137809 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867 |
GO:0070911 |
Process |
Global genome nucleotide-excision repair |
TAS |
|
GO:0070914 |
Process |
UV-damage excision repair |
IDA |
22334663 |
GO:0071987 |
Function |
WD40-repeat domain binding |
IPI |
16949367 |
GO:0080008 |
Component |
Cul4-RING E3 ubiquitin ligase complex |
IDA |
18381890, 28886238, 31686031 |
GO:0080008 |
Component |
Cul4-RING E3 ubiquitin ligase complex |
IMP |
16949367 |
GO:0097602 |
Function |
Cullin family protein binding |
IPI |
14739464 |
GO:1901990 |
Process |
Regulation of mitotic cell cycle phase transition |
IMP |
17088560 |
GO:1902188 |
Process |
Positive regulation of viral release from host cell |
IMP |
23137809 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q16531 |
Protein name |
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding f |
Protein function |
Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMe |
PDB |
2B5L
,
2B5M
,
2B5N
,
2HYE
,
3E0C
,
3EI1
,
3EI2
,
3EI3
,
3EI4
,
3I7H
,
3I7K
,
3I7L
,
3I7N
,
3I7O
,
3I7P
,
3I89
,
3I8C
,
3I8E
,
4A08
,
4A09
,
4A0A
,
4A0B
,
4A0K
,
4A0L
,
4A11
,
4CI1
,
4CI2
,
4CI3
,
4E54
,
4E5Z
,
4TZ4
,
5FQD
,
5HXB
,
5JK7
,
5V3O
,
6BN7
,
6BN8
,
6BN9
,
6BNB
,
6BOY
,
6DSZ
,
6FCV
,
6H0F
,
6H0G
,
6PAI
,
6Q0R
,
6Q0V
,
6Q0W
,
6R8Y
,
6R8Z
,
6R90
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF10433 |
MMS1_N |
75 → 543 |
|
Domain |
PF03178 |
CPSF_A |
788 → 1099 |
CPSF A subunit region |
Family |
|
Sequence |
|
Sequence length |
1140 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 |
21364753 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Stomach neoplasms |
Malignant neoplasm of stomach, Stomach Neoplasms |
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21364753 |
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