DCTN1 (dynactin subunit 1)

Gene

• Entrez ID: 1639
• Gene name: Dynactin subunit 1
• Gene symbol: DCTN1
• Synonyms: DAP-150, DP-150, HMND14, P135
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functi

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs55862001	T>C	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs67586389	C>G,T	Pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant, non coding transcript variant
rs72466485	C>T	Pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant, non coding transcript variant
rs72466486	T>G	Pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant, non coding transcript variant
rs72466487	T>C,G	Pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant, non coding transcript variant
rs72466489	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant, non coding transcript variant
rs72466494	C>T	Benign, likely-benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs72466496	G>A	Benign, risk-factor, likely-benign, benign-likely-benign	Coding sequence variant, missense variant, non coding transcript variant
rs72659383	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs121909342	C>G,T	Uncertain-significance, pathogenic	Non coding transcript variant, genic upstream transcript variant, coding sequence variant, missense variant
rs121909343	A>G	Risk-factor	Non coding transcript variant, coding sequence variant, missense variant
rs121909344	G>A,C	Uncertain-significance, risk-factor	Non coding transcript variant, coding sequence variant, missense variant
rs121909345	C>T	Risk-factor	Non coding transcript variant, coding sequence variant, missense variant
rs150204862	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Genic upstream transcript variant, coding sequence variant, synonymous variant, non coding transcript variant
rs200834352	C>T	Likely-pathogenic, likely-benign	Coding sequence variant, non coding transcript variant, missense variant
rs377519506	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, synonymous variant
rs566433112	T>C	Pathogenic, uncertain-significance	Genic upstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs886039227	A>C	Pathogenic	Coding sequence variant, non coding transcript variant, genic upstream transcript variant, missense variant
rs886039228	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, genic upstream transcript variant, missense variant
rs886039229	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, genic upstream transcript variant, missense variant
rs1393363759	C>A,G,T	Uncertain-significance, likely-pathogenic	Splice donor variant, genic upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050276	hsa-miR-25-3p	CLASH	23622248
MIRT048854	hsa-miR-93-5p	CLASH	23622248
MIRT044073	hsa-miR-361-5p	CLASH	23622248
MIRT036100	hsa-miR-1296-5p	CLASH	23622248
MIRT927127	hsa-miR-3064-5p	CLIP-seq
MIRT927128	hsa-miR-3179	CLIP-seq
MIRT927129	hsa-miR-4446-3p	CLIP-seq
MIRT927130	hsa-miR-4656	CLIP-seq
MIRT927131	hsa-miR-4687-3p	CLIP-seq
MIRT927132	hsa-miR-4721	CLIP-seq
MIRT927133	hsa-miR-125a-5p	CLIP-seq
MIRT927134	hsa-miR-125b	CLIP-seq
MIRT927135	hsa-miR-127-5p	CLIP-seq
MIRT927136	hsa-miR-1909	CLIP-seq
MIRT927137	hsa-miR-214	CLIP-seq
MIRT927127	hsa-miR-3064-5p	CLIP-seq
MIRT927138	hsa-miR-3173-3p	CLIP-seq
MIRT927128	hsa-miR-3179	CLIP-seq
MIRT927139	hsa-miR-3619-5p	CLIP-seq
MIRT927140	hsa-miR-3664-3p	CLIP-seq
MIRT927141	hsa-miR-4319	CLIP-seq
MIRT927142	hsa-miR-4419a	CLIP-seq
MIRT927129	hsa-miR-4446-3p	CLIP-seq
MIRT927143	hsa-miR-4476	CLIP-seq
MIRT927144	hsa-miR-4492	CLIP-seq
MIRT927145	hsa-miR-4498	CLIP-seq
MIRT927146	hsa-miR-4510	CLIP-seq
MIRT927147	hsa-miR-4533	CLIP-seq
MIRT927148	hsa-miR-4640-3p	CLIP-seq
MIRT927149	hsa-miR-4649-3p	CLIP-seq
MIRT927130	hsa-miR-4656	CLIP-seq
MIRT927131	hsa-miR-4687-3p	CLIP-seq
MIRT927132	hsa-miR-4721	CLIP-seq
MIRT927150	hsa-miR-4749-3p	CLIP-seq
MIRT927151	hsa-miR-4779	CLIP-seq
MIRT927152	hsa-miR-486-3p	CLIP-seq
MIRT927153	hsa-miR-544b	CLIP-seq
MIRT927154	hsa-miR-615-5p	CLIP-seq
MIRT927155	hsa-miR-761	CLIP-seq
MIRT927156	hsa-miR-762	CLIP-seq
MIRT927157	hsa-miR-873	CLIP-seq
MIRT927158	hsa-miR-887	CLIP-seq
MIRT1974580	hsa-miR-1286	CLIP-seq
MIRT927128	hsa-miR-3179	CLIP-seq
MIRT1974581	hsa-miR-4688	CLIP-seq
MIRT1974582	hsa-miR-4766-5p	CLIP-seq
MIRT927152	hsa-miR-486-3p	CLIP-seq
MIRT1974583	hsa-miR-488	CLIP-seq
MIRT1974584	hsa-miR-662	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000132	Process	Establishment of mitotic spindle orientation	IBA	21873635
GO:0000132	Process	Establishment of mitotic spindle orientation	IMP	22327364
GO:0000278	Process	Mitotic cell cycle	NAS	1828535
GO:0000776	Component	Kinetochore	IBA	21873635
GO:0000776	Component	Kinetochore	IDA	19468067, 23027904
GO:0000922	Component	Spindle pole	IBA	21873635
GO:0000922	Component	Spindle pole	IDA	14718566
GO:0003774	Function	Motor activity	IEA
GO:0005515	Function	Protein binding	IPI	9361024, 9722614, 12857853, 15107855, 17139249, 17532294, 17828275, 17828277, 17932487, 18000879, 18615096, 18922795, 19619496, 19935774, 20133940, 20679239, 20719959, 20978158, 22159412, 22261744, 22777741, 22797915, 23414759, 23524952, 23574715, 23874158, 24867236, 24997520, 25189
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005635	Component	Nuclear envelope	IDA	20679239
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	18305234
GO:0005813	Component	Centrosome	IDA	20719959, 21399614, 23985322, 25774020
GO:0005814	Component	Centriole	IDA	23213374, 23386061, 25774020
GO:0005819	Component	Spindle	IDA	25774020
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IDA	21525035, 22777741, 25774020
GO:0005875	Component	Microtubule associated complex	IBA	21873635
GO:0005875	Component	Microtubule associated complex	IMP	16505168
GO:0005938	Component	Cell cortex	IDA	23027904
GO:0005938	Component	Cell cortex	IDA	23509069
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0007097	Process	Nuclear migration	IBA	21873635
GO:0007399	Process	Nervous system development	NAS	17360970
GO:0007528	Process	Neuromuscular junction development	IMP	18305234
GO:0008017	Function	Microtubule binding	IDA	23874158, 26972003
GO:0008017	Function	Microtubule binding	IMP	16505168
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	TAS
GO:0010457	Process	Centriole-centriole cohesion	IMP	23386061
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0015631	Function	Tubulin binding	IDA	23874158
GO:0016020	Component	Membrane	HDA	19946888
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0019901	Function	Protein kinase binding	IPI	17139249
GO:0021517	Process	Ventral spinal cord development	IMP	18305234
GO:0030286	Component	Dynein complex	IEA
GO:0030424	Component	Axon	IBA	21873635
GO:0030904	Component	Retromer complex	IDA	19619496
GO:0031116	Process	Positive regulation of microtubule polymerization	IDA	23874158
GO:0031116	Process	Positive regulation of microtubule polymerization	IMP	16505168
GO:0031122	Process	Cytoplasmic microtubule organization	IBA	21873635
GO:0034454	Process	Microtubule anchoring at centrosome	IMP	23386061
GO:0035371	Component	Microtubule plus-end	IBA	21873635
GO:0035371	Component	Microtubule plus-end	IDA	26972003
GO:0036498	Process	IRE1-mediated unfolded protein response	TAS
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	19619496
GO:0043005	Component	Neuron projection	IDA	18364389
GO:0043025	Component	Neuronal cell body	IDA	18364389
GO:0045171	Component	Intercellular bridge	IDA
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0050905	Process	Neuromuscular process	IMP	18305234
GO:0051010	Function	Microtubule plus-end binding	IBA	21873635
GO:0051081	Process	Nuclear envelope disassembly	IMP	20679239
GO:0051301	Process	Cell division	IEA
GO:0060236	Process	Regulation of mitotic spindle organization	IMP	23027904
GO:0061744	Process	Motor behavior	IMP	18305234, 18364389
GO:0070050	Process	Neuron cellular homeostasis	IMP	18305234
GO:0072686	Component	Mitotic spindle	IDA
GO:0090063	Process	Positive regulation of microtubule nucleation	IDA	23874158
GO:0097711	Process	Ciliary basal body-plasma membrane docking	TAS
GO:0098930	Process	Axonal transport	IMP	18364389
GO:0099558	Process	Maintenance of synapse structure	TAS	18305234
GO:0099738	Component	Cell cortex region	IDA	22327364
GO:0120103	Component	Centriolar subdistal appendage	IDA	23213374
GO:1904398	Process	Positive regulation of neuromuscular junction development	IMP	18364389
GO:1905515	Process	Non-motile cilium assembly	IMP	25774020
GO:1990535	Process	Neuron projection maintenance	IMP	18305234, 18364389

Other IDs

• MIM: 601143
• HGNC: 2711
• e!Ensembl: ENSG00000204843

Protein

• UniProt ID: Q14203
• Protein name: Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
• Protein function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by r
• PDB: 1TXQ, 2COY, 2HKN, 2HKQ, 2HL3, 2HL5, 2HQH, 3E2U, 3TQ7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01302	CAP_GLY	29 → 94	CAP-Gly domain	Domain
  PF12455	Dynactin	523 → 805	Dynein associated protein	Family

• Sequence:

  MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
  ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE
  GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
  SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
  DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
  ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
  KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
  STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
  TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
  SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
  GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL
  SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
  TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI
  ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV
  LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
  NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
  IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
  ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS
  VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG
  SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
  KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH
  RLVLTQEQLHQLHSRLIS

• Sequence length: 1278

Pathways

KEGG:

Motor proteins
Vasopressin-regulated water reabsorption
Amyotrophic lateral sclerosis
Huntington disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection

Reactome:

MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
XBP1(S) activates chaperone genes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis, Familial	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	23941283
Distal hereditary motor neuronopathy	Distal hereditary motor neuropathy type 7	rs104894345, rs104894351, rs137852970, rs137852972, rs267607143, rs267607145, rs28939680, rs29001571, rs28937568, rs28937569, rs104894020, rs121909112, rs121909113, rs121909342, rs786205090, rs137852644, rs137852646, rs121913595, rs387906904, rs387907242, rs398123028, rs398122838, rs730880031, rs730882139, rs730882140, rs267607623, rs797044802, rs746581714, rs756614404, rs770272088, rs876661124, rs879253868, rs879254085, rs764813110, rs1060502838, rs1064796370, rs1554338260, rs137852973, rs1347223331, rs377626365, rs772217003, rs1553174566, rs1324667543, rs557327165, rs1441260635, rs1565929080, rs770593694, rs1584026191, rs372181708, rs758322672, rs1587668798, rs1587671674, rs972425138, rs1594427564, rs1594445698, rs1594453111, rs1337346956, rs1240319744, rs199839840, rs754422011, rs1595599240, rs1595600898, rs1555408333, rs774079947, rs1584034430, rs562669797, rs749383814, rs762573767, rs767263669, rs746212067, rs1182614290, rs1018405924	12627231
Frontotemporal dementia	Frontotemporal dementia	rs63751273, rs63750376, rs63750424, rs63750972, rs1568327531, rs63750570, rs63750756, rs63751165, rs63750512, rs63751438, rs63750912, rs63750711, rs63750635, rs63750349, rs63750092, rs63749801, rs63751399, rs199476352, rs63751035, rs63749974, rs63750568, rs63750013, rs63751394, rs63750308, rs63751011, rs63750095, rs794729672, rs794729669, rs63749817, rs794729670, rs193026789, rs794729671, rs1085307051, rs1566630811, rs1566630884, rs1567885658, rs1567886206, rs1567886445, rs1567886478, rs1567887015, rs1567887777, rs1567888461, rs1566630791, rs1598408073, rs1570725499, rs1598408336
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	16505168, 27025386, 19279216, 12627231, 28251916, 18364389, 27573046, 26954557, 15326253, 19136952, 16240349, 23143281, 18094236
Parkinson disease	Parkinsonian Disorders, Autosomal Dominant Juvenile Parkinson Disease, PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	19136952
Perry syndrome	Perry Syndrome	rs121909342, rs72466487, rs67586389, rs886039227	12627231, 25185702, 23874158, 23143281, 28251916, 16505168, 27132499, 24881494, 24676999, 19136952, 18094236, 27025386, 26972003, 26954557, 27346608, 27573046, 18364389, 19279216

Unknown
Disease name	Disease term	dbSNP ID	References
Anxiety disorder	Anxiety
Dementia	Dementia
Distal amyotrophy	Distal amyotrophy	rs1457770815
Dysarthria	Dysarthria
Dyssomnia	Dyssomnias
Facial paralysis	Facial paralysis
Laryngospasm	Laryngospasm
Mental depression	Depressive disorder	rs587778876, rs587778877
Mood disorder	Mood Disorders		19136952
Mood swings	Mood swings
Neuronopathy	Neuronopathy, Distal Hereditary Motor, Type Viib		12627231, 23143281, 28251916, 19136952, 26954557, 16505168, 27573046, 27025386, 22777741, 18364389, 18094236, 19279216
Parkinsonian disease	Autosomal Dominant Parkinsonism, Autosomal Recessive Parkinsonism, Familial Juvenile Parkinsonism, Parkinsonism, Juvenile		19136952
Pseudobulbar palsy	Pseudobulbar Palsy
Ramsay hunt paralysis syndrome	Ramsay Hunt Paralysis Syndrome		19136952
Respiratory failure	Respiratory Failure
Sleep apnea	Sleep Apnea Syndromes
Sleep disorders	Sleep Disorders
Supranuclear gaze palsy	Vertical supranuclear gaze palsy
Vocal cord paralysis	Vocal Cord Paralysis