Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
163 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Adaptor related protein complex 2 subunit beta 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
AP2B1 |
SynonymsGene synonyms aliases
|
ADTB2, AP105B, AP2-BETA, CLAPB1 |
ChromosomeChromosome number
|
17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q12 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma m |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001822 |
Process |
Kidney development |
IEA |
|
GO:0003281 |
Process |
Ventricular septum development |
IEA |
|
GO:0005048 |
Function |
Signal sequence binding |
TAS |
12121421 |
GO:0005515 |
Function |
Protein binding |
IPI |
9341158, 12086608, 12221107, 15533940, 16189514, 20603002, 23676497, 24130457, 24189400, 25061211, 25416956, 26680585, 29892012, 30021884 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0006886 |
Process |
Intracellular protein transport |
IEA |
|
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016192 |
Process |
Vesicle-mediated transport |
IBA |
21873635 |
GO:0019886 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS |
|
GO:0030122 |
Component |
AP-2 adaptor complex |
IDA |
23676497 |
GO:0030122 |
Component |
AP-2 adaptor complex |
IMP |
12086608 |
GO:0030122 |
Component |
AP-2 adaptor complex |
TAS |
12121421 |
GO:0030131 |
Component |
Clathrin adaptor complex |
IDA |
8262066 |
GO:0030276 |
Function |
Clathrin binding |
IBA |
21873635 |
GO:0030276 |
Function |
Clathrin binding |
IDA |
8262066 |
GO:0030276 |
Function |
Clathrin binding |
IPI |
19509056 |
GO:0030276 |
Function |
Clathrin binding |
TAS |
12121421 |
GO:0030666 |
Component |
Endocytic vesicle membrane |
TAS |
|
GO:0030669 |
Component |
Clathrin-coated endocytic vesicle membrane |
TAS |
|
GO:0032802 |
Process |
Low-density lipoprotein particle receptor catabolic process |
TAS |
|
GO:0034383 |
Process |
Low-density lipoprotein particle clearance |
TAS |
|
GO:0035615 |
Function |
Clathrin adaptor activity |
TAS |
12121421 |
GO:0035904 |
Process |
Aorta development |
IEA |
|
GO:0036020 |
Component |
Endolysosome membrane |
TAS |
|
GO:0044877 |
Function |
Protein-containing complex binding |
IEA |
|
GO:0045334 |
Component |
Clathrin-coated endocytic vesicle |
NAS |
25898166 |
GO:0045807 |
Process |
Positive regulation of endocytosis |
IEA |
|
GO:0048013 |
Process |
Ephrin receptor signaling pathway |
TAS |
|
GO:0048268 |
Process |
Clathrin coat assembly |
IEA |
|
GO:0050690 |
Process |
Regulation of defense response to virus by virus |
TAS |
|
GO:0060071 |
Process |
Wnt signaling pathway, planar cell polarity pathway |
TAS |
|
GO:0060976 |
Process |
Coronary vasculature development |
IEA |
|
GO:0061024 |
Process |
Membrane organization |
TAS |
|
GO:0072583 |
Process |
Clathrin-dependent endocytosis |
IDA |
23676497 |
GO:0072583 |
Process |
Clathrin-dependent endocytosis |
TAS |
12121421 |
GO:0098794 |
Component |
Postsynapse |
IEA |
|
GO:0098884 |
Process |
Postsynaptic neurotransmitter receptor internalization |
IEA |
|
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:1901215 |
Process |
Negative regulation of neuron death |
IEA |
|
GO:1905477 |
Process |
Positive regulation of protein localization to membrane |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P63010 |
Protein name |
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin |
Protein function |
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be invo |
PDB |
1E42
,
2G30
,
2IV8
,
2IV9
,
2JKR
,
2JKT
,
2VGL
,
2XA7
,
4UQI
,
5M5R
,
6QH5
,
6QH6
,
6QH7
,
6URI
,
6YAE
,
6YAF
,
6YAH
,
6YAI
,
7OG1
,
7OHO
,
7OM8
,
7Z5C
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01602 |
Adaptin_N |
10 → 534 |
Adaptin N terminal region |
Family |
PF02883 |
Alpha_adaptinC2 |
711 → 817 |
Adaptin C-terminal domain |
Domain |
PF09066 |
B2-adapt-app_C |
827 → 935 |
Beta2-adaptin appendage, C-terminal sub-domain |
Domain |
|
Sequence |
|
Sequence length |
937 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
31374203 |
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