DAP (death associated protein)

Gene

• Entrez ID: 1611
• Gene name: Death associated protein
• Gene symbol: DAP
• Synonyms: DAP1
• Chromosome: 5
• Chromosome location: 5p15.2
• Summary: This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gen

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005726	hsa-miR-183-5p	qRT-PCR	20602797
MIRT018510	hsa-miR-335-5p	Microarray	18185580
MIRT923065	hsa-miR-105	CLIP-seq
MIRT923066	hsa-miR-1178	CLIP-seq
MIRT923067	hsa-miR-1207-3p	CLIP-seq
MIRT923068	hsa-miR-124	CLIP-seq
MIRT923069	hsa-miR-1248	CLIP-seq
MIRT923070	hsa-miR-1253	CLIP-seq
MIRT923071	hsa-miR-1256	CLIP-seq
MIRT923072	hsa-miR-125a-3p	CLIP-seq
MIRT923073	hsa-miR-1273g	CLIP-seq
MIRT923074	hsa-miR-1290	CLIP-seq
MIRT923075	hsa-miR-1299	CLIP-seq
MIRT923076	hsa-miR-134	CLIP-seq
MIRT923077	hsa-miR-138	CLIP-seq
MIRT923078	hsa-miR-208a	CLIP-seq
MIRT923079	hsa-miR-208b	CLIP-seq
MIRT923080	hsa-miR-216a	CLIP-seq
MIRT923081	hsa-miR-216b	CLIP-seq
MIRT923082	hsa-miR-29a	CLIP-seq
MIRT923083	hsa-miR-29b	CLIP-seq
MIRT923084	hsa-miR-29c	CLIP-seq
MIRT923085	hsa-miR-3065-3p	CLIP-seq
MIRT923086	hsa-miR-3118	CLIP-seq
MIRT923087	hsa-miR-3144-3p	CLIP-seq
MIRT923088	hsa-miR-3152-5p	CLIP-seq
MIRT923089	hsa-miR-3159	CLIP-seq
MIRT923090	hsa-miR-3167	CLIP-seq
MIRT923091	hsa-miR-323-5p	CLIP-seq
MIRT923092	hsa-miR-3545-3p	CLIP-seq
MIRT923093	hsa-miR-3614-5p	CLIP-seq
MIRT923094	hsa-miR-3658	CLIP-seq
MIRT923095	hsa-miR-3667-5p	CLIP-seq
MIRT923096	hsa-miR-3714	CLIP-seq
MIRT923097	hsa-miR-371-5p	CLIP-seq
MIRT923098	hsa-miR-371b-5p	CLIP-seq
MIRT923099	hsa-miR-383	CLIP-seq
MIRT923100	hsa-miR-3910	CLIP-seq
MIRT923101	hsa-miR-3934	CLIP-seq
MIRT923102	hsa-miR-4279	CLIP-seq
MIRT923103	hsa-miR-4297	CLIP-seq
MIRT923104	hsa-miR-4434	CLIP-seq
MIRT923105	hsa-miR-4456	CLIP-seq
MIRT923106	hsa-miR-4477b	CLIP-seq
MIRT923107	hsa-miR-4516	CLIP-seq
MIRT923108	hsa-miR-4521	CLIP-seq
MIRT923109	hsa-miR-4530	CLIP-seq
MIRT923110	hsa-miR-4531	CLIP-seq
MIRT923111	hsa-miR-4760-5p	CLIP-seq
MIRT923112	hsa-miR-4772-5p	CLIP-seq
MIRT923113	hsa-miR-4773	CLIP-seq
MIRT923114	hsa-miR-4774-3p	CLIP-seq
MIRT923115	hsa-miR-4782-5p	CLIP-seq
MIRT923116	hsa-miR-499-5p	CLIP-seq
MIRT923117	hsa-miR-506	CLIP-seq
MIRT923118	hsa-miR-513c	CLIP-seq
MIRT923119	hsa-miR-514b-5p	CLIP-seq
MIRT923120	hsa-miR-516b	CLIP-seq
MIRT923121	hsa-miR-550a	CLIP-seq
MIRT923122	hsa-miR-578	CLIP-seq
MIRT923123	hsa-miR-670	CLIP-seq
MIRT923124	hsa-miR-764	CLIP-seq
MIRT923125	hsa-miR-767-3p	CLIP-seq
MIRT923126	hsa-miR-873	CLIP-seq
MIRT923127	hsa-miR-876-3p	CLIP-seq
MIRT923128	hsa-miR-876-5p	CLIP-seq
MIRT923129	hsa-miR-885-3p	CLIP-seq
MIRT923130	hsa-miR-922	CLIP-seq
MIRT923131	hsa-miR-942	CLIP-seq
MIRT1922678	hsa-miR-151-3p	CLIP-seq
MIRT1922679	hsa-miR-3681	CLIP-seq
MIRT1973473	hsa-miR-103a	CLIP-seq
MIRT923065	hsa-miR-105	CLIP-seq
MIRT1973474	hsa-miR-107	CLIP-seq
MIRT1973475	hsa-miR-1184	CLIP-seq
MIRT923069	hsa-miR-1248	CLIP-seq
MIRT923077	hsa-miR-138	CLIP-seq
MIRT1973476	hsa-miR-150	CLIP-seq
MIRT1973477	hsa-miR-188-3p	CLIP-seq
MIRT1973478	hsa-miR-193a-5p	CLIP-seq
MIRT923080	hsa-miR-216a	CLIP-seq
MIRT923081	hsa-miR-216b	CLIP-seq
MIRT923087	hsa-miR-3144-3p	CLIP-seq
MIRT1973479	hsa-miR-3179	CLIP-seq
MIRT1973480	hsa-miR-3661	CLIP-seq
MIRT1973481	hsa-miR-3675-5p	CLIP-seq
MIRT1973482	hsa-miR-3691-3p	CLIP-seq
MIRT923097	hsa-miR-371-5p	CLIP-seq
MIRT923098	hsa-miR-371b-5p	CLIP-seq
MIRT923099	hsa-miR-383	CLIP-seq
MIRT1973483	hsa-miR-3913-3p	CLIP-seq
MIRT1973484	hsa-miR-3918	CLIP-seq
MIRT923101	hsa-miR-3934	CLIP-seq
MIRT1973485	hsa-miR-3944-5p	CLIP-seq
MIRT1973486	hsa-miR-4270	CLIP-seq
MIRT923103	hsa-miR-4297	CLIP-seq
MIRT1973487	hsa-miR-4328	CLIP-seq
MIRT1973488	hsa-miR-4441	CLIP-seq
MIRT1973489	hsa-miR-4464	CLIP-seq
MIRT1973490	hsa-miR-4469	CLIP-seq
MIRT1973491	hsa-miR-4512	CLIP-seq
MIRT1973492	hsa-miR-4633-3p	CLIP-seq
MIRT1973493	hsa-miR-4635	CLIP-seq
MIRT1973494	hsa-miR-4713-5p	CLIP-seq
MIRT1973495	hsa-miR-4748	CLIP-seq
MIRT923112	hsa-miR-4772-5p	CLIP-seq
MIRT1973496	hsa-miR-489	CLIP-seq
MIRT923118	hsa-miR-513c	CLIP-seq
MIRT923119	hsa-miR-514b-5p	CLIP-seq
MIRT1973497	hsa-miR-519a	CLIP-seq
MIRT1973498	hsa-miR-519b-3p	CLIP-seq
MIRT1973499	hsa-miR-519c-3p	CLIP-seq
MIRT1973500	hsa-miR-532-3p	CLIP-seq
MIRT1973501	hsa-miR-542-3p	CLIP-seq
MIRT923121	hsa-miR-550a	CLIP-seq
MIRT1973502	hsa-miR-550b	CLIP-seq
MIRT1973503	hsa-miR-552	CLIP-seq
MIRT923122	hsa-miR-578	CLIP-seq
MIRT1973504	hsa-miR-631	CLIP-seq
MIRT923126	hsa-miR-873	CLIP-seq
MIRT923129	hsa-miR-885-3p	CLIP-seq
MIRT923130	hsa-miR-922	CLIP-seq
MIRT923131	hsa-miR-942	CLIP-seq
MIRT923065	hsa-miR-105	CLIP-seq
MIRT2209046	hsa-miR-1197	CLIP-seq
MIRT2209047	hsa-miR-1251	CLIP-seq
MIRT2209048	hsa-miR-1271	CLIP-seq
MIRT2209049	hsa-miR-182	CLIP-seq
MIRT923087	hsa-miR-3144-3p	CLIP-seq
MIRT2209050	hsa-miR-3622b-5p	CLIP-seq
MIRT2209051	hsa-miR-3675-3p	CLIP-seq
MIRT923099	hsa-miR-383	CLIP-seq
MIRT1973483	hsa-miR-3913-3p	CLIP-seq
MIRT923101	hsa-miR-3934	CLIP-seq
MIRT2209052	hsa-miR-4305	CLIP-seq
MIRT2209053	hsa-miR-4496	CLIP-seq
MIRT2209054	hsa-miR-4514	CLIP-seq
MIRT2209055	hsa-miR-4642	CLIP-seq
MIRT2209056	hsa-miR-4645-5p	CLIP-seq
MIRT2209057	hsa-miR-4673	CLIP-seq
MIRT2209058	hsa-miR-4692	CLIP-seq
MIRT2209059	hsa-miR-4733-3p	CLIP-seq
MIRT923112	hsa-miR-4772-5p	CLIP-seq
MIRT1973496	hsa-miR-489	CLIP-seq
MIRT2209060	hsa-miR-711	CLIP-seq
MIRT923126	hsa-miR-873	CLIP-seq
MIRT2209061	hsa-miR-9	CLIP-seq
MIRT2209062	hsa-miR-96	CLIP-seq
MIRT923065	hsa-miR-105	CLIP-seq
MIRT2386709	hsa-miR-149	CLIP-seq
MIRT2386710	hsa-miR-3064-5p	CLIP-seq
MIRT2386711	hsa-miR-3689a-3p	CLIP-seq
MIRT2386712	hsa-miR-3689c	CLIP-seq
MIRT1973489	hsa-miR-4464	CLIP-seq
MIRT2386713	hsa-miR-4728-5p	CLIP-seq
MIRT2209059	hsa-miR-4733-3p	CLIP-seq
MIRT1973495	hsa-miR-4748	CLIP-seq
MIRT2386714	hsa-miR-4794	CLIP-seq
MIRT923129	hsa-miR-885-3p	CLIP-seq
MIRT2448027	hsa-miR-3184	CLIP-seq
MIRT2448028	hsa-miR-423-5p	CLIP-seq
MIRT2448029	hsa-miR-4263	CLIP-seq
MIRT2448030	hsa-miR-4426	CLIP-seq
MIRT2448031	hsa-miR-4489	CLIP-seq
MIRT2448032	hsa-miR-4647	CLIP-seq
MIRT2448033	hsa-miR-4662b	CLIP-seq
MIRT2448034	hsa-miR-576-5p	CLIP-seq
MIRT1973475	hsa-miR-1184	CLIP-seq
MIRT2209046	hsa-miR-1197	CLIP-seq
MIRT2512880	hsa-miR-1205	CLIP-seq
MIRT2512881	hsa-miR-1207-5p	CLIP-seq
MIRT2512882	hsa-miR-1226	CLIP-seq
MIRT2209047	hsa-miR-1251	CLIP-seq
MIRT923070	hsa-miR-1253	CLIP-seq
MIRT2512883	hsa-miR-1287	CLIP-seq
MIRT923074	hsa-miR-1290	CLIP-seq
MIRT923075	hsa-miR-1299	CLIP-seq
MIRT2512884	hsa-miR-1343	CLIP-seq
MIRT2512885	hsa-miR-1909	CLIP-seq
MIRT2512886	hsa-miR-3130-3p	CLIP-seq
MIRT2512887	hsa-miR-3135b	CLIP-seq
MIRT2512888	hsa-miR-3158-5p	CLIP-seq
MIRT923090	hsa-miR-3167	CLIP-seq
MIRT2512889	hsa-miR-3192	CLIP-seq
MIRT2512890	hsa-miR-324-5p	CLIP-seq
MIRT2512891	hsa-miR-3610	CLIP-seq
MIRT1973480	hsa-miR-3661	CLIP-seq
MIRT2209051	hsa-miR-3675-3p	CLIP-seq
MIRT2386711	hsa-miR-3689a-3p	CLIP-seq
MIRT2386712	hsa-miR-3689c	CLIP-seq
MIRT923096	hsa-miR-3714	CLIP-seq
MIRT2209052	hsa-miR-4305	CLIP-seq
MIRT2512892	hsa-miR-4436b-3p	CLIP-seq
MIRT2512893	hsa-miR-4468	CLIP-seq
MIRT923106	hsa-miR-4477b	CLIP-seq
MIRT2512894	hsa-miR-4479	CLIP-seq
MIRT2209053	hsa-miR-4496	CLIP-seq
MIRT2512895	hsa-miR-4504	CLIP-seq
MIRT2512896	hsa-miR-4505	CLIP-seq
MIRT2209054	hsa-miR-4514	CLIP-seq
MIRT2512897	hsa-miR-4527	CLIP-seq
MIRT2209056	hsa-miR-4645-5p	CLIP-seq
MIRT2512898	hsa-miR-4650-5p	CLIP-seq
MIRT2512899	hsa-miR-4667-3p	CLIP-seq
MIRT2209057	hsa-miR-4673	CLIP-seq
MIRT2512900	hsa-miR-4676-5p	CLIP-seq
MIRT2209058	hsa-miR-4692	CLIP-seq
MIRT2512901	hsa-miR-4694-5p	CLIP-seq
MIRT2512902	hsa-miR-4715-3p	CLIP-seq
MIRT2386713	hsa-miR-4728-5p	CLIP-seq
MIRT2209059	hsa-miR-4733-3p	CLIP-seq
MIRT2512903	hsa-miR-4763-3p	CLIP-seq
MIRT2512904	hsa-miR-4771	CLIP-seq
MIRT923115	hsa-miR-4782-5p	CLIP-seq
MIRT2512905	hsa-miR-4793-3p	CLIP-seq
MIRT2512906	hsa-miR-501-3p	CLIP-seq
MIRT2512907	hsa-miR-502-3p	CLIP-seq
MIRT923120	hsa-miR-516b	CLIP-seq
MIRT2512908	hsa-miR-544	CLIP-seq
MIRT2512909	hsa-miR-548an	CLIP-seq
MIRT2512910	hsa-miR-548c-3p	CLIP-seq
MIRT2512911	hsa-miR-575	CLIP-seq
MIRT1973504	hsa-miR-631	CLIP-seq
MIRT2209060	hsa-miR-711	CLIP-seq
MIRT923128	hsa-miR-876-5p	CLIP-seq
MIRT2512912	hsa-miR-940	CLIP-seq
MIRT1973475	hsa-miR-1184	CLIP-seq
MIRT2209046	hsa-miR-1197	CLIP-seq
MIRT2512880	hsa-miR-1205	CLIP-seq
MIRT2512881	hsa-miR-1207-5p	CLIP-seq
MIRT2512882	hsa-miR-1226	CLIP-seq
MIRT2209047	hsa-miR-1251	CLIP-seq
MIRT923070	hsa-miR-1253	CLIP-seq
MIRT2512883	hsa-miR-1287	CLIP-seq
MIRT923074	hsa-miR-1290	CLIP-seq
MIRT923075	hsa-miR-1299	CLIP-seq
MIRT2512884	hsa-miR-1343	CLIP-seq
MIRT2512885	hsa-miR-1909	CLIP-seq
MIRT2512886	hsa-miR-3130-3p	CLIP-seq
MIRT2512887	hsa-miR-3135b	CLIP-seq
MIRT2512888	hsa-miR-3158-5p	CLIP-seq
MIRT923090	hsa-miR-3167	CLIP-seq
MIRT2512889	hsa-miR-3192	CLIP-seq
MIRT2512890	hsa-miR-324-5p	CLIP-seq
MIRT2512891	hsa-miR-3610	CLIP-seq
MIRT1973480	hsa-miR-3661	CLIP-seq
MIRT2209051	hsa-miR-3675-3p	CLIP-seq
MIRT2386711	hsa-miR-3689a-3p	CLIP-seq
MIRT2386712	hsa-miR-3689c	CLIP-seq
MIRT923096	hsa-miR-3714	CLIP-seq
MIRT2209052	hsa-miR-4305	CLIP-seq
MIRT2512892	hsa-miR-4436b-3p	CLIP-seq
MIRT2512893	hsa-miR-4468	CLIP-seq
MIRT923106	hsa-miR-4477b	CLIP-seq
MIRT2512894	hsa-miR-4479	CLIP-seq
MIRT2209053	hsa-miR-4496	CLIP-seq
MIRT2512895	hsa-miR-4504	CLIP-seq
MIRT2512896	hsa-miR-4505	CLIP-seq
MIRT2209054	hsa-miR-4514	CLIP-seq
MIRT2512897	hsa-miR-4527	CLIP-seq
MIRT2209056	hsa-miR-4645-5p	CLIP-seq
MIRT2512898	hsa-miR-4650-5p	CLIP-seq
MIRT2512899	hsa-miR-4667-3p	CLIP-seq
MIRT2209057	hsa-miR-4673	CLIP-seq
MIRT2512900	hsa-miR-4676-5p	CLIP-seq
MIRT2209058	hsa-miR-4692	CLIP-seq
MIRT2512901	hsa-miR-4694-5p	CLIP-seq
MIRT2512902	hsa-miR-4715-3p	CLIP-seq
MIRT2386713	hsa-miR-4728-5p	CLIP-seq
MIRT2209059	hsa-miR-4733-3p	CLIP-seq
MIRT2512903	hsa-miR-4763-3p	CLIP-seq
MIRT2512904	hsa-miR-4771	CLIP-seq
MIRT923115	hsa-miR-4782-5p	CLIP-seq
MIRT2512905	hsa-miR-4793-3p	CLIP-seq
MIRT2512906	hsa-miR-501-3p	CLIP-seq
MIRT2512907	hsa-miR-502-3p	CLIP-seq
MIRT923120	hsa-miR-516b	CLIP-seq
MIRT2512908	hsa-miR-544	CLIP-seq
MIRT2512909	hsa-miR-548an	CLIP-seq
MIRT2512910	hsa-miR-548c-3p	CLIP-seq
MIRT2512911	hsa-miR-575	CLIP-seq
MIRT1973504	hsa-miR-631	CLIP-seq
MIRT2209060	hsa-miR-711	CLIP-seq
MIRT923128	hsa-miR-876-5p	CLIP-seq
MIRT2512912	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0006914	Process	Autophagy	IEA
GO:0006915	Process	Apoptotic process	IGI	7828849
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	1087798
GO:0010507	Process	Negative regulation of autophagy	IBA	21873635
GO:0010507	Process	Negative regulation of autophagy	IMP	20537536
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IMP	1087798
GO:0034198	Process	Cellular response to amino acid starvation	IBA	21873635
GO:0034198	Process	Cellular response to amino acid starvation	IDA	20537536
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	1087798
GO:0070513	Function	Death domain binding	IBA	21873635
GO:0070513	Function	Death domain binding	IPI	1087798
GO:0097190	Process	Apoptotic signaling pathway	IBA	21873635
GO:0097190	Process	Apoptotic signaling pathway	IMP	1087798, 7828849

Other IDs

• MIM: 600954
• HGNC: 2672
• e!Ensembl: ENSG00000112977

Protein

• UniProt ID: P51397
• Protein name: Death-associated protein 1 (DAP-1)
• Protein function: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15228	DAP	12 → 102	Death-associated protein	Family

• Sequence:

  MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFIS
  GVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK

• Sequence length: 102

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	23128233, 26192919
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	28067908, 26974007, 26192919
Ulcerative colitis	Ulcerative Colitis		26974007, 21297633, 26192919