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DGKH (diacylglycerol kinase eta)

Gene

Diacylglycerol kinase eta

DGKH

DGKeta

13

13q14.11

This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar di

Show/Hide all(188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023493	hsa-miR-1-3p	Microarray	18668037
MIRT711623	hsa-miR-6873-5p	HITS-CLIP	19536157
MIRT711622	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT711620	hsa-miR-4457	HITS-CLIP	19536157
MIRT711621	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT711618	hsa-miR-6804-5p	HITS-CLIP	19536157
MIRT711619	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT711616	hsa-miR-3161	HITS-CLIP	19536157
MIRT659056	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT659055	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT659054	hsa-miR-4744	HITS-CLIP	23824327
MIRT659053	hsa-miR-4509	HITS-CLIP	23824327
MIRT659052	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT659051	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT659050	hsa-miR-766-5p	HITS-CLIP	23824327
MIRT659049	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT659048	hsa-miR-1305	HITS-CLIP	23824327
MIRT659047	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT659046	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT659045	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	20371350
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT478148	hsa-miR-575	PAR-CLIP	20371350
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	20371350
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT478148	hsa-miR-575	PAR-CLIP	20371350
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	20371350
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT478148	hsa-miR-575	PAR-CLIP	20371350
MIRT545500	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT545499	hsa-miR-4643	PAR-CLIP	21572407
MIRT558399	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT558398	hsa-miR-567	PAR-CLIP	21572407
MIRT558397	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT545498	hsa-miR-466	PAR-CLIP	21572407
MIRT545497	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT558396	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT558394	hsa-miR-3924	PAR-CLIP	21572407
MIRT558395	hsa-miR-568	PAR-CLIP	21572407
MIRT558393	hsa-miR-297	PAR-CLIP	21572407
MIRT545500	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT545499	hsa-miR-4643	PAR-CLIP	21572407
MIRT545498	hsa-miR-466	PAR-CLIP	21572407
MIRT545497	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT538088	hsa-miR-4282	PAR-CLIP	22012620
MIRT447732	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT538086	hsa-miR-3163	PAR-CLIP	22012620
MIRT538087	hsa-miR-4709-5p	PAR-CLIP	22012620
MIRT538085	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT538084	hsa-miR-19a-3p	PAR-CLIP	22012620
MIRT538083	hsa-miR-19b-3p	PAR-CLIP	22012620
MIRT538082	hsa-miR-889-3p	PAR-CLIP	22012620
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	23446348
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT478148	hsa-miR-575	PAR-CLIP	23446348
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	23592263
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	23592263
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT478148	hsa-miR-575	PAR-CLIP	23592263
MIRT447732	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447731	hsa-miR-577	PAR-CLIP	22100165
MIRT447730	hsa-miR-656-3p	PAR-CLIP	22100165
MIRT447729	hsa-miR-3935	PAR-CLIP	22100165
MIRT447728	hsa-miR-183-3p	PAR-CLIP	22100165
MIRT447727	hsa-miR-4452	PAR-CLIP	22100165
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT478148	hsa-miR-575	PAR-CLIP	26701625
MIRT478148	hsa-miR-575	PAR-CLIP	26701625
MIRT478148	hsa-miR-575	PAR-CLIP	26701625
MIRT478148	hsa-miR-575	PAR-CLIP	26701625
MIRT478148	hsa-miR-575	PAR-CLIP	26701625
MIRT478148	hsa-miR-575	PAR-CLIP	26701625
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT659048	hsa-miR-1305	PAR-CLIP	27292025
MIRT659048	hsa-miR-1305	PAR-CLIP	27292025
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	27292025
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	27292025
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	27292025
MIRT478148	hsa-miR-575	PAR-CLIP	27292025
MIRT478148	hsa-miR-575	PAR-CLIP	27292025
MIRT478148	hsa-miR-575	PAR-CLIP	27292025
MIRT478148	hsa-miR-575	PAR-CLIP	27292025
MIRT478148	hsa-miR-575	PAR-CLIP	27292025
MIRT478148	hsa-miR-575	PAR-CLIP	27292025
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT711623	hsa-miR-6873-5p	HITS-CLIP	19536157
MIRT711622	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT711620	hsa-miR-4457	HITS-CLIP	19536157
MIRT711621	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT711618	hsa-miR-6804-5p	HITS-CLIP	19536157
MIRT711619	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT711616	hsa-miR-3161	HITS-CLIP	19536157
MIRT659056	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT659055	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT659054	hsa-miR-4744	HITS-CLIP	23824327
MIRT659053	hsa-miR-4509	HITS-CLIP	23824327
MIRT659052	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT659051	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT659050	hsa-miR-766-5p	HITS-CLIP	23824327
MIRT659049	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT659048	hsa-miR-1305	HITS-CLIP	23824327
MIRT659047	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT659046	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT659045	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	20371350
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT478148	hsa-miR-575	PAR-CLIP	20371350
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	20371350
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT478148	hsa-miR-575	PAR-CLIP	20371350
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	20371350
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT478148	hsa-miR-575	PAR-CLIP	20371350
MIRT545500	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT545499	hsa-miR-4643	PAR-CLIP	21572407
MIRT558399	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT558398	hsa-miR-567	PAR-CLIP	21572407
MIRT558397	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT545498	hsa-miR-466	PAR-CLIP	21572407
MIRT545497	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT558396	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT558394	hsa-miR-3924	PAR-CLIP	21572407
MIRT558395	hsa-miR-568	PAR-CLIP	21572407
MIRT558393	hsa-miR-297	PAR-CLIP	21572407
MIRT545500	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT545499	hsa-miR-4643	PAR-CLIP	21572407
MIRT545498	hsa-miR-466	PAR-CLIP	21572407
MIRT545497	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT538088	hsa-miR-4282	PAR-CLIP	22012620
MIRT447732	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT538086	hsa-miR-3163	PAR-CLIP	22012620
MIRT538087	hsa-miR-4709-5p	PAR-CLIP	22012620
MIRT538085	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT538084	hsa-miR-19a-3p	PAR-CLIP	22012620
MIRT538083	hsa-miR-19b-3p	PAR-CLIP	22012620
MIRT538082	hsa-miR-889-3p	PAR-CLIP	22012620
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	23446348
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT478148	hsa-miR-575	PAR-CLIP	23446348
MIRT478151	hsa-miR-4798-3p	PAR-CLIP	23592263
MIRT478150	hsa-miR-6858-3p	PAR-CLIP	23592263
MIRT478149	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT478148	hsa-miR-575	PAR-CLIP	23592263
MIRT447732	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447731	hsa-miR-577	PAR-CLIP	22100165
MIRT447730	hsa-miR-656-3p	PAR-CLIP	22100165
MIRT447729	hsa-miR-3935	PAR-CLIP	22100165
MIRT447728	hsa-miR-183-3p	PAR-CLIP	22100165
MIRT447727	hsa-miR-4452	PAR-CLIP	22100165
MIRT934219	hsa-miR-3978	CLIP-seq
MIRT1976562	hsa-miR-2115	CLIP-seq
MIRT1976563	hsa-miR-3149	CLIP-seq
MIRT1976564	hsa-miR-3977	CLIP-seq
MIRT1976565	hsa-miR-4330	CLIP-seq
MIRT1976566	hsa-miR-4691-3p	CLIP-seq
MIRT1976567	hsa-miR-4691-5p	CLIP-seq
MIRT1976568	hsa-miR-507	CLIP-seq
MIRT1976569	hsa-miR-516a-3p	CLIP-seq
MIRT1976570	hsa-miR-557	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003951	Function	NAD+ kinase activity	IEA
GO:0004143	Function	Diacylglycerol kinase activity	IBA	21873635
GO:0004143	Function	Diacylglycerol kinase activity	IDA	23949095
GO:0004143	Function	Diacylglycerol kinase activity	IMP	12810723
GO:0004143	Function	Diacylglycerol kinase activity	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	12810723
GO:0005768	Component	Endosome	IDA	12810723
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006654	Process	Phosphatidic acid biosynthetic process	ISS
GO:0007205	Process	Protein kinase C-activating G protein-coupled receptor signaling pathway	IMP	12810723
GO:0015629	Component	Actin cytoskeleton	ISS
GO:0030168	Process	Platelet activation	TAS
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0046339	Process	Diacylglycerol metabolic process	IBA	21873635
GO:0046339	Process	Diacylglycerol metabolic process	ISS
GO:0046473	Process	Phosphatidic acid metabolic process	IDA	23949095
GO:0046834	Process	Lipid phosphorylation	IBA	21873635
GO:0046834	Process	Lipid phosphorylation	ISS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
604071	2854	ENSG00000102780

Protein

UniProt ID

Protein name

Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)

Protein function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the si

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	66 → 158	PH domain	Domain
PF00130	C1_1	176 → 228	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00130	C1_1	248 → 301	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00781	DAGK_cat	332 → 454	Diacylglycerol kinase catalytic domain	Family
PF00609	DAGK_acc	770 → 927	Diacylglycerol kinase accessory domain	Family
PF07647	SAM_2	1148 → 1211	SAM domain (Sterile alpha motif)	Domain

Sequence

MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ
IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST
KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA
CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED
EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL
GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA
QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG
NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS
EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA
DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG
DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE
TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII
CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD
AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP
SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH
HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE
DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL
AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER
VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK
QKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGH
VKRILQGIKELGRSTPQSEV

Sequence length

1220

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways Phosphatidylinositol signaling system Phospholipase D signaling pathway Choline metabolism in cancer		Effects of PIP2 hydrolysis

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	25221879
Esophagus neoplasm	Esophageal Neoplasms	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		22892719, 21771265, 22048461, 24958494, 17486107, 21654738
Diabetic nephropathy	Diabetic Nephropathy		20665664
Glomerulosclerosis	Nodular glomerulosclerosis		20665664
Mental depression	Unipolar Depression	rs587778876, rs587778877	21654738
Nephrolithiasis	Nephrolithiasis		22396660
Urolithiasis	Urolithiasis		30975718

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