DGKB (diacylglycerol kinase beta)

Gene

• Entrez ID: 1607
• Gene name: Diacylglycerol kinase beta
• Gene symbol: DGKB
• Synonyms: DAGK2, DGK, DGK-BETA
• Chromosome: 7
• Chromosome location: 7p21.2
• Summary: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT933832	hsa-miR-122	CLIP-seq
MIRT933833	hsa-miR-149	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT933835	hsa-miR-3064-5p	CLIP-seq
MIRT933836	hsa-miR-3065-5p	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT933838	hsa-miR-3153	CLIP-seq
MIRT933839	hsa-miR-3160-5p	CLIP-seq
MIRT933840	hsa-miR-3185	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT933843	hsa-miR-383	CLIP-seq
MIRT933844	hsa-miR-4261	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933846	hsa-miR-4310	CLIP-seq
MIRT933847	hsa-miR-4424	CLIP-seq
MIRT933848	hsa-miR-4426	CLIP-seq
MIRT933849	hsa-miR-4427	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT933851	hsa-miR-4647	CLIP-seq
MIRT933852	hsa-miR-4659a-3p	CLIP-seq
MIRT933853	hsa-miR-4659b-3p	CLIP-seq
MIRT933854	hsa-miR-4662b	CLIP-seq
MIRT933855	hsa-miR-4668-5p	CLIP-seq
MIRT933856	hsa-miR-4680-3p	CLIP-seq
MIRT933857	hsa-miR-4701-5p	CLIP-seq
MIRT933858	hsa-miR-4709-3p	CLIP-seq
MIRT933859	hsa-miR-4772-5p	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT933861	hsa-miR-495	CLIP-seq
MIRT933862	hsa-miR-541	CLIP-seq
MIRT933863	hsa-miR-548ac	CLIP-seq
MIRT933864	hsa-miR-548ae	CLIP-seq
MIRT933865	hsa-miR-548aj	CLIP-seq
MIRT933866	hsa-miR-548am	CLIP-seq
MIRT933867	hsa-miR-548d-3p	CLIP-seq
MIRT933868	hsa-miR-548p	CLIP-seq
MIRT933869	hsa-miR-548x	CLIP-seq
MIRT933870	hsa-miR-548z	CLIP-seq
MIRT933871	hsa-miR-588	CLIP-seq
MIRT933872	hsa-miR-653	CLIP-seq
MIRT933873	hsa-miR-654-5p	CLIP-seq
MIRT933874	hsa-miR-760	CLIP-seq
MIRT933875	hsa-miR-9	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT933833	hsa-miR-149	CLIP-seq
MIRT1976484	hsa-miR-203	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT1976485	hsa-miR-3187-3p	CLIP-seq
MIRT1976486	hsa-miR-34b	CLIP-seq
MIRT1976487	hsa-miR-3545-3p	CLIP-seq
MIRT1976488	hsa-miR-3614-5p	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT1976489	hsa-miR-3663-5p	CLIP-seq
MIRT1976490	hsa-miR-3908	CLIP-seq
MIRT1976491	hsa-miR-3942-5p	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT1976492	hsa-miR-4435	CLIP-seq
MIRT1976493	hsa-miR-4635	CLIP-seq
MIRT933852	hsa-miR-4659a-3p	CLIP-seq
MIRT933853	hsa-miR-4659b-3p	CLIP-seq
MIRT1976494	hsa-miR-4680-5p	CLIP-seq
MIRT933857	hsa-miR-4701-5p	CLIP-seq
MIRT1976495	hsa-miR-4703-5p	CLIP-seq
MIRT1976496	hsa-miR-4717-3p	CLIP-seq
MIRT1976497	hsa-miR-4740-3p	CLIP-seq
MIRT1976498	hsa-miR-4755-3p	CLIP-seq
MIRT1976499	hsa-miR-4763-5p	CLIP-seq
MIRT1976500	hsa-miR-4766-3p	CLIP-seq
MIRT1976501	hsa-miR-4772-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT1976504	hsa-miR-548s	CLIP-seq
MIRT933871	hsa-miR-588	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT933833	hsa-miR-149	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT933835	hsa-miR-3064-5p	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT2211879	hsa-miR-3180-5p	CLIP-seq
MIRT2211880	hsa-miR-3182	CLIP-seq
MIRT2211881	hsa-miR-338-3p	CLIP-seq
MIRT2211882	hsa-miR-3647-3p	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933846	hsa-miR-4310	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT2211883	hsa-miR-4438	CLIP-seq
MIRT2211884	hsa-miR-4530	CLIP-seq
MIRT933852	hsa-miR-4659a-3p	CLIP-seq
MIRT933853	hsa-miR-4659b-3p	CLIP-seq
MIRT2211885	hsa-miR-4727-5p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976497	hsa-miR-4740-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT2211887	hsa-miR-498	CLIP-seq
MIRT2211888	hsa-miR-499-3p	CLIP-seq
MIRT2211889	hsa-miR-499a-3p	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT933874	hsa-miR-760	CLIP-seq
MIRT2386866	hsa-miR-452	CLIP-seq
MIRT2386867	hsa-miR-4676-3p	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT2448187	hsa-miR-2110	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT2448188	hsa-miR-3150a-3p	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT2448190	hsa-miR-4271	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2448192	hsa-miR-4725-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT2448187	hsa-miR-2110	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT2448188	hsa-miR-3150a-3p	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT2448190	hsa-miR-4271	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2448192	hsa-miR-4725-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT2515652	hsa-miR-1227	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT2515653	hsa-miR-197	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT2211883	hsa-miR-4438	CLIP-seq
MIRT2515654	hsa-miR-455-5p	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976501	hsa-miR-4772-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT2515655	hsa-miR-5096	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT2515652	hsa-miR-1227	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT2515653	hsa-miR-197	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT2211883	hsa-miR-4438	CLIP-seq
MIRT2515654	hsa-miR-455-5p	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976501	hsa-miR-4772-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT2515655	hsa-miR-5096	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003951	Function	NAD+ kinase activity	IEA
GO:0004143	Function	Diacylglycerol kinase activity	IBA	21873635
GO:0004143	Function	Diacylglycerol kinase activity	IDA	22627129
GO:0005509	Function	Calcium ion binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006654	Process	Phosphatidic acid biosynthetic process	ISS
GO:0007205	Process	Protein kinase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0008289	Function	Lipid binding	IDA	22627129
GO:0009617	Process	Response to bacterium	IEA
GO:0030168	Process	Platelet activation	TAS
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0046339	Process	Diacylglycerol metabolic process	IBA	21873635
GO:0046339	Process	Diacylglycerol metabolic process	ISS
GO:0046486	Process	Glycerolipid metabolic process	IDA	22627129
GO:0046834	Process	Lipid phosphorylation	IBA	21873635
GO:0046834	Process	Lipid phosphorylation	IDA	22627129
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099175	Process	Regulation of postsynapse organization	IEA

Other IDs

• MIM: 604070
• HGNC: 2850
• e!Ensembl: ENSG00000136267

Protein

• UniProt ID: Q9Y6T7
• Protein name: Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)
• Protein function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14513	DAG_kinase_N	6 → 149	Diacylglycerol kinase N-terminus	Domain
  PF13499	EF-hand_7	151 → 222	EF-hand domain pair	Domain
  PF00130	C1_1	245 → 297	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00130	C1_1	310 → 361	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00781	DAGK_cat	438 → 559	Diacylglycerol kinase catalytic domain	Family
  PF00609	DAGK_acc	582 → 762	Diacylglycerol kinase accessory domain	Family

• Sequence:

  MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
  EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR
  TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ
  MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK
  DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK
  SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC
  GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS
  VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL
  NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE
  GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH
  IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA
  ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL
  EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPM
  LMGPPPKTGLFCSLVKRTRNRSKE

• Sequence length: 804

Pathways

KEGG:

Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Choline metabolism in cancer

Reactome:

Effects of PIP2 hydrolysis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	29892015, 30061737
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28869590, 24509480, 22885922, 30054458, 30718926
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20976192
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	20976192
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	rs199865688, rs397515994, rs757096307	30061737, 29892015