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DAB2 (DAB adaptor protein 2)

Gene

1601

DAB adaptor protein 2

DAB2

DOC-2, DOC2

5p13.1

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains

Show/Hide all(347)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018855	hsa-miR-335-5p	Microarray	18185580
MIRT030166	hsa-miR-26b-5p	Microarray	19088304
MIRT053634	hsa-miR-93-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24037530
MIRT053634	hsa-miR-93-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24037530
MIRT053634	hsa-miR-93-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot, colony formation	24037530
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615732	hsa-miR-4693-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615732	hsa-miR-4693-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615732	hsa-miR-4693-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT478464	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT478463	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT478461	hsa-miR-4272	PAR-CLIP	23592263
MIRT478462	hsa-miR-1323	PAR-CLIP	23592263
MIRT478460	hsa-miR-548o-3p	PAR-CLIP	23592263
MIRT478459	hsa-miR-7515	PAR-CLIP	23592263
MIRT478458	hsa-miR-3179	PAR-CLIP	23592263
MIRT478457	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT478455	hsa-miR-190b	PAR-CLIP	23592263
MIRT478456	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT478454	hsa-miR-604	PAR-CLIP	23592263
MIRT478453	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT478452	hsa-miR-647	PAR-CLIP	23592263
MIRT732332	hsa-miR-106b-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26769181
MIRT732332	hsa-miR-106b-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26769181
MIRT053634	hsa-miR-93-5p	Luciferase reporter assay, qRT-PCR, Western blot	25892549
MIRT053634	hsa-miR-93-5p	Luciferase reporter assay, qRT-PCR, Western blot	25892549
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615732	hsa-miR-4693-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615732	hsa-miR-4693-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615732	hsa-miR-4693-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611056	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT611055	hsa-miR-7976	HITS-CLIP	23824327
MIRT611054	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT611053	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT611052	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT611051	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT611050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT611049	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT611048	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT611047	hsa-miR-8061	HITS-CLIP	23824327
MIRT611046	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT478464	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT478463	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT478461	hsa-miR-4272	PAR-CLIP	23592263
MIRT478462	hsa-miR-1323	PAR-CLIP	23592263
MIRT478460	hsa-miR-548o-3p	PAR-CLIP	23592263
MIRT478459	hsa-miR-7515	PAR-CLIP	23592263
MIRT478458	hsa-miR-3179	PAR-CLIP	23592263
MIRT478457	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT478455	hsa-miR-190b	PAR-CLIP	23592263
MIRT478456	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT478454	hsa-miR-604	PAR-CLIP	23592263
MIRT478453	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT478452	hsa-miR-647	PAR-CLIP	23592263
MIRT922544	hsa-miR-1267	CLIP-seq
MIRT922545	hsa-miR-3143	CLIP-seq
MIRT922546	hsa-miR-3920	CLIP-seq
MIRT922547	hsa-miR-4474-3p	CLIP-seq
MIRT922548	hsa-miR-4753-5p	CLIP-seq
MIRT922549	hsa-miR-543	CLIP-seq
MIRT922550	hsa-miR-874	CLIP-seq
MIRT1547844	hsa-miR-153	CLIP-seq
MIRT1547845	hsa-miR-4436b-3p	CLIP-seq
MIRT1547846	hsa-miR-448	CLIP-seq
MIRT1547847	hsa-miR-513a-3p	CLIP-seq
MIRT1547848	hsa-miR-548t	CLIP-seq
MIRT2208902	hsa-miR-4803	CLIP-seq
MIRT2428088	hsa-miR-1183	CLIP-seq
MIRT2428089	hsa-miR-1231	CLIP-seq
MIRT2428090	hsa-miR-1271	CLIP-seq
MIRT2428091	hsa-miR-149	CLIP-seq
MIRT2428092	hsa-miR-182	CLIP-seq
MIRT2428093	hsa-miR-187	CLIP-seq
MIRT2428094	hsa-miR-188-3p	CLIP-seq
MIRT2428095	hsa-miR-199a-3p	CLIP-seq
MIRT2428096	hsa-miR-199b-3p	CLIP-seq
MIRT2428097	hsa-miR-3064-5p	CLIP-seq
MIRT2428098	hsa-miR-3129-5p	CLIP-seq
MIRT2428099	hsa-miR-320a	CLIP-seq
MIRT2428100	hsa-miR-320b	CLIP-seq
MIRT2428101	hsa-miR-320c	CLIP-seq
MIRT2428102	hsa-miR-320d	CLIP-seq
MIRT2428103	hsa-miR-320e	CLIP-seq
MIRT2428104	hsa-miR-330-3p	CLIP-seq
MIRT2428105	hsa-miR-335	CLIP-seq
MIRT2428106	hsa-miR-3647-3p	CLIP-seq
MIRT2428107	hsa-miR-4429	CLIP-seq
MIRT1547845	hsa-miR-4436b-3p	CLIP-seq
MIRT2428108	hsa-miR-4476	CLIP-seq
MIRT2428109	hsa-miR-4633-5p	CLIP-seq
MIRT2428110	hsa-miR-4729	CLIP-seq
MIRT2428111	hsa-miR-4794	CLIP-seq
MIRT2428112	hsa-miR-548b-3p	CLIP-seq
MIRT2428113	hsa-miR-579	CLIP-seq
MIRT2428114	hsa-miR-598	CLIP-seq
MIRT2428115	hsa-miR-606	CLIP-seq
MIRT2428116	hsa-miR-936	CLIP-seq
MIRT2428117	hsa-miR-96	CLIP-seq
MIRT2512692	hsa-miR-1292	CLIP-seq
MIRT2512693	hsa-miR-1294	CLIP-seq
MIRT2512694	hsa-miR-1305	CLIP-seq
MIRT2512695	hsa-miR-139-5p	CLIP-seq
MIRT2512696	hsa-miR-140-3p	CLIP-seq
MIRT2512697	hsa-miR-143	CLIP-seq
MIRT2512698	hsa-miR-144	CLIP-seq
MIRT2512699	hsa-miR-150	CLIP-seq
MIRT2512700	hsa-miR-185	CLIP-seq
MIRT2512701	hsa-miR-186	CLIP-seq
MIRT2512702	hsa-miR-190	CLIP-seq
MIRT2512703	hsa-miR-2116	CLIP-seq
MIRT2512704	hsa-miR-25	CLIP-seq
MIRT2512705	hsa-miR-3132	CLIP-seq
MIRT2512706	hsa-miR-3150b-3p	CLIP-seq
MIRT2512707	hsa-miR-3154	CLIP-seq
MIRT2512708	hsa-miR-3166	CLIP-seq
MIRT2512709	hsa-miR-3189-3p	CLIP-seq
MIRT2512710	hsa-miR-32	CLIP-seq
MIRT2512711	hsa-miR-3545-3p	CLIP-seq
MIRT2512712	hsa-miR-3607-5p	CLIP-seq
MIRT2512713	hsa-miR-363	CLIP-seq
MIRT2512714	hsa-miR-3646	CLIP-seq
MIRT2428106	hsa-miR-3647-3p	CLIP-seq
MIRT2512715	hsa-miR-3662	CLIP-seq
MIRT2512716	hsa-miR-3665	CLIP-seq
MIRT2512717	hsa-miR-367	CLIP-seq
MIRT2512718	hsa-miR-3678-3p	CLIP-seq
MIRT2512719	hsa-miR-3689a-3p	CLIP-seq
MIRT2512720	hsa-miR-3689c	CLIP-seq
MIRT2512721	hsa-miR-3691-3p	CLIP-seq
MIRT2512722	hsa-miR-3714	CLIP-seq
MIRT2512723	hsa-miR-375	CLIP-seq
MIRT2512724	hsa-miR-382	CLIP-seq
MIRT2512725	hsa-miR-3934	CLIP-seq
MIRT2512726	hsa-miR-409-3p	CLIP-seq
MIRT2512727	hsa-miR-4260	CLIP-seq
MIRT2512728	hsa-miR-4273	CLIP-seq
MIRT2512729	hsa-miR-4282	CLIP-seq
MIRT2512730	hsa-miR-4283	CLIP-seq
MIRT2512731	hsa-miR-4306	CLIP-seq
MIRT2512732	hsa-miR-4316	CLIP-seq
MIRT2512733	hsa-miR-4471	CLIP-seq
MIRT2428108	hsa-miR-4476	CLIP-seq
MIRT2512734	hsa-miR-4489	CLIP-seq
MIRT2512735	hsa-miR-450b-5p	CLIP-seq
MIRT2512736	hsa-miR-451b	CLIP-seq
MIRT2512737	hsa-miR-4539	CLIP-seq
MIRT2428109	hsa-miR-4633-5p	CLIP-seq
MIRT2512738	hsa-miR-4644	CLIP-seq
MIRT2512739	hsa-miR-4646-5p	CLIP-seq
MIRT2512740	hsa-miR-4650-3p	CLIP-seq
MIRT2512741	hsa-miR-4677-5p	CLIP-seq
MIRT2512742	hsa-miR-4689	CLIP-seq
MIRT2512743	hsa-miR-4700-3p	CLIP-seq
MIRT2512744	hsa-miR-4713-5p	CLIP-seq
MIRT2512745	hsa-miR-4714-5p	CLIP-seq
MIRT2512746	hsa-miR-4736	CLIP-seq
MIRT2512747	hsa-miR-4770	CLIP-seq
MIRT2512748	hsa-miR-4771	CLIP-seq
MIRT2512749	hsa-miR-4777-5p	CLIP-seq
MIRT2512750	hsa-miR-4784	CLIP-seq
MIRT2208902	hsa-miR-4803	CLIP-seq
MIRT2512751	hsa-miR-494	CLIP-seq
MIRT2512752	hsa-miR-518d-5p	CLIP-seq
MIRT2512753	hsa-miR-519b-5p	CLIP-seq
MIRT2512754	hsa-miR-519c-5p	CLIP-seq
MIRT2512755	hsa-miR-520c-5p	CLIP-seq
MIRT2512756	hsa-miR-526a	CLIP-seq
MIRT2512757	hsa-miR-532-3p	CLIP-seq
MIRT2512758	hsa-miR-539	CLIP-seq
MIRT2512759	hsa-miR-548aa	CLIP-seq
MIRT2512760	hsa-miR-548o	CLIP-seq
MIRT2512761	hsa-miR-556-3p	CLIP-seq
MIRT2428113	hsa-miR-579	CLIP-seq
MIRT2512762	hsa-miR-621	CLIP-seq
MIRT2512763	hsa-miR-642a	CLIP-seq
MIRT2512764	hsa-miR-663b	CLIP-seq
MIRT2512765	hsa-miR-765	CLIP-seq
MIRT2512766	hsa-miR-890	CLIP-seq
MIRT2512767	hsa-miR-92a	CLIP-seq
MIRT2512768	hsa-miR-92b	CLIP-seq
MIRT2512769	hsa-miR-940	CLIP-seq
MIRT2512692	hsa-miR-1292	CLIP-seq
MIRT2512693	hsa-miR-1294	CLIP-seq
MIRT2512694	hsa-miR-1305	CLIP-seq
MIRT2512695	hsa-miR-139-5p	CLIP-seq
MIRT2512696	hsa-miR-140-3p	CLIP-seq
MIRT2512697	hsa-miR-143	CLIP-seq
MIRT2512698	hsa-miR-144	CLIP-seq
MIRT2512699	hsa-miR-150	CLIP-seq
MIRT2512700	hsa-miR-185	CLIP-seq
MIRT2512701	hsa-miR-186	CLIP-seq
MIRT2512702	hsa-miR-190	CLIP-seq
MIRT2512703	hsa-miR-2116	CLIP-seq
MIRT2512704	hsa-miR-25	CLIP-seq
MIRT2512705	hsa-miR-3132	CLIP-seq
MIRT2512706	hsa-miR-3150b-3p	CLIP-seq
MIRT2512707	hsa-miR-3154	CLIP-seq
MIRT2512708	hsa-miR-3166	CLIP-seq
MIRT2512709	hsa-miR-3189-3p	CLIP-seq
MIRT2512710	hsa-miR-32	CLIP-seq
MIRT2512711	hsa-miR-3545-3p	CLIP-seq
MIRT2512713	hsa-miR-363	CLIP-seq
MIRT2512714	hsa-miR-3646	CLIP-seq
MIRT2428106	hsa-miR-3647-3p	CLIP-seq
MIRT2512715	hsa-miR-3662	CLIP-seq
MIRT2512716	hsa-miR-3665	CLIP-seq
MIRT2512717	hsa-miR-367	CLIP-seq
MIRT2512718	hsa-miR-3678-3p	CLIP-seq
MIRT2512719	hsa-miR-3689a-3p	CLIP-seq
MIRT2512720	hsa-miR-3689c	CLIP-seq
MIRT2512721	hsa-miR-3691-3p	CLIP-seq
MIRT2512722	hsa-miR-3714	CLIP-seq
MIRT2512723	hsa-miR-375	CLIP-seq
MIRT2512724	hsa-miR-382	CLIP-seq
MIRT2512725	hsa-miR-3934	CLIP-seq
MIRT2512726	hsa-miR-409-3p	CLIP-seq
MIRT2512727	hsa-miR-4260	CLIP-seq
MIRT2512728	hsa-miR-4273	CLIP-seq
MIRT2512729	hsa-miR-4282	CLIP-seq
MIRT2512730	hsa-miR-4283	CLIP-seq
MIRT2512731	hsa-miR-4306	CLIP-seq
MIRT2512732	hsa-miR-4316	CLIP-seq
MIRT2512733	hsa-miR-4471	CLIP-seq
MIRT2428108	hsa-miR-4476	CLIP-seq
MIRT2512734	hsa-miR-4489	CLIP-seq
MIRT2512735	hsa-miR-450b-5p	CLIP-seq
MIRT2512736	hsa-miR-451b	CLIP-seq
MIRT2512737	hsa-miR-4539	CLIP-seq
MIRT2428109	hsa-miR-4633-5p	CLIP-seq
MIRT2512738	hsa-miR-4644	CLIP-seq
MIRT2512739	hsa-miR-4646-5p	CLIP-seq
MIRT2512740	hsa-miR-4650-3p	CLIP-seq
MIRT2512741	hsa-miR-4677-5p	CLIP-seq
MIRT2512742	hsa-miR-4689	CLIP-seq
MIRT2512743	hsa-miR-4700-3p	CLIP-seq
MIRT2512744	hsa-miR-4713-5p	CLIP-seq
MIRT2512745	hsa-miR-4714-5p	CLIP-seq
MIRT2512746	hsa-miR-4736	CLIP-seq
MIRT2512747	hsa-miR-4770	CLIP-seq
MIRT2512748	hsa-miR-4771	CLIP-seq
MIRT2512750	hsa-miR-4784	CLIP-seq
MIRT2208902	hsa-miR-4803	CLIP-seq
MIRT2512751	hsa-miR-494	CLIP-seq
MIRT2512757	hsa-miR-532-3p	CLIP-seq
MIRT2512758	hsa-miR-539	CLIP-seq
MIRT2512759	hsa-miR-548aa	CLIP-seq
MIRT2512760	hsa-miR-548o	CLIP-seq
MIRT2512761	hsa-miR-556-3p	CLIP-seq
MIRT2428113	hsa-miR-579	CLIP-seq
MIRT2512762	hsa-miR-621	CLIP-seq
MIRT2512763	hsa-miR-642a	CLIP-seq
MIRT2512765	hsa-miR-765	CLIP-seq
MIRT2512766	hsa-miR-890	CLIP-seq
MIRT2512767	hsa-miR-92a	CLIP-seq
MIRT2512768	hsa-miR-92b	CLIP-seq
MIRT2512769	hsa-miR-940	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
GATA6	Activation	16024609
VHL	Activation	15824735

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	12805222
GO:0001650	Component	Fibrillar center	IDA
GO:0001934	Process	Positive regulation of protein phosphorylation	IMP	12805222
GO:0005515	Function	Protein binding	IPI	11387212, 11967127, 12805222, 15247260, 17474147, 20936779, 22491013, 32814053
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005905	Component	Clathrin-coated pit	IDA	12857860
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006898	Process	Receptor-mediated endocytosis	IBA	21873635
GO:0006915	Process	Apoptotic process	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IMP	19581412
GO:0007275	Process	Multicellular organism development	IEA
GO:0008022	Function	Protein C-terminus binding	IPI	15837803
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IDA	15734730
GO:0010862	Process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IDA	11387212
GO:0015031	Process	Protein transport	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030136	Component	Clathrin-coated vesicle	IDA	19581412
GO:0030335	Process	Positive regulation of cell migration	IMP	19581412
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IDA	11387212
GO:0030665	Component	Clathrin-coated vesicle membrane	IEA
GO:0032091	Process	Negative regulation of protein binding	IMP	12805222
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	12805222
GO:0035026	Process	Leading edge cell differentiation	IMP	19581412
GO:0035615	Function	Clathrin adaptor activity	IMP	16984970
GO:0038024	Function	Cargo receptor activity	IMP	16984970
GO:0043066	Process	Negative regulation of apoptotic process	IDA	15734730
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045807	Process	Positive regulation of endocytosis	IBA	21873635
GO:0045807	Process	Positive regulation of endocytosis	IMP	19581412, 21995445
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	12805222
GO:0046332	Function	SMAD binding	IDA	11387212
GO:0060391	Process	Positive regulation of SMAD protein signal transduction	IDA	11387212
GO:0060766	Process	Negative regulation of androgen receptor signaling pathway	IMP	16267015
GO:0061024	Process	Membrane organization	TAS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	12805222
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	ISS
GO:1903077	Process	Negative regulation of protein localization to plasma membrane	IMP	19581412
GO:2000096	Process	Positive regulation of Wnt signaling pathway, planar cell polarity pathway	IMP	12805222
GO:2000370	Process	Positive regulation of clathrin-dependent endocytosis	IMP	16984970
GO:2000643	Process	Positive regulation of early endosome to late endosome transport	IMP	21995445

MIM	HGNC	e!Ensembl
601236	2662	ENSG00000153071

Protein

UniProt ID

P98082

Protein name

Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)

Protein function

Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosph

PDB

2LSW , 6O5O , 6OVF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00640	PID	50 → 176	Phosphotyrosine interaction domain (PTB/PID)	Domain

Sequence

MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDV
PDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNK
ISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKK
KIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLN
SEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPF
TQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQ
AGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSV
QSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQ
PNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGF
SQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFP
APAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQL
RQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPR
QVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA

Sequence length

770

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Associated diseases

Show/Hide Causal Diseases (4)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes	Diabetes	rs80356611	31451708
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	31451708
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	20383146, 22479191
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497	22158540

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Kidney failure	Kidney Failure, Chronic		20383146, 31152163
Pancreatic carcinoma	Pancreatic carcinoma		22158540

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