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SLC5A12 (solute carrier family 5 member 12)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
159963
Gene nameGene Name - the full gene name approved by the HGNC.
Solute carrier family 5 member 12
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SLC5A12
SynonymsGene synonyms aliases
SMCT2
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p14.2
SummarySummary of gene provided in NCBI Entrez Gene.
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the h
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT721584 hsa-miR-6890-3p HITS-CLIP 19536157
MIRT721583 hsa-miR-205-5p HITS-CLIP 19536157
MIRT721582 hsa-miR-4268 HITS-CLIP 19536157
MIRT721581 hsa-miR-4448 HITS-CLIP 19536157
MIRT721580 hsa-miR-505-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005343 Function Organic acid:sodium symporter activity TAS
GO:0005654 Component Nucleoplasm IDA
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane TAS
GO:0006811 Process Ion transport TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q1EHB4
Protein name Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)
Protein function Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter (PubMed:17692818). Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00474 SSF
41 445
Sodium:solute symporter family
Family
Sequence
Sequence length 618
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Multifunctional anion exchangers
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 25918132
Unknown
Disease name Disease term dbSNP ID References
Erectile dysfunction Erectile dysfunction 30583798

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