USP54 (ubiquitin specific peptidase 54)

Gene

• Entrez ID: 159195
• Gene name: Ubiquitin specific peptidase 54
• Gene symbol: USP54
• Synonyms: C10orf29, bA137L10.3, bA137L10.4
• Chromosome: 10
• Chromosome location: 10q22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024483	hsa-miR-215-5p	Microarray	19074876
MIRT026658	hsa-miR-192-5p	Microarray	19074876
MIRT052169	hsa-let-7b-5p	CLASH	23622248
MIRT035898	hsa-miR-1303	CLASH	23622248
MIRT1480360	hsa-miR-1193	CLIP-seq
MIRT1480361	hsa-miR-122	CLIP-seq
MIRT1480362	hsa-miR-1224-5p	CLIP-seq
MIRT1480363	hsa-miR-1244	CLIP-seq
MIRT1480364	hsa-miR-1273f	CLIP-seq
MIRT1480365	hsa-miR-1289	CLIP-seq
MIRT1480366	hsa-miR-143	CLIP-seq
MIRT1480367	hsa-miR-150	CLIP-seq
MIRT1480368	hsa-miR-1976	CLIP-seq
MIRT1480369	hsa-miR-2392	CLIP-seq
MIRT1480370	hsa-miR-299-5p	CLIP-seq
MIRT1480371	hsa-miR-3135b	CLIP-seq
MIRT1480372	hsa-miR-3152-3p	CLIP-seq
MIRT1480373	hsa-miR-3187-3p	CLIP-seq
MIRT1480374	hsa-miR-3198	CLIP-seq
MIRT1480375	hsa-miR-320e	CLIP-seq
MIRT1480376	hsa-miR-3614-3p	CLIP-seq
MIRT1480377	hsa-miR-3688-5p	CLIP-seq
MIRT1480378	hsa-miR-3915	CLIP-seq
MIRT1480379	hsa-miR-3921	CLIP-seq
MIRT1480380	hsa-miR-4259	CLIP-seq
MIRT1480381	hsa-miR-4279	CLIP-seq
MIRT1480382	hsa-miR-4294	CLIP-seq
MIRT1480383	hsa-miR-4297	CLIP-seq
MIRT1480384	hsa-miR-4309	CLIP-seq
MIRT1480385	hsa-miR-4328	CLIP-seq
MIRT1480386	hsa-miR-4425	CLIP-seq
MIRT1480387	hsa-miR-4435	CLIP-seq
MIRT1480388	hsa-miR-4461	CLIP-seq
MIRT1480389	hsa-miR-4466	CLIP-seq
MIRT1480390	hsa-miR-4480	CLIP-seq
MIRT1480391	hsa-miR-4522	CLIP-seq
MIRT1480392	hsa-miR-4534	CLIP-seq
MIRT1480393	hsa-miR-4639-3p	CLIP-seq
MIRT1480394	hsa-miR-4649-3p	CLIP-seq
MIRT1480395	hsa-miR-4653-5p	CLIP-seq
MIRT1480396	hsa-miR-4687-3p	CLIP-seq
MIRT1480397	hsa-miR-4689	CLIP-seq
MIRT1480398	hsa-miR-4701-5p	CLIP-seq
MIRT1480399	hsa-miR-4703-3p	CLIP-seq
MIRT1480400	hsa-miR-4708-5p	CLIP-seq
MIRT1480401	hsa-miR-4714-5p	CLIP-seq
MIRT1480402	hsa-miR-4715-5p	CLIP-seq
MIRT1480403	hsa-miR-4722-3p	CLIP-seq
MIRT1480404	hsa-miR-4751	CLIP-seq
MIRT1480405	hsa-miR-4770	CLIP-seq
MIRT1480406	hsa-miR-520d-5p	CLIP-seq
MIRT1480407	hsa-miR-524-5p	CLIP-seq
MIRT1480408	hsa-miR-548s	CLIP-seq
MIRT1480409	hsa-miR-582-5p	CLIP-seq
MIRT1480410	hsa-miR-588	CLIP-seq
MIRT1480411	hsa-miR-629	CLIP-seq
MIRT1480412	hsa-miR-640	CLIP-seq
MIRT1480413	hsa-miR-675	CLIP-seq
MIRT2144519	hsa-miR-106a	CLIP-seq
MIRT2144520	hsa-miR-106b	CLIP-seq
MIRT1480360	hsa-miR-1193	CLIP-seq
MIRT1480363	hsa-miR-1244	CLIP-seq
MIRT2144521	hsa-miR-1257	CLIP-seq
MIRT1480364	hsa-miR-1273f	CLIP-seq
MIRT1480365	hsa-miR-1289	CLIP-seq
MIRT2144522	hsa-miR-129-5p	CLIP-seq
MIRT2144523	hsa-miR-1302	CLIP-seq
MIRT1480366	hsa-miR-143	CLIP-seq
MIRT2144524	hsa-miR-17	CLIP-seq
MIRT2144525	hsa-miR-197	CLIP-seq
MIRT1480368	hsa-miR-1976	CLIP-seq
MIRT2144526	hsa-miR-20a	CLIP-seq
MIRT2144527	hsa-miR-20b	CLIP-seq
MIRT1480369	hsa-miR-2392	CLIP-seq
MIRT2144528	hsa-miR-3122	CLIP-seq
MIRT1480373	hsa-miR-3187-3p	CLIP-seq
MIRT1480374	hsa-miR-3198	CLIP-seq
MIRT2144529	hsa-miR-3199	CLIP-seq
MIRT2144530	hsa-miR-34a	CLIP-seq
MIRT2144531	hsa-miR-34c-5p	CLIP-seq
MIRT1480376	hsa-miR-3614-3p	CLIP-seq
MIRT2144532	hsa-miR-3913-5p	CLIP-seq
MIRT1480380	hsa-miR-4259	CLIP-seq
MIRT2144533	hsa-miR-4266	CLIP-seq
MIRT1480381	hsa-miR-4279	CLIP-seq
MIRT2144534	hsa-miR-4284	CLIP-seq
MIRT1480382	hsa-miR-4294	CLIP-seq
MIRT1480383	hsa-miR-4297	CLIP-seq
MIRT2144535	hsa-miR-4298	CLIP-seq
MIRT1480384	hsa-miR-4309	CLIP-seq
MIRT1480386	hsa-miR-4425	CLIP-seq
MIRT1480387	hsa-miR-4435	CLIP-seq
MIRT2144536	hsa-miR-449a	CLIP-seq
MIRT2144537	hsa-miR-449b	CLIP-seq
MIRT1480392	hsa-miR-4534	CLIP-seq
MIRT1480393	hsa-miR-4639-3p	CLIP-seq
MIRT1480398	hsa-miR-4701-5p	CLIP-seq
MIRT1480399	hsa-miR-4703-3p	CLIP-seq
MIRT1480400	hsa-miR-4708-5p	CLIP-seq
MIRT1480402	hsa-miR-4715-5p	CLIP-seq
MIRT2144538	hsa-miR-4716-5p	CLIP-seq
MIRT1480403	hsa-miR-4722-3p	CLIP-seq
MIRT1480405	hsa-miR-4770	CLIP-seq
MIRT2144539	hsa-miR-4781-3p	CLIP-seq
MIRT2144540	hsa-miR-483-5p	CLIP-seq
MIRT2144541	hsa-miR-498	CLIP-seq
MIRT2144542	hsa-miR-5095	CLIP-seq
MIRT2144543	hsa-miR-5096	CLIP-seq
MIRT2144544	hsa-miR-519d	CLIP-seq
MIRT2144545	hsa-miR-548aa	CLIP-seq
MIRT1480408	hsa-miR-548s	CLIP-seq
MIRT2144546	hsa-miR-580	CLIP-seq
MIRT1480410	hsa-miR-588	CLIP-seq
MIRT2144547	hsa-miR-589	CLIP-seq
MIRT1480412	hsa-miR-640	CLIP-seq
MIRT2144548	hsa-miR-93	CLIP-seq
MIRT2144519	hsa-miR-106a	CLIP-seq
MIRT2144520	hsa-miR-106b	CLIP-seq
MIRT1480360	hsa-miR-1193	CLIP-seq
MIRT1480363	hsa-miR-1244	CLIP-seq
MIRT2364859	hsa-miR-1245b-5p	CLIP-seq
MIRT2144521	hsa-miR-1257	CLIP-seq
MIRT1480364	hsa-miR-1273f	CLIP-seq
MIRT2144523	hsa-miR-1302	CLIP-seq
MIRT1480366	hsa-miR-143	CLIP-seq
MIRT2364860	hsa-miR-146b-3p	CLIP-seq
MIRT2144524	hsa-miR-17	CLIP-seq
MIRT2364861	hsa-miR-1909	CLIP-seq
MIRT2144525	hsa-miR-197	CLIP-seq
MIRT1480368	hsa-miR-1976	CLIP-seq
MIRT2144526	hsa-miR-20a	CLIP-seq
MIRT2144527	hsa-miR-20b	CLIP-seq
MIRT1480369	hsa-miR-2392	CLIP-seq
MIRT2364862	hsa-miR-2964a-5p	CLIP-seq
MIRT2144528	hsa-miR-3122	CLIP-seq
MIRT2364863	hsa-miR-3142	CLIP-seq
MIRT2364864	hsa-miR-3149	CLIP-seq
MIRT2364865	hsa-miR-3173-5p	CLIP-seq
MIRT1480373	hsa-miR-3187-3p	CLIP-seq
MIRT2144529	hsa-miR-3199	CLIP-seq
MIRT2144530	hsa-miR-34a	CLIP-seq
MIRT2144531	hsa-miR-34c-5p	CLIP-seq
MIRT2364866	hsa-miR-3529	CLIP-seq
MIRT1480376	hsa-miR-3614-3p	CLIP-seq
MIRT2364867	hsa-miR-3616-3p	CLIP-seq
MIRT2364868	hsa-miR-3622a-5p	CLIP-seq
MIRT2364869	hsa-miR-3682-3p	CLIP-seq
MIRT2364870	hsa-miR-379	CLIP-seq
MIRT2144532	hsa-miR-3913-5p	CLIP-seq
MIRT2364871	hsa-miR-3934	CLIP-seq
MIRT1480380	hsa-miR-4259	CLIP-seq
MIRT2144533	hsa-miR-4266	CLIP-seq
MIRT2364872	hsa-miR-4269	CLIP-seq
MIRT1480381	hsa-miR-4279	CLIP-seq
MIRT2144534	hsa-miR-4284	CLIP-seq
MIRT1480383	hsa-miR-4297	CLIP-seq
MIRT2144535	hsa-miR-4298	CLIP-seq
MIRT1480386	hsa-miR-4425	CLIP-seq
MIRT1480387	hsa-miR-4435	CLIP-seq
MIRT2364873	hsa-miR-4438	CLIP-seq
MIRT2364874	hsa-miR-4443	CLIP-seq
MIRT2364875	hsa-miR-4451	CLIP-seq
MIRT2364876	hsa-miR-4464	CLIP-seq
MIRT2144536	hsa-miR-449a	CLIP-seq
MIRT2144537	hsa-miR-449b	CLIP-seq
MIRT2364877	hsa-miR-4502	CLIP-seq
MIRT2364878	hsa-miR-4532	CLIP-seq
MIRT2364879	hsa-miR-4650-3p	CLIP-seq
MIRT2364880	hsa-miR-4660	CLIP-seq
MIRT1480398	hsa-miR-4701-5p	CLIP-seq
MIRT1480399	hsa-miR-4703-3p	CLIP-seq
MIRT1480400	hsa-miR-4708-5p	CLIP-seq
MIRT1480402	hsa-miR-4715-5p	CLIP-seq
MIRT2144538	hsa-miR-4716-5p	CLIP-seq
MIRT1480403	hsa-miR-4722-3p	CLIP-seq
MIRT2364881	hsa-miR-4735-5p	CLIP-seq
MIRT2364882	hsa-miR-4748	CLIP-seq
MIRT1480405	hsa-miR-4770	CLIP-seq
MIRT2364883	hsa-miR-4772-3p	CLIP-seq
MIRT2364884	hsa-miR-4775	CLIP-seq
MIRT2144539	hsa-miR-4781-3p	CLIP-seq
MIRT2364885	hsa-miR-4794	CLIP-seq
MIRT2144540	hsa-miR-483-5p	CLIP-seq
MIRT2144541	hsa-miR-498	CLIP-seq
MIRT2144542	hsa-miR-5095	CLIP-seq
MIRT2144543	hsa-miR-5096	CLIP-seq
MIRT2144544	hsa-miR-519d	CLIP-seq
MIRT1480408	hsa-miR-548s	CLIP-seq
MIRT2144546	hsa-miR-580	CLIP-seq
MIRT1480410	hsa-miR-588	CLIP-seq
MIRT2144547	hsa-miR-589	CLIP-seq
MIRT2364886	hsa-miR-590-3p	CLIP-seq
MIRT1480412	hsa-miR-640	CLIP-seq
MIRT2364887	hsa-miR-645	CLIP-seq
MIRT2364888	hsa-miR-874	CLIP-seq
MIRT2364889	hsa-miR-885-3p	CLIP-seq
MIRT2144548	hsa-miR-93	CLIP-seq
MIRT2144521	hsa-miR-1257	CLIP-seq
MIRT1480364	hsa-miR-1273f	CLIP-seq
MIRT1480366	hsa-miR-143	CLIP-seq
MIRT2364861	hsa-miR-1909	CLIP-seq
MIRT2144530	hsa-miR-34a	CLIP-seq
MIRT2144531	hsa-miR-34c-5p	CLIP-seq
MIRT2144533	hsa-miR-4266	CLIP-seq
MIRT1480389	hsa-miR-4466	CLIP-seq
MIRT2144536	hsa-miR-449a	CLIP-seq
MIRT2144537	hsa-miR-449b	CLIP-seq
MIRT1480400	hsa-miR-4708-5p	CLIP-seq
MIRT1480405	hsa-miR-4770	CLIP-seq
MIRT2144539	hsa-miR-4781-3p	CLIP-seq
MIRT2144546	hsa-miR-580	CLIP-seq
MIRT2144547	hsa-miR-589	CLIP-seq
MIRT1480413	hsa-miR-675	CLIP-seq
MIRT1480368	hsa-miR-1976	CLIP-seq
MIRT1480376	hsa-miR-3614-3p	CLIP-seq
MIRT1480381	hsa-miR-4279	CLIP-seq
MIRT1480383	hsa-miR-4297	CLIP-seq
MIRT2364878	hsa-miR-4532	CLIP-seq
MIRT1480403	hsa-miR-4722-3p	CLIP-seq
MIRT2144541	hsa-miR-498	CLIP-seq
MIRT2658689	hsa-miR-1207-5p	CLIP-seq
MIRT1480361	hsa-miR-122	CLIP-seq
MIRT1480363	hsa-miR-1244	CLIP-seq
MIRT2364859	hsa-miR-1245b-5p	CLIP-seq
MIRT2144521	hsa-miR-1257	CLIP-seq
MIRT2658690	hsa-miR-1261	CLIP-seq
MIRT1480364	hsa-miR-1273f	CLIP-seq
MIRT2658691	hsa-miR-1285	CLIP-seq
MIRT1480365	hsa-miR-1289	CLIP-seq
MIRT2144522	hsa-miR-129-5p	CLIP-seq
MIRT2658692	hsa-miR-1307	CLIP-seq
MIRT2658693	hsa-miR-140-3p	CLIP-seq
MIRT1480366	hsa-miR-143	CLIP-seq
MIRT2364860	hsa-miR-146b-3p	CLIP-seq
MIRT2364861	hsa-miR-1909	CLIP-seq
MIRT2658694	hsa-miR-1972	CLIP-seq
MIRT1480368	hsa-miR-1976	CLIP-seq
MIRT2658695	hsa-miR-199a-3p	CLIP-seq
MIRT2658696	hsa-miR-199b-3p	CLIP-seq
MIRT2658697	hsa-miR-2052	CLIP-seq
MIRT2658698	hsa-miR-221	CLIP-seq
MIRT2658699	hsa-miR-222	CLIP-seq
MIRT1480369	hsa-miR-2392	CLIP-seq
MIRT2364862	hsa-miR-2964a-5p	CLIP-seq
MIRT2658700	hsa-miR-3064-3p	CLIP-seq
MIRT2658701	hsa-miR-3129-5p	CLIP-seq
MIRT1480371	hsa-miR-3135b	CLIP-seq
MIRT2364863	hsa-miR-3142	CLIP-seq
MIRT2658702	hsa-miR-3165	CLIP-seq
MIRT2364865	hsa-miR-3173-5p	CLIP-seq
MIRT2658703	hsa-miR-3187-5p	CLIP-seq
MIRT1480374	hsa-miR-3198	CLIP-seq
MIRT1480375	hsa-miR-320e	CLIP-seq
MIRT2144530	hsa-miR-34a	CLIP-seq
MIRT2144531	hsa-miR-34c-5p	CLIP-seq
MIRT1480376	hsa-miR-3614-3p	CLIP-seq
MIRT2364867	hsa-miR-3616-3p	CLIP-seq
MIRT2364869	hsa-miR-3682-3p	CLIP-seq
MIRT2658704	hsa-miR-369-3p	CLIP-seq
MIRT2144533	hsa-miR-4266	CLIP-seq
MIRT1480381	hsa-miR-4279	CLIP-seq
MIRT2144534	hsa-miR-4284	CLIP-seq
MIRT1480382	hsa-miR-4294	CLIP-seq
MIRT1480383	hsa-miR-4297	CLIP-seq
MIRT1480384	hsa-miR-4309	CLIP-seq
MIRT2364874	hsa-miR-4443	CLIP-seq
MIRT2364876	hsa-miR-4464	CLIP-seq
MIRT1480389	hsa-miR-4466	CLIP-seq
MIRT1480390	hsa-miR-4480	CLIP-seq
MIRT2144536	hsa-miR-449a	CLIP-seq
MIRT2144537	hsa-miR-449b	CLIP-seq
MIRT2364877	hsa-miR-4502	CLIP-seq
MIRT2364878	hsa-miR-4532	CLIP-seq
MIRT1480392	hsa-miR-4534	CLIP-seq
MIRT2658705	hsa-miR-4638-5p	CLIP-seq
MIRT1480393	hsa-miR-4639-3p	CLIP-seq
MIRT2364880	hsa-miR-4660	CLIP-seq
MIRT2658706	hsa-miR-4666-5p	CLIP-seq
MIRT1480400	hsa-miR-4708-5p	CLIP-seq
MIRT1480403	hsa-miR-4722-3p	CLIP-seq
MIRT2364882	hsa-miR-4748	CLIP-seq
MIRT2658707	hsa-miR-4763-3p	CLIP-seq
MIRT1480405	hsa-miR-4770	CLIP-seq
MIRT2364883	hsa-miR-4772-3p	CLIP-seq
MIRT2144539	hsa-miR-4781-3p	CLIP-seq
MIRT2144541	hsa-miR-498	CLIP-seq
MIRT2144546	hsa-miR-580	CLIP-seq
MIRT2144547	hsa-miR-589	CLIP-seq
MIRT2658708	hsa-miR-612	CLIP-seq
MIRT2658709	hsa-miR-619	CLIP-seq
MIRT1480412	hsa-miR-640	CLIP-seq
MIRT2364887	hsa-miR-645	CLIP-seq
MIRT1480413	hsa-miR-675	CLIP-seq
MIRT2658710	hsa-miR-7	CLIP-seq
MIRT2364888	hsa-miR-874	CLIP-seq
MIRT2364889	hsa-miR-885-3p	CLIP-seq
MIRT2658689	hsa-miR-1207-5p	CLIP-seq
MIRT1480361	hsa-miR-122	CLIP-seq
MIRT1480363	hsa-miR-1244	CLIP-seq
MIRT2364859	hsa-miR-1245b-5p	CLIP-seq
MIRT2144521	hsa-miR-1257	CLIP-seq
MIRT1480364	hsa-miR-1273f	CLIP-seq
MIRT2658691	hsa-miR-1285	CLIP-seq
MIRT1480365	hsa-miR-1289	CLIP-seq
MIRT2144522	hsa-miR-129-5p	CLIP-seq
MIRT2658692	hsa-miR-1307	CLIP-seq
MIRT2658693	hsa-miR-140-3p	CLIP-seq
MIRT1480366	hsa-miR-143	CLIP-seq
MIRT2364860	hsa-miR-146b-3p	CLIP-seq
MIRT2364861	hsa-miR-1909	CLIP-seq
MIRT2658694	hsa-miR-1972	CLIP-seq
MIRT1480368	hsa-miR-1976	CLIP-seq
MIRT2658695	hsa-miR-199a-3p	CLIP-seq
MIRT2658696	hsa-miR-199b-3p	CLIP-seq
MIRT2658697	hsa-miR-2052	CLIP-seq
MIRT2658698	hsa-miR-221	CLIP-seq
MIRT2658699	hsa-miR-222	CLIP-seq
MIRT1480369	hsa-miR-2392	CLIP-seq
MIRT2364862	hsa-miR-2964a-5p	CLIP-seq
MIRT2658700	hsa-miR-3064-3p	CLIP-seq
MIRT2658701	hsa-miR-3129-5p	CLIP-seq
MIRT1480371	hsa-miR-3135b	CLIP-seq
MIRT2364863	hsa-miR-3142	CLIP-seq
MIRT2364865	hsa-miR-3173-5p	CLIP-seq
MIRT2658703	hsa-miR-3187-5p	CLIP-seq
MIRT1480374	hsa-miR-3198	CLIP-seq
MIRT1480375	hsa-miR-320e	CLIP-seq
MIRT1480376	hsa-miR-3614-3p	CLIP-seq
MIRT2364867	hsa-miR-3616-3p	CLIP-seq
MIRT2694842	hsa-miR-3660	CLIP-seq
MIRT2364869	hsa-miR-3682-3p	CLIP-seq
MIRT2658704	hsa-miR-369-3p	CLIP-seq
MIRT2144533	hsa-miR-4266	CLIP-seq
MIRT1480381	hsa-miR-4279	CLIP-seq
MIRT1480382	hsa-miR-4294	CLIP-seq
MIRT1480383	hsa-miR-4297	CLIP-seq
MIRT1480384	hsa-miR-4309	CLIP-seq
MIRT2364874	hsa-miR-4443	CLIP-seq
MIRT2364876	hsa-miR-4464	CLIP-seq
MIRT1480389	hsa-miR-4466	CLIP-seq
MIRT1480390	hsa-miR-4480	CLIP-seq
MIRT2364877	hsa-miR-4502	CLIP-seq
MIRT2694843	hsa-miR-4526	CLIP-seq
MIRT2364878	hsa-miR-4532	CLIP-seq
MIRT1480392	hsa-miR-4534	CLIP-seq
MIRT2658705	hsa-miR-4638-5p	CLIP-seq
MIRT2364880	hsa-miR-4660	CLIP-seq
MIRT2658706	hsa-miR-4666-5p	CLIP-seq
MIRT1480400	hsa-miR-4708-5p	CLIP-seq
MIRT1480403	hsa-miR-4722-3p	CLIP-seq
MIRT2694844	hsa-miR-4728-3p	CLIP-seq
MIRT2364882	hsa-miR-4748	CLIP-seq
MIRT2658707	hsa-miR-4763-3p	CLIP-seq
MIRT1480405	hsa-miR-4770	CLIP-seq
MIRT2144539	hsa-miR-4781-3p	CLIP-seq
MIRT2144541	hsa-miR-498	CLIP-seq
MIRT2144546	hsa-miR-580	CLIP-seq
MIRT2144547	hsa-miR-589	CLIP-seq
MIRT2658708	hsa-miR-612	CLIP-seq
MIRT2658709	hsa-miR-619	CLIP-seq
MIRT2694845	hsa-miR-628-5p	CLIP-seq
MIRT2364887	hsa-miR-645	CLIP-seq
MIRT1480413	hsa-miR-675	CLIP-seq
MIRT2658710	hsa-miR-7	CLIP-seq
MIRT2364888	hsa-miR-874	CLIP-seq
MIRT2364889	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IEA
GO:0005515	Function	Protein binding	IPI	16713569, 25416956
GO:0016579	Process	Protein deubiquitination	IEA
GO:0018215	Process	Protein phosphopantetheinylation	IEA

Other IDs

• MIM: HGNC
• e!Ensembl: HGNC

Protein

• UniProt ID: Q70EL1
• Protein name: Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54)
• Protein function: Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavag
• PDB: 8C61
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00443	UCH	31 → 349	Ubiquitin carboxyl-terminal hydrolase	Family

• Sequence:

  MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRS
  FRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDD
  AAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQ
  MVHYISTTSLCNQAICMLERREKPSPSMFGELLQNASTMGDLRNCPSNCGERIRIRRVLM
  NAPQIITIGLVWDSDHSDLAEDVIHSLGTCLKLGDLFFRVTDDRAKQSELYLVGMICYYG
  KHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVTKCIKGHYQPLLLLYADPQGTPVSTQ
  DLPPQAEFQSYSRTCYDSEDSGREPSISSDTRTDSSTESYPYKHSHHESVVSHFSSDSQG
  TVIYNVENDSMSQSSRDTGHLTDSECNQKHTSKKGSLIERKRSSGRVRRKGDEPQASGYH
  SEGETLKEKQAPRNASKPSSSTNRLRDFKETVSNMIHNRPSLASQTNVGSHCRGRGGDQP
  DKKPPRTLPLHSRDWEIESTSSESKSSSSSKYRPTWRPKRESLNIDSIFSKDKRKHCGYT
  QLSPFSEDSAKEFIPDEPSKPPSYDIKFGGPSPQYKRWGPARPGSHLLEQHPRLIQRMES
  GYESSERNSSSPVSLDAALPESSNVYRDPSAKRSAGLVPSWRHIPKSHSSSILEVDSTAS
  MGGWTKSQPFSGEEISSKSELDELQEEVARRAQEQELRRKREKELEAAKGFNPHPSRFMD
  LDELQNQGRSDGFERSLQEAESVFEESLHLEQKGDCAAALALCNEAISKLRLALHGASCS
  THSRALVDKKLQISIRKARSLQDRMQQQQSPQQPSQPSACLPTQAGTLSQPTSEQPIPLQ
  VLLSQEAQLESGMDTEFGASSFFHSPASCHESHSSLSPESSAPQHSSPSRSALKLLTSVE
  VDNIEPSAFHRQGLPKAPGWTEKNSHHSWEPLDAPEGKLQGSRCDNSSCSKLPPQEGRGI
  AQEQLFQEKKDPANPSPVMPGIATSERGDEHSLGCSPSNSSAQPSLPLYRTCHPIMPVAS
  SFVLHCPDPVQKTNQCLQGQSLKTSLTLKVDRGSEETYRPEFPSTKGLVRSLAEQFQRMQ
  GVSMRDSTGFKDRSLSGSLRKNSSPSDSKPPFSQGQEKGHWPWAKQQSSLEGGDRPLSWE
  ESTEHSSLALNSGLPNGETSSGGQPRLAEPDIYQEKLSQVRDVRSKDLGSSTDLGTSLPL
  DSWVNITRFCDSQLKHGAPRPGMKSSPHDSHTCVTYPERNHILLHPHWNQDTEQETSELE
  SLYQASLQASQAGCSGWGQQDTAWHPLSQTGSADGMGRRLHSAHDPGLSKTSTAEMEHGL
  HEARTVRTSQATPCRGLSRECGEDEQYSAENLRRISRSLSGTVVSEREEAPVSSHSFDSS
  NVRKPLETGHRCSSSSSLPVIHDPSVFLLGPQLYLPQPQFLSPDVLMPTMAGEPNRLPGT
  SRSVQQFLAMCDRGETSQGAKYTGRTLNYQSLPHRSRTDNSWAPWSETNQHIGTRFLTTP
  GCNPQLTYTATLPERSKGLQVPHTQSWSDLFHSPSHPPIVHPVYPPSSSLHVPLRSAWNS
  DPVPGSRTPGPRRVDMPPDDDWRQSSYASHSGHRRTVGEGFLFVLSDAPRREQIRARVLQ
  HSQW

• Sequence length: 1684

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243