CYP4A11 (cytochrome P450 family 4 subfamily A member 11)

Gene

• Entrez ID: 1579
• Gene name: Cytochrome P450 family 4 subfamily A member 11
• Gene symbol: CYP4A11
• Synonyms: CP4Y, CYP4A2, CYP4AII, CYPIVA11
• Chromosome: 1
• Chromosome location: 1p33
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028966	hsa-miR-26b-5p	Microarray	19088304
MIRT484062	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT484063	hsa-miR-4781-3p	PAR-CLIP	23592263
MIRT484061	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT484060	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT484059	hsa-miR-4270	PAR-CLIP	23592263
MIRT484058	hsa-miR-4441	PAR-CLIP	23592263
MIRT484057	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT484056	hsa-miR-6134	PAR-CLIP	23592263
MIRT484055	hsa-miR-4683	PAR-CLIP	23592263
MIRT484054	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT484053	hsa-miR-6745	PAR-CLIP	23592263
MIRT484051	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT484052	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT484050	hsa-miR-1293	PAR-CLIP	23592263
MIRT484049	hsa-miR-4483	PAR-CLIP	23592263
MIRT484048	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT484047	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT484046	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT484045	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT484044	hsa-miR-3127-5p	PAR-CLIP	23592263
MIRT484043	hsa-miR-1270	PAR-CLIP	23592263
MIRT484042	hsa-miR-620	PAR-CLIP	23592263
MIRT459111	hsa-miR-3154	PAR-CLIP	23592263
MIRT459110	hsa-miR-4690-5p	PAR-CLIP	23592263
MIRT459109	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT459107	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT459108	hsa-miR-940	PAR-CLIP	23592263
MIRT459106	hsa-miR-9500	PAR-CLIP	23592263
MIRT459105	hsa-miR-4514	PAR-CLIP	23592263
MIRT459104	hsa-miR-4692	PAR-CLIP	23592263
MIRT459103	hsa-miR-3185	PAR-CLIP	23592263
MIRT459102	hsa-miR-7515	PAR-CLIP	23592263
MIRT459101	hsa-miR-3665	PAR-CLIP	23592263
MIRT459100	hsa-miR-4736	PAR-CLIP	23592263
MIRT459099	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT459098	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT459097	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT459096	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT028966	hsa-miR-26b-5p	Microarray	27756246
MIRT028966	hsa-miR-26b-5p	Microarray	27756246
MIRT484062	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT484063	hsa-miR-4781-3p	PAR-CLIP	23592263
MIRT484061	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT484060	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT484059	hsa-miR-4270	PAR-CLIP	23592263
MIRT484058	hsa-miR-4441	PAR-CLIP	23592263
MIRT484057	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT484056	hsa-miR-6134	PAR-CLIP	23592263
MIRT484055	hsa-miR-4683	PAR-CLIP	23592263
MIRT484054	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT484053	hsa-miR-6745	PAR-CLIP	23592263
MIRT484051	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT484052	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT484050	hsa-miR-1293	PAR-CLIP	23592263
MIRT484049	hsa-miR-4483	PAR-CLIP	23592263
MIRT484048	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT484047	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT484046	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT484045	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT484044	hsa-miR-3127-5p	PAR-CLIP	23592263
MIRT484043	hsa-miR-1270	PAR-CLIP	23592263
MIRT484042	hsa-miR-620	PAR-CLIP	23592263
MIRT459111	hsa-miR-3154	PAR-CLIP	23592263
MIRT459110	hsa-miR-4690-5p	PAR-CLIP	23592263
MIRT459109	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT459107	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT459108	hsa-miR-940	PAR-CLIP	23592263
MIRT459106	hsa-miR-9500	PAR-CLIP	23592263
MIRT459105	hsa-miR-4514	PAR-CLIP	23592263
MIRT459104	hsa-miR-4692	PAR-CLIP	23592263
MIRT459103	hsa-miR-3185	PAR-CLIP	23592263
MIRT459102	hsa-miR-7515	PAR-CLIP	23592263
MIRT459101	hsa-miR-3665	PAR-CLIP	23592263
MIRT459100	hsa-miR-4736	PAR-CLIP	23592263
MIRT459099	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT459098	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT459097	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT459096	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT921628	hsa-miR-3132	CLIP-seq
MIRT921629	hsa-miR-3529	CLIP-seq
MIRT921630	hsa-miR-379	CLIP-seq
MIRT921631	hsa-miR-3927	CLIP-seq
MIRT921632	hsa-miR-4453	CLIP-seq
MIRT921633	hsa-miR-4457	CLIP-seq
MIRT921634	hsa-miR-4538	CLIP-seq
MIRT921635	hsa-miR-4694-5p	CLIP-seq
MIRT921636	hsa-miR-4717-5p	CLIP-seq
MIRT921637	hsa-miR-4753-5p	CLIP-seq
MIRT921638	hsa-miR-552	CLIP-seq
MIRT921628	hsa-miR-3132	CLIP-seq
MIRT921629	hsa-miR-3529	CLIP-seq
MIRT921630	hsa-miR-379	CLIP-seq
MIRT921631	hsa-miR-3927	CLIP-seq
MIRT921636	hsa-miR-4717-5p	CLIP-seq
MIRT921637	hsa-miR-4753-5p	CLIP-seq
MIRT921628	hsa-miR-3132	CLIP-seq
MIRT921629	hsa-miR-3529	CLIP-seq
MIRT921630	hsa-miR-379	CLIP-seq
MIRT921631	hsa-miR-3927	CLIP-seq
MIRT921638	hsa-miR-552	CLIP-seq
MIRT921632	hsa-miR-4453	CLIP-seq
MIRT921634	hsa-miR-4538	CLIP-seq
MIRT921635	hsa-miR-4694-5p	CLIP-seq
MIRT921636	hsa-miR-4717-5p	CLIP-seq
MIRT921637	hsa-miR-4753-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	18433732
GO:0001822	Process	Kidney development	IBA	21873635
GO:0003091	Process	Renal water homeostasis	IEP	10660572
GO:0003095	Process	Pressure natriuresis	IEP	10660572
GO:0005506	Function	Iron ion binding	IEA
GO:0005737	Component	Cytoplasm	IDA	10660572
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006631	Process	Fatty acid metabolic process	TAS
GO:0006691	Process	Leukotriene metabolic process	IDA	9799565
GO:0008391	Function	Arachidonic acid monooxygenase activity	IBA	21873635
GO:0008392	Function	Arachidonic acid epoxygenase activity	IDA	9618440
GO:0016324	Component	Apical plasma membrane	IDA	10660572
GO:0018685	Function	Alkane 1-monooxygenase activity	IBA	21873635
GO:0018685	Function	Alkane 1-monooxygenase activity	IDA	18433732
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0019369	Process	Arachidonic acid metabolic process	IBA	21873635
GO:0019369	Process	Arachidonic acid metabolic process	IDA	10660572
GO:0019373	Process	Epoxygenase P450 pathway	IDA	9618440
GO:0020037	Function	Heme binding	IEA
GO:0031408	Process	Oxylipin biosynthetic process	IEA
GO:0032305	Process	Positive regulation of icosanoid secretion	IMP	18391101
GO:0036101	Process	Leukotriene B4 catabolic process	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	9618440, 9799565, 10660572
GO:0043651	Process	Linoleic acid metabolic process	IBA	21873635
GO:0046456	Process	Icosanoid biosynthetic process	IBA	21873635
GO:0048252	Process	Lauric acid metabolic process	IBA	21873635
GO:0050051	Function	Leukotriene-B4 20-monooxygenase activity	IDA	9799565
GO:0055078	Process	Sodium ion homeostasis	IEP	10660572
GO:0070330	Function	Aromatase activity	IEA
GO:0097267	Process	Omega-hydroxylase P450 pathway	TAS
GO:0102033	Function	Long-chain fatty acid omega-hydroxylase activity	IEA

Other IDs

• MIM: 601310
• HGNC: 2642
• e!Ensembl: ENSG00000187048

Protein

• UniProt ID: Q02928
• Protein name: Cytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty ac
• Protein function: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Mechanistically, uses mol
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00067	p450	51 → 505	Cytochrome P450	Domain

• Sequence:

  MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF
  GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY
  RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD
  SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND
  TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
  ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS
  ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
  NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL
  LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL

• Sequence length: 519

Pathways

Reactome:

PPARA activates gene expression
Fatty acids
Miscellaneous substrates
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560