CDCA2 (cell division cycle associated 2)

Gene

• Entrez ID: 157313
• Gene name: Cell division cycle associated 2
• Gene symbol: CDCA2
• Synonyms: PPP1R81, Repo-Man
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016459	hsa-miR-193b-3p	Microarray	20304954
MIRT040857	hsa-miR-18a-3p	CLASH	23622248
MIRT647373	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT647371	hsa-miR-5688	HITS-CLIP	23824327
MIRT647372	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT647370	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT647373	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT647371	hsa-miR-5688	HITS-CLIP	23824327
MIRT647372	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT647370	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT878747	hsa-miR-1292	CLIP-seq
MIRT878748	hsa-miR-3123	CLIP-seq
MIRT878749	hsa-miR-4291	CLIP-seq
MIRT878750	hsa-miR-4305	CLIP-seq
MIRT878751	hsa-miR-4310	CLIP-seq
MIRT878752	hsa-miR-4471	CLIP-seq
MIRT878750	hsa-miR-4305	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA	22801782
GO:0005829	Component	Cytosol	IDA
GO:0007049	Process	Cell cycle	IEA
GO:0007059	Process	Chromosome segregation	IEA
GO:0035307	Process	Positive regulation of protein dephosphorylation	IMP	22801782
GO:0051301	Process	Cell division	IEA

Other IDs

• MIM: 618785
• HGNC: 14623
• e!Ensembl: ENSG00000184661

Protein

• UniProt ID: Q69YH5
• Protein name: Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)
• Protein function: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anap
• PDB: 5INB, 5IOH, 5SW9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15276	PP1_bind	389 → 449	Protein phosphatase 1 binding	Family

• Sequence:

  MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTV
  TVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKS
  PLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLT
  RKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETS
  VDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVS
  SDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSL
  ISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP
  VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETL
  SGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRR
  KSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP
  EMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFC
  SYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEE
  RVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCN
  RLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR
  SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDL
  ENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENS
  QGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGE
  RKQ

• Sequence length: 1023

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560