CYP2C18 (cytochrome P450 family 2 subfamily C member 18)

Gene

• Entrez ID: 1562
• Gene name: Cytochrome P450 family 2 subfamily C member 18
• Gene symbol: CYP2C18
• Synonyms: CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
• Chromosome: 10
• Chromosome location: 10q23.33
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2208605	hsa-miR-2278	CLIP-seq
MIRT2208606	hsa-miR-23a	CLIP-seq
MIRT2208607	hsa-miR-23b	CLIP-seq
MIRT2208608	hsa-miR-23c	CLIP-seq
MIRT2208609	hsa-miR-2467-3p	CLIP-seq
MIRT2208610	hsa-miR-3123	CLIP-seq
MIRT2208611	hsa-miR-3678-3p	CLIP-seq
MIRT2208612	hsa-miR-3919	CLIP-seq
MIRT2208613	hsa-miR-412	CLIP-seq
MIRT2208614	hsa-miR-4640-5p	CLIP-seq
MIRT2208615	hsa-miR-4726-5p	CLIP-seq
MIRT2208616	hsa-miR-518d-5p	CLIP-seq
MIRT2208617	hsa-miR-519b-5p	CLIP-seq
MIRT2208618	hsa-miR-519c-5p	CLIP-seq
MIRT2208619	hsa-miR-520c-5p	CLIP-seq
MIRT2208620	hsa-miR-526a	CLIP-seq
MIRT2428045	hsa-miR-1206	CLIP-seq
MIRT2428046	hsa-miR-3126-5p	CLIP-seq
MIRT2428047	hsa-miR-4419a	CLIP-seq
MIRT2428048	hsa-miR-4510	CLIP-seq
MIRT2428049	hsa-miR-4764-5p	CLIP-seq
MIRT2428050	hsa-miR-526b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	TAS	8110777
GO:0005506	Function	Iron ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006082	Process	Organic acid metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008392	Function	Arachidonic acid epoxygenase activity	IBA	21873635
GO:0008395	Function	Steroid hydroxylase activity	IBA	21873635
GO:0008401	Function	Retinoic acid 4-hydroxylase activity	IDA	11093772
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA	21873635
GO:0019373	Process	Epoxygenase P450 pathway	IBA	21873635
GO:0019825	Function	Oxygen binding	TAS	8110777
GO:0020037	Function	Heme binding	IBA	21873635
GO:0042573	Process	Retinoic acid metabolic process	IDA	11093772
GO:0042738	Process	Exogenous drug catabolic process	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0070330	Function	Aromatase activity	IEA

Other IDs

• MIM: 601131
• HGNC: 2620
• e!Ensembl: ENSG00000108242

Protein

• UniProt ID: P33260
• Protein name: Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c)
• Protein function: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom in
• PDB: 2CIK, 2H6P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00067	p450	30 → 487	Cytochrome P450	Domain

• Sequence:

  MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
  KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS
  VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI
  KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE
  TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
  LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
  KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
  PLYQLCFIPV

• Sequence length: 490

Pathways

KEGG:

Retinol metabolism
Metabolic pathways
Serotonergic synapse
Chemical carcinogenesis - DNA adducts

Reactome:

Xenobiotics

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	21716162

Unknown
Disease name	Disease term	dbSNP ID	References
Gliosarcoma	gliosarcoma		9766669
Prostatic neoplasms	Prostatic Neoplasms		21716162