CYP2B6 (cytochrome P450 family 2 subfamily B member 6)

Gene

• Entrez ID: 1555
• Gene name: Cytochrome P450 family 2 subfamily B member 6
• Gene symbol: CYP2B6
• Synonyms: CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This prot

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2279343	A>G	Drug-response, benign	Coding sequence variant, missense variant
rs2279345	T>A,C,G	Drug-response	Intron variant
rs3745274	G>A,T	Drug-response	Synonymous variant, coding sequence variant, missense variant
rs4803419	C>T	Drug-response	Intron variant
rs28399499	T>C	Drug-response	Coding sequence variant, missense variant
rs34097093	C>T	Drug-response	Stop gained, coding sequence variant
rs36079186	T>C	Drug-response	Coding sequence variant, missense variant
rs139801276	T>C	Drug-response	Missense variant, coding sequence variant
rs186335453	G>C,T	Drug-response	Missense variant, coding sequence variant
rs281864907	T>A	Drug-response	Coding sequence variant, stop gained
rs371424910	T>C	Drug-response	Missense variant, coding sequence variant
rs373489637	T>G	Drug-response	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051706	hsa-let-7e-5p	CLASH	23622248
MIRT647556	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT647555	hsa-miR-1470	HITS-CLIP	23824327
MIRT647554	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT647553	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647552	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT647551	hsa-miR-4287	HITS-CLIP	23824327
MIRT647550	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647549	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT647548	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT647547	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT647546	hsa-miR-498	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626337	hsa-miR-1247-5p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT458552	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT458551	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT458550	hsa-miR-4532	PAR-CLIP	23592263
MIRT458549	hsa-miR-4787-5p	PAR-CLIP	23592263
MIRT458548	hsa-miR-4537	PAR-CLIP	23592263
MIRT458547	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT458546	hsa-miR-6086	PAR-CLIP	23592263
MIRT458545	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458544	hsa-miR-3689d	PAR-CLIP	23592263
MIRT458543	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT458542	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT458541	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT458540	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT458539	hsa-miR-4651	PAR-CLIP	23592263
MIRT458538	hsa-miR-608	PAR-CLIP	23592263
MIRT458537	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT458536	hsa-miR-6745	PAR-CLIP	23592263
MIRT458535	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458534	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT458533	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT458532	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458531	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT734347	hsa-miR-605-3p	Luciferase reporter assay, qRT-PCR, Western blotting	31766967
MIRT736659	hsa-miR-4254	RNA-seq	32772362
MIRT736660	hsa-miR-6867-5p	RNA-seq	32772362
MIRT647556	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT647555	hsa-miR-1470	HITS-CLIP	23824327
MIRT647554	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT647553	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647552	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT647551	hsa-miR-4287	HITS-CLIP	23824327
MIRT647550	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647549	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT647548	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT647547	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT647546	hsa-miR-498	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626337	hsa-miR-1247-5p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT458552	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT458551	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT458550	hsa-miR-4532	PAR-CLIP	23592263
MIRT458549	hsa-miR-4787-5p	PAR-CLIP	23592263
MIRT458548	hsa-miR-4537	PAR-CLIP	23592263
MIRT458547	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT458546	hsa-miR-6086	PAR-CLIP	23592263
MIRT458545	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458544	hsa-miR-3689d	PAR-CLIP	23592263
MIRT458543	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT458542	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT458541	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT458540	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT458539	hsa-miR-4651	PAR-CLIP	23592263
MIRT458538	hsa-miR-608	PAR-CLIP	23592263
MIRT458537	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT458536	hsa-miR-6745	PAR-CLIP	23592263
MIRT458535	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458534	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT458533	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT458532	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458531	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT921289	hsa-miR-1265	CLIP-seq
MIRT921290	hsa-miR-1273e	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921297	hsa-miR-297	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921300	hsa-miR-3115	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921302	hsa-miR-3138	CLIP-seq
MIRT921303	hsa-miR-3149	CLIP-seq
MIRT921304	hsa-miR-3153	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921306	hsa-miR-34b	CLIP-seq
MIRT921307	hsa-miR-3613-3p	CLIP-seq
MIRT921308	hsa-miR-3614-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT921310	hsa-miR-3671	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921313	hsa-miR-371-5p	CLIP-seq
MIRT921314	hsa-miR-371b-5p	CLIP-seq
MIRT921315	hsa-miR-374a	CLIP-seq
MIRT921316	hsa-miR-374b	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921322	hsa-miR-4433	CLIP-seq
MIRT921323	hsa-miR-4459	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921325	hsa-miR-4491	CLIP-seq
MIRT921326	hsa-miR-4504	CLIP-seq
MIRT921327	hsa-miR-4520a-3p	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT921330	hsa-miR-4652-3p	CLIP-seq
MIRT921331	hsa-miR-4657	CLIP-seq
MIRT921332	hsa-miR-4668-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921340	hsa-miR-4764-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT921342	hsa-miR-4775	CLIP-seq
MIRT921343	hsa-miR-4778-5p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT921346	hsa-miR-568	CLIP-seq
MIRT921347	hsa-miR-590-3p	CLIP-seq
MIRT921348	hsa-miR-640	CLIP-seq
MIRT921349	hsa-miR-656	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT1972981	hsa-miR-1285	CLIP-seq
MIRT1972982	hsa-miR-1293	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT1972983	hsa-miR-3187-5p	CLIP-seq
MIRT1972984	hsa-miR-3652	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT1972985	hsa-miR-4430	CLIP-seq
MIRT1972986	hsa-miR-4483	CLIP-seq
MIRT1972987	hsa-miR-4505	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT1972988	hsa-miR-4793-3p	CLIP-seq
MIRT1972989	hsa-miR-4802-3p	CLIP-seq
MIRT1972990	hsa-miR-564	CLIP-seq
MIRT1972991	hsa-miR-612	CLIP-seq
MIRT921349	hsa-miR-656	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT921289	hsa-miR-1265	CLIP-seq
MIRT2208593	hsa-miR-128	CLIP-seq
MIRT1972981	hsa-miR-1285	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921302	hsa-miR-3138	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT2208594	hsa-miR-3176	CLIP-seq
MIRT1972983	hsa-miR-3187-5p	CLIP-seq
MIRT921306	hsa-miR-34b	CLIP-seq
MIRT921308	hsa-miR-3614-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT2208595	hsa-miR-3922-3p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT2208596	hsa-miR-4252	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT2208597	hsa-miR-4302	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921322	hsa-miR-4433	CLIP-seq
MIRT921323	hsa-miR-4459	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921325	hsa-miR-4491	CLIP-seq
MIRT2208598	hsa-miR-4501	CLIP-seq
MIRT921327	hsa-miR-4520a-3p	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921331	hsa-miR-4657	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2208599	hsa-miR-4672	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT2208600	hsa-miR-4709-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921340	hsa-miR-4764-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT1972988	hsa-miR-4793-3p	CLIP-seq
MIRT2208601	hsa-miR-4798-3p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT2208602	hsa-miR-508-5p	CLIP-seq
MIRT1972990	hsa-miR-564	CLIP-seq
MIRT921347	hsa-miR-590-3p	CLIP-seq
MIRT1972991	hsa-miR-612	CLIP-seq
MIRT921349	hsa-miR-656	CLIP-seq
MIRT2208603	hsa-miR-661	CLIP-seq
MIRT2208604	hsa-miR-766	CLIP-seq
MIRT1972981	hsa-miR-1285	CLIP-seq
MIRT1972983	hsa-miR-3187-5p	CLIP-seq
MIRT921306	hsa-miR-34b	CLIP-seq
MIRT921308	hsa-miR-3614-5p	CLIP-seq
MIRT2386661	hsa-miR-3672	CLIP-seq
MIRT2208596	hsa-miR-4252	CLIP-seq
MIRT2208597	hsa-miR-4302	CLIP-seq
MIRT921322	hsa-miR-4433	CLIP-seq
MIRT921323	hsa-miR-4459	CLIP-seq
MIRT2208600	hsa-miR-4709-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT1972988	hsa-miR-4793-3p	CLIP-seq
MIRT2208602	hsa-miR-508-5p	CLIP-seq
MIRT1972991	hsa-miR-612	CLIP-seq
MIRT2208603	hsa-miR-661	CLIP-seq
MIRT2208604	hsa-miR-766	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT2447916	hsa-miR-3675-3p	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT2447917	hsa-miR-4662a-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2447918	hsa-miR-4684-5p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT2208593	hsa-miR-128	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT2512468	hsa-miR-3120-5p	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921307	hsa-miR-3613-3p	CLIP-seq
MIRT2512469	hsa-miR-3664-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT2386661	hsa-miR-3672	CLIP-seq
MIRT2447916	hsa-miR-3675-3p	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921313	hsa-miR-371-5p	CLIP-seq
MIRT921314	hsa-miR-371b-5p	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT2512470	hsa-miR-4330	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT2512471	hsa-miR-4522	CLIP-seq
MIRT2512472	hsa-miR-4536	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT2447917	hsa-miR-4662a-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2208599	hsa-miR-4672	CLIP-seq
MIRT2447918	hsa-miR-4684-5p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT2512473	hsa-miR-4797-5p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT2512474	hsa-miR-759	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT2208593	hsa-miR-128	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT2386661	hsa-miR-3672	CLIP-seq
MIRT2447916	hsa-miR-3675-3p	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT2512470	hsa-miR-4330	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT2512472	hsa-miR-4536	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT2447917	hsa-miR-4662a-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2208599	hsa-miR-4672	CLIP-seq
MIRT2447918	hsa-miR-4684-5p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AHR	Unknown	19928584
ATF5	Activation	18332083
EGR1	Activation	18303024
HNF4A	Unknown	18666237
NR1I2	Unknown	18096673;19928584
NR1I3	Activation	19702527
NR1I3	Unknown	19928584
NR5A1	Unknown	7789992

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IDA	19651758
GO:0005506	Function	Iron ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006082	Process	Organic acid metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	IDA	20061448
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008202	Process	Steroid metabolic process	IMP	18356043
GO:0008390	Function	Testosterone 16-alpha-hydroxylase activity	IDA	21289075
GO:0008392	Function	Arachidonic acid epoxygenase activity	IBA	21873635
GO:0008395	Function	Steroid hydroxylase activity	IBA	21873635
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA	21873635
GO:0017144	Process	Drug metabolic process	IDA	19651758
GO:0017144	Process	Drug metabolic process	IMP	18356043
GO:0019373	Process	Epoxygenase P450 pathway	IBA	21873635
GO:0020037	Function	Heme binding	IBA	21873635
GO:0020037	Function	Heme binding	IDA	20061448
GO:0042180	Process	Cellular ketone metabolic process	IDA	19651758
GO:0042738	Process	Exogenous drug catabolic process	IBA	21873635
GO:0042738	Process	Exogenous drug catabolic process	IDA	19029318
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0062184	Function	Testosterone 16-beta-hydroxylase activity	IDA	21289075
GO:0062187	Function	Anandamide 8,9 epoxidase activity	IDA	21289075
GO:0062188	Function	Anandamide 11,12 epoxidase activity	IDA	21289075
GO:0062189	Function	Anandamide 14,15 epoxidase activity	IDA	21289075
GO:0101021	Function	Estrogen 2-hydroxylase activity	IDA	12865317

Other IDs

• MIM: 123930
• HGNC: 2615
• e!Ensembl: ENSG00000197408

Protein

• UniProt ID: P20813
• Protein name: Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)
• Protein function: A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:12865317, PubMed:21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a wat
• PDB: 3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8, 5UAP, 5UDA, 5UEC, 5UFG, 5WBG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00067	p450	31 → 488	Cytochrome P450	Domain

• Sequence:

  MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
  WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
  SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
  INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
  ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
  DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
  KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
  PPTYQIRFLPR

• Sequence length: 491

Pathways

KEGG:

Arachidonic acid metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Chemical carcinogenesis - receptor activation
Lipid and atherosclerosis

Reactome:

Fatty acids
Xenobiotics
CYP2E1 reactions

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Gliosarcoma	gliosarcoma		9766669, 11389073
Kidney failure	Kidney Failure, Chronic		15248218
Liver carcinoma	Liver carcinoma		28284560
Nonorganic psychosis	Nonorganic psychosis		17968817
Psychosis	Psychotic Disorders		17968817