ADRB3 (adrenoceptor beta 3)

Gene

• Entrez ID: 155
• Gene name: Adrenoceptor beta 3
• Gene symbol: ADRB3
• Synonyms: BETA3AR
• Chromosome: 8
• Chromosome location: 8p11.23
• Summary: The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs4994	A>G	Risk-factor	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT610939	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT610940	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23313552
MIRT610941	hsa-miR-8485	HITS-CLIP	27418678
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23313552
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23313552

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	11316759

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002025	Process	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	21873635
GO:0002032	Process	Desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA	15123695
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004939	Function	Beta-adrenergic receptor activity	IDA	15123695
GO:0005515	Function	Protein binding	IPI	15123695
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005975	Process	Carbohydrate metabolic process	TAS	2570461
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	2570461
GO:0006112	Process	Energy reserve metabolic process	TAS	1718744
GO:0006898	Process	Receptor-mediated endocytosis	IDA	15123695
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	2570461
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	1718744
GO:0007190	Process	Activation of adenylate cyclase activity	IDA	15123695
GO:0015052	Function	Beta3-adrenergic receptor activity	IBA	21873635
GO:0015052	Function	Beta3-adrenergic receptor activity	IMP	9892244
GO:0042803	Function	Protein homodimerization activity	IDA	15123695
GO:0043235	Component	Receptor complex	IDA	15123695
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	15123695
GO:0051379	Function	Epinephrine binding	IBA	21873635
GO:0051380	Function	Norepinephrine binding	IDA	15123695
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	21873635
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	7493988, 12387862

Other IDs

• MIM: 109691
• HGNC: 288
• e!Ensembl: ENSG00000188778

Protein

• UniProt ID: P13945
• Protein name: Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor)
• Protein function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
• PDB: 2CDW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	54 → 346	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
  AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
  VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
  GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
  ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
  FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
  CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS

• Sequence length: 408

Pathways

KEGG:

Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Thermogenesis
Regulation of lipolysis in adipocytes
Renin secretion
Salivary secretion

Reactome:

Adrenoceptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Disease name	Disease term	References
	Congestive heart failure	15009959, 17440824
	Heart failure	17440824, 15009959
	Left-Sided Heart Failure	17440824, 15009959
	Heart Failure, Right-Sided	15009959, 17440824
	Hyperlipidemia	16027735
	Left Ventricular Hypertrophy	17345787
	Myocardial Failure	15009959, 17440824
	Obesity