GediPNet logo

CYP1A2 (cytochrome P450 family 1 subfamily A member 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1544
Gene nameGene Name - the full gene name approved by the HGNC.
Cytochrome P450 family 1 subfamily A member 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CYP1A2
SynonymsGene synonyms aliases
CP12, CYPIA2, P3-450, P450(PA)
ChromosomeChromosome number
15
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q24.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encode
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT052168 hsa-let-7b-5p CLASH 23622248
MIRT619678 hsa-miR-508-5p HITS-CLIP 23824327
MIRT619677 hsa-miR-1273g-3p HITS-CLIP 23824327
MIRT619676 hsa-miR-6849-3p HITS-CLIP 23824327
MIRT619675 hsa-miR-221-5p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
AHR Unknown 21357676
FOS Unknown 12135113
HNF1A Unknown 7723729
JUN Unknown 12135113
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004497 Function Monooxygenase activity IBA 21873635
GO:0004497 Function Monooxygenase activity IDA 15327587, 19651758
GO:0004497 Function Monooxygenase activity TAS
GO:0005506 Function Iron ion binding IEA
GO:0005515 Function Protein binding IPI 26988023, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P05177
Protein name Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
Protein function A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistical
PDB 2HI4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00067 p450
42 505
Cytochrome P450
Domain
Sequence
Sequence length 516
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Steroid hormone biosynthesis
Caffeine metabolism
Tryptophan metabolism
Linoleic acid metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
  Methylation
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Aflatoxin activation and detoxification
Biosynthesis of protectins
Biosynthesis of maresin-like SPMs
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Anencephaly Iniencephaly, Exencephaly rs773607884 20641098
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 22072123
Cholestasis Cholestasis rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 27565560
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 20797314
Unknown
Disease name Disease term dbSNP ID References
Acrania Acrania 20641098
Craniorachischisis Craniorachischisis 20641098
Diastematomyelia Diastematomyelia 20641098
Liver carcinoma Liver carcinoma 28284560

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412