SLC2A12 (solute carrier family 2 member 12)

Gene

• Entrez ID: 154091
• Gene name: Solute carrier family 2 member 12
• Gene symbol: SLC2A12
• Synonyms: GLUT12, GLUT8
• Chromosome: 6
• Chromosome location: 6q23.2
• Summary: SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017063	hsa-miR-335-5p	Microarray	18185580
MIRT518651	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT518651	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT518651	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT518652	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518652	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT518652	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT518652	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT518653	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518653	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518653	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT518653	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT518654	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT518654	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT518654	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT518655	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT518655	hsa-miR-223-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT518655	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT518655	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT518656	hsa-miR-767-5p	PAR-CLIP	23446348
MIRT518656	hsa-miR-767-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT518656	hsa-miR-767-5p	PAR-CLIP	20371350
MIRT518657	hsa-miR-502-3p	PAR-CLIP	23446348
MIRT518657	hsa-miR-502-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518657	hsa-miR-502-3p	PAR-CLIP	20371350
MIRT518658	hsa-miR-501-3p	PAR-CLIP	23446348
MIRT518658	hsa-miR-501-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518658	hsa-miR-501-3p	PAR-CLIP	20371350
MIRT518659	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518659	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT518659	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT518659	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT783863	hsa-miR-147a	HITS-CLIP	27418678
MIRT784216	hsa-miR-2113	HITS-CLIP	27418678
MIRT786998	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT788943	hsa-miR-6818-5p	HITS-CLIP	27418678

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0008645	Process	Hexose transmembrane transport	TAS
GO:0012505	Component	Endomembrane system	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:1904659	Process	Glucose transmembrane transport	IEA

Other IDs

• MIM: 610372
• HGNC: 18067
• e!Ensembl: ENSG00000146411

Protein

• UniProt ID: Q8TD20
• Protein name: Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)
• Protein function: Insulin-independent facilitative glucose transporter.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00083	Sugar_tr	43 → 375	Sugar (and other) transporter	Family
  PF00083	Sugar_tr	441 → 564	Sugar (and other) transporter	Family

• Sequence:

  MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI
  ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG
  SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL
  SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL
  RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY
  ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT
  MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM
  PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG
  PMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLA
  SLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLE
  CNKLCGRGQSRQLSPET

• Sequence length: 617

Pathways

Reactome:

Cellular hexose transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778