ZNF595 (zinc finger protein 595)

Gene

• Entrez ID: 152687
• Gene name: Zinc finger protein 595
• Gene symbol: ZNF595
• Synonyms: -
• Chromosome: 4
• Chromosome location: 4p16.3
• Summary: This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1531319	hsa-miR-10a	CLIP-seq
MIRT1531320	hsa-miR-10b	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT1531322	hsa-miR-1273e	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531324	hsa-miR-1827	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531326	hsa-miR-214	CLIP-seq
MIRT1531327	hsa-miR-2964a-3p	CLIP-seq
MIRT1531328	hsa-miR-302f	CLIP-seq
MIRT1531329	hsa-miR-3120-5p	CLIP-seq
MIRT1531330	hsa-miR-339-5p	CLIP-seq
MIRT1531331	hsa-miR-3613-3p	CLIP-seq
MIRT1531332	hsa-miR-3619-5p	CLIP-seq
MIRT1531333	hsa-miR-3647-3p	CLIP-seq
MIRT1531334	hsa-miR-3664-3p	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT1531336	hsa-miR-3665	CLIP-seq
MIRT1531337	hsa-miR-3670	CLIP-seq
MIRT1531338	hsa-miR-3689d	CLIP-seq
MIRT1531339	hsa-miR-371-5p	CLIP-seq
MIRT1531340	hsa-miR-371b-5p	CLIP-seq
MIRT1531341	hsa-miR-4421	CLIP-seq
MIRT1531342	hsa-miR-4433	CLIP-seq
MIRT1531343	hsa-miR-4459	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531345	hsa-miR-4502	CLIP-seq
MIRT1531346	hsa-miR-4522	CLIP-seq
MIRT1531347	hsa-miR-4530	CLIP-seq
MIRT1531348	hsa-miR-4633-5p	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531350	hsa-miR-4684-5p	CLIP-seq
MIRT1531351	hsa-miR-4698	CLIP-seq
MIRT1531352	hsa-miR-4699-3p	CLIP-seq
MIRT1531353	hsa-miR-4714-5p	CLIP-seq
MIRT1531354	hsa-miR-4722-5p	CLIP-seq
MIRT1531355	hsa-miR-4724-5p	CLIP-seq
MIRT1531356	hsa-miR-4729	CLIP-seq
MIRT1531357	hsa-miR-4768-3p	CLIP-seq
MIRT1531358	hsa-miR-4773	CLIP-seq
MIRT1531359	hsa-miR-532-5p	CLIP-seq
MIRT1531360	hsa-miR-593	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531362	hsa-miR-761	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT1531364	hsa-miR-940	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT2160601	hsa-miR-3942-5p	CLIP-seq
MIRT2160602	hsa-miR-4300	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT2160603	hsa-miR-4703-5p	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2160604	hsa-miR-920	CLIP-seq
MIRT2379867	hsa-miR-100	CLIP-seq
MIRT2379868	hsa-miR-1228	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT2379869	hsa-miR-1293	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT2379870	hsa-miR-2467-5p	CLIP-seq
MIRT2379871	hsa-miR-3122	CLIP-seq
MIRT2379872	hsa-miR-3165	CLIP-seq
MIRT2379873	hsa-miR-3188	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT2379874	hsa-miR-3689a-3p	CLIP-seq
MIRT2379875	hsa-miR-3689c	CLIP-seq
MIRT2379876	hsa-miR-3913-5p	CLIP-seq
MIRT2160601	hsa-miR-3942-5p	CLIP-seq
MIRT2379877	hsa-miR-3975	CLIP-seq
MIRT2160602	hsa-miR-4300	CLIP-seq
MIRT2379878	hsa-miR-4483	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT2160603	hsa-miR-4703-5p	CLIP-seq
MIRT2379879	hsa-miR-4728-5p	CLIP-seq
MIRT1531357	hsa-miR-4768-3p	CLIP-seq
MIRT2379880	hsa-miR-485-5p	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2160604	hsa-miR-920	CLIP-seq
MIRT2379881	hsa-miR-99a	CLIP-seq
MIRT2379882	hsa-miR-99b	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2379867	hsa-miR-100	CLIP-seq
MIRT1531319	hsa-miR-10a	CLIP-seq
MIRT1531320	hsa-miR-10b	CLIP-seq
MIRT2379868	hsa-miR-1228	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT2671993	hsa-miR-1285	CLIP-seq
MIRT2379869	hsa-miR-1293	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531329	hsa-miR-3120-5p	CLIP-seq
MIRT2379871	hsa-miR-3122	CLIP-seq
MIRT2379872	hsa-miR-3165	CLIP-seq
MIRT2671994	hsa-miR-3187-5p	CLIP-seq
MIRT2671995	hsa-miR-338-3p	CLIP-seq
MIRT1531330	hsa-miR-339-5p	CLIP-seq
MIRT2671996	hsa-miR-3611	CLIP-seq
MIRT1531331	hsa-miR-3613-3p	CLIP-seq
MIRT2671997	hsa-miR-3622b-5p	CLIP-seq
MIRT1531333	hsa-miR-3647-3p	CLIP-seq
MIRT1531334	hsa-miR-3664-3p	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT1531337	hsa-miR-3670	CLIP-seq
MIRT2379874	hsa-miR-3689a-3p	CLIP-seq
MIRT2379875	hsa-miR-3689c	CLIP-seq
MIRT1531339	hsa-miR-371-5p	CLIP-seq
MIRT1531340	hsa-miR-371b-5p	CLIP-seq
MIRT2379876	hsa-miR-3913-5p	CLIP-seq
MIRT2671998	hsa-miR-3945	CLIP-seq
MIRT2671999	hsa-miR-4253	CLIP-seq
MIRT2672000	hsa-miR-4289	CLIP-seq
MIRT2672001	hsa-miR-4310	CLIP-seq
MIRT1531341	hsa-miR-4421	CLIP-seq
MIRT1531342	hsa-miR-4433	CLIP-seq
MIRT2672002	hsa-miR-4435	CLIP-seq
MIRT1531343	hsa-miR-4459	CLIP-seq
MIRT2379878	hsa-miR-4483	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531346	hsa-miR-4522	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531350	hsa-miR-4684-5p	CLIP-seq
MIRT1531355	hsa-miR-4724-5p	CLIP-seq
MIRT2379879	hsa-miR-4728-5p	CLIP-seq
MIRT1531357	hsa-miR-4768-3p	CLIP-seq
MIRT1531358	hsa-miR-4773	CLIP-seq
MIRT2672003	hsa-miR-556-5p	CLIP-seq
MIRT1531360	hsa-miR-593	CLIP-seq
MIRT2672004	hsa-miR-612	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2379881	hsa-miR-99a	CLIP-seq
MIRT2379882	hsa-miR-99b	CLIP-seq
MIRT2379867	hsa-miR-100	CLIP-seq
MIRT1531319	hsa-miR-10a	CLIP-seq
MIRT1531320	hsa-miR-10b	CLIP-seq
MIRT2379868	hsa-miR-1228	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT2671993	hsa-miR-1285	CLIP-seq
MIRT2379869	hsa-miR-1293	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531329	hsa-miR-3120-5p	CLIP-seq
MIRT2379871	hsa-miR-3122	CLIP-seq
MIRT2671994	hsa-miR-3187-5p	CLIP-seq
MIRT2671995	hsa-miR-338-3p	CLIP-seq
MIRT1531330	hsa-miR-339-5p	CLIP-seq
MIRT2671996	hsa-miR-3611	CLIP-seq
MIRT1531331	hsa-miR-3613-3p	CLIP-seq
MIRT2671997	hsa-miR-3622b-5p	CLIP-seq
MIRT1531333	hsa-miR-3647-3p	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT2379874	hsa-miR-3689a-3p	CLIP-seq
MIRT2379875	hsa-miR-3689c	CLIP-seq
MIRT1531339	hsa-miR-371-5p	CLIP-seq
MIRT1531340	hsa-miR-371b-5p	CLIP-seq
MIRT2379876	hsa-miR-3913-5p	CLIP-seq
MIRT2671998	hsa-miR-3945	CLIP-seq
MIRT2671999	hsa-miR-4253	CLIP-seq
MIRT2672000	hsa-miR-4289	CLIP-seq
MIRT2672001	hsa-miR-4310	CLIP-seq
MIRT1531341	hsa-miR-4421	CLIP-seq
MIRT2672002	hsa-miR-4435	CLIP-seq
MIRT2379878	hsa-miR-4483	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531346	hsa-miR-4522	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531350	hsa-miR-4684-5p	CLIP-seq
MIRT1531355	hsa-miR-4724-5p	CLIP-seq
MIRT2379879	hsa-miR-4728-5p	CLIP-seq
MIRT1531358	hsa-miR-4773	CLIP-seq
MIRT1531360	hsa-miR-593	CLIP-seq
MIRT2672004	hsa-miR-612	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2379881	hsa-miR-99a	CLIP-seq
MIRT2379882	hsa-miR-99b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8IYB9
• Protein name: Zinc finger protein 595
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	3 → 44	KRAB box	Family
  PF00096	zf-C2H2	200 → 222	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	228 → 250	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	256 → 278	Zinc finger, C2H2 type	Domain
  PF13912	zf-C2H2_6	284 → 308		Domain
  PF00096	zf-C2H2	312 → 334	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	340 → 362	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	368 → 390	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	396 → 418	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	424 → 446	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	452 → 474	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	508 → 530	Zinc finger, C2H2 type	Domain
  PF13912	zf-C2H2_6	535 → 561		Domain
  PF00096	zf-C2H2	564 → 586	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	592 → 614	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	620 → 642	Zinc finger, C2H2 type	Domain

• Sequence:

  MELVTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLGFVISNPDLVTCLEQIK
  EPCNLKIHETAAKPPAICSPFSQDLSPVQGIEDSFHKLILKRYEKCGHENLQLRKGCKRV
  NECKVQKGVNNGVYQCLSTTQSKIFQCNTCVKVFSKFSNSNKHKIRHTGEKPFKCTECGR
  SFYMSHLTQHTGIHAGEKPYKCEKCGKAFNRSTSLSKHKRIHTGEKPYTCEECGKAFRRS
  TVLNEHKKIHTGEKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCKECGKAFRWSTSLN
  EHKNIHTGEKPYKCKECGKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHRS
  IHSEQKLYKCEECGKAFTWSSSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKRIHTG
  EKPYTCEECGKAFNQSSTLILHKRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPY
  KCEECGKAFIWSASLNEHKNIHTGEKPYKCKECGKAFNQSSGLIIHRSIHSEQKLYKCEE
  CGKAFTRSTALNEHKKIHSGEKPYKCKECGKAYNLSSTLTKHKRIHTGEKPFTCEECGKA
  FNWSSSLTKHKIIHTGEKSYKCEECGKAFNRPSTLTVHKRIHTGKEHS

• Sequence length: 648

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30166627