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CTSS (cathepsin S)

Gene

Cathepsin S

CTSS

1q21.3

The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT704399	hsa-miR-8066	HITS-CLIP	23313552
MIRT704398	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT704397	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT704396	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT704395	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT704394	hsa-miR-4459	HITS-CLIP	23313552
MIRT704393	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT704392	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704391	hsa-miR-544b	HITS-CLIP	23313552
MIRT704390	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT704389	hsa-miR-4794	HITS-CLIP	23313552
MIRT704388	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT704387	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT704386	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT704385	hsa-miR-3672	HITS-CLIP	23313552
MIRT704384	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT440859	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440857	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440859	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727921	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727920	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727919	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727918	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440857	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT733948	hsa-miR-4498	Luciferase reporter assay, qRT-PCR	33013913
MIRT736399	hsa-miR-369-3p	qRT-PCR, Flow cytometry	33679688
MIRT736410	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT704399	hsa-miR-8066	HITS-CLIP	23313552
MIRT704398	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT704397	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT704396	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT704395	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT704394	hsa-miR-4459	HITS-CLIP	23313552
MIRT704393	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT704392	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704391	hsa-miR-544b	HITS-CLIP	23313552
MIRT704390	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT704389	hsa-miR-4794	HITS-CLIP	23313552
MIRT704388	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT704387	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT704386	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT704385	hsa-miR-3672	HITS-CLIP	23313552
MIRT704384	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT916015	hsa-miR-1182	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT916017	hsa-miR-1299	CLIP-seq
MIRT916018	hsa-miR-193a-5p	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT916020	hsa-miR-3120-3p	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916022	hsa-miR-3182	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916027	hsa-miR-3664-5p	CLIP-seq
MIRT916028	hsa-miR-431	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916030	hsa-miR-4477a	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916032	hsa-miR-4659a-3p	CLIP-seq
MIRT916033	hsa-miR-4659b-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916035	hsa-miR-4782-5p	CLIP-seq
MIRT916036	hsa-miR-516b	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT916038	hsa-miR-1275	CLIP-seq
MIRT916039	hsa-miR-135a	CLIP-seq
MIRT916040	hsa-miR-135b	CLIP-seq
MIRT916041	hsa-miR-140-3p	CLIP-seq
MIRT916042	hsa-miR-185	CLIP-seq
MIRT916043	hsa-miR-203	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916045	hsa-miR-3150a-3p	CLIP-seq
MIRT916046	hsa-miR-3163	CLIP-seq
MIRT916047	hsa-miR-3175	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT916048	hsa-miR-329	CLIP-seq
MIRT916049	hsa-miR-340	CLIP-seq
MIRT916050	hsa-miR-342-5p	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916051	hsa-miR-362-3p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT916055	hsa-miR-4269	CLIP-seq
MIRT916056	hsa-miR-4275	CLIP-seq
MIRT916057	hsa-miR-4306	CLIP-seq
MIRT916058	hsa-miR-4314	CLIP-seq
MIRT916059	hsa-miR-4428	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916060	hsa-miR-4505	CLIP-seq
MIRT916061	hsa-miR-4514	CLIP-seq
MIRT916062	hsa-miR-4525	CLIP-seq
MIRT916063	hsa-miR-4644	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916064	hsa-miR-4651	CLIP-seq
MIRT916065	hsa-miR-4664-5p	CLIP-seq
MIRT916066	hsa-miR-4665-5p	CLIP-seq
MIRT916067	hsa-miR-4667-5p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916068	hsa-miR-4690-5p	CLIP-seq
MIRT916069	hsa-miR-4692	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT916071	hsa-miR-4700-5p	CLIP-seq
MIRT916072	hsa-miR-4723-5p	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT916074	hsa-miR-4731-5p	CLIP-seq
MIRT916075	hsa-miR-4738-3p	CLIP-seq
MIRT916076	hsa-miR-4773	CLIP-seq
MIRT916077	hsa-miR-483-3p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT916079	hsa-miR-548g	CLIP-seq
MIRT916080	hsa-miR-604	CLIP-seq
MIRT916081	hsa-miR-608	CLIP-seq
MIRT916082	hsa-miR-625	CLIP-seq
MIRT916083	hsa-miR-637	CLIP-seq
MIRT916084	hsa-miR-647	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT916085	hsa-miR-939	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT1971642	hsa-miR-1827	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT1971643	hsa-miR-3545-3p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT1971644	hsa-miR-3929	CLIP-seq
MIRT1971645	hsa-miR-4267	CLIP-seq
MIRT916056	hsa-miR-4275	CLIP-seq
MIRT1971646	hsa-miR-4419b	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT1971647	hsa-miR-4478	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT1971648	hsa-miR-4649-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT1971649	hsa-miR-4680-5p	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT1971650	hsa-miR-4722-5p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT1971651	hsa-miR-940	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916068	hsa-miR-4690-5p	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT2465143	hsa-miR-10a	CLIP-seq
MIRT2465144	hsa-miR-10b	CLIP-seq
MIRT2465145	hsa-miR-1268	CLIP-seq
MIRT2465146	hsa-miR-1268b	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT2465147	hsa-miR-339-5p	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT2465148	hsa-miR-4421	CLIP-seq
MIRT2465149	hsa-miR-4486	CLIP-seq
MIRT916060	hsa-miR-4505	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT2465150	hsa-miR-511	CLIP-seq
MIRT2465151	hsa-miR-548c-3p	CLIP-seq
MIRT2465152	hsa-miR-585	CLIP-seq
MIRT2510555	hsa-miR-103b	CLIP-seq
MIRT2510556	hsa-miR-106a	CLIP-seq
MIRT2510557	hsa-miR-106b	CLIP-seq
MIRT2465143	hsa-miR-10a	CLIP-seq
MIRT2465144	hsa-miR-10b	CLIP-seq
MIRT916015	hsa-miR-1182	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT2465145	hsa-miR-1268	CLIP-seq
MIRT2465146	hsa-miR-1268b	CLIP-seq
MIRT2510558	hsa-miR-1279	CLIP-seq
MIRT916017	hsa-miR-1299	CLIP-seq
MIRT2510559	hsa-miR-1323	CLIP-seq
MIRT2510560	hsa-miR-150	CLIP-seq
MIRT2510561	hsa-miR-17	CLIP-seq
MIRT916018	hsa-miR-193a-5p	CLIP-seq
MIRT2510562	hsa-miR-20a	CLIP-seq
MIRT2510563	hsa-miR-20b	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT2510564	hsa-miR-302a	CLIP-seq
MIRT2510565	hsa-miR-302b	CLIP-seq
MIRT2510566	hsa-miR-302c	CLIP-seq
MIRT2510567	hsa-miR-302d	CLIP-seq
MIRT2510568	hsa-miR-302e	CLIP-seq
MIRT916020	hsa-miR-3120-3p	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT2510569	hsa-miR-3148	CLIP-seq
MIRT916022	hsa-miR-3182	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT2465147	hsa-miR-339-5p	CLIP-seq
MIRT2510570	hsa-miR-3613-3p	CLIP-seq
MIRT2510571	hsa-miR-3617	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916027	hsa-miR-3664-5p	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT2510572	hsa-miR-371-5p	CLIP-seq
MIRT2510573	hsa-miR-371b-5p	CLIP-seq
MIRT2510574	hsa-miR-372	CLIP-seq
MIRT2510575	hsa-miR-373	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT2510576	hsa-miR-3940-5p	CLIP-seq
MIRT2510577	hsa-miR-3977	CLIP-seq
MIRT2510578	hsa-miR-423-3p	CLIP-seq
MIRT916028	hsa-miR-431	CLIP-seq
MIRT2465148	hsa-miR-4421	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT2510579	hsa-miR-4438	CLIP-seq
MIRT2465149	hsa-miR-4486	CLIP-seq
MIRT2510580	hsa-miR-4507	CLIP-seq
MIRT2510581	hsa-miR-4638-5p	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916032	hsa-miR-4659a-3p	CLIP-seq
MIRT916033	hsa-miR-4659b-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT2510582	hsa-miR-4714-3p	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT2510583	hsa-miR-4735-5p	CLIP-seq
MIRT2510584	hsa-miR-4775	CLIP-seq
MIRT916035	hsa-miR-4782-5p	CLIP-seq
MIRT2510585	hsa-miR-4797-5p	CLIP-seq
MIRT2510586	hsa-miR-494	CLIP-seq
MIRT2510587	hsa-miR-501-3p	CLIP-seq
MIRT2510588	hsa-miR-502-3p	CLIP-seq
MIRT2510589	hsa-miR-5095	CLIP-seq
MIRT2465150	hsa-miR-511	CLIP-seq
MIRT916036	hsa-miR-516b	CLIP-seq
MIRT2510590	hsa-miR-519d	CLIP-seq
MIRT2510591	hsa-miR-520a-3p	CLIP-seq
MIRT2510592	hsa-miR-520b	CLIP-seq
MIRT2510593	hsa-miR-520c-3p	CLIP-seq
MIRT2510594	hsa-miR-520d-3p	CLIP-seq
MIRT2510595	hsa-miR-520e	CLIP-seq
MIRT2510596	hsa-miR-520f	CLIP-seq
MIRT2510597	hsa-miR-526b	CLIP-seq
MIRT2510598	hsa-miR-548a-3p	CLIP-seq
MIRT2465151	hsa-miR-548c-3p	CLIP-seq
MIRT2510599	hsa-miR-548e	CLIP-seq
MIRT2510600	hsa-miR-548f	CLIP-seq
MIRT2510601	hsa-miR-548o	CLIP-seq
MIRT2510602	hsa-miR-562	CLIP-seq
MIRT2510603	hsa-miR-578	CLIP-seq
MIRT2465152	hsa-miR-585	CLIP-seq
MIRT2510604	hsa-miR-590-3p	CLIP-seq
MIRT2510605	hsa-miR-635	CLIP-seq
MIRT2510606	hsa-miR-641	CLIP-seq
MIRT2510607	hsa-miR-642b	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT2510608	hsa-miR-767-5p	CLIP-seq
MIRT2510609	hsa-miR-93	CLIP-seq
MIRT2510610	hsa-miR-944	CLIP-seq
MIRT2510555	hsa-miR-103b	CLIP-seq
MIRT2465143	hsa-miR-10a	CLIP-seq
MIRT2465144	hsa-miR-10b	CLIP-seq
MIRT916015	hsa-miR-1182	CLIP-seq
MIRT2678806	hsa-miR-1200	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT916017	hsa-miR-1299	CLIP-seq
MIRT2510559	hsa-miR-1323	CLIP-seq
MIRT916018	hsa-miR-193a-5p	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT916020	hsa-miR-3120-3p	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT2510569	hsa-miR-3148	CLIP-seq
MIRT916022	hsa-miR-3182	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT2465147	hsa-miR-339-5p	CLIP-seq
MIRT2510570	hsa-miR-3613-3p	CLIP-seq
MIRT2510571	hsa-miR-3617	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916027	hsa-miR-3664-5p	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT2510572	hsa-miR-371-5p	CLIP-seq
MIRT2510573	hsa-miR-371b-5p	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT2510576	hsa-miR-3940-5p	CLIP-seq
MIRT916028	hsa-miR-431	CLIP-seq
MIRT2678807	hsa-miR-4324	CLIP-seq
MIRT2465148	hsa-miR-4421	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT2510580	hsa-miR-4507	CLIP-seq
MIRT2678808	hsa-miR-450b-5p	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916032	hsa-miR-4659a-3p	CLIP-seq
MIRT916033	hsa-miR-4659b-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT2510582	hsa-miR-4714-3p	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT916035	hsa-miR-4782-5p	CLIP-seq
MIRT2510585	hsa-miR-4797-5p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT2510586	hsa-miR-494	CLIP-seq
MIRT2465150	hsa-miR-511	CLIP-seq
MIRT916036	hsa-miR-516b	CLIP-seq
MIRT2678809	hsa-miR-518a-5p	CLIP-seq
MIRT2678810	hsa-miR-527	CLIP-seq
MIRT2510598	hsa-miR-548a-3p	CLIP-seq
MIRT2465151	hsa-miR-548c-3p	CLIP-seq
MIRT2510599	hsa-miR-548e	CLIP-seq
MIRT2510600	hsa-miR-548f	CLIP-seq
MIRT2510601	hsa-miR-548o	CLIP-seq
MIRT2510605	hsa-miR-635	CLIP-seq
MIRT2510606	hsa-miR-641	CLIP-seq
MIRT2510607	hsa-miR-642b	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT2510610	hsa-miR-944	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SPI1	Activation	16365419

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001968	Function	Fibronectin binding	IPI	22952693
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0002250	Process	Adaptive immune response	IEP	15196205
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA	21873635
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	8612130, 12788072, 22952693
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS
GO:0005518	Function	Collagen binding	IDA	22952693
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	9524075, 22952693
GO:0005764	Component	Lysosome	IBA	21873635
GO:0005764	Component	Lysosome	IDA	15196205
GO:0005770	Component	Late endosome	IDA	22365146
GO:0006508	Process	Proteolysis	IDA	12788072, 22864553
GO:0006955	Process	Immune response	IBA	21873635
GO:0010447	Process	Response to acidic pH	IDA	22864553
GO:0016485	Process	Protein processing	IDA	22864553
GO:0019882	Process	Antigen processing and presentation	TAS	15196205
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	30612035
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030574	Process	Collagen catabolic process	IDA	22952693
GO:0034769	Process	Basement membrane disassembly	IDA	22952693
GO:0036021	Component	Endolysosome lumen	TAS
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043236	Function	Laminin binding	IDA	22952693
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043394	Function	Proteoglycan binding	IPI	22952693
GO:0045335	Component	Phagocytic vesicle	IDA	30612035
GO:0048002	Process	Antigen processing and presentation of peptide antigen	IDA	8612130
GO:0051603	Process	Proteolysis involved in cellular protein catabolic process	IBA	21873635
GO:0051603	Process	Proteolysis involved in cellular protein catabolic process	IDA	22952693
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28344315
GO:0097067	Process	Cellular response to thyroid hormone stimulus	IEP	21217776
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:2001259	Process	Positive regulation of cation channel activity	IDA	22864553

MIM	HGNC	e!Ensembl
116845	2545	ENSG00000163131

Protein

UniProt ID

P25774

Protein name

Cathepsin S (EC 3.4.22.27)

Protein function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities

PDB

1GLO , 1MS6 , 1NPZ , 1NQC , 2C0Y , 2F1G , 2FQ9 , 2FRA , 2FRQ , 2FT2 , 2FUD , 2FYE , 2G6D , 2G7Y , 2H7J , 2HH5 , 2HHN , 2HXZ , 2OP3 , 2R9M , 2R9N , 2R9O , 3IEJ , 3N3G , 3N4C , 3OVX , 4P6E , 4P6G , 5QBU , 5QBV , 5QBW , 5QBX , 5QBY , 5QBZ , 5QC0 , 5QC1 , 5QC2 , 5QC3 , 5QC4 , 5QC5 , 5QC6 , 5QC7 , 5QC8 , 5QC9 , 5QCA , 5QCB , 5QCC , 5QCD , 5QCE , 5QCF , 5QCG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08246	Inhibitor_I29	28 → 88	Cathepsin propeptide inhibitor domain (I29)	Domain
PF00112	Peptidase_C1	115 → 330	Papain family cysteine protease	Domain

Sequence

MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI

Sequence length

331

Interactions

View interactions

	KEGG		Reactome
	Lysosome Phagosome Apoptosis Antigen processing and presentation Tuberculosis		Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation

Associated diseases

Show/Hide Causal Diseases (4)

Causal
Disease name	Disease term	dbSNP ID	References
Basal cell neoplasm	Basal Cell Neoplasm, Basal Cell Cancer	rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813	31174203
Carcinoma	Basal cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	31174203
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	21156398

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