PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

Gene

• Entrez ID: 151742
• Gene name: Protein phosphatase, Mg2+/Mn2+ dependent 1L
• Gene symbol: PPM1L
• Synonyms: PP2C-epsilon, PP2CE, PPM1-LIKE
• Chromosome: 3
• Chromosome location: 3q25.33-q26.1
• Summary: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that le

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017625	hsa-miR-335-5p	Microarray	18185580
MIRT030870	hsa-miR-21-5p	Sequencing	20371350
MIRT672807	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT672806	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672805	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT672804	hsa-miR-4456	HITS-CLIP	23824327
MIRT672803	hsa-miR-138-5p	HITS-CLIP	23824327
MIRT672802	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT672801	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT492562	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT672800	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT672799	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT672798	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672797	hsa-miR-8071	HITS-CLIP	23824327
MIRT672796	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT672795	hsa-miR-3165	HITS-CLIP	23824327
MIRT672793	hsa-miR-8056	HITS-CLIP	23824327
MIRT672794	hsa-miR-7977	HITS-CLIP	23824327
MIRT672792	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT672791	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT672790	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT672789	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT672788	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT672787	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT672786	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT672785	hsa-miR-3689c	HITS-CLIP	23824327
MIRT672784	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT672783	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672782	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT672781	hsa-miR-3122	HITS-CLIP	23824327
MIRT672780	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT672779	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT672778	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT654845	hsa-miR-103b	HITS-CLIP	23824327
MIRT654844	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT654843	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT654842	hsa-miR-544a	HITS-CLIP	23824327
MIRT654841	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT654840	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT654839	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654838	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT654837	hsa-miR-4501	HITS-CLIP	23824327
MIRT654836	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT654835	hsa-miR-31-5p	HITS-CLIP	23824327
MIRT654834	hsa-miR-6809-5p	HITS-CLIP	23824327
MIRT555409	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT555408	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT555407	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT555405	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT555406	hsa-miR-940	PAR-CLIP	21572407
MIRT555404	hsa-miR-3929	PAR-CLIP	21572407
MIRT555403	hsa-miR-4419b	PAR-CLIP	21572407
MIRT555402	hsa-miR-4478	PAR-CLIP	21572407
MIRT555401	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT492574	hsa-miR-4459	PAR-CLIP	21572407
MIRT555400	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT555399	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT555398	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT555397	hsa-miR-767-3p	PAR-CLIP	21572407
MIRT555396	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT555395	hsa-miR-1827	PAR-CLIP	21572407
MIRT555394	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT555393	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT555392	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT555391	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT555390	hsa-miR-3650	PAR-CLIP	21572407
MIRT555389	hsa-miR-665	PAR-CLIP	21572407
MIRT492584	hsa-miR-6165	PAR-CLIP	23592263
MIRT492583	hsa-miR-4779	PAR-CLIP	23592263
MIRT492582	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT492581	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT492580	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT492579	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT492578	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT492577	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT492575	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT492576	hsa-miR-761	PAR-CLIP	23592263
MIRT492574	hsa-miR-4459	PAR-CLIP	23592263
MIRT492573	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT492572	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT492570	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT492569	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT492568	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT492566	hsa-miR-8085	PAR-CLIP	23592263
MIRT492567	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT492565	hsa-miR-3175	PAR-CLIP	23592263
MIRT492564	hsa-miR-23a-5p	PAR-CLIP	23592263
MIRT492563	hsa-miR-23b-5p	PAR-CLIP	23592263
MIRT492562	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT672807	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT672806	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672805	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT672804	hsa-miR-4456	HITS-CLIP	23824327
MIRT672803	hsa-miR-138-5p	HITS-CLIP	23824327
MIRT672802	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT672801	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT492562	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT672800	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT672799	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT672798	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672797	hsa-miR-8071	HITS-CLIP	23824327
MIRT672796	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT672795	hsa-miR-3165	HITS-CLIP	23824327
MIRT672793	hsa-miR-8056	HITS-CLIP	23824327
MIRT672794	hsa-miR-7977	HITS-CLIP	23824327
MIRT672792	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT672791	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT672790	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT672789	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT672788	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT672787	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT672786	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT672785	hsa-miR-3689c	HITS-CLIP	23824327
MIRT672784	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT672783	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672782	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT672781	hsa-miR-3122	HITS-CLIP	23824327
MIRT672780	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT672779	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT672778	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT654845	hsa-miR-103b	HITS-CLIP	23824327
MIRT654844	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT654843	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT654842	hsa-miR-544a	HITS-CLIP	23824327
MIRT654841	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT654840	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT654839	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654838	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT654837	hsa-miR-4501	HITS-CLIP	23824327
MIRT654836	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT654835	hsa-miR-31-5p	HITS-CLIP	23824327
MIRT654834	hsa-miR-6809-5p	HITS-CLIP	23824327
MIRT555409	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT555408	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT555407	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT555405	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT555406	hsa-miR-940	PAR-CLIP	21572407
MIRT555404	hsa-miR-3929	PAR-CLIP	21572407
MIRT555403	hsa-miR-4419b	PAR-CLIP	21572407
MIRT555402	hsa-miR-4478	PAR-CLIP	21572407
MIRT555401	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT492574	hsa-miR-4459	PAR-CLIP	21572407
MIRT555400	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT555399	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT555398	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT555397	hsa-miR-767-3p	PAR-CLIP	21572407
MIRT555396	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT555395	hsa-miR-1827	PAR-CLIP	21572407
MIRT555394	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT555393	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT555392	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT555391	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT555390	hsa-miR-3650	PAR-CLIP	21572407
MIRT555389	hsa-miR-665	PAR-CLIP	21572407
MIRT492584	hsa-miR-6165	PAR-CLIP	23592263
MIRT492583	hsa-miR-4779	PAR-CLIP	23592263
MIRT492582	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT492581	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT492580	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT492579	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT492578	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT492577	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT492575	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT492576	hsa-miR-761	PAR-CLIP	23592263
MIRT492574	hsa-miR-4459	PAR-CLIP	23592263
MIRT492573	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT492572	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT492570	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT492569	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT492568	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT492566	hsa-miR-8085	PAR-CLIP	23592263
MIRT492567	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT492565	hsa-miR-3175	PAR-CLIP	23592263
MIRT492564	hsa-miR-23a-5p	PAR-CLIP	23592263
MIRT492563	hsa-miR-23b-5p	PAR-CLIP	23592263
MIRT492562	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT1254630	hsa-miR-103a	CLIP-seq
MIRT1254631	hsa-miR-107	CLIP-seq
MIRT1254632	hsa-miR-1179	CLIP-seq
MIRT1254633	hsa-miR-1184	CLIP-seq
MIRT1254634	hsa-miR-1202	CLIP-seq
MIRT1254635	hsa-miR-1231	CLIP-seq
MIRT1254636	hsa-miR-124	CLIP-seq
MIRT1254637	hsa-miR-1255a	CLIP-seq
MIRT1254638	hsa-miR-1255b	CLIP-seq
MIRT1254639	hsa-miR-125a-3p	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254641	hsa-miR-1321	CLIP-seq
MIRT1254642	hsa-miR-134	CLIP-seq
MIRT1254643	hsa-miR-139-5p	CLIP-seq
MIRT1254644	hsa-miR-141	CLIP-seq
MIRT1254645	hsa-miR-188-3p	CLIP-seq
MIRT1254646	hsa-miR-1976	CLIP-seq
MIRT1254647	hsa-miR-200a	CLIP-seq
MIRT1254648	hsa-miR-204	CLIP-seq
MIRT1254649	hsa-miR-211	CLIP-seq
MIRT1254650	hsa-miR-24	CLIP-seq
MIRT1254651	hsa-miR-300	CLIP-seq
MIRT1254652	hsa-miR-3118	CLIP-seq
MIRT1254653	hsa-miR-3121-5p	CLIP-seq
MIRT1254654	hsa-miR-3146	CLIP-seq
MIRT1254655	hsa-miR-3164	CLIP-seq
MIRT1254656	hsa-miR-330-3p	CLIP-seq
MIRT1254657	hsa-miR-331-3p	CLIP-seq
MIRT1254658	hsa-miR-342-5p	CLIP-seq
MIRT1254659	hsa-miR-3646	CLIP-seq
MIRT1254660	hsa-miR-3667-5p	CLIP-seq
MIRT1254661	hsa-miR-3677-5p	CLIP-seq
MIRT1254662	hsa-miR-3691-5p	CLIP-seq
MIRT1254663	hsa-miR-3714	CLIP-seq
MIRT1254664	hsa-miR-381	CLIP-seq
MIRT1254665	hsa-miR-3910	CLIP-seq
MIRT1254666	hsa-miR-3934	CLIP-seq
MIRT1254667	hsa-miR-3972	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT1254669	hsa-miR-425	CLIP-seq
MIRT1254670	hsa-miR-4270	CLIP-seq
MIRT1254671	hsa-miR-4329	CLIP-seq
MIRT1254672	hsa-miR-4421	CLIP-seq
MIRT1254673	hsa-miR-4422	CLIP-seq
MIRT1254674	hsa-miR-4437	CLIP-seq
MIRT1254675	hsa-miR-4441	CLIP-seq
MIRT1254676	hsa-miR-4450	CLIP-seq
MIRT1254677	hsa-miR-4474-5p	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254679	hsa-miR-4521	CLIP-seq
MIRT1254680	hsa-miR-4522	CLIP-seq
MIRT1254681	hsa-miR-4525	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT1254683	hsa-miR-4651	CLIP-seq
MIRT1254684	hsa-miR-4664-5p	CLIP-seq
MIRT1254685	hsa-miR-4666-3p	CLIP-seq
MIRT1254686	hsa-miR-4667-5p	CLIP-seq
MIRT1254687	hsa-miR-4674	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254689	hsa-miR-4699-3p	CLIP-seq
MIRT1254690	hsa-miR-4700-5p	CLIP-seq
MIRT1254691	hsa-miR-4716-5p	CLIP-seq
MIRT1254692	hsa-miR-4733-3p	CLIP-seq
MIRT1254693	hsa-miR-4739	CLIP-seq
MIRT1254694	hsa-miR-4755-3p	CLIP-seq
MIRT1254695	hsa-miR-4756-5p	CLIP-seq
MIRT1254696	hsa-miR-4786-5p	CLIP-seq
MIRT1254697	hsa-miR-4789-3p	CLIP-seq
MIRT1254698	hsa-miR-488	CLIP-seq
MIRT1254699	hsa-miR-506	CLIP-seq
MIRT1254700	hsa-miR-520d-5p	CLIP-seq
MIRT1254701	hsa-miR-524-5p	CLIP-seq
MIRT1254702	hsa-miR-532-3p	CLIP-seq
MIRT1254703	hsa-miR-548p	CLIP-seq
MIRT1254704	hsa-miR-608	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq
MIRT1254706	hsa-miR-637	CLIP-seq
MIRT1254707	hsa-miR-642b	CLIP-seq
MIRT1254708	hsa-miR-651	CLIP-seq
MIRT1254709	hsa-miR-653	CLIP-seq
MIRT1254710	hsa-miR-654-3p	CLIP-seq
MIRT1254711	hsa-miR-764	CLIP-seq
MIRT1254712	hsa-miR-769-5p	CLIP-seq
MIRT2075141	hsa-miR-1197	CLIP-seq
MIRT2075142	hsa-miR-1208	CLIP-seq
MIRT2075143	hsa-miR-1243	CLIP-seq
MIRT1254637	hsa-miR-1255a	CLIP-seq
MIRT1254638	hsa-miR-1255b	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254643	hsa-miR-139-5p	CLIP-seq
MIRT2075144	hsa-miR-148a	CLIP-seq
MIRT2075145	hsa-miR-148b	CLIP-seq
MIRT2075146	hsa-miR-152	CLIP-seq
MIRT1254646	hsa-miR-1976	CLIP-seq
MIRT2075147	hsa-miR-3148	CLIP-seq
MIRT2075148	hsa-miR-3153	CLIP-seq
MIRT2075149	hsa-miR-371-5p	CLIP-seq
MIRT2075150	hsa-miR-371b-5p	CLIP-seq
MIRT2075151	hsa-miR-3978	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT2075152	hsa-miR-4254	CLIP-seq
MIRT2075153	hsa-miR-4311	CLIP-seq
MIRT1254672	hsa-miR-4421	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT2075154	hsa-miR-4639-3p	CLIP-seq
MIRT2075155	hsa-miR-4668-5p	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254692	hsa-miR-4733-3p	CLIP-seq
MIRT2075156	hsa-miR-513c	CLIP-seq
MIRT2075157	hsa-miR-514b-5p	CLIP-seq
MIRT1254700	hsa-miR-520d-5p	CLIP-seq
MIRT1254701	hsa-miR-524-5p	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq
MIRT1254634	hsa-miR-1202	CLIP-seq
MIRT1254639	hsa-miR-125a-3p	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254642	hsa-miR-134	CLIP-seq
MIRT1254643	hsa-miR-139-5p	CLIP-seq
MIRT1254644	hsa-miR-141	CLIP-seq
MIRT1254647	hsa-miR-200a	CLIP-seq
MIRT2301777	hsa-miR-205	CLIP-seq
MIRT1254652	hsa-miR-3118	CLIP-seq
MIRT2075148	hsa-miR-3153	CLIP-seq
MIRT1254655	hsa-miR-3164	CLIP-seq
MIRT2301778	hsa-miR-3187-3p	CLIP-seq
MIRT2301779	hsa-miR-3926	CLIP-seq
MIRT1254667	hsa-miR-3972	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT2301780	hsa-miR-4420	CLIP-seq
MIRT2301781	hsa-miR-4435	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254680	hsa-miR-4522	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254689	hsa-miR-4699-3p	CLIP-seq
MIRT2301782	hsa-miR-4701-5p	CLIP-seq
MIRT1254694	hsa-miR-4755-3p	CLIP-seq
MIRT2301783	hsa-miR-513a-5p	CLIP-seq
MIRT2301784	hsa-miR-548s	CLIP-seq
MIRT2301785	hsa-miR-570	CLIP-seq
MIRT2301786	hsa-miR-588	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS
GO:0004724	Function	Magnesium-dependent protein serine/threonine phosphatase activity	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007178	Process	Transmembrane receptor protein serine/threonine kinase signaling pathway	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA

Other IDs

• MIM: 611931
• HGNC: 16381
• e!Ensembl: ENSG00000163590

Protein

• UniProt ID: Q5SGD2
• Protein name: Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon)
• Protein function: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	91 → 344	Protein phosphatase 2C	Family

• Sequence:

  MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVK
  GKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTH
  PSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM
  LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERK
  RIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA
  SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ
  

• Sequence length: 360

Pathways

Reactome:

Sphingolipid de novo biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	18344982