DTX3L (deltex E3 ubiquitin ligase 3L)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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151636 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Deltex E3 ubiquitin ligase 3L |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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DTX3L |
SynonymsGene synonyms aliases
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BBAP, RNF143 |
ChromosomeChromosome number
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3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q21.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000209 |
Process |
Protein polyubiquitination |
TAS |
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GO:0002230 |
Process |
Positive regulation of defense response to virus by host |
IGI |
26479788 |
GO:0004842 |
Function |
Ubiquitin-protein transferase activity |
IDA |
19818714, 28525742 |
GO:0004842 |
Function |
Ubiquitin-protein transferase activity |
IMP |
23230272, 24790097, 26479788 |
GO:0004857 |
Function |
Enzyme inhibitor activity |
IMP |
24790097 |
GO:0005515 |
Function |
Protein binding |
IPI |
16809771, 23230272, 24790097, 25416956, 26479788, 32296183, 32814053 |
GO:0005634 |
Component |
Nucleus |
IDA |
16809771 |
GO:0005634 |
Component |
Nucleus |
IDA |
26479788 |
GO:0005654 |
Component |
Nucleoplasm |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
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GO:0005737 |
Component |
Cytoplasm |
IDA |
16809771, 24790097, 26479788 |
GO:0005764 |
Component |
Lysosome |
IDA |
24790097 |
GO:0005765 |
Component |
Lysosomal membrane |
IEA |
|
GO:0005769 |
Component |
Early endosome |
IDA |
24790097 |
GO:0005829 |
Component |
Cytosol |
IDA |
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GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0006302 |
Process |
Double-strand break repair |
IMP |
23230272 |
GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
IMP |
26479788 |
GO:0006974 |
Process |
Cellular response to DNA damage stimulus |
IMP |
19818714 |
GO:0007219 |
Process |
Notch signaling pathway |
IBA |
21873635 |
GO:0008047 |
Function |
Enzyme activator activity |
IDA |
28525742 |
GO:0008333 |
Process |
Endosome to lysosome transport |
IMP |
24790097 |
GO:0010390 |
Process |
Histone monoubiquitination |
IDA |
19818714, 28525742 |
GO:0015031 |
Process |
Protein transport |
IEA |
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GO:0016032 |
Process |
Viral process |
IEA |
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GO:0016567 |
Process |
Protein ubiquitination |
IBA |
21873635 |
GO:0019899 |
Function |
Enzyme binding |
IPI |
28525742 |
GO:0031901 |
Component |
Early endosome membrane |
IEA |
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GO:0032092 |
Process |
Positive regulation of protein binding |
IMP |
26479788 |
GO:0032991 |
Component |
Protein-containing complex |
IDA |
24790097, 26479788 |
GO:0033522 |
Process |
Histone H2A ubiquitination |
IMP |
26479788 |
GO:0033523 |
Process |
Histone H2B ubiquitination |
IMP |
26479788 |
GO:0035563 |
Process |
Positive regulation of chromatin binding |
IGI |
26479788 |
GO:0042393 |
Function |
Histone binding |
IDA |
19818714 |
GO:0042393 |
Function |
Histone binding |
IPI |
26479788 |
GO:0044389 |
Function |
Ubiquitin-like protein ligase binding |
IPI |
24790097 |
GO:0045087 |
Process |
Innate immune response |
IEA |
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GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IGI |
26479788 |
GO:0046872 |
Function |
Metal ion binding |
IEA |
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GO:0051444 |
Process |
Negative regulation of ubiquitin-protein transferase activity |
IMP |
24790097 |
GO:0051607 |
Process |
Defense response to virus |
IEA |
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GO:0051865 |
Process |
Protein autoubiquitination |
IMP |
24790097 |
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
IBA |
21873635 |
GO:0070936 |
Process |
Protein K48-linked ubiquitination |
IDA |
26479788 |
GO:0097677 |
Function |
STAT family protein binding |
IPI |
26479788 |
GO:1900182 |
Process |
Positive regulation of protein localization to nucleus |
IGI |
26479788 |
GO:1901666 |
Process |
Positive regulation of NAD+ ADP-ribosyltransferase activity |
IDA |
28525742 |
GO:1902966 |
Process |
Positive regulation of protein localization to early endosome |
IMP |
24790097 |
GO:2000646 |
Process |
Positive regulation of receptor catabolic process |
IMP |
24790097 |
GO:2001034 |
Process |
Positive regulation of double-strand break repair via nonhomologous end joining |
IMP |
28525742 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q8TDB6 |
Protein name |
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) |
Protein function |
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiqu |
PDB |
3PG6
,
8R79
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13923 |
zf-C3HC4_2 |
560 → 599 |
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Domain |
PF18102 |
DTC |
607 → 739 |
Deltex C-terminal domain |
Domain |
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Sequence |
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Sequence length |
740 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Breast cancer |
Malignant neoplasm of breast |
rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243 |
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