Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
151556 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
G protein-coupled receptor 155 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
GPR155 |
SynonymsGene synonyms aliases
|
DEP.7, DEPDC3, LYCHOS, PGR22 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2q31.1 |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q7Z3F1 |
Protein name |
Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) |
Protein function |
Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption |
PDB |
8U54
,
8U56
,
8U58
,
8U5C
,
8U5N
,
8U5Q
,
8U5V
,
8U5X
,
8WR3
,
8Y56
,
8Z8Z
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF03547 |
Mem_trans |
42 → 205 |
Membrane transport protein |
Family |
PF03547 |
Mem_trans |
191 → 362 |
Membrane transport protein |
Family |
PF00610 |
DEP |
766 → 833 |
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) |
Domain |
|
Sequence |
|
Sequence length |
870 |
Interactions |
View interactions |
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Autism |
Autistic Disorder |
rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634 |
17519220 |
|