GDF7 (growth differentiation factor 7)

Gene

• Entrez ID: 151449
• Gene name: Growth differentiation factor 7
• Gene symbol: GDF7
• Synonyms: BMP12
• Chromosome: 2
• Chromosome location: 2p24.1
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048114	hsa-miR-197-3p	CLASH	23622248
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT711488	hsa-miR-1207-3p	HITS-CLIP	19536157
MIRT711487	hsa-miR-3687	HITS-CLIP	19536157
MIRT711486	hsa-miR-4442	HITS-CLIP	19536157
MIRT711485	hsa-miR-3135b	HITS-CLIP	19536157
MIRT711484	hsa-miR-1289	HITS-CLIP	19536157
MIRT711483	hsa-miR-4294	HITS-CLIP	19536157
MIRT711482	hsa-miR-3198	HITS-CLIP	19536157
MIRT711481	hsa-miR-4309	HITS-CLIP	19536157
MIRT657900	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT657899	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT657898	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT657897	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT657896	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT657895	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT657894	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT657893	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT657892	hsa-miR-587	HITS-CLIP	23824327
MIRT657891	hsa-miR-3685	HITS-CLIP	23824327
MIRT657890	hsa-miR-384	HITS-CLIP	23824327
MIRT732843	hsa-miR-204-5p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	33461605
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT711488	hsa-miR-1207-3p	HITS-CLIP	19536157
MIRT711487	hsa-miR-3687	HITS-CLIP	19536157
MIRT711486	hsa-miR-4442	HITS-CLIP	19536157
MIRT711485	hsa-miR-3135b	HITS-CLIP	19536157
MIRT711484	hsa-miR-1289	HITS-CLIP	19536157
MIRT711483	hsa-miR-4294	HITS-CLIP	19536157
MIRT711482	hsa-miR-3198	HITS-CLIP	19536157
MIRT711481	hsa-miR-4309	HITS-CLIP	19536157
MIRT657900	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT657899	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT657898	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT657897	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT657896	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT657895	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT657894	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT657893	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT657892	hsa-miR-587	HITS-CLIP	23824327
MIRT657891	hsa-miR-3685	HITS-CLIP	23824327
MIRT657890	hsa-miR-384	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	16049014
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0007411	Process	Axon guidance	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0010862	Process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	21873635
GO:0010862	Process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IDA	16049014
GO:0021509	Process	Roof plate formation	IEA
GO:0021527	Process	Spinal cord association neuron differentiation	IEA
GO:0022612	Process	Gland morphogenesis	IEA
GO:0030509	Process	BMP signaling pathway	IBA	21873635
GO:0030509	Process	BMP signaling pathway	IDA	16049014
GO:0030855	Process	Epithelial cell differentiation	IEA
GO:0030901	Process	Midbrain development	IEA
GO:0032924	Process	Activin receptor signaling pathway	IDA	16049014
GO:0042802	Function	Identical protein binding	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	16049014
GO:0048608	Process	Reproductive structure development	IEA
GO:0048754	Process	Branching morphogenesis of an epithelial tube	IEA
GO:0048853	Process	Forebrain morphogenesis	IEA
GO:0060389	Process	Pathway-restricted SMAD protein phosphorylation	IDA	16049014
GO:0060395	Process	SMAD protein signal transduction	IBA	21873635
GO:0060571	Process	Morphogenesis of an epithelial fold	IEA
GO:2001051	Process	Positive regulation of tendon cell differentiation	IEA

Other IDs

• MIM: 604651
• HGNC: 4222
• e!Ensembl: ENSG00000143869

Protein

• UniProt ID: Q7Z4P5
• Protein name: Growth/differentiation factor 7 (GDF-7)
• Protein function: May play an active role in the motor area of the primate neocortex.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00688	TGFb_propeptide	66 → 278	TGF-beta propeptide	Family
  PF00019	TGF_beta	348 → 449	Transforming growth factor beta like domain	Domain

• Sequence:

  MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPVRSPGGGGGGGGGGRTLAQAAGAA
  AVPAAAVPRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHGRADT
  ITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGAELRVLRRGSPESGPGSWTSPPLL
  LLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGP
  VPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPL
  PDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKE
  LGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARL
  SPISILYIDAANNVVYKQYEDMVVEACGCR

• Sequence length: 450

Pathways

KEGG:

Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Axon guidance
Hippo signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29892016

Unknown
Disease name	Disease term	dbSNP ID	References
Barrett esophagus	Barrett Esophagus	rs41341748	27527254
Esophageal cancer	Adenocarcinoma Of Esophagus		27527254