PLB1 (phospholipase B1)

Gene

• Entrez ID: 151056
• Gene name: Phospholipase B1
• Gene symbol: PLB1
• Synonyms: PLB, PLB/LIP
• Chromosome: 2
• Chromosome location: 2p23.2
• Summary: This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activit

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1239483	hsa-miR-1224-5p	CLIP-seq
MIRT1239484	hsa-miR-2909	CLIP-seq
MIRT1239485	hsa-miR-4267	CLIP-seq
MIRT1239486	hsa-miR-4710	CLIP-seq
MIRT1239487	hsa-miR-4751	CLIP-seq
MIRT1239488	hsa-miR-4790-3p	CLIP-seq
MIRT1239489	hsa-miR-711	CLIP-seq
MIRT2070444	hsa-miR-1269	CLIP-seq
MIRT2070445	hsa-miR-1269b	CLIP-seq
MIRT2070446	hsa-miR-4529-3p	CLIP-seq
MIRT2392624	hsa-miR-1287	CLIP-seq
MIRT2392625	hsa-miR-1827	CLIP-seq
MIRT2392626	hsa-miR-1972	CLIP-seq
MIRT2392627	hsa-miR-3135b	CLIP-seq
MIRT2392628	hsa-miR-3173-5p	CLIP-seq
MIRT2392629	hsa-miR-3612	CLIP-seq
MIRT2392630	hsa-miR-370	CLIP-seq
MIRT2392631	hsa-miR-4443	CLIP-seq
MIRT2392632	hsa-miR-4717-5p	CLIP-seq
MIRT2392633	hsa-miR-650	CLIP-seq
MIRT2392634	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HIRA	Repression	9809417

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0004620	Function	Phospholipase activity	IBA	21873635
GO:0004622	Function	Lysophospholipase activity	IBA	21873635
GO:0004623	Function	Phospholipase A2 activity	IBA	21873635
GO:0004623	Function	Phospholipase A2 activity	TAS
GO:0004806	Function	Triglyceride lipase activity	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006644	Process	Phospholipid metabolic process	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0031526	Component	Brush border membrane	IBA	21873635
GO:0036151	Process	Phosphatidylcholine acyl-chain remodeling	TAS
GO:0042572	Process	Retinol metabolic process	IEA
GO:0050253	Function	Retinyl-palmitate esterase activity	IBA	21873635
GO:0050253	Function	Retinyl-palmitate esterase activity	TAS
GO:0102545	Function	Phosphatidyl phospholipase B activity	IEA
GO:0102567	Function	Phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	IEA
GO:0102568	Function	Phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	IEA
GO:2000344	Process	Positive regulation of acrosome reaction	IEA

Other IDs

• MIM: 610179
• HGNC: 30041
• e!Ensembl: ENSG00000163803

Protein

• UniProt ID: Q6P1J6
• Protein name: Phospholipase B1, membrane-associated (Phospholipase B) (hPLB) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A2) (EC 3.1.1.4) (Phospholipase B/lipase) (PLB/LIP) (Triacylglycerol lipase) (EC 3.1.1.3)
• Protein function: Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00657	Lipase_GDSL	394 → 668	GDSL-like Lipase/Acylhydrolase	Family
  PF00657	Lipase_GDSL	741 → 1015	GDSL-like Lipase/Acylhydrolase	Family
  PF00657	Lipase_GDSL	1097 → 1362	GDSL-like Lipase/Acylhydrolase	Family

• Sequence:

  MGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSK
  SVHSLKPSDIKFVAAIGNLEIPPDPGTGDLEKQDWTERPQQVCMGVMTVLSDIIRYFSPS
  VPMPVCHTGKRVIPHDGAEDLWIQAQELVRNMKENLQLDFQFDWKLINVFFSNASQCYLC
  PSAQQNGLAAGGVDELMGVLDYLQQEVPRAFVNLVDLSEVAEVSRQYHGTWLSPAPEPCN
  CSEETTRLAKVVMQWSYQEAWNSLLASSRYSEQESFTVVFQPFFYETTPSLHSEDPRLQD
  STTLAWHLWNRMMEPAGEKDEPLSVKHGRPMKCPSQESPYLFSYRNSNYLTRLQKPQDKL
  EVREGAEIRCPDKDPSDTVPTSVHRLKPADINVIGALGDSLTAGNGAGSTPGNVLDVLTQ
  YRGLSWSVGGDENIGTVTTLANILREFNPSLKGFSVGTGKETSPNAFLNQAVAGGRAEDL
  PVQARRLVDLMKNDTRIHFQEDWKIITLFIGGNDLCDFCNDLVHYSPQNFTDNIGKALDI
  LHAEVPRAFVNLVTVLEIVNLRELYQEKKVYCPRMILRSLCPCVLKFDDNSTELATLIEF
  NKKFQEKTHQLIESGRYDTREDFTVVVQPFFENVDMPKTSEGLPDNSFFAPDCFHFSSKS
  HSRAASALWNNMLEPVGQKTTRHKFENKINITCPNQVQPFLRTYKNSMQGHGTWLPCRDR
  APSALHPTSVHALRPADIQVVAALGDSLTAGNGIGSKPDDLPDVTTQYRGLSYSAGGDGS
  LENVTTLPNILREFNRNLTGYAVGTGDANDTNAFLNQAVPGAKAEDLMSQVQTLMQKMKD
  DHRVNFHEDWKVITVLIGGSDLCDYCTDSNLYSAANFVHHLRNALDVLHREVPRVLVNLV
  DFLNPTIMRQVFLGNPDKCPVQQASVLCNCVLTLRENSQELARLEAFSRAYRSSMRELVG
  SGRYDTQEDFSVVLQPFFQNIQLPVLADGLPDTSFFAPDCIHPNQKFHSQLARALWTNML
  EPLGSKTETLDLRAEMPITCPTQNEPFLRTPRNSNYTYPIKPAIENWGSDFLCTEWKASN
  SVPTSVHQLRPADIKVVAALGDSLTTAVGARPNNSSDLPTSWRGLSWSIGGDGNLETHTT
  LPNILKKFNPYLLGFSTSTWEGTAGLNVAAEGARARDMPAQAWDLVERMKNSPDINLEKD
  WKLVTLFIGVNDLCHYCENPEAHLATEYVQHIQQALDILSEELPRAFVNVVEVMELASLY
  QGQGGKCAMLAAQNNCTCLRHSQSSLEKQELKKVNWNLQHGISSFSYWHQYTQREDFAVV
  VQPFFQNTLTPLNERGDTDLTFFSEDCFHFSDRGHAEMAIALWNNMLEPVGRKTTSNNFT
  HSRAKLKCPSPESPYLYTLRNSRLLPDQAEEAPEVLYWAVPVAAGVGLVVGIIGTVVWRC
  RRGGRREDPPMSLRTVAL

• Sequence length: 1458

Pathways

KEGG:

Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Vitamin digestion and absorption

Reactome:

Acyl chain remodelling of PC
Retinoid metabolism and transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	30940143
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	24520335