Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
1508 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Cathepsin B |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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CTSB |
SynonymsGene synonyms aliases
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APPS, CPSB, KWE, RECEUP |
ChromosomeChromosome number
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8 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
8p23.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein pro |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0002224 |
Process |
Toll-like receptor signaling pathway |
TAS |
|
GO:0004197 |
Function |
Cysteine-type endopeptidase activity |
IBA |
21873635 |
GO:0004197 |
Function |
Cysteine-type endopeptidase activity |
IDA |
6203523, 22952693 |
GO:0005515 |
Function |
Protein binding |
IPI |
6203523, 7890620, 8083219, 16237761, 16364318, 17064696, 18718938, 20706999, 32814053 |
GO:0005518 |
Function |
Collagen binding |
IDA |
22952693 |
GO:0005576 |
Component |
Extracellular region |
TAS |
|
GO:0005615 |
Component |
Extracellular space |
IBA |
21873635 |
GO:0005615 |
Component |
Extracellular space |
IDA |
22952693 |
GO:0005615 |
Component |
Extracellular space |
ISS |
22261194 |
GO:0005622 |
Component |
Intracellular anatomical structure |
TAS |
1645961 |
GO:0005764 |
Component |
Lysosome |
IBA |
21873635 |
GO:0005764 |
Component |
Lysosome |
IDA |
1837142, 2350688 |
GO:0006508 |
Process |
Proteolysis |
IDA |
7890620, 8811434 |
GO:0008233 |
Function |
Peptidase activity |
IDA |
7890620 |
GO:0008234 |
Function |
Cysteine-type peptidase activity |
IDA |
8612130, 8811434 |
GO:0016324 |
Component |
Apical plasma membrane |
IEA |
|
GO:0030574 |
Process |
Collagen catabolic process |
IDA |
22952693 |
GO:0030574 |
Process |
Collagen catabolic process |
TAS |
|
GO:0030855 |
Process |
Epithelial cell differentiation |
IEP |
21492153 |
GO:0036021 |
Component |
Endolysosome lumen |
TAS |
|
GO:0042470 |
Component |
Melanosome |
IEA |
|
GO:0042981 |
Process |
Regulation of apoptotic process |
TAS |
16130169 |
GO:0043312 |
Process |
Neutrophil degranulation |
TAS |
|
GO:0043394 |
Function |
Proteoglycan binding |
IPI |
22952693 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IDA |
15614436 |
GO:0050790 |
Process |
Regulation of catalytic activity |
IEA |
|
GO:0051603 |
Process |
Proteolysis involved in cellular protein catabolic process |
IBA |
21873635 |
GO:0051603 |
Process |
Proteolysis involved in cellular protein catabolic process |
IDA |
22952693 |
GO:0062023 |
Component |
Collagen-containing extracellular matrix |
HDA |
25037231, 28344315, 28675934 |
GO:0062023 |
Component |
Collagen-containing extracellular matrix |
HDA |
28327460 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19199708, 23533145 |
GO:0097067 |
Process |
Cellular response to thyroid hormone stimulus |
IEP |
21217776 |
GO:1904813 |
Component |
Ficolin-1-rich granule lumen |
TAS |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P07858 |
Protein name |
Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] |
Protein function |
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/t |
PDB |
1CSB
,
1GMY
,
1HUC
,
1PBH
,
2IPP
,
2PBH
,
3AI8
,
3CBJ
,
3CBK
,
3K9M
,
3PBH
,
5MBL
,
5MBM
,
6AY2
,
8B4T
,
8B5F
,
8HE9
,
8HEI
,
8HEN
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF08127 |
Propeptide_C1 |
26 → 65 |
Peptidase family C1 propeptide |
Motif |
PF00112 |
Peptidase_C1 |
80 → 329 |
Papain family cysteine protease |
Domain |
|
Sequence |
|
Sequence length |
339 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Glioblastoma |
Glioblastoma, Glioblastoma Multiforme |
rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 |
22287159 |
Myopathy |
Myopathy |
rs137854521, rs386834236, rs121908557, rs121909092, rs111033570, rs104894299, rs104894294, rs121909273, rs121909274, rs121909275, rs199474699, rs199476140, rs118192165, rs118192169, rs118192166, rs193922856, rs281865489, rs397514675, rs397514676, rs397514677, rs367543058, rs118192117, rs193922837, rs118192129, rs118192143, rs118192153, rs118192133, rs118192156, rs118192149, rs118192148, rs118192183, rs118192147, rs118192123, rs118192127, rs118192142, rs118192144, rs118192178, rs118192151, rs118192150, rs118192184, rs118192154, rs118192134, rs118192155, rs193922893, rs118192132, rs118192146, rs193922867, rs193922884, rs587777528, rs527236030, rs587777672, rs587777673, rs587777674, rs587777675, rs587783343, rs2754158, rs786204796, rs748277951, rs797046047, rs797046064, rs797046060, rs797045479, rs797045931, rs797045932, rs797045934, rs797045935, rs797045477, rs797045478, rs1057518851, rs1057518855, rs1057518773, rs1057518866, rs1555322610, rs1555806119, rs761483896, rs144071404, rs1198364572, rs1568614042, rs978984063, rs1568604308, rs1332371891, rs1601842249, rs777176261, rs1249621033, rs1278804520, rs1568613962, rs1568510406, rs1597512576, rs193922887, rs371455345, rs1603452200, rs1599634685, rs1575065895, rs1575201712, rs139715157, rs1974129338 |
7099197 |
Papillary renal carcinoma |
Papillary Renal Cell Carcinoma |
rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724 |
15108329 |
Parkinson disease |
Parkinson Disease |
rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106 |
28892059 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
19503093 |
Renal carcinoma |
Renal Cell Carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney |
rs121913668, rs121913670, rs121913243, rs786202724 |
15108329 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Chromophobe carcinoma |
Chromophobe Renal Cell Carcinoma |
rs137853247 |
15108329 |
Giant cell glioblastoma |
Giant Cell Glioblastoma |
|
22287159 |
Hyperhidrosis palmaris et plantaris |
Hyperhidrosis Palmaris Et Plantaris |
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Keratolytic winter erythema |
Keratolytic winter erythema |
|
28457472 |
Prostatic neoplasms |
Prostatic Neoplasms |
|
19503093 |
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