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CTSB (cathepsin B)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1508
Gene nameGene Name - the full gene name approved by the HGNC.
Cathepsin B
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CTSB
SynonymsGene synonyms aliases
APPS, CPSB, KWE, RECEUP
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p23.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein pro
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049702 hsa-miR-92a-3p CLASH 23622248
MIRT046187 hsa-miR-27b-3p CLASH 23622248
MIRT725558 hsa-miR-183-5p HITS-CLIP 19536157
MIRT725557 hsa-miR-1271-5p HITS-CLIP 19536157
MIRT725556 hsa-miR-96-5p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
ETS1 Unknown 10701774
NFKB1 Activation 15102937;18598236
RELA Activation 15102937;18598236
SP1 Unknown 10701774
SP3 Unknown 10701774
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002224 Process Toll-like receptor signaling pathway TAS
GO:0004197 Function Cysteine-type endopeptidase activity IBA 21873635
GO:0004197 Function Cysteine-type endopeptidase activity IDA 6203523, 22952693
GO:0005515 Function Protein binding IPI 6203523, 7890620, 8083219, 16237761, 16364318, 17064696, 18718938, 20706999, 32814053
GO:0005518 Function Collagen binding IDA 22952693
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P07858
Protein name Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
Protein function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/t
PDB 1CSB , 1GMY , 1HUC , 1PBH , 2IPP , 2PBH , 3AI8 , 3CBJ , 3CBK , 3K9M , 3PBH , 5MBL , 5MBM , 6AY2 , 8B4T , 8B5F , 8HE9 , 8HEI , 8HEN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08127 Propeptide_C1
26 65
Peptidase family C1 propeptide
Motif
PF00112 Peptidase_C1
80 329
Papain family cysteine protease
Domain
Sequence
Sequence length 339
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Autophagy - animal
Lysosome
Apoptosis
Antigen processing and presentation
NOD-like receptor signaling pathway
Renin secretion
  Collagen degradation
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 22287159
Myopathy Myopathy rs137854521, rs386834236, rs121908557, rs121909092, rs111033570, rs104894299, rs104894294, rs121909273, rs121909274, rs121909275, rs199474699, rs199476140, rs118192165, rs118192169, rs118192166, rs193922856, rs281865489, rs397514675, rs397514676, rs397514677, rs367543058, rs118192117, rs193922837, rs118192129, rs118192143, rs118192153, rs118192133, rs118192156, rs118192149, rs118192148, rs118192183, rs118192147, rs118192123, rs118192127, rs118192142, rs118192144, rs118192178, rs118192151, rs118192150, rs118192184, rs118192154, rs118192134, rs118192155, rs193922893, rs118192132, rs118192146, rs193922867, rs193922884, rs587777528, rs527236030, rs587777672, rs587777673, rs587777674, rs587777675, rs587783343, rs2754158, rs786204796, rs748277951, rs797046047, rs797046064, rs797046060, rs797045479, rs797045931, rs797045932, rs797045934, rs797045935, rs797045477, rs797045478, rs1057518851, rs1057518855, rs1057518773, rs1057518866, rs1555322610, rs1555806119, rs761483896, rs144071404, rs1198364572, rs1568614042, rs978984063, rs1568604308, rs1332371891, rs1601842249, rs777176261, rs1249621033, rs1278804520, rs1568613962, rs1568510406, rs1597512576, rs193922887, rs371455345, rs1603452200, rs1599634685, rs1575065895, rs1575201712, rs139715157, rs1974129338 7099197
Papillary renal carcinoma Papillary Renal Cell Carcinoma rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724 15108329
Parkinson disease Parkinson Disease rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106 28892059
Unknown
Disease name Disease term dbSNP ID References
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma rs137853247 15108329
Giant cell glioblastoma Giant Cell Glioblastoma 22287159
Hyperhidrosis palmaris et plantaris Hyperhidrosis Palmaris Et Plantaris
Keratolytic winter erythema Keratolytic winter erythema 28457472

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