HORMAD2 (HORMA domain containing 2)

Gene

• Entrez ID: 150280
• Gene name: HORMA domain containing 2
• Gene symbol: HORMAD2
• Synonyms: CT46.2
• Chromosome: 22
• Chromosome location: 22q12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019018	hsa-miR-335-5p	Microarray	18185580
MIRT647091	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT647089	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT647088	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT647086	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT647087	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT647085	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT647091	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT647089	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT647088	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT647086	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT647087	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT647085	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT1053024	hsa-miR-1237	CLIP-seq
MIRT1053025	hsa-miR-1248	CLIP-seq
MIRT1053026	hsa-miR-128	CLIP-seq
MIRT1053027	hsa-miR-183	CLIP-seq
MIRT1053028	hsa-miR-199a-3p	CLIP-seq
MIRT1053029	hsa-miR-199b-3p	CLIP-seq
MIRT1053030	hsa-miR-27a	CLIP-seq
MIRT1053031	hsa-miR-27b	CLIP-seq
MIRT1053032	hsa-miR-3074-5p	CLIP-seq
MIRT1053033	hsa-miR-3121-3p	CLIP-seq
MIRT1053034	hsa-miR-3121-5p	CLIP-seq
MIRT1053035	hsa-miR-3124-3p	CLIP-seq
MIRT1053036	hsa-miR-3129-5p	CLIP-seq
MIRT1053037	hsa-miR-3613-3p	CLIP-seq
MIRT1053038	hsa-miR-3617	CLIP-seq
MIRT1053039	hsa-miR-370	CLIP-seq
MIRT1053040	hsa-miR-4315	CLIP-seq
MIRT1053041	hsa-miR-4639-5p	CLIP-seq
MIRT1053042	hsa-miR-4668-3p	CLIP-seq
MIRT1053043	hsa-miR-4766-3p	CLIP-seq
MIRT1053044	hsa-miR-4799-5p	CLIP-seq
MIRT1053045	hsa-miR-500a	CLIP-seq
MIRT1053046	hsa-miR-513a-5p	CLIP-seq
MIRT1053047	hsa-miR-548c-3p	CLIP-seq
MIRT1053048	hsa-miR-548p	CLIP-seq
MIRT1053049	hsa-miR-641	CLIP-seq
MIRT1053032	hsa-miR-3074-5p	CLIP-seq
MIRT1053035	hsa-miR-3124-3p	CLIP-seq
MIRT1053038	hsa-miR-3617	CLIP-seq
MIRT1053039	hsa-miR-370	CLIP-seq
MIRT1053041	hsa-miR-4639-5p	CLIP-seq
MIRT1053049	hsa-miR-641	CLIP-seq
MIRT1053032	hsa-miR-3074-5p	CLIP-seq
MIRT1053035	hsa-miR-3124-3p	CLIP-seq
MIRT1053038	hsa-miR-3617	CLIP-seq
MIRT1053039	hsa-miR-370	CLIP-seq
MIRT1053041	hsa-miR-4639-5p	CLIP-seq
MIRT1053049	hsa-miR-641	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000795	Component	Synaptonemal complex	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	ISS
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0051177	Process	Meiotic sister chromatid cohesion	ISS
GO:0051321	Process	Meiotic cell cycle	ISS

Other IDs

• MIM: 618842
• HGNC: 28383
• e!Ensembl: ENSG00000176635

Protein

• UniProt ID: Q8N7B1
• Protein name: HORMA domain-containing protein 2
• Protein function: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02301	HORMA	31 → 228	HORMA domain	Domain

• Sequence:

  MATAQLSHCITIHKASKETVFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGE
  RHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMY
  QFKFKYTKEGATMDFDSHSSSTSFESGTNNEDIKKASVLLIRKLYILMQDLEPLPNNVVL
  TMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATK
  VIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSECSRKKRKVSEPVK
  VFIPNRK

• Sequence length: 307

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	25751624, 30054458
Glomerulonephritis	IGA Glomerulonephritis	rs778043831	25305756
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	23128233, 19915574, 28067908, 26192919
Kidney disease	Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	21399633
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	21725308
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	22190364

Unknown
Disease name	Disease term	dbSNP ID	References
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26192919, 28067908
Ulcerative colitis	Ulcerative Colitis		26192919