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CTBP2 (C-terminal binding protein 2)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1488
Gene nameGene Name - the full gene name approved by the HGNC.
C-terminal binding protein 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CTBP2
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.13
SummarySummary of gene provided in NCBI Entrez Gene.
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding dom
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT006173 hsa-miR-141-3p Luciferase reporter assay, Western blot 21867514
MIRT006173 hsa-miR-141-3p Luciferase reporter assay, Western blot 21867514
MIRT006173 hsa-miR-141-3p Luciferase reporter assay, Western blot 21867514
MIRT023997 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT051934 hsa-let-7b-5p CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
HIPK2 Unknown 23393140
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 20705609
GO:0001226 Function RNA polymerase II transcription corepressor binding IPI 29628311
GO:0003682 Function Chromatin binding IEA
GO:0003713 Function Transcription coactivator activity IEA
GO:0003714 Function Transcription corepressor activity TAS 20705609
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P56545
Protein name C-terminal-binding protein 2 (CtBP2)
Protein function Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). ; Isoform 2 probably acts as a scaffold for specialized synapses.
PDB 2OME , 4LCJ , 6WKW , 8ATI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00389 2-Hacid_dh
36 → 358
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 Domain
PF02826 2-Hacid_dh_C
139 → 323
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
 Domain
Sequence
Sequence length 445
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Wnt signaling pathway
Notch signaling pathway
Pathways in cancer
Chronic myeloid leukemia 		  Repression of WNT target genes
TCF7L2 mutants don't bind CTBP
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Nasopharyngeal carcinoma Nasopharyngeal carcinoma rs200046052 20512145
Prostate cancer Malignant neoplasm of prostate, Prostate carcinoma rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 18264096, 18264096, 29892016
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 18264096

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