ADRA1A (adrenoceptor alpha 1A)

Gene

• Entrez ID: 148
• Gene name: Adrenoceptor alpha 1A
• Gene symbol: ADRA1A
• Synonyms: ADRA1C, ADRA1L1, ALPHA1AAR
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of whi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041983	hsa-miR-484	CLASH	23622248
MIRT769775	hsa-miR-105	CLIP-seq
MIRT769776	hsa-miR-199a-3p	CLIP-seq
MIRT769777	hsa-miR-199b-3p	CLIP-seq
MIRT769778	hsa-miR-223	CLIP-seq
MIRT769779	hsa-miR-3129-5p	CLIP-seq
MIRT769780	hsa-miR-323b-5p	CLIP-seq
MIRT769781	hsa-miR-3545-3p	CLIP-seq
MIRT769782	hsa-miR-4474-3p	CLIP-seq
MIRT769783	hsa-miR-4539	CLIP-seq
MIRT769784	hsa-miR-4687-3p	CLIP-seq
MIRT769785	hsa-miR-4697-3p	CLIP-seq
MIRT769786	hsa-miR-582-3p	CLIP-seq
MIRT769787	hsa-miR-936	CLIP-seq
MIRT769788	hsa-miR-1827	CLIP-seq
MIRT769789	hsa-miR-24	CLIP-seq
MIRT769790	hsa-miR-3122	CLIP-seq
MIRT769791	hsa-miR-3689a-3p	CLIP-seq
MIRT769792	hsa-miR-3689c	CLIP-seq
MIRT769793	hsa-miR-3913-5p	CLIP-seq
MIRT769794	hsa-miR-3929	CLIP-seq
MIRT769795	hsa-miR-4284	CLIP-seq
MIRT769796	hsa-miR-4419b	CLIP-seq
MIRT769797	hsa-miR-4478	CLIP-seq
MIRT769798	hsa-miR-4514	CLIP-seq
MIRT769799	hsa-miR-4649-3p	CLIP-seq
MIRT769800	hsa-miR-4692	CLIP-seq
MIRT769801	hsa-miR-4728-5p	CLIP-seq
MIRT769802	hsa-miR-485-5p	CLIP-seq
MIRT769803	hsa-miR-564	CLIP-seq
MIRT769804	hsa-miR-940	CLIP-seq
MIRT769788	hsa-miR-1827	CLIP-seq
MIRT769790	hsa-miR-3122	CLIP-seq
MIRT1927074	hsa-miR-335	CLIP-seq
MIRT769791	hsa-miR-3689a-3p	CLIP-seq
MIRT769792	hsa-miR-3689c	CLIP-seq
MIRT769793	hsa-miR-3913-5p	CLIP-seq
MIRT769794	hsa-miR-3929	CLIP-seq
MIRT769796	hsa-miR-4419b	CLIP-seq
MIRT769797	hsa-miR-4478	CLIP-seq
MIRT769798	hsa-miR-4514	CLIP-seq
MIRT769799	hsa-miR-4649-3p	CLIP-seq
MIRT769800	hsa-miR-4692	CLIP-seq
MIRT769801	hsa-miR-4728-5p	CLIP-seq
MIRT769802	hsa-miR-485-5p	CLIP-seq
MIRT769804	hsa-miR-940	CLIP-seq
MIRT769788	hsa-miR-1827	CLIP-seq
MIRT769789	hsa-miR-24	CLIP-seq
MIRT769790	hsa-miR-3122	CLIP-seq
MIRT1927074	hsa-miR-335	CLIP-seq
MIRT769791	hsa-miR-3689a-3p	CLIP-seq
MIRT769792	hsa-miR-3689c	CLIP-seq
MIRT769793	hsa-miR-3913-5p	CLIP-seq
MIRT769794	hsa-miR-3929	CLIP-seq
MIRT769795	hsa-miR-4284	CLIP-seq
MIRT769796	hsa-miR-4419b	CLIP-seq
MIRT769797	hsa-miR-4478	CLIP-seq
MIRT769798	hsa-miR-4514	CLIP-seq
MIRT769799	hsa-miR-4649-3p	CLIP-seq
MIRT769800	hsa-miR-4692	CLIP-seq
MIRT769801	hsa-miR-4728-5p	CLIP-seq
MIRT769802	hsa-miR-485-5p	CLIP-seq
MIRT769804	hsa-miR-940	CLIP-seq
MIRT769788	hsa-miR-1827	CLIP-seq
MIRT769790	hsa-miR-3122	CLIP-seq
MIRT769791	hsa-miR-3689a-3p	CLIP-seq
MIRT769792	hsa-miR-3689c	CLIP-seq
MIRT769793	hsa-miR-3913-5p	CLIP-seq
MIRT769794	hsa-miR-3929	CLIP-seq
MIRT769796	hsa-miR-4419b	CLIP-seq
MIRT769797	hsa-miR-4478	CLIP-seq
MIRT769798	hsa-miR-4514	CLIP-seq
MIRT769799	hsa-miR-4649-3p	CLIP-seq
MIRT769800	hsa-miR-4692	CLIP-seq
MIRT769801	hsa-miR-4728-5p	CLIP-seq
MIRT769802	hsa-miR-485-5p	CLIP-seq
MIRT769804	hsa-miR-940	CLIP-seq
MIRT769788	hsa-miR-1827	CLIP-seq
MIRT769790	hsa-miR-3122	CLIP-seq
MIRT769791	hsa-miR-3689a-3p	CLIP-seq
MIRT769792	hsa-miR-3689c	CLIP-seq
MIRT769793	hsa-miR-3913-5p	CLIP-seq
MIRT769794	hsa-miR-3929	CLIP-seq
MIRT769796	hsa-miR-4419b	CLIP-seq
MIRT769797	hsa-miR-4478	CLIP-seq
MIRT769798	hsa-miR-4514	CLIP-seq
MIRT769799	hsa-miR-4649-3p	CLIP-seq
MIRT769800	hsa-miR-4692	CLIP-seq
MIRT769801	hsa-miR-4728-5p	CLIP-seq
MIRT769802	hsa-miR-485-5p	CLIP-seq
MIRT769804	hsa-miR-940	CLIP-seq
MIRT2470510	hsa-miR-2115	CLIP-seq
MIRT2470511	hsa-miR-345	CLIP-seq
MIRT2470512	hsa-miR-4267	CLIP-seq
MIRT2470513	hsa-miR-579	CLIP-seq
MIRT2470510	hsa-miR-2115	CLIP-seq
MIRT2470511	hsa-miR-345	CLIP-seq
MIRT2470512	hsa-miR-4267	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREB1	Unknown	10520459
SP1	Unknown	10520459
TFAP2A	Unknown	10520459

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001985	Process	Negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	IEA
GO:0001994	Process	Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IEA
GO:0001996	Process	Positive regulation of heart rate by epinephrine-norepinephrine	IBA	21873635
GO:0001997	Process	Positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA
GO:0003084	Process	Positive regulation of systemic arterial blood pressure	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004937	Function	Alpha1-adrenergic receptor activity	IBA	21873635
GO:0004937	Function	Alpha1-adrenergic receptor activity	ISS
GO:0004937	Function	Alpha1-adrenergic receptor activity	NAS	9490024
GO:0004937	Function	Alpha1-adrenergic receptor activity	TAS	7737411
GO:0005515	Function	Protein binding	IPI	24567387, 25775528, 27331810, 28862946
GO:0005634	Component	Nucleus	IDA	22120526
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	24567387
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA	24567387
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005901	Component	Caveola	IEA
GO:0006915	Process	Apoptotic process	TAS	10671514
GO:0006939	Process	Smooth muscle contraction	TAS	8183249
GO:0007165	Process	Signal transduction	TAS	8396931
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007202	Process	Activation of phospholipase C activity	ISS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	ISS
GO:0007267	Process	Cell-cell signaling	IBA	21873635
GO:0007512	Process	Adult heart development	IEA
GO:0007568	Process	Aging	ISS
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	10860850
GO:0009725	Process	Response to hormone	ISS
GO:0010507	Process	Negative regulation of autophagy	IEA
GO:0010613	Process	Positive regulation of cardiac muscle hypertrophy	IEA
GO:0030018	Component	Z disc	IEA
GO:0030315	Component	T-tubule	IEA
GO:0031965	Component	Nuclear membrane	IDA	22120526
GO:0032230	Process	Positive regulation of synaptic transmission, GABAergic	ISS
GO:0035024	Process	Negative regulation of Rho protein signal transduction	ISS
GO:0035556	Process	Intracellular signal transduction	TAS	10671514
GO:0042493	Process	Response to drug	ISS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043410	Process	Positive regulation of MAPK cascade	IBA	21873635
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	22120526
GO:0045760	Process	Positive regulation of action potential	ISS
GO:0045907	Process	Positive regulation of vasoconstriction	IBA	21873635
GO:0045907	Process	Positive regulation of vasoconstriction	ISS
GO:0045987	Process	Positive regulation of smooth muscle contraction	IEA
GO:0046982	Function	Protein heterodimerization activity	IDA	22120526
GO:0060073	Process	Micturition	IEA
GO:0060402	Process	Calcium ion transport into cytosol	ISS
GO:0060452	Process	Positive regulation of cardiac muscle contraction	ISS
GO:0061049	Process	Cell growth involved in cardiac muscle cell development	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	21873635
GO:0090037	Process	Positive regulation of protein kinase C signaling	ISS
GO:0097195	Process	Pilomotor reflex	IEA
GO:0098691	Component	Dopaminergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099055	Component	Integral component of postsynaptic membrane	IEA
GO:0099056	Component	Integral component of presynaptic membrane	IEA
GO:0150099	Process	Neuron-glial cell signaling	ISS
GO:1903997	Process	Positive regulation of non-membrane spanning protein tyrosine kinase activity	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 104221
• HGNC: 277
• e!Ensembl: ENSG00000120907

Protein

• UniProt ID: P35348
• Protein name: Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)
• Protein function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regu
• PDB: 7YM8, 7YMH, 7YMJ, 8HN1, 8THK, 8THL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	43 → 326	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
  SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
  EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
  APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
  FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
  HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
  TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV

• Sequence length: 466

Pathways

KEGG:

Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion

Reactome:

Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21302347

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		16894394
Liver carcinoma	Liver carcinoma		28284560
Liver cirrhosis	Liver Cirrhosis		16782692
Liver fibrosis	Fibrosis, Liver		16782692
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	20493668