CSTF3 (cleavage stimulation factor subunit 3)

Gene

• Entrez ID: 1479
• Gene name: Cleavage stimulation factor subunit 3
• Gene symbol: CSTF3
• Synonyms: CSTF-77
• Chromosome: 11
• Chromosome location: 11p13
• Summary: The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3` end cleavage of pre-mRNAs

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022875	hsa-miR-124-3p	Microarray	18668037
MIRT023876	hsa-miR-1-3p	Proteomics	18668040
MIRT030582	hsa-miR-24-3p	Microarray	19748357
MIRT045842	hsa-miR-132-3p	CLASH	23622248
MIRT043935	hsa-miR-378a-3p	CLASH	23622248
MIRT913599	hsa-miR-142-3p	CLIP-seq
MIRT913600	hsa-miR-298	CLIP-seq
MIRT913601	hsa-miR-3158-5p	CLIP-seq
MIRT913602	hsa-miR-4418	CLIP-seq
MIRT913603	hsa-miR-4420	CLIP-seq
MIRT913604	hsa-miR-509-3-5p	CLIP-seq
MIRT913605	hsa-miR-509-5p	CLIP-seq
MIRT913606	hsa-miR-648	CLIP-seq
MIRT913607	hsa-miR-3689a-5p	CLIP-seq
MIRT913608	hsa-miR-3689b	CLIP-seq
MIRT913609	hsa-miR-3689e	CLIP-seq
MIRT913610	hsa-miR-3689f	CLIP-seq
MIRT913611	hsa-miR-3942-3p	CLIP-seq
MIRT2510026	hsa-miR-3145-5p	CLIP-seq
MIRT2510027	hsa-miR-409-3p	CLIP-seq
MIRT2510028	hsa-miR-452	CLIP-seq
MIRT2510029	hsa-miR-4676-3p	CLIP-seq
MIRT2510030	hsa-miR-4684-3p	CLIP-seq
MIRT2510031	hsa-miR-4698	CLIP-seq
MIRT2510032	hsa-miR-4738-3p	CLIP-seq
MIRT2510033	hsa-miR-548g	CLIP-seq
MIRT2510034	hsa-miR-891b	CLIP-seq
MIRT2510026	hsa-miR-3145-5p	CLIP-seq
MIRT2678730	hsa-miR-3667-5p	CLIP-seq
MIRT2510027	hsa-miR-409-3p	CLIP-seq
MIRT2510028	hsa-miR-452	CLIP-seq
MIRT2510029	hsa-miR-4676-3p	CLIP-seq
MIRT2510030	hsa-miR-4684-3p	CLIP-seq
MIRT2510031	hsa-miR-4698	CLIP-seq
MIRT2510032	hsa-miR-4738-3p	CLIP-seq
MIRT2510033	hsa-miR-548g	CLIP-seq
MIRT2510034	hsa-miR-891b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	7590244
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006369	Process	Termination of RNA polymerase II transcription	TAS
GO:0006378	Process	MRNA polyadenylation	TAS	7984242
GO:0006379	Process	MRNA cleavage	TAS	7984242
GO:0031123	Process	RNA 3'-end processing	IBA	21873635
GO:0031124	Process	MRNA 3'-end processing	TAS

Other IDs

• MIM: 600367
• HGNC: 2485
• e!Ensembl: ENSG00000176102

Protein

• UniProt ID: Q12996
• Protein name: Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)
• Protein function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
• PDB: 6B3X, 6URO, 7ZY4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05843	Suf	375 → 649	Suppressor of forked protein (Suf)	Family

• Sequence:

  MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQ
  FPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKE
  KMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPM
  INIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQ
  NTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQY
  LEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVH
  SIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEY
  YCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEK
  SGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASE
  LKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPP
  GLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIIT
  GGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR

• Sequence length: 717

Pathways

KEGG:

mRNA surveillance pathway

Reactome:

mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	22491018

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	27622933
Mood disorder	Mood Disorders		27622933