NCAN (neurocan)

Gene

• Entrez ID: 1463
• Gene name: Neurocan
• Gene symbol: NCAN
• Synonyms: CSPG3
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043672	hsa-miR-342-3p	CLASH	23622248
MIRT724671	hsa-miR-6165	HITS-CLIP	19536157
MIRT724670	hsa-miR-214-3p	HITS-CLIP	19536157
MIRT724669	hsa-miR-3619-5p	HITS-CLIP	19536157
MIRT724668	hsa-miR-761	HITS-CLIP	19536157
MIRT724667	hsa-miR-4530	HITS-CLIP	19536157
MIRT724666	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT724665	hsa-miR-1286	HITS-CLIP	19536157
MIRT724664	hsa-miR-711	HITS-CLIP	19536157
MIRT724663	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT570234	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT570233	hsa-miR-8068	PAR-CLIP	20371350
MIRT570232	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT570231	hsa-miR-147a	PAR-CLIP	20371350
MIRT570230	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT570229	hsa-miR-4455	PAR-CLIP	20371350
MIRT570228	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT731610	hsa-miR-24-3p	Luciferase reporter assay, qRT-PCR, Western blot	27349868
MIRT731610	hsa-miR-24-3p	Luciferase reporter assay, qRT-PCR, Western blot	27349868
MIRT724671	hsa-miR-6165	HITS-CLIP	19536157
MIRT724670	hsa-miR-214-3p	HITS-CLIP	19536157
MIRT724669	hsa-miR-3619-5p	HITS-CLIP	19536157
MIRT724668	hsa-miR-761	HITS-CLIP	19536157
MIRT724667	hsa-miR-4530	HITS-CLIP	19536157
MIRT724666	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT724665	hsa-miR-1286	HITS-CLIP	19536157
MIRT724664	hsa-miR-711	HITS-CLIP	19536157
MIRT724663	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT570234	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT570233	hsa-miR-8068	PAR-CLIP	20371350
MIRT570232	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT570231	hsa-miR-147a	PAR-CLIP	20371350
MIRT570230	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT570229	hsa-miR-4455	PAR-CLIP	20371350
MIRT570228	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT1175714	hsa-miR-125a-5p	CLIP-seq
MIRT1175715	hsa-miR-125b	CLIP-seq
MIRT1175716	hsa-miR-1264	CLIP-seq
MIRT1175717	hsa-miR-1273f	CLIP-seq
MIRT1175718	hsa-miR-1290	CLIP-seq
MIRT1175719	hsa-miR-1343	CLIP-seq
MIRT1175720	hsa-miR-147	CLIP-seq
MIRT1175721	hsa-miR-183	CLIP-seq
MIRT1175722	hsa-miR-2113	CLIP-seq
MIRT1175723	hsa-miR-297	CLIP-seq
MIRT1175724	hsa-miR-3149	CLIP-seq
MIRT1175725	hsa-miR-3166	CLIP-seq
MIRT1175726	hsa-miR-3167	CLIP-seq
MIRT1175727	hsa-miR-3169	CLIP-seq
MIRT1175728	hsa-miR-3647-3p	CLIP-seq
MIRT1175729	hsa-miR-3685	CLIP-seq
MIRT1175730	hsa-miR-3690	CLIP-seq
MIRT1175731	hsa-miR-376c	CLIP-seq
MIRT1175732	hsa-miR-378g	CLIP-seq
MIRT1175733	hsa-miR-380	CLIP-seq
MIRT1175734	hsa-miR-384	CLIP-seq
MIRT1175735	hsa-miR-4254	CLIP-seq
MIRT1175736	hsa-miR-4271	CLIP-seq
MIRT1175737	hsa-miR-4282	CLIP-seq
MIRT1175738	hsa-miR-4287	CLIP-seq
MIRT1175739	hsa-miR-4319	CLIP-seq
MIRT1175740	hsa-miR-4324	CLIP-seq
MIRT1175741	hsa-miR-4469	CLIP-seq
MIRT1175742	hsa-miR-4495	CLIP-seq
MIRT1175743	hsa-miR-4504	CLIP-seq
MIRT1175744	hsa-miR-4515	CLIP-seq
MIRT1175745	hsa-miR-4534	CLIP-seq
MIRT1175746	hsa-miR-455-5p	CLIP-seq
MIRT1175747	hsa-miR-4685-3p	CLIP-seq
MIRT1175748	hsa-miR-4685-5p	CLIP-seq
MIRT1175749	hsa-miR-4716-3p	CLIP-seq
MIRT1175750	hsa-miR-4725-3p	CLIP-seq
MIRT1175751	hsa-miR-4732-3p	CLIP-seq
MIRT1175752	hsa-miR-4778-3p	CLIP-seq
MIRT1175753	hsa-miR-4802-5p	CLIP-seq
MIRT1175754	hsa-miR-508-3p	CLIP-seq
MIRT1175755	hsa-miR-542-3p	CLIP-seq
MIRT1175756	hsa-miR-567	CLIP-seq
MIRT1175757	hsa-miR-599	CLIP-seq
MIRT1175758	hsa-miR-625	CLIP-seq
MIRT1175759	hsa-miR-670	CLIP-seq
MIRT1175760	hsa-miR-876-5p	CLIP-seq
MIRT2050857	hsa-miR-1207-3p	CLIP-seq
MIRT2050858	hsa-miR-1302	CLIP-seq
MIRT2050859	hsa-miR-198	CLIP-seq
MIRT2050860	hsa-miR-2278	CLIP-seq
MIRT2050861	hsa-miR-4298	CLIP-seq
MIRT2050862	hsa-miR-520a-5p	CLIP-seq
MIRT2050863	hsa-miR-525-5p	CLIP-seq
MIRT2050864	hsa-miR-603	CLIP-seq
MIRT2279969	hsa-miR-1207-5p	CLIP-seq
MIRT2279970	hsa-miR-141	CLIP-seq
MIRT2279971	hsa-miR-149	CLIP-seq
MIRT2050859	hsa-miR-198	CLIP-seq
MIRT2279972	hsa-miR-200a	CLIP-seq
MIRT2050860	hsa-miR-2278	CLIP-seq
MIRT2279973	hsa-miR-24	CLIP-seq
MIRT2279974	hsa-miR-3154	CLIP-seq
MIRT2279975	hsa-miR-3155	CLIP-seq
MIRT2279976	hsa-miR-3155b	CLIP-seq
MIRT2279977	hsa-miR-3157-5p	CLIP-seq
MIRT2279978	hsa-miR-3183	CLIP-seq
MIRT2279979	hsa-miR-3925-3p	CLIP-seq
MIRT2279980	hsa-miR-4270	CLIP-seq
MIRT2279981	hsa-miR-4279	CLIP-seq
MIRT2279982	hsa-miR-4418	CLIP-seq
MIRT2279983	hsa-miR-4436b-3p	CLIP-seq
MIRT2279984	hsa-miR-4441	CLIP-seq
MIRT2279985	hsa-miR-4691-3p	CLIP-seq
MIRT2279986	hsa-miR-4723-3p	CLIP-seq
MIRT2279987	hsa-miR-4763-3p	CLIP-seq
MIRT2279988	hsa-miR-484	CLIP-seq
MIRT2279989	hsa-miR-509-3-5p	CLIP-seq
MIRT2279990	hsa-miR-509-5p	CLIP-seq
MIRT2050862	hsa-miR-520a-5p	CLIP-seq
MIRT2050863	hsa-miR-525-5p	CLIP-seq
MIRT2279991	hsa-miR-617	CLIP-seq
MIRT2279992	hsa-miR-651	CLIP-seq
MIRT2279993	hsa-miR-766	CLIP-seq
MIRT2279994	hsa-miR-935	CLIP-seq
MIRT2391405	hsa-miR-3151	CLIP-seq
MIRT2391406	hsa-miR-342-5p	CLIP-seq
MIRT2391407	hsa-miR-377	CLIP-seq
MIRT2391408	hsa-miR-4651	CLIP-seq
MIRT2391409	hsa-miR-4664-5p	CLIP-seq
MIRT2391410	hsa-miR-486-3p	CLIP-seq
MIRT2050864	hsa-miR-603	CLIP-seq
MIRT2391411	hsa-miR-608	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA	21873635
GO:0005509	Function	Calcium ion binding	IEA
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA	21873635
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030206	Process	Chondroitin sulfate biosynthetic process	TAS
GO:0030207	Process	Chondroitin sulfate catabolic process	TAS
GO:0030208	Process	Dermatan sulfate biosynthetic process	TAS
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0043202	Component	Lysosomal lumen	TAS

Other IDs

• MIM: 600826
• HGNC: 2465
• e!Ensembl: ENSG00000130287

Protein

• UniProt ID: O14594
• Protein name: Neurocan core protein (Chondroitin sulfate proteoglycan 3)
• Protein function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	43 → 158	Immunoglobulin V-set domain	Domain
  PF00193	Xlink	160 → 254	Extracellular link domain	Domain
  PF00193	Xlink	261 → 356	Extracellular link domain	Domain
  PF00008	EGF	1012 → 1042	EGF-like domain	Domain
  PF00059	Lectin_C	1105 → 1210	Lectin C-type domain	Domain
  PF00084	Sushi	1215 → 1271	Sushi repeat (SCR repeat)	Domain

• Sequence:

  MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCL
  FTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRR
  ANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQE
  ACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSY
  GRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEG
  LDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHH
  PTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILE
  EKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRR
  GRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSP
  WADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATP
  DLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAH
  GEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAE
  HSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQD
  PWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDA
  SGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPE
  PEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLL
  PVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHG
  GTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSF
  CEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGH
  ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPC
  NYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRS
  NGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNF
  C

• Sequence length: 1321

Pathways

Reactome:

A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22497794, 23795679, 25220293

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder, Depression, Bipolar		23795679, 23198940, 31043756, 25220293, 21353194, 23712748, 24955366, 31043756
Urinary bladder cancer	Malignant neoplasm of urinary bladder		26039340
Bladder neoplasm	Bladder Neoplasm		26039340
Depressed bipolar disorder	Depressed bipolar I disorder		31043756
Manic disorder	Manic, Manic Disorder		31043756
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease		21423719