TTC7B (tetratricopeptide repeat domain 7B)

Gene

• Entrez ID: 145567
• Gene name: Tetratricopeptide repeat domain 7B
• Gene symbol: TTC7B
• Synonyms: TTC7L1, c14_5685
• Chromosome: 14
• Chromosome location: 14q32.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020039	hsa-miR-375	Microarray	20215506
MIRT021405	hsa-miR-9-5p	Microarray	17612493
MIRT049562	hsa-miR-92a-3p	CLASH	23622248
MIRT1461870	hsa-miR-1245b-3p	CLIP-seq
MIRT1461871	hsa-miR-125a-3p	CLIP-seq
MIRT1461872	hsa-miR-127-5p	CLIP-seq
MIRT1461873	hsa-miR-1285	CLIP-seq
MIRT1461874	hsa-miR-1293	CLIP-seq
MIRT1461875	hsa-miR-1587	CLIP-seq
MIRT1461876	hsa-miR-183	CLIP-seq
MIRT1461877	hsa-miR-23a	CLIP-seq
MIRT1461878	hsa-miR-23b	CLIP-seq
MIRT1461879	hsa-miR-23c	CLIP-seq
MIRT1461880	hsa-miR-3128	CLIP-seq
MIRT1461881	hsa-miR-3150a-3p	CLIP-seq
MIRT1461882	hsa-miR-3151	CLIP-seq
MIRT1461883	hsa-miR-3175	CLIP-seq
MIRT1461884	hsa-miR-3187-5p	CLIP-seq
MIRT1461885	hsa-miR-3613-3p	CLIP-seq
MIRT1461886	hsa-miR-3665	CLIP-seq
MIRT1461887	hsa-miR-378g	CLIP-seq
MIRT1461888	hsa-miR-3921	CLIP-seq
MIRT1461889	hsa-miR-3926	CLIP-seq
MIRT1461890	hsa-miR-4314	CLIP-seq
MIRT1461891	hsa-miR-4316	CLIP-seq
MIRT1461892	hsa-miR-4330	CLIP-seq
MIRT1461893	hsa-miR-4446-5p	CLIP-seq
MIRT1461894	hsa-miR-4459	CLIP-seq
MIRT1461895	hsa-miR-4470	CLIP-seq
MIRT1461896	hsa-miR-4483	CLIP-seq
MIRT1461897	hsa-miR-4486	CLIP-seq
MIRT1461898	hsa-miR-4492	CLIP-seq
MIRT1461899	hsa-miR-4498	CLIP-seq
MIRT1461900	hsa-miR-4640-5p	CLIP-seq
MIRT1461901	hsa-miR-4649-3p	CLIP-seq
MIRT1461902	hsa-miR-4651	CLIP-seq
MIRT1461903	hsa-miR-4653-5p	CLIP-seq
MIRT1461904	hsa-miR-4655-3p	CLIP-seq
MIRT1461905	hsa-miR-4656	CLIP-seq
MIRT1461906	hsa-miR-4674	CLIP-seq
MIRT1461907	hsa-miR-4675	CLIP-seq
MIRT1461908	hsa-miR-4710	CLIP-seq
MIRT1461909	hsa-miR-4717-3p	CLIP-seq
MIRT1461910	hsa-miR-4722-5p	CLIP-seq
MIRT1461911	hsa-miR-4726-5p	CLIP-seq
MIRT1461912	hsa-miR-4736	CLIP-seq
MIRT1461913	hsa-miR-4741	CLIP-seq
MIRT1461914	hsa-miR-4755-5p	CLIP-seq
MIRT1461915	hsa-miR-4779	CLIP-seq
MIRT1461916	hsa-miR-4796-3p	CLIP-seq
MIRT1461917	hsa-miR-486-3p	CLIP-seq
MIRT1461918	hsa-miR-491-5p	CLIP-seq
MIRT1461919	hsa-miR-495	CLIP-seq
MIRT1461920	hsa-miR-505	CLIP-seq
MIRT1461921	hsa-miR-520g	CLIP-seq
MIRT1461922	hsa-miR-520h	CLIP-seq
MIRT1461923	hsa-miR-541	CLIP-seq
MIRT1461924	hsa-miR-608	CLIP-seq
MIRT1461925	hsa-miR-612	CLIP-seq
MIRT1461926	hsa-miR-640	CLIP-seq
MIRT1461927	hsa-miR-642a	CLIP-seq
MIRT1461928	hsa-miR-654-5p	CLIP-seq
MIRT1461929	hsa-miR-659	CLIP-seq
MIRT1461930	hsa-miR-762	CLIP-seq
MIRT1461931	hsa-miR-939	CLIP-seq
MIRT2138760	hsa-miR-1	CLIP-seq
MIRT2138761	hsa-miR-1207-3p	CLIP-seq
MIRT2138762	hsa-miR-138	CLIP-seq
MIRT1461875	hsa-miR-1587	CLIP-seq
MIRT2138763	hsa-miR-206	CLIP-seq
MIRT1461877	hsa-miR-23a	CLIP-seq
MIRT1461878	hsa-miR-23b	CLIP-seq
MIRT1461879	hsa-miR-23c	CLIP-seq
MIRT1461880	hsa-miR-3128	CLIP-seq
MIRT1461885	hsa-miR-3613-3p	CLIP-seq
MIRT1461895	hsa-miR-4470	CLIP-seq
MIRT2138764	hsa-miR-4473	CLIP-seq
MIRT1461898	hsa-miR-4492	CLIP-seq
MIRT1461899	hsa-miR-4498	CLIP-seq
MIRT1461905	hsa-miR-4656	CLIP-seq
MIRT2138765	hsa-miR-4663	CLIP-seq
MIRT1461906	hsa-miR-4674	CLIP-seq
MIRT1461907	hsa-miR-4675	CLIP-seq
MIRT1461913	hsa-miR-4741	CLIP-seq
MIRT2138766	hsa-miR-512-3p	CLIP-seq
MIRT2138767	hsa-miR-520f	CLIP-seq
MIRT2138768	hsa-miR-613	CLIP-seq
MIRT1461929	hsa-miR-659	CLIP-seq
MIRT1461930	hsa-miR-762	CLIP-seq
MIRT1461872	hsa-miR-127-5p	CLIP-seq
MIRT1461874	hsa-miR-1293	CLIP-seq
MIRT1461876	hsa-miR-183	CLIP-seq
MIRT2359640	hsa-miR-3127-3p	CLIP-seq
MIRT1461881	hsa-miR-3150a-3p	CLIP-seq
MIRT1461883	hsa-miR-3175	CLIP-seq
MIRT2359641	hsa-miR-3180	CLIP-seq
MIRT2359642	hsa-miR-3180-3p	CLIP-seq
MIRT2359643	hsa-miR-3189-3p	CLIP-seq
MIRT2359644	hsa-miR-3196	CLIP-seq
MIRT2359645	hsa-miR-4260	CLIP-seq
MIRT1461894	hsa-miR-4459	CLIP-seq
MIRT2138764	hsa-miR-4473	CLIP-seq
MIRT1461896	hsa-miR-4483	CLIP-seq
MIRT1461902	hsa-miR-4651	CLIP-seq
MIRT1461909	hsa-miR-4717-3p	CLIP-seq
MIRT1461910	hsa-miR-4722-5p	CLIP-seq
MIRT1461915	hsa-miR-4779	CLIP-seq
MIRT1461917	hsa-miR-486-3p	CLIP-seq
MIRT1461918	hsa-miR-491-5p	CLIP-seq
MIRT2138766	hsa-miR-512-3p	CLIP-seq
MIRT2138767	hsa-miR-520f	CLIP-seq
MIRT1461923	hsa-miR-541	CLIP-seq
MIRT1461924	hsa-miR-608	CLIP-seq
MIRT1461928	hsa-miR-654-5p	CLIP-seq
MIRT1461931	hsa-miR-939	CLIP-seq
MIRT1461881	hsa-miR-3150a-3p	CLIP-seq
MIRT1461883	hsa-miR-3175	CLIP-seq
MIRT1461918	hsa-miR-491-5p	CLIP-seq
MIRT1461923	hsa-miR-541	CLIP-seq
MIRT1461928	hsa-miR-654-5p	CLIP-seq
MIRT1461931	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23229899, 26571211, 32296183
GO:0005829	Component	Cytosol	IDA	23229899
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	23229899
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046854	Process	Phosphatidylinositol phosphorylation	IDA	23229899, 26571211
GO:0072659	Process	Protein localization to plasma membrane	IBA	21873635
GO:0072659	Process	Protein localization to plasma membrane	IDA	23229899, 26571211

Other IDs

• MIM: 620060
• HGNC: 19858
• e!Ensembl: ENSG00000165914

Protein

• UniProt ID: Q86TV6
• Protein name: Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)
• Protein function: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging
• PDB: 5DSE, 6BQ1, 9B9G, 9BAX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13181	TPR_8	397 → 430	Tetratricopeptide repeat	Repeat
  PF12895	ANAPC3	494 → 575		Domain
  PF13424	TPR_12	728 → 795		Repeat
  PF13181	TPR_8	798 → 831	Tetratricopeptide repeat	Repeat

• Sequence:

  MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEH
  PLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIY
  ARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
  DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVG
  RFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN
  TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
  SASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL
  KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTY
  SLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQ
  ALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD
  EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHA
  TSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQ
  EAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRY
  SLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP
  RVL

• Sequence length: 843

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	Cutaneous Melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	30429480

Unknown
Disease name	Disease term	dbSNP ID	References
Malignant melanoma of skin	Malignant melanoma of skin of lower limb, Malignant melanoma of skin of upper limb	rs16891982	30429480